Erik Gylfe

Kungl. Vetenskaps-Societetens ledamöter 1710–2025

Gylfe, Erik

Acta Universitatis Upsaliensis, 2025

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Bo Hellman, 19 June 1930-4 December 2023

Gylfe, Erik; Tengholm, Anders

Part of Diabetologia, p. 1165-1167, 2024

• DOI for Bo Hellman, 19 June 1930-4 December 2023

Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells

Yang, Mingyu; Dyachok, Oleg; Xu, Yunjian; Gylfe, Erik et al.

Part of Cellular Signalling, 2023

• DOI for Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells
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γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion

Yu, Qian; Lai, Bao Khanh; Ahooghalandari, Parvin; Helander, Anders et al.

Part of Journal of Biological Chemistry, 2020

• DOI for γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion
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Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Part of Diabetologia, p. 1212-1224, 2019

• DOI for Glucose controls glucagon secretion by directly modulating cAMP in alpha cells
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Bo Hellman, 19 June 1930-4 December 2023

Gylfe, Erik; Tengholm, Anders

Part of Diabetologia, p. 1165-1167, 2024

• DOI for Bo Hellman, 19 June 1930-4 December 2023

Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells

Yang, Mingyu; Dyachok, Oleg; Xu, Yunjian; Gylfe, Erik et al.

Part of Cellular Signalling, 2023

• DOI for Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells
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γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion

Yu, Qian; Lai, Bao Khanh; Ahooghalandari, Parvin; Helander, Anders et al.

Part of Journal of Biological Chemistry, 2020

• DOI for γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion
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Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Part of Diabetologia, p. 1212-1224, 2019

• DOI for Glucose controls glucagon secretion by directly modulating cAMP in alpha cells
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A genetically encoded low-affinity Ca2+ sensor unmasks autocrine purinergic signalling in beta cells

Yang, Mingyu; Idevall-Hagren, Olof; Gylfe, Erik; Tengholm, Anders

Part of Diabetologia, 2018

Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging

Shuai, Hongyan; Xu, Yunjian; Yu, Qian; Gylfe, Erik et al.

Part of Pflügers Archiv, p. 1765-1777, 2016

• DOI for Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging
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Glucose lowers cAMP to inhibit glucagon secretion by a direct effect on alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Part of Diabetologia, 2016

Submembrane ATP and Ca²⁺ kinetics in α‑cells: unexpected signaling for glucagon secretion

Li, Jia; Yu, Qian; Ahooghalandari, Parvin; Gribble, Fiona M et al.

Part of The FASEB Journal, p. 3379-3388, 2015

• DOI for Submembrane ATP and Ca²⁺ kinetics in α‑cells: unexpected signaling for glucagon secretion

Submembrane ATP and Ca2+ kinetics in alpha-cells: unexpected signaling for glucagon secretion

Li, Jia; Yu, Qian; Ahooghalandari, Parvin; Gribble, Fiona M. et al.

Part of The FASEB Journal, p. 3379-3388, 2015

• DOI for Submembrane ATP and Ca2+ kinetics in alpha-cells: unexpected signaling for glucagon secretion

Paradoxical Ca2+ kinetics in islet-located glucagon-releasing alpha cells

Yu, Qian; Li, Jia; Ahooghalandari, Parvin; Tengholm, Anders et al.

Part of Diabetologia, 2015

Paradoxical synchronisation of Ca2+ oscillations between alpha and beta cells within intact pancreatic islets

Yu, Qian; Li, Jia; Tengholm, Anders; Gylfe, Erik

Part of Diabetologia, 2014

Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+

Li, Jia; Shuai, Hongyan; Gylfe, Erik; Tengholm, Anders

Part of Diabetologia, p. 1577-1586, 2013

• DOI for Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+
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Glucose Control of Glucagon Secretion: There Is More to It Than K-ATP Channels

Gylfe, Erik

Part of Diabetes, p. 1391-1393, 2013

• DOI for Glucose Control of Glucagon Secretion: There Is More to It Than K-ATP Channels

cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells

Tian, Geng; Tepikin, Alexei V.; Tengholm, Anders; Gylfe, Erik

Part of Journal of Biological Chemistry, p. 9862-9872, 2012

• DOI for cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells
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Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon

Hellman, Bo; Salehi, Albert; Grapengiesser, Eva; Gylfe, Erik

Part of Biochemical and Biophysical Research Communications - BBRC, p. 1219-1223, 2012

• DOI for Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon

The Neurotransmitter ATP Triggers Ca²⁺ Responses Promoting Coordination of Pancreatic Islet Oscillations

Gylfe, Erik; Grapengiesser, Eva; Dansk, Heléne; Hellman, Bo

Part of Pancreas, p. 258-263, 2012

• DOI for The Neurotransmitter ATP Triggers Ca²⁺ Responses Promoting Coordination of Pancreatic Islet Oscillations

Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets

Tian, Geng; Sandler, Stellan; Gylfe, Erik; Tengholm, Anders

Part of Diabetes, p. 1535-1543, 2011

• DOI for Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets

Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet beta-Cells

Dezaki, Katsuya; Damdindorj, Boldbaatar; Sone, Hideyuki; Dyachok, Oleg et al.

Part of Diabetes, p. 2315-2324, 2011

• DOI for Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet beta-Cells

cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Idevall Hagren, Olof; Barg, Sebastian; Gylfe, Erik; Tengholm, Anders

Part of Journal of Biological Chemistry, p. 23005-23016, 2010

• DOI for cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Crosstalk between cAMP- and Zn2+-signalling in insulin secretion

Dyachok, Oleg; Idevall, Olof; Tengholm, Anders; Gylfe, Erik

Part of Diabetologia, 2010

Glucose regulation of STIM1 translocation reflecting store-operated channel modulation in pancreatic islet cells

Tian, Geng; Tepikin, A. V.; Tengholm, Anders; Gylfe, Erik

Part of Diabetologia, 2010

Glucose induces oscillations of the ATP/ADP ratio in individual beta cells

Li, Jia; Gylfe, Erik; Tengholm, Anders

Part of Diabetologia, 2010

Glucose generates coincident insulin and somatostatin pulses and anti-synchronous glucagon pulses from human pancreatic islets

Hellman, Bo; Salehi, Albert; Gylfe, Erik; Dansk, Heléne et al.

Part of Endocrinology, p. 5334-5340, 2009

• DOI for Glucose generates coincident insulin and somatostatin pulses and anti-synchronous glucagon pulses from human pancreatic islets

Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion

Dyachok, Oleg; Idevall-Hagren, Olof; Sågetorp, Jenny; Tian, Geng et al.

Part of Cell Metabolism, p. 26-37, 2008

• DOI for Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
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Insulinoscillationer - en kliniskt betydelsefull rytmik. Diabetesläkemedel bör öka den pulsatila komponenten av insulinfrisättningen: Insulin oscillations -- clinically important rhythm. Antidiabetics should increase the pulsatile component of insulin release

Hellman, Bo; Gylfe, Erik; Grapengiesser, Eva; Dansk, Helene et al.

Part of Läkartidningen, p. 2236-2239, 2007

Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells

Vieira, Elaine; Salehi, Albert; Gylfe, Erik

Part of Diabetologia, p. 370-379, 2007

• DOI for Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells
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Paradoxical stimulation of glucagon secretion by high glucose concentrations

Salehi, Albert; Vieira, Elaine; Gylfe, Erik

Part of Diabetes, p. 2318-2323, 2006

• DOI for Paradoxical stimulation of glucagon secretion by high glucose concentrations
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Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca²⁺ in insulin-secreting β-cells

Thore, Sophia; Dyachok, Oleg; Gylfe, Erik; Tengholm, Anders

Part of Journal of Cell Science, p. 4463-4471, 2005

• DOI for Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca²⁺ in insulin-secreting β-cells
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Protein Kinase C Modulates Agonist-sensitive Release of Ca2+ from Internal Stores in HEK293 Cells Overexpressing the Calcium Sensing Receptor.

Sakwe, Amos M; Rask, Lars; Gylfe, Erik

Part of J Biol Chem, p. 4436-41, 2005

Ca²⁺-induced Ca²⁺ release by activation of inositol 1,4,5-trisphosphate receptors in primary pancreatic β-cells

Dyachok, Oleg; Tufveson, Gunnar; Gylfe, Erik

Part of Cell Calcium, p. 1-9, 2004

• DOI for Ca²⁺-induced Ca²⁺ release by activation of inositol 1,4,5-trisphosphate receptors in primary pancreatic β-cells
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Ca²+-induced Ca²+ Release via Inositol 1,4,5-trisphosphate Receptors Is Amplified by Protein Kinase A and Triggers Exocytosis in Pancreatic β-Cells

Dyachok, Oleg; Gylfe, Erik

Part of Journal of Biological Chemistry, p. 45455-45461, 2004

• DOI for Ca²+-induced Ca²+ Release via Inositol 1,4,5-trisphosphate Receptors Is Amplified by Protein Kinase A and Triggers Exocytosis in Pancreatic β-Cells
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A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic Alfa-cell

Liu, Yi-Jia; Vieira, Elaine; Gylfe, Erik

Part of Cell Calcium, p. 357-365, 2004

Involvement of Alfa1 and Beta-adrenoceptors in adrenaline stimulation fo the glucagon-secreting mouse Alfa-cell

Vieira, Elaine; Liu, Yi-Jia; Gylfe, Erik

Part of Naunyn-Schmiedeberg´s Arch Pharmacol, p. 179-183, 2004

The Hepatitis C Virus Core Protein Modulates T Cell Responses by Inducing Spontaneous and Altering T-cell Receptor-triggered Ca²⁺ Oscillations

Bergqvist, Anders; Sundström, Sara; Dimberg, Lina Y.; Gylfe, Erik et al.

Part of Journal of Biological Chemistry, p. 18877-18883, 2003

• DOI for The Hepatitis C Virus Core Protein Modulates T Cell Responses by Inducing Spontaneous and Altering T-cell Receptor-triggered Ca²⁺ Oscillations

Store-operated influx of Ca²⁺ in the pancreatic β-cells exhibits graded dependence on the filling of the endoplasmic reticulum

Dyachok, Oleg; Gylfe, Erik

Part of Journal of Cell Science, p. 2179-2186, 2001

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Defective glucose-dependent cytosolic Ca2+ handling in islets of GK and nSTZ rat models of type 2 diabetes

Marie, JC; Bailbe, D; Gylfe, Erik; Portha, B

Part of J Endocrinol, p. 169, 2001

Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the Interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells

Lindholm, Cecilia K; Gylfe, Erik; Zhang, Weigu; Samelson, Lawrence E et al.

Part of Journal of Biological Chemistry, p. 28050-28057, 1999

• DOI for Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the Interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells

Oscillatory Ca2+ signaling in somatostatin-producing cells from the human pancreas

Berts, Alf; Liu, Yi-Jia; Gylfe, Erik; Hellman, Bo

Part of Metabolism, p. 366-369, 1997

• DOI for Oscillatory Ca2+ signaling in somatostatin-producing cells from the human pancreas

Suppression of Ca2+ oscillations in glucagon-producing alfa2-cells by insulin/glucose and amino acids

Berts, Alf; Ball, Andrew; Gylfe, Erik; Hellman, Bo

Part of Biochimica et Biophysica Acta, p. 212-216, 1996

Glucose stimulation of somatostatin-producing islet cells involves oscillatory Ca2+ signaling

Berts, A; Dryselius, S; Gylfe, E; Hellman, B

Part of Endocrinology, p. 693, 1996

Glucose induces oscillations of cytoplasmic Ca2+, Sr2+ and Ba2+ in pancreatic beta-cells without participation of the thapsigargin-sensitive store

Liu, Y-J; Grapengiesser, Eva; Gylfe, Erik; Hellman, Bo

Part of Cell Calcium, p. 165-173, 1995

Coincidence of early glucose-induced depolarization with lowering of cytoplasmic Ca2+ in mouse pancreatic beta-cells

Chow, R H; Lund, P-E; Löser, S; Panten, U et al.

Part of Journal of Physiology, p. 607-617, 1995

Ca2+-induced Ca2+ oscillations in parathyroid cells

Ridefelt, Peter; Bjorklund, E; Åkerström, Göran; Olsson, MJ et al.

Part of Biochem Biophys Rew Commun, p. 903, 1995

Effects of the antihypercalcemic drugs gallium nitrate and pamidronate on hormone release of pathologic human parathyroid cells

Ridelfelt, Peter; Gylfe, Erik; Åkerström, Göran; Ljunghall, Sverker et al.

Part of Surgery, p. 56, 1995

Glucose controls glucagon secretion by directly modulating cAMP in α‑cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

cAMP signalling in insulin and glucagon secretion

Tengholm, Anders; Gylfe, Erik

Part of Diabetes, obesity and metabolism, p. 42-53, 2017

• DOI for cAMP signalling in insulin and glucagon secretion

Glucose control of glucagon secretion: 'There's a brand-new gimmick every year'

Gylfe, Erik

Part of Upsala Journal of Medical Sciences, p. 120-132, 2016

• DOI for Glucose control of glucagon secretion: 'There's a brand-new gimmick every year'
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Neurotransmitter control of islet hormone pulsatility

Gylfe, Erik; Tengholm, Anders

Part of Diabetes, obesity and metabolism, p. 102-110, 2014

• DOI for Neurotransmitter control of islet hormone pulsatility

Glucose regulation of glucagon secretion

Gylfe, Erik; Gilon, Patrick

Part of Diabetes Research and Clinical Practice, p. 1-10, 2014

• DOI for Glucose regulation of glucagon secretion

Oscillatory control of insulin secretion

Tengholm, Anders; Gylfe, Erik

Part of Molecular and Cellular Endocrinology, p. 58-72, 2009

• DOI for Oscillatory control of insulin secretion
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Kungl. Vetenskaps-Societetens ledamöter 1710–2025

Gylfe, Erik

Acta Universitatis Upsaliensis, 2025

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Ca2+ signalling underlying pulsatile insulin secretion

Gylfe, Erik

Part of Diabetes mellitus combat the challenge, p. 96-115, 2005

Department of Medical Cell Biology: Annual Report 2013

Gylfe, Erik

Uppsala universitet, 2014

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Department of Medical Cell Biology: Annual Report 2012

Gylfe, Erik

Institutionen för medicinsk cellbiologi, 2013

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Department of Medical Cell Biology: Annual Report 2011

Gylfe, Erik

Institutionen för medicinsk cellbiologi, 2012

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Department of Medical Cell Biology: Annual Report 2010

Gylfe, Erik

Institutionen för medicinsk cellbiologi, Uppsala universitet, 2011

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Department of Medical Cell Biology: Annual Report 2009

Gylfe, Erik

Institutionen för medicinsk cellbiologi, Uppsala universitet, 2010

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Quantitative assessment of glucose-regulated cAMP signalling and protein kinase A-mediated glucagon secretion.

Yu, Qian; Gylfe, Erik; Tengholm, Anders