Anders Tengholm

Mechanistic insights and approaches for beta cell regeneration

Karampelias, Christos; Liu, Ka-Cheuk; Tengholm, Anders; Andersson, Olov

Ingår i Nature Chemical Biology, s. 807-818, 2025

• DOI för Mechanistic insights and approaches for beta cell regeneration

Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes

Yang, Mingyu; Mandal, Kousik; Södergren, Moa; Dumral, Özge et al.

Ingår i Acta Physiologica, 2025

• DOI för Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes
• Ladda ner fulltext (pdf) av Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes

OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

Panagiotou, Styliani; Tan, Kia Wee; Nguyen, Phuoc My; Mueller, Andreas et al.

Ingår i Cell Reports, 2024

• DOI för OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion
• Ladda ner fulltext (pdf) av OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

Bo Hellman, 19 June 1930-4 December 2023

Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, s. 1165-1167, 2024

• DOI för Bo Hellman, 19 June 1930-4 December 2023

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Ingår i Diabetologia, s. 1642-1662, 2024

• DOI för RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
• Ladda ner fulltext (pdf) av RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes

Yang, Mingyu; Mandal, Kousik; Södergren, Moa; Dumral, Özge et al.

Ingår i Acta Physiologica, 2025

• DOI för Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes
• Ladda ner fulltext (pdf) av Real-time detection of somatostatin release from single islets reveals hypersecretion in type 2 diabetes

OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

Panagiotou, Styliani; Tan, Kia Wee; Nguyen, Phuoc My; Mueller, Andreas et al.

Ingår i Cell Reports, 2024

• DOI för OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion
• Ladda ner fulltext (pdf) av OSBP-mediated PI(4)P-cholesterol exchange at endoplasmic reticulum-secretory granule contact sites controls insulin secretion

Bo Hellman, 19 June 1930-4 December 2023

Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, s. 1165-1167, 2024

• DOI för Bo Hellman, 19 June 1930-4 December 2023

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Ingår i Diabetologia, s. 1642-1662, 2024

• DOI för RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
• Ladda ner fulltext (pdf) av RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Insulin release from isolated cat islets of Langerhans

Strage, Emma M.; Ley, Cecilia; Westermark, Gunilla T.; Tengholm, Anders

Ingår i Domestic Animal Endocrinology, 2024

• DOI för Insulin release from isolated cat islets of Langerhans
• Ladda ner fulltext (pdf) av Insulin release from isolated cat islets of Langerhans

Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells

Yang, Mingyu; Dyachok, Oleg; Xu, Yunjian; Gylfe, Erik et al.

Ingår i Cellular Signalling, 2023

• DOI för Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells
• Ladda ner fulltext (pdf) av Indicator-dependent differences in detection of local intracellular Ca2+release events evoked by voltage-gated Ca2+entry in pancreatic & beta;-cells

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Ingår i Nature Biotechnology, s. 1042-1055, 2022

• DOI för Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
• Ladda ner fulltext (pdf) av Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

Vishnu, N.; Hamilton, A.; Bagge, A.; Wernersson, A. et al.

Ingår i Molecular Metabolism, 2021

• DOI för Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion

Glucose-induced cAMP elevation in β-cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling

Shuai, Hongyan; Xu, Yunjian; Ahooghalandari, Parvin; Tengholm, Anders

Ingår i Acta Physiologica, 2021

• DOI för Glucose-induced cAMP elevation in β-cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling
• Ladda ner fulltext (pdf) av Glucose-induced cAMP elevation in β-cells involves amplification of constitutive and glucagon-activated GLP-1 receptor signalling

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Ingår i Nature Communications, 2020

• DOI för Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
• Ladda ner fulltext (pdf) av Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion

Yu, Qian; Lai, Bao Khanh; Ahooghalandari, Parvin; Helander, Anders et al.

Ingår i Journal of Biological Chemistry, 2020

• DOI för γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion
• Ladda ner fulltext (pdf) av γ-Hydroxybutyrate does not mediate glucose inhibition of glucagon secretion

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Petrenko, Volodymyr; Gandasi, Nikhil; Sage, Daniel; Tengholm, Anders et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 2484-2495, 2020

• DOI för In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis
• Ladda ner fulltext (pdf) av In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Cyclic AMP links glucose stimulation to somatostatin secretion in delta-cells

Tengholm, Anders

Ingår i The Journal of General Physiology, s. 1062-1065, 2019

• DOI för Cyclic AMP links glucose stimulation to somatostatin secretion in delta-cells

Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB

Pietilä, Ilkka; van Mourik, Djenolan; Tamelander, Andreas; Kriz, Vitezslav et al.

Ingår i Cells, 2019

• DOI för Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB
• Ladda ner fulltext (pdf) av Temporal Dynamics of VEGFA-Induced VEGFR2/FAK Co-Localization Depend on SHB

A membrane permeable prodrug of S223 for selective Epac2 activation in living cells

Xu, Yunjian; Schwede, Frank; Wienk, Hans; Tengholm, Anders et al.

Ingår i Cells, 2019

• DOI för A membrane permeable prodrug of S223 for selective Epac2 activation in living cells
• Ladda ner fulltext (pdf) av A membrane permeable prodrug of S223 for selective Epac2 activation in living cells

Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Ingår i Diabetologia, s. 1212-1224, 2019

• DOI för Glucose controls glucagon secretion by directly modulating cAMP in alpha cells
• Ladda ner fulltext (pdf) av Glucose controls glucagon secretion by directly modulating cAMP in alpha cells

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Gucek, Alenka; Gandasi, Nikhil R; Omar-Hmeadi, Muhmmad; Bakke, Marit et al.

Ingår i eLIFE, 2019

• DOI för Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
• Ladda ner fulltext (pdf) av Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Mojtaba Ghiasi, Seyed; Dahlby, Tina; Hede Andersen, Caroline; Haataja, Leena et al.

Ingår i Diabetes, s. 747-760, 2019

• DOI för The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells

Wang, Xuan; Jiang, Lin; Wallerman, Ola; Younis, Shady et al.

Ingår i The FASEB Journal, s. 88-100, 2019

• DOI för ZBED6 negatively regulates insulin production, neuronal differentiation, and cell aggregation in MIN6 cells

Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Ingår i EBioMedicine, 2018

• DOI för Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
• Ladda ner fulltext (pdf) av Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

A genetically encoded low-affinity Ca2+ sensor unmasks autocrine purinergic signalling in beta cells

Yang, Mingyu; Idevall-Hagren, Olof; Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, 2018

Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Alenkvist, Ida; Gandasi, Nikhil R; Barg, Sebastian; Tengholm, Anders

Ingår i Diabetes, s. 2610-2622, 2017

• DOI för Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging

Shuai, Hongyan; Xu, Yunjian; Yu, Qian; Gylfe, Erik et al.

Ingår i Pflügers Archiv, s. 1765-1777, 2016

• DOI för Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging
• Ladda ner fulltext (pdf) av Fluorescent protein vectors for pancreatic islet cell identification in live-cell imaging

Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

Tuomi, Tiinamaija; Nagorny, Cecilia L. F.; Singh, Pratibha; Bennet, Hedvig et al.

Ingår i Cell Metabolism, s. 1067-1077, 2016

• DOI för Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes

Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in beta Cells

Wuttke, Anne; Yu, Qian; Tengholm, Anders

Ingår i Journal of Biological Chemistry, s. 14986-14995, 2016

• DOI för Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in beta Cells
• Ladda ner fulltext (pdf) av Autocrine Signaling Underlies Fast Repetitive Plasma Membrane Translocation of Conventional and Novel Protein Kinase C Isoforms in beta Cells

CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

Abels, Mia; Riva, Matteo; Bennet, Hedvig; Ahlqvist, Emma et al.

Ingår i Diabetologia, s. 1928-1937, 2016

• DOI för CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion

Glucose lowers cAMP to inhibit glucagon secretion by a direct effect on alpha cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Ingår i Diabetologia, 2016

ZBED6 negatively regulates insulin content, glucose-stimulated insulin secretion, neuronal differentiation and cell aggregation in MIN6 cells

Wang, Xuan; Jiang, L.; Wallerman, Ola; Yu, Qian et al.

Ingår i Diabetologia, 2016

Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide

Wan Saudi, Wan Salman; Halim, Mohammed Abdul; Gillberg, Linda; Rudholm-Feldreich, Tobias et al.

Ingår i American Journal of Physiology - Gastrointestinal and Liver Physiology, 2015

• DOI för Neuropeptide S inhibits gastrointestinal motility and increases mucosal permeability through nitric oxide

Prolonged exposure to palmitate deteriorates glucose-induced cAMP generation and pulsatile insulin secretion

Tian, Geng; Tengholm, Anders

Ingår i Diabetes/Metabolism Research Reviews, s. 9-10, 2015

Submembrane ATP and Ca²⁺ kinetics in α‑cells: unexpected signaling for glucagon secretion

Li, Jia; Yu, Qian; Ahooghalandari, Parvin; Gribble, Fiona M et al.

Ingår i The FASEB Journal, s. 3379-3388, 2015

• DOI för Submembrane ATP and Ca²⁺ kinetics in α‑cells: unexpected signaling for glucagon secretion

Submembrane ATP and Ca2+ kinetics in alpha-cells: unexpected signaling for glucagon secretion

Li, Jia; Yu, Qian; Ahooghalandari, Parvin; Gribble, Fiona M. et al.

Ingår i The FASEB Journal, s. 3379-3388, 2015

• DOI för Submembrane ATP and Ca2+ kinetics in alpha-cells: unexpected signaling for glucagon secretion

Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate

Tian, Geng; Sol, Eri Maria; Xu, Yunjian; Shuai, Hongyan et al.

Ingår i Diabetes, s. 904-915, 2015

• DOI för Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate
• Ladda ner fulltext (pdf) av Impaired cAMP generation contributes to defective glucose-stimulated insulin secretion after long-term exposure to palmitate

Paradoxical Ca2+ kinetics in islet-located glucagon-releasing alpha cells

Yu, Qian; Li, Jia; Ahooghalandari, Parvin; Tengholm, Anders et al.

Ingår i Diabetologia, 2015

CART is a novel glucose-dependent peptide with antidiabetic actions in humans

Abels, M.; Riva, M.; Poon, W.; Bennet, H. et al.

Ingår i Diabetologia, 2015

Purinergic P2Y1 receptors take centre stage in autocrine stimulation of human beta cells

Tengholm, Anders

Ingår i Diabetologia, s. 2436-2439, 2014

• DOI för Purinergic P2Y1 receptors take centre stage in autocrine stimulation of human beta cells
• Ladda ner fulltext (pdf) av Purinergic P2Y1 receptors take centre stage in autocrine stimulation of human beta cells

Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets

Alenkvist, Ida; Dyachok, Oleg; Tian, Geng; Li, Jia et al.

Ingår i Journal of Endocrinology, s. 267-275, 2014

• DOI för Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets
• Ladda ner fulltext (pdf) av Absence of Shb impairs insulin secretion by elevated FAK activity in pancreatic islets

Paradoxical synchronisation of Ca2+ oscillations between alpha and beta cells within intact pancreatic islets

Yu, Qian; Li, Jia; Tengholm, Anders; Gylfe, Erik

Ingår i Diabetologia, 2014

P2Y₁ receptor-dependent diacylglycerol signaling microdomains in β cells promote insulin secretion

Wuttke, Anne; Idevall-Hagren, Olof; Tengholm, Anders

Ingår i The FASEB Journal, s. 1610-1620, 2013

• DOI för P2Y₁ receptor-dependent diacylglycerol signaling microdomains in β cells promote insulin secretion

Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic beta Cells

Idevall-Hagren, Olof; Jakobsson, Ida; Xu, Yunjian; Tengholm, Anders

Ingår i Science Signaling, 2013

• DOI för Spatial Control of Epac2 Activity by cAMP and Ca2+-Mediated Activation of Ras in Pancreatic beta Cells

Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl

Mokhtari, Dariush; Al-Amin, Abdullah; Turpaev, Kyrill; Li, Tingting et al.

Ingår i Diabetologia, s. 1327-1338, 2013

• DOI för Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl
• Ladda ner fulltext (pdf) av Imatinib mesilate-induced phosphatidylinositol 3-kinase signalling and improved survival in insulin-producing cells: role of Src homology 2-containing inositol 5'-phosphatase interaction with c-Abl

The role of mechanical force and ROS in integrin-dependent signals

Zeller, Kathrin Stephanie; Riaz, Anjum; Sarve, Hamid; Li, Jia et al.

Ingår i PLOS ONE, 2013

• DOI för The role of mechanical force and ROS in integrin-dependent signals
• Ladda ner fulltext (pdf) av The role of mechanical force and ROS in integrin-dependent signals

DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms

Hoivik, Erling A.; Witsoe, Solveig L.; Bergheim, Inger R.; Xu, Yunjian et al.

Ingår i PLOS ONE, 2013

• DOI för DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms
• Ladda ner fulltext (pdf) av DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms

Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

Zang, Guangxiang; Christoffersson, Gustaf; Tian, Geng; Harun-Or-Rashid, Mohammad et al.

Ingår i Cellular Signalling, s. 85-92, 2013

• DOI för Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells
• Ladda ner fulltext (pdf) av Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

Autocrine signals mediate plasma membrane translocation of protein kinase C in insulin-secreting cells

Tengholm, Anders; Wuttke, Anne

Ingår i Diabetologia, 2013

Functional differences between aggregated and dispersed insulin-producing cells

Chowdhury, Azazul Islam; Dyachok, Oleg; Tengholm, Anders; Sandler, Stellan et al.

Ingår i Diabetologia, s. 1557-1568, 2013

• DOI för Functional differences between aggregated and dispersed insulin-producing cells
• Ladda ner fulltext (pdf) av Functional differences between aggregated and dispersed insulin-producing cells

Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+

Li, Jia; Shuai, Hongyan; Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, s. 1577-1586, 2013

• DOI för Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+
• Ladda ner fulltext (pdf) av Oscillations of sub-membrane ATP in glucose-stimulated beta cells depend on negative feedback from Ca2+

Prolonged exposure to palmitate deteriorates glucose-induced cAMP generation and pulsatile insulin secretion

Tian, Geng; Sol, E. -RM.; Xu, Yunjian; Tengholm, Anders

Ingår i Diabetologia, 2013

cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells

Tian, Geng; Tepikin, Alexei V.; Tengholm, Anders; Gylfe, Erik

Ingår i Journal of Biological Chemistry, s. 9862-9872, 2012

• DOI för cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells
• Ladda ner fulltext (pdf) av cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells

Anchored phosphatases modulate glucose homeostasis

Hinke, Simon A.; Navedo, Manuel F.; Ulman, Allison; Whiting, Jennifer L. et al.

Ingår i EMBO Journal, s. 3991-4004, 2012

• DOI för Anchored phosphatases modulate glucose homeostasis

Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion

Tian, Geng; Sågetorp, Jenny; Xu, Yunjian; Shuai, Hongyan et al.

Ingår i Journal of Cell Science, s. 5084-5095, 2012

• DOI för Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion

Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets

Tian, Geng; Sandler, Stellan; Gylfe, Erik; Tengholm, Anders

Ingår i Diabetes, s. 1535-1543, 2011

• DOI för Glucose- and Hormone-Induced cAMP Oscillations in α- and β-Cells Within Intact Pancreatic Islets

Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet beta-Cells

Dezaki, Katsuya; Damdindorj, Boldbaatar; Sone, Hideyuki; Dyachok, Oleg et al.

Ingår i Diabetes, s. 2315-2324, 2011

• DOI för Ghrelin Attenuates cAMP-PKA Signaling to Evoke Insulinostatic Cascade in Islet beta-Cells

PI3-kinase p110 alpha mediates beta 1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading

Zeller, Kathrin S.; Idevall Hagren, Olof; Stefansson, Anne; Velling, Teet et al.

Ingår i Cellular Signalling, s. 1838-1848, 2010

• DOI för PI3-kinase p110 alpha mediates beta 1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading

Ca2+ and cAMP Signaling in Human Embryonic Stem Cell-Derived Dopamine Neurons

Malmersjö, Seth; Liste, Isabel; Dyachok, Oleg; Tengholm, Anders et al.

Ingår i Stem Cells and Development, s. 1355-1364, 2010

• DOI för Ca2+ and cAMP Signaling in Human Embryonic Stem Cell-Derived Dopamine Neurons

Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane

Hafizi, Sassan; Gustafsson, Anna; Oslakovic, Cecilia; Idevall-Hagren, Olof et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 396-401, 2010

• DOI för Tensin2 reduces intracellular phosphatidylinositol 3,4,5-trisphosphate levels at the plasma membrane

Glucose induces oscillations of the ATP/ADP ratio in individual beta cells

Li, Jia; Gylfe, Erik; Tengholm, Anders

Ingår i Diabetologia, 2010

Glucose regulation of STIM1 translocation reflecting store-operated channel modulation in pancreatic islet cells

Tian, Geng; Tepikin, A. V.; Tengholm, Anders; Gylfe, Erik

Ingår i Diabetologia, 2010

Crosstalk between cAMP- and Zn2+-signalling in insulin secretion

Dyachok, Oleg; Idevall, Olof; Tengholm, Anders; Gylfe, Erik

Ingår i Diabetologia, 2010

Spatial control of Epac2 by cAMP and Ca2+

Idevall, Olof; Tengholm, Anders

Ingår i Diabetologia, 2010

cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Idevall Hagren, Olof; Barg, Sebastian; Gylfe, Erik; Tengholm, Anders

Ingår i Journal of Biological Chemistry, s. 23005-23016, 2010

• DOI för cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Ultraviolet becomes accessible

Illy, Elizabeth; Tengholm, Anders

Ingår i BioOptics World, s. 22-26, 2010

Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P₂ dynamics in secretagogue-stimulated β-cells

Wuttke, Anne; Sågetorp, Jenny; Tengholm, Anders

Ingår i Journal of Cell Science, s. 1492-1502, 2010

• DOI för Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P₂ dynamics in secretagogue-stimulated β-cells

Wnt-5a-induced Phosphorylation of DARPP-32 Inhibits Breast Cancer Cell Migration in a CREB-dependent Manner

Hansen, Christian; Howlin, Jillian; Tengholm, Anders; Dyachok, Oleg et al.

Ingår i Journal of Biological Chemistry, s. 27533-27543, 2009

• DOI för Wnt-5a-induced Phosphorylation of DARPP-32 Inhibits Breast Cancer Cell Migration in a CREB-dependent Manner

Capacitative Ca2+ Entry via Orai1 and Stromal Interacting Molecule 1 (STIM1) Regulates Adenylyl Cyclase Type 8

Martin, Agnes C. L.; Willoughby, Debbie; Ciruela, Antonio; Ayling, Laura-Jo et al.

Ingår i Molecular Pharmacology, s. 830-842, 2009

• DOI för Capacitative Ca2+ Entry via Orai1 and Stromal Interacting Molecule 1 (STIM1) Regulates Adenylyl Cyclase Type 8

Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion

Dyachok, Oleg; Idevall-Hagren, Olof; Sågetorp, Jenny; Tian, Geng et al.

Ingår i Cell Metabolism, s. 26-37, 2008

• DOI för Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion
• Ladda ner fulltext (pdf) av Glucose-induced cyclic AMP oscillations regulate pulsatile insulin secretion

Cyclic AMP: swing that message!

Tengholm, Anders

Ingår i Cellular and Molecular Life Sciences (CMLS), s. 382-385, 2007

• DOI för Cyclic AMP: swing that message!

Rapid turnover of phosphatidylinositol-4,5-bisphosphate in insulin-secreting cells mediated by Ca2+ and the ATP-to-ADP ratio

Thore, Sophia; Wuttke, Anne; Tengholm, Anders

Ingår i Diabetes, s. 818-826, 2007

• DOI för Rapid turnover of phosphatidylinositol-4,5-bisphosphate in insulin-secreting cells mediated by Ca2+ and the ATP-to-ADP ratio

Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion

Zhang, Fan; Zhang, Qimin; Tengholm, Anders; Sjöholm, Åke

Ingår i American Journal of Physiology - Cell Physiology, 2006

• DOI för Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion

Glucose and insulin synergistically activate phosphatidylinositol 3-kinase to trigger oscillations of phosphatidylinositol 3,4,5-trisphosphate in beta-cells

Idevall Hagren, Olof; Tengholm, Anders

Ingår i Journal of Biological Chemistry, s. 39121-39127, 2006

• DOI för Glucose and insulin synergistically activate phosphatidylinositol 3-kinase to trigger oscillations of phosphatidylinositol 3,4,5-trisphosphate in beta-cells

cAMP oscillations restrict protein kinase A redistribution in insulin-secreting cells.

Dyachok, O; Sagetorp, J; Isakov, Y; Tengholm, A

Ingår i Biochem Soc Trans, s. 498-501, 2006

Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells.

Dyachok, Oleg; Isakov, Yegor; Sågetorp, Jenny; Tengholm, Anders

Ingår i Nature, s. 349-52, 2006

Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca²⁺ in insulin-secreting β-cells

Thore, Sophia; Dyachok, Oleg; Gylfe, Erik; Tengholm, Anders

Ingår i Journal of Cell Science, s. 4463-4471, 2005

• DOI för Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca²⁺ in insulin-secreting β-cells
• Ladda ner fulltext (pdf) av Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca²⁺ in insulin-secreting β-cells

siRNA Produced by Recombinant Dicer Mediates Efficient Gene Silencing in Islet Cells.

Hägerkvist, Robert; Mokhtari, Dariush; Myers, Jason W; Tengholm, Anders et al.

Ingår i Ann N Y Acad Sci, s. 114-22, 2005

Oscillations of Phospholipase C Activity Triggered by Depolarizatio and Ca2+ Influx in Insulin-secreting Cells

Thore, Sophia; Dyachok, Oleg; Tengholm, Anders

Ingår i The Journal of Biological Chemistry (JBC), s. 19396-19400, 2004

Glucose controls glucagon secretion by directly modulating cAMP in α‑cells

Yu, Qian; Shuai, Hongyan; Ahooghalandari, Parvin; Gylfe, Erik et al.

Mechanistic insights and approaches for beta cell regeneration

Karampelias, Christos; Liu, Ka-Cheuk; Tengholm, Anders; Andersson, Olov

Ingår i Nature Chemical Biology, s. 807-818, 2025

• DOI för Mechanistic insights and approaches for beta cell regeneration

Metabolic regulation of calcium signaling in beta cells

Idevall Hagren, Olof; Tengholm, Anders

Ingår i Seminars in Cell and Developmental Biology, s. 20-30, 2020

• DOI för Metabolic regulation of calcium signaling in beta cells

cAMP signalling in insulin and glucagon secretion

Tengholm, Anders; Gylfe, Erik

Ingår i Diabetes, obesity and metabolism, s. 42-53, 2017

• DOI för cAMP signalling in insulin and glucagon secretion

Neurotransmitter control of islet hormone pulsatility

Gylfe, Erik; Tengholm, Anders

Ingår i Diabetes, obesity and metabolism, s. 102-110, 2014

• DOI för Neurotransmitter control of islet hormone pulsatility

Cyclic AMP dynamics in the pancreatic beta-cell

Tengholm, Anders

Ingår i Upsala Journal of Medical Sciences, s. 355-369, 2012

• DOI för Cyclic AMP dynamics in the pancreatic beta-cell

Oscillatory control of insulin secretion

Tengholm, Anders; Gylfe, Erik

Ingår i Molecular and Cellular Endocrinology, s. 58-72, 2009

• DOI för Oscillatory control of insulin secretion
• Ladda ner fulltext (pdf) av Oscillatory control of insulin secretion

Spatio-Temporal Dynamics of Phosphatidylinositol-3,4,5-Trisphosphate Signalling

Tengholm, Anders; Idevall-Hagren, Olof

Ingår i Vitamines and Hormones, s. 287-311, 2009

• DOI för Spatio-Temporal Dynamics of Phosphatidylinositol-3,4,5-Trisphosphate Signalling

Fluorescent Translocation Reporters for Sub–plasma Membrane cAMP Imaging

Dyachok, Oleg; Xu, Yunjian; Idevall, Olof; Tengholm, Anders

Ingår i cAMP Signaling, s. 319-338, Humana Press, 2022

• DOI för Fluorescent Translocation Reporters for Sub–plasma Membrane cAMP Imaging

Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters

Tengholm, Anders; Idevall-Hagren, Olof

Ingår i cAMP Signaling, s. 85-101, Springer-Verlag New York, 2015

• DOI för Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters
• Ladda ner fulltext (pdf) av Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters

Imaging phosphoinositide dynamics in living cells

Wuttke, Anne; Idevall-Hagren, Olof; Tengholm, Anders

Ingår i Inositol Phosphates and Lipids, s. 219-235, Humana Press, 2010

• DOI för Imaging phosphoinositide dynamics in living cells
• Ladda ner fulltext (pdf) av Imaging phosphoinositide dynamics in living cells

Exocytotic release of ATP triggers diacylglycerol spiking in insulin-secreting cells

Wuttke, Anne; Idevall-Hagren, Olof; Tengholm, Anders

Ingår i Minutes Of The 46th General Assembly Of The European Association For The Study Of Diabetes, 2011

• DOI för Exocytotic release of ATP triggers diacylglycerol spiking in insulin-secreting cells

Glucose and muscarinic stimulation trigger distinct diacylglycerol signals in pancreatic beta cells

Wuttke, Anne; Emanuelsson, H.; Tengholm, Anders

2010

Secretagogue-induced elevation of the plasma membrane PtdIns4P concentration in individual insulin-secreting cells

Wuttke, Anne; Tengholm, Anders

Ingår i 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, SEP 30-OCT 02, 2009, 2009

In situ characterisation of plasma membrane PtdIns(4)P and PtdIns(4,5)P 2 turnover in individual insulin secreting cells

Wuttke, Anne; Tengholm, Anders

2008

Type III phosphatidylinositol 4-kinases mediate plasma membrane PIP2 synthesis in insulin-secreting cells

Wuttke, Anne; Sagetorp, J.; Welsh, Nils; Tengholm, Anders

Ingår i 43rd easd annual meeting of the european association for the study of diabetes, 2007

• DOI för Type III phosphatidylinositol 4-kinases mediate plasma membrane PIP2 synthesis in insulin-secreting cells

Quantitative assessment of glucose-regulated cAMP signalling and protein kinase A-mediated glucagon secretion.

Yu, Qian; Gylfe, Erik; Tengholm, Anders

Effects of Ca²⁺ and autocrine signals on cAMP dynamics in β-cells

Shuai, Hongyan; Tengholm, Anders

Glucagon and GLP-1 evoke cAMP elevations in sub-populations of mouse and human α-cells

Shuai, Hongyan; Tengholm, Anders

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.