Marco Marcia

Targeting the conserved active site of splicing machines with specific and selective small molecule modulators.

Silvestri, Ilaria; Manigrasso, Jacopo; Andreani, Alessandro; Brindani, Nicoletta et al.

Ingår i Nature Communications, s. 4980, 2024

• DOI för Targeting the conserved active site of splicing machines with specific and selective small molecule modulators.

Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.

Uroda, Tina; Chillón, Isabel; Annibale, Paolo; Teulon, Jean-Marie et al.

Ingår i Nature Protocols, s. 2107-2139, 2020

• DOI för Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.

Visualizing group II intron dynamics between the first and second steps of splicing.

Manigrasso, Jacopo; Chillón, Isabel; Genna, Vito; Vidossich, Pietro et al.

Ingår i Nature Communications, s. 2837, 2020

• DOI för Visualizing group II intron dynamics between the first and second steps of splicing.

Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway.

Uroda, Tina; Anastasakou, Eleni; Rossi, Annalisa; Teulon, Jean-Marie et al.

Ingår i Molecular Cell, s. 982-995000000000, 2019

• DOI för Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway.

Visualizing group II intron catalysis through the stages of splicing.

Marcia, Marco; Pyle, Anna Marie

Ingår i Cell, s. 497-507, 2012

• DOI för Visualizing group II intron catalysis through the stages of splicing.

Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy

Jadhav, Shekhar; Maiorca, Mauro; Manigrasso, Jacopo; Saha, Spandan et al.

Ingår i Nature Communications, 2025

• DOI för Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy
• Ladda ner fulltext (pdf) av Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy

biGMamAct: efficient CRISPR/Cas9-mediated docking of large functional DNA cargoes at the ACTB locus

Pelosse, Martin; Marcia, Marco

Ingår i SYNTHETIC BIOLOGY, 2025

• DOI för biGMamAct: efficient CRISPR/Cas9-mediated docking of large functional DNA cargoes at the ACTB locus
• Ladda ner fulltext (pdf) av biGMamAct: efficient CRISPR/Cas9-mediated docking of large functional DNA cargoes at the ACTB locus

On the Power and Challenges of Atomistic Molecular Dynamics to Investigate RNA Molecules

Muscat, Stefano; Martino, Gianfranco; Manigrasso, Jacopo; Marcia, Marco et al.

Ingår i Journal of Chemical Theory and Computation, s. 6992-7008, 2024

• DOI för On the Power and Challenges of Atomistic Molecular Dynamics to Investigate RNA Molecules

Targeting the conserved active site of splicing machines with specific and selective small molecule modulators.

Silvestri, Ilaria; Manigrasso, Jacopo; Andreani, Alessandro; Brindani, Nicoletta et al.

Ingår i Nature Communications, s. 4980, 2024

• DOI för Targeting the conserved active site of splicing machines with specific and selective small molecule modulators.

G·U base pairing motifs in long non-coding RNAs.

Sabalette, Karina Belen; Makarova, Liubov; Marcia, Marco

Ingår i Biochimie, s. 123-140, 2023

• DOI för G·U base pairing motifs in long non-coding RNAs.

Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy

Jadhav, Shekhar; Maiorca, Mauro; Manigrasso, Jacopo; Saha, Spandan et al.

Ingår i Nature Communications, 2025

• DOI för Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy
• Ladda ner fulltext (pdf) av Dynamic assembly of a large multidomain ribozyme visualized by cryo-electron microscopy

biGMamAct: efficient CRISPR/Cas9-mediated docking of large functional DNA cargoes at the ACTB locus

Pelosse, Martin; Marcia, Marco

Ingår i SYNTHETIC BIOLOGY, 2025

• DOI för biGMamAct: efficient CRISPR/Cas9-mediated docking of large functional DNA cargoes at the ACTB locus
• Ladda ner fulltext (pdf) av biGMamAct: efficient CRISPR/Cas9-mediated docking of large functional DNA cargoes at the ACTB locus

Targeting the conserved active site of splicing machines with specific and selective small molecule modulators.

Silvestri, Ilaria; Manigrasso, Jacopo; Andreani, Alessandro; Brindani, Nicoletta et al.

Ingår i Nature Communications, s. 4980, 2024

• DOI för Targeting the conserved active site of splicing machines with specific and selective small molecule modulators.

G·U base pairing motifs in long non-coding RNAs.

Sabalette, Karina Belen; Makarova, Liubov; Marcia, Marco

Ingår i Biochimie, s. 123-140, 2023

• DOI för G·U base pairing motifs in long non-coding RNAs.

The new world of RNA diagnostics and therapeutics.

Blandino, Giovanni; Dinami, Roberto; Marcia, Marco; Anastasiadou, Eleni et al.

Ingår i Journal of Experimental & Clinical Cancer Research, s. 189, 2023

• DOI för The new world of RNA diagnostics and therapeutics.

ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts.

Pecori, Riccardo; Chillón, Isabel; Lo Giudice, Claudio; Arnold, Annette et al.

Ingår i Frontiers in cell and developmental biology, s. 1080626, 2022

• DOI för ADAR RNA editing on antisense RNAs results in apparent U-to-C base changes on overlapping sense transcripts.

The multiple molecular dimensions of long noncoding RNAs that regulate gene expression and tumorigenesis.

Marcia, Marco

Ingår i Current Opinion in Oncology, s. 141-147, 2022

• DOI för The multiple molecular dimensions of long noncoding RNAs that regulate gene expression and tumorigenesis.

Finding the Ion in the RNA-Stack: Can Computational Models Accurately Predict Key Functional Elements in Large Macromolecular Complexes?

Marcia, Marco; Manigrasso, Jacopo; De Vivo, Marco

Ingår i Journal of Chemical Information and Modeling, s. 2511-2515, 2021

• DOI för Finding the Ion in the RNA-Stack: Can Computational Models Accurately Predict Key Functional Elements in Large Macromolecular Complexes?

Noncoding RNAs: biology and applications-a Keystone Symposia report.

Cable, Jennifer; Heard, Edith; Hirose, Tetsuro; Prasanth, Kannanganattu V et al.

Ingår i Annals of the New York Academy of Sciences, s. 118-141, 2021

• DOI för Noncoding RNAs: biology and applications-a Keystone Symposia report.

Screening strategies for identifying RNA- and ribonucleoprotein-targeted compounds.

Martin, William J; Grandi, Paola; Marcia, Marco

Ingår i TIPS - Trends in Pharmacological Sciences, s. 758-771, 2021

• DOI för Screening strategies for identifying RNA- and ribonucleoprotein-targeted compounds.

Computer-aided design of RNA-targeted small molecules: A growing need in drug discovery

Manigrasso, Jacopo; Marcia, Marco; De Vivo, Marco

Ingår i Chem, s. 2965-2988, 2021

• DOI för Computer-aided design of RNA-targeted small molecules: A growing need in drug discovery

Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.

Uroda, Tina; Chillón, Isabel; Annibale, Paolo; Teulon, Jean-Marie et al.

Ingår i Nature Protocols, s. 2107-2139, 2020

• DOI för Visualizing the functional 3D shape and topography of long noncoding RNAs by single-particle atomic force microscopy and in-solution hydrodynamic techniques.

Visualizing group II intron dynamics between the first and second steps of splicing.

Manigrasso, Jacopo; Chillón, Isabel; Genna, Vito; Vidossich, Pietro et al.

Ingår i Nature Communications, s. 2837, 2020

• DOI för Visualizing group II intron dynamics between the first and second steps of splicing.

The molecular structure of long non-coding RNAs: emerging patterns and functional implications.

Chillón, Isabel; Marcia, Marco

Ingår i Critical reviews in biochemistry and molecular biology, s. 662-690, 2020

• DOI för The molecular structure of long non-coding RNAs: emerging patterns and functional implications.

A group II intron-encoded protein interacts with the cellular replicative machinery through the β-sliding clamp.

García-Rodríguez, Fernando M; Neira, José L; Marcia, Marco; Molina-Sánchez, María D et al.

Ingår i Nucleic Acids Research, s. 7605-7617, 2019

• DOI för A group II intron-encoded protein interacts with the cellular replicative machinery through the β-sliding clamp.

Topology and enzymatic properties of a canonical Polycomb repressive complex 1 isoform.

Colombo, Matteo; Pessey, Ombeline; Marcia, Marco

Ingår i FEBS Letters, s. 1837-1848, 2019

• DOI för Topology and enzymatic properties of a canonical Polycomb repressive complex 1 isoform.

A Transient and Flexible Cation-π Interaction Promotes Hydrolysis of Nucleic Acids in DNA and RNA Nucleases.

Genna, Vito; Marcia, Marco; De Vivo, Marco

Ingår i Journal of the American Chemical Society, s. 10770-10776, 2019

• DOI för A Transient and Flexible Cation-π Interaction Promotes Hydrolysis of Nucleic Acids in DNA and RNA Nucleases.

Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway.

Uroda, Tina; Anastasakou, Eleni; Rossi, Annalisa; Teulon, Jean-Marie et al.

Ingår i Molecular Cell, s. 982-995000000000, 2019

• DOI för Conserved Pseudoknots in lncRNA MEG3 Are Essential for Stimulation of the p53 Pathway.

Second-Shell Basic Residues Expand the Two-Metal-Ion Architecture of DNA and RNA Processing Enzymes.

Genna, Vito; Colombo, Matteo; De Vivo, Marco; Marcia, Marco

Ingår i Structure, s. 40-5000, 2018

• DOI för Second-Shell Basic Residues Expand the Two-Metal-Ion Architecture of DNA and RNA Processing Enzymes.

Identification of high-confidence RNA regulatory elements by combinatorial classification of RNA-protein binding sites.

Li, Yang Eric; Xiao, Mu; Shi, Binbin; Yang, Yu-Cheng T et al.

Ingår i Genome Biology, s. 169, 2017

• DOI för Identification of high-confidence RNA regulatory elements by combinatorial classification of RNA-protein binding sites.

Using Molecular Replacement Phasing to Study the Structure and Function of RNA.

Marcia, Marco

Ingår i Methods in Molecular Biology, s. 233-57, 2016

• DOI för Using Molecular Replacement Phasing to Study the Structure and Function of RNA.

HOTAIR forms an intricate and modular secondary structure.

Somarowthu, Srinivas; Legiewicz, Michal; Chillón, Isabel; Marcia, Marco et al.

Ingår i Molecular Cell, s. 353-61, 2015

• DOI för HOTAIR forms an intricate and modular secondary structure.

Native Purification and Analysis of Long RNAs.

Chillón, Isabel; Marcia, Marco; Legiewicz, Michal; Liu, Fei et al.

Ingår i Methods in Enzymology, s. 3-37, 2015

• DOI för Native Purification and Analysis of Long RNAs.

Crystal structure of group II intron domain 1 reveals a template for RNA assembly.

Zhao, Chen; Rajashankar, Kanagalaghatta R; Marcia, Marco; Pyle, Anna Marie

Ingår i Nature Chemical Biology, s. 967-72, 2015

• DOI för Crystal structure of group II intron domain 1 reveals a template for RNA assembly.

Production of fully assembled and active Aquifex aeolicus F1FO ATP synthase in Escherichia coli.

Zhang, Chunli; Allegretti, Matteo; Vonck, Janet; Langer, Julian D et al.

Ingår i Biochimica et Biophysica Acta, s. 34-40, 2014

• DOI för Production of fully assembled and active Aquifex aeolicus F1FO ATP synthase in Escherichia coli.

Principles of ion recognition in RNA: insights from the group II intron structures.

Marcia, Marco; Pyle, Anna Marie

Ingår i RNA, s. 516-27, 2014

• DOI för Principles of ion recognition in RNA: insights from the group II intron structures.

Now on display: a gallery of group II intron structures at different stages of catalysis.

Marcia, Marco; Somarowthu, Srinivas; Pyle, Anna Marie

Ingår i Mobile DNA, s. 14, 2013

• DOI för Now on display: a gallery of group II intron structures at different stages of catalysis.

Solving nucleic acid structures by molecular replacement: examples from group II intron studies.

Marcia, Marco; Humphris-Narayanan, Elisabeth; Keating, Kevin S; Somarowthu, Srinivas et al.

Ingår i Acta Crystallographica Section D, s. 2174-85, 2013

• DOI för Solving nucleic acid structures by molecular replacement: examples from group II intron studies.

Role of the N-terminal signal peptide in the membrane insertion of Aquifex aeolicus F1F0 ATP synthase c-subunit.

Zhang, Chunli; Marcia, Marco; Langer, Julian D; Peng, Guohong et al.

Ingår i The FEBS Journal, s. 3425-35, 2013

• DOI för Role of the N-terminal signal peptide in the membrane insertion of Aquifex aeolicus F1F0 ATP synthase c-subunit.

Visualizing group II intron catalysis through the stages of splicing.

Marcia, Marco; Pyle, Anna Marie

Ingår i Cell, s. 497-507, 2012

• DOI för Visualizing group II intron catalysis through the stages of splicing.

Ion binding and internal hydration in the multidrug resistance secondary active transporter NorM investigated by molecular dynamics simulations.

Vanni, Stefano; Campomanes, Pablo; Marcia, Marco; Rothlisberger, Ursula

Ingår i Biochemistry, s. 1281-7, 2012

• DOI för Ion binding and internal hydration in the multidrug resistance secondary active transporter NorM investigated by molecular dynamics simulations.

Characterizing a monotopic membrane enzyme. Biochemical, enzymatic and crystallization studies on Aquifex aeolicus sulfide: quinone oxidoreductase.

Marcia, Marco; Langer, Julian D; Parcej, David; Vogel, Vitali et al.

Ingår i Biochimica et Biophysica Acta, s. 2114-23, 2010

• DOI för Characterizing a monotopic membrane enzyme. Biochemical, enzymatic and crystallization studies on Aquifex aeolicus sulfide: quinone oxidoreductase.

A new structure-based classification of sulfide: quinone oxidoreductases.

Marcia, Marco; Ermler, Ulrich; Peng, Guohong; Michel, Hartmut

Ingår i Proteins, s. 1073-83, 2010

• DOI för A new structure-based classification of sulfide: quinone oxidoreductases.

PICKScreens, A New Database for the Comparison of Crystallization Screens for Biological Macromolecules

Hedderich, Tanja; Marcia, Marco; Köpke, Jürgen; Michel, Hartmut

Ingår i Crystal Growth & Design, s. 488-491, 2010

• DOI för PICKScreens, A New Database for the Comparison of Crystallization Screens for Biological Macromolecules

The structure of Aquifex aeolicus sulfide: quinone oxidoreductase, a basis to understand sulfide detoxification and respiration.

Marcia, Marco; Ermler, Ulrich; Peng, Guohong; Michel, Hartmut

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 9625-30, 2009

• DOI för The structure of Aquifex aeolicus sulfide: quinone oxidoreductase, a basis to understand sulfide detoxification and respiration.

On the Power and Challenges of Atomistic Molecular Dynamics to Investigate RNA Molecules

Muscat, Stefano; Martino, Gianfranco; Manigrasso, Jacopo; Marcia, Marco et al.

Ingår i Journal of Chemical Theory and Computation, s. 6992-7008, 2024

• DOI för On the Power and Challenges of Atomistic Molecular Dynamics to Investigate RNA Molecules