Maria Selmer
Professor vid Institutionen för cell- och molekylärbiologi; Uppsala RNA Research Centre - URRC
- Telefon:
- 018-471 41 77
- Mobiltelefon:
- 070-167 97 61
- E-post:
- Maria.Selmer@icm.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 596
751 24 Uppsala
Professor i biologi, särskilt strukturbiologi. Docent vid Institutionen för cell- och molekylärbiologi; Strukturbiologi
- Telefon:
- 018-471 41 77
- Mobiltelefon:
- 070-167 97 61
- E-post:
- maria.selmer@icm.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 596
75124 Uppsala
Nyckelord
- antibiotic resistance
- ribosome
- antibiotic
- structural biology
- bacteriophage
Biografi
- Civilingenjörsexamen i kemiteknik, Lunds Universitet 1995
- Tekn Dr I kemi med inriktning mot molekylär biofysik 2002. Handledare: Anders Liljas
- Postdoc, Wenner-Gren Fellow vid MRC-LMB, Cambridge, UK 2002-2006. Handledare: Venki Ramakrishnan.
- Forskarassistent, Institutionen för Cell och Molekylärbiologi, Uppsala Universitet 2006
- Docent i Strukturbiologi 2009
- Universitetslektor i Strukturbiologi 2012
- Professor i Strukturbiologi 2015
Forskning
Min forskargrupp använder integrerad strukturbiologi inom två olika områden; proteinsyntes kopplad till antibiotikaresistens och evolution av proteiners struktur och funktion. Vi använder röntgenkristallografi och kryo-elektronmikroskopi i kombination med biokemiska och biofysikaliska metoder. Vår forskning beskrivs här.

Publikationer
Urval av publikationer
-
Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
Ingår i eLIFE, 2021
- DOI för Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
- Ladda ner fulltext (pdf) av Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
-
Ingår i Journal of Biological Chemistry, s. 15948-15956, 2020
- DOI för Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
- Ladda ner fulltext (pdf) av Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
-
Ingår i Biomolecules, 2020
- DOI för Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring: An Inactive Enzyme with Intact Substrate Binding
- Ladda ner fulltext (pdf) av Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring: An Inactive Enzyme with Intact Substrate Binding
-
Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis
Ingår i Antimicrobial Agents and Chemotherapy, 2020
-
Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
Ingår i Scientific Reports, 2019
- DOI för Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
- Ladda ner fulltext (pdf) av Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
-
Ingår i Journal of Biological Chemistry, s. 11481-11490, 2018
- DOI för Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
- Ladda ner fulltext (pdf) av Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
-
Ingår i Nature Ecology & Evolution, s. 1321-1330, 2018
-
Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 4727-4732, 2017
- DOI för Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes
-
Ingår i Journal of Biological Chemistry, s. 24657-24668, 2015
-
Ingår i Open Biology, s. 120016, 2012
-
Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
Ingår i Nucleic Acids Research, s. 10507-20, 2012
- DOI för Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
- Ladda ner fulltext (pdf) av Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
-
Ribosome engineering to promote new crystal forms
Ingår i Acta Crystallographica Section D, s. 578-583, 2012
-
Ingår i Journal of Biological Chemistry, s. 30257-30267, 2012
-
The structure of the ribosome with elongation factor G trapped in the posttranslocational state
Ingår i Science, s. 694-699, 2009
-
Ingår i RNA, s. 817-823, 2007
Senaste publikationer
-
Origin and Evolution of Very Large Extracellular Proteins in Fructophilic Lactic Acid Bacteria
Ingår i Genome Biology and Evolution, 2026
- DOI för Origin and Evolution of Very Large Extracellular Proteins in Fructophilic Lactic Acid Bacteria
- Ladda ner fulltext (pdf) av Origin and Evolution of Very Large Extracellular Proteins in Fructophilic Lactic Acid Bacteria
-
Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Ingår i Nature Communications, 2025
- DOI för Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
- Ladda ner fulltext (pdf) av Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
-
Mechanisms of fusidic acid resistance
Ingår i Biochemical Society Transactions, s. 1011-1022, 2025
-
Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center
Ingår i Nature Communications, 2025
- DOI för Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center
- Ladda ner fulltext (pdf) av Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center
-
Ingår i Scientific Reports, 2024
- DOI för Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane
- Ladda ner fulltext (pdf) av Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane
Alla publikationer
Artiklar i tidskrift
-
Origin and Evolution of Very Large Extracellular Proteins in Fructophilic Lactic Acid Bacteria
Ingår i Genome Biology and Evolution, 2026
- DOI för Origin and Evolution of Very Large Extracellular Proteins in Fructophilic Lactic Acid Bacteria
- Ladda ner fulltext (pdf) av Origin and Evolution of Very Large Extracellular Proteins in Fructophilic Lactic Acid Bacteria
-
Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
Ingår i Nature Communications, 2025
- DOI för Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
- Ladda ner fulltext (pdf) av Structural mechanism of FusB-mediated rescue from fusidic acid inhibition of protein synthesis
-
Mechanisms of fusidic acid resistance
Ingår i Biochemical Society Transactions, s. 1011-1022, 2025
-
Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center
Ingår i Nature Communications, 2025
- DOI för Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center
- Ladda ner fulltext (pdf) av Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center
-
Ingår i Scientific Reports, 2024
- DOI för Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane
- Ladda ner fulltext (pdf) av Structures of the Staphylococcus aureus ribosome inhibited by fusidic acid and fusidic acid cyclopentane
-
Ingår i Cell Reports, 2023
- DOI för Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase
- Ladda ner fulltext (pdf) av Phage T3 overcomes the BREX defense through SAM cleavage and inhibition of SAM synthesis by SAM lyase
-
Structural Consequences of Deproteinating the 50S Ribosome
Ingår i Biomolecules, 2022
- DOI för Structural Consequences of Deproteinating the 50S Ribosome
- Ladda ner fulltext (pdf) av Structural Consequences of Deproteinating the 50S Ribosome
-
Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
Ingår i eLIFE, 2021
- DOI för Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
- Ladda ner fulltext (pdf) av Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family
-
Ingår i Journal of Biological Chemistry, 2021
- DOI för Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis
- Ladda ner fulltext (pdf) av Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis
-
Oligomerization and characteristics of phosphoenolpyruvate carboxylase in Synechococcus PCC 7002
Ingår i Scientific Reports, 2020
- DOI för Oligomerization and characteristics of phosphoenolpyruvate carboxylase in Synechococcus PCC 7002
- Ladda ner fulltext (pdf) av Oligomerization and characteristics of phosphoenolpyruvate carboxylase in Synechococcus PCC 7002
-
Ingår i Journal of Biological Chemistry, s. 15948-15956, 2020
- DOI för Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
- Ladda ner fulltext (pdf) av Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
-
Ingår i Biomolecules, 2020
- DOI för Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring: An Inactive Enzyme with Intact Substrate Binding
- Ladda ner fulltext (pdf) av Structure and Characterization of Phosphoglucomutase 5 from Atlantic and Baltic Herring: An Inactive Enzyme with Intact Substrate Binding
-
Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis
Ingår i Antimicrobial Agents and Chemotherapy, 2020
-
Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
Ingår i Scientific Reports, 2019
- DOI för Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
- Ladda ner fulltext (pdf) av Crystal structure of ErmE-23S rRNA methyltransferase in macrolide resistance
-
Ingår i Journal of Biological Chemistry, s. 11481-11490, 2018
- DOI för Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
- Ladda ner fulltext (pdf) av Structural mechanism of AadA, a dual specificity aminoglycoside adenylyltransferase from Salmonella enterica
-
Ingår i Nature Ecology & Evolution, s. 1321-1330, 2018
-
Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 4727-4732, 2017
- DOI för Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes
-
Two proofreading steps amplify the accuracy of genetic code translation
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 13744-13749, 2016
-
Ingår i Journal of Biological Chemistry, s. 24657-24668, 2015
-
Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase
Ingår i Acta Crystallographica Section D, s. 2267-2277, 2015
- DOI för Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase
- Ladda ner fulltext (pdf) av Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase
-
Investigating Ribosome Conformations with Multi-Resolution Modeling
Ingår i Biophysical Journal, 2014
-
Ingår i PLOS ONE, 2014
- DOI för Resistance to beta-Lactam Antibiotics Conferred by Point Mutations in Penicillin-Binding Proteins PBP3, PBP4 and PBP6 in Salmonella enterica
- Ladda ner fulltext (pdf) av Resistance to beta-Lactam Antibiotics Conferred by Point Mutations in Penicillin-Binding Proteins PBP3, PBP4 and PBP6 in Salmonella enterica
-
Energetic pathway sampling in a protein interaction domain
Ingår i Structure, s. 1193-1202, 2013
- DOI för Energetic pathway sampling in a protein interaction domain
- Ladda ner fulltext (pdf) av Energetic pathway sampling in a protein interaction domain
-
Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
Ingår i Nucleic Acids Research, s. 9537-9548, 2013
- DOI för Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
- Ladda ner fulltext (pdf) av Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ
-
Ingår i Acta Crystallographica. Section F, s. 1001-1003, 2013
- DOI för Purification, crystallization and preliminary X-ray diffraction analysis of the 23S rRNA methyltransferase RlmJ from Escherichia coli
- Ladda ner fulltext (pdf) av Purification, crystallization and preliminary X-ray diffraction analysis of the 23S rRNA methyltransferase RlmJ from Escherichia coli
-
Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
Ingår i PLOS ONE, 2012
- DOI för Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
- Ladda ner fulltext (pdf) av Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
-
Ingår i Open Biology, s. 120016, 2012
-
Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
Ingår i Nucleic Acids Research, s. 10507-20, 2012
- DOI för Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
- Ladda ner fulltext (pdf) av Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA
-
Ribosome engineering to promote new crystal forms
Ingår i Acta Crystallographica Section D, s. 578-583, 2012
-
Ingår i Journal of Biological Chemistry, s. 30257-30267, 2012
-
Staphylococcus aureus elongation factor G - structure and analysis of a target for fusidic acid
Ingår i The FEBS Journal, s. 3789-3803, 2010
-
Ingår i Journal of Biological Chemistry, s. 18051-18059, 2010
-
The structure of the ribosome with elongation factor G trapped in the posttranslocational state
Ingår i Science, s. 694-699, 2009
-
Crystal structure of the ribosome recycling factor bound to the ribosome
Ingår i Nature Structural & Molecular Biology, s. 733-737, 2007
-
Ingår i RNA, s. 817-823, 2007
Artiklar, forskningsöversikt
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Exit biology: battle for the nascent chain
Ingår i Structure, s. 498-500, 2008