Gastroenterology and Hepatology
Inflammatory bowel diseases (IBD), with Crohn's disease and ulcerative colitis as major types, are important causes of chronic morbidity. These disorders are characterized by inflammation of the gastrointestinal tract, and have an episodic, lifetime course, requiring long-term health care. The incidence of IBD has increased dramatically during the last 50 years, but for unknown reasons. The pathogenic mechanisms causing IBD are also largely unknown, as is the episodic nature of these disorders. We address these questions through experimental, clinical and epidemiological studies. Aiming to improve the medical care of patients with IBD and other inflammatory diseases, we try to delineate events at the molecular and cellular level leading to disease, and to identify diagnostic and predictive markers.
Description of our research
Diagnosis of IBD is complicated and involves endoscopy and analysis of biopsies. There is therefore a great need for novel diagnostic biomarkers as well as prognostic and activity markers. We are evaluating a range of inflammatory biomarkers, including nitric oxide, several cytokines and eosinophil proteins. With respect to pathological mechanisms of IBD, we perform array experiments to analyze gene expression in active IBD, search for autoantigenes and analyze the possible involvement of eosinophils and viruses in the disease process.
We also have a large interest in the enteric nervous system, and how gut peptides like GLP-1 and Ghrelin regulate motility, blood flow and secretion in IBD and in irritable bowel syndrome. For these studies we utilize e.g. a "SmartPill", a wireless motility capsule that records physiological parameters during it's passage through the gastrointestinal tract.
Group members
Publications
Part of Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025
- DOI for Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier
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Part of Journal of Nutrition, p. 185-196, 2025
- DOI for Postprandial Effects of Four Test Meals Containing Wholegrain Rye or Refined Wheat Foods on Circulating Incretins, Ghrelin, Glucose, and Inflammatory Markers
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Long-term major adverse liver outcomes in 1,260 patients with non-cirrhotic NAFLD
Part of JHEP Reports, 2024
- DOI for Long-term major adverse liver outcomes in 1,260 patients with non-cirrhotic NAFLD
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Sex and gender in inflammatory bowel disease outcomes and research
Part of The Lancet Gastroenterology & Hepatology, p. 1041-1051, 2024
Forty years of successful national research collaboration in liver disease: the Swedish experience
Part of Scandinavian Journal of Gastroenterology, p. 1314-1321, 2024
- DOI for Forty years of successful national research collaboration in liver disease: the Swedish experience
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Part of Scandinavian Journal of Gastroenterology, p. 232-238, 2024
- DOI for Endoscopic underwater detection and resection of anal squamous intraepithelial lesions in non-anesthetized patients - a feasibility study and comparison with standard surgical treatment
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Medicinal grade opium tincture for severe diarrhea: effect revisited in observational study
Part of Current Opinion in Gastroenterology, p. 196-202, 2024
Part of Clinical and Translational Gastroenterology, 2024
- DOI for Fecal and Serum Granulocyte Protein Levels in Inflammatory Bowel Disease and Irritable Bowel Syndrome and Their Relation to Disease Activity
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Part of American Journal of Clinical Nutrition, p. 187-195, 2024
- DOI for Substitutions of saturated fat intakes with other macronutrients and foods and risk of NAFLD cirrhosis and all-cause hepatocellular carcinoma: a prospective cohort study
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Part of American Journal of Clinical Nutrition, p. 985-986, 2024
Part of Gastroenterology, 2024
99% of patients with NAFLD meet MASLD criteria and natural history is therefore identical
Part of Journal of Hepatology, 2024
Part of Liver international, p. 1689-1699, 2024
- DOI for Liver stiffness predicts progression to liver-related events in patients with chronic liver disease: A cohort study of 14 414 patients
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Performance of novel collagen turnover biomarkers to detect increased liver stiffness in MASLD
Part of Journal of Internal Medicine, p. 177-186, 2024
- DOI for Performance of novel collagen turnover biomarkers to detect increased liver stiffness in MASLD
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Daily Experiences and Perceived Quality of Care for Patients with Liver Cirrhosis
2024
Part of BMC Nursing, 2024
- DOI for Patient perceived quality of cirrhosis care – adjunctive nurse-based care versus standard medical care: a pragmatic multicentre randomised controlled study
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Plasma Protein Profiling to Discern Indolent from Advanced Systemic Mastocytosis
Part of Journal of Molecular Diagnostics, p. 792-804, 2024
- DOI for Plasma Protein Profiling to Discern Indolent from Advanced Systemic Mastocytosis
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Part of Scandinavian Journal of Gastroenterology, p. 543-546, 2024
- DOI for Diarrhoea of unknown cause: medical treatment in a stepwise manner: Management of Idiopathic Diarrhoea Based on Experience of Step-Up Medical Treatment
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2024
Part of Alimentary Pharmacology and Therapeutics, p. 765-777, 2024
Identification of diverticular disease in Swedish healthcare registers: a validation study
Part of Scandinavian Journal of Gastroenterology, p. 176-182, 2024
- DOI for Identification of diverticular disease in Swedish healthcare registers: a validation study
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Part of Metabolomics, 2024
- DOI for Exploration of differential responses to FODMAPs and gluten in people with irritable bowel syndrome- a double-blind randomized cross-over challenge study
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Part of Nature Communications, 2024
- DOI for Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
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Part of Journal of Crohn's & Colitis, 2024
Part of Hepatology, 2024
Part of United European Gastroenterology journal, p. 1378-1387, 2024
Risk of major adverse liver outcomes among first-degree relatives of individuals with MASLD
Part of Liver international, p. 1253-1264, 2024
- DOI for Risk of major adverse liver outcomes among first-degree relatives of individuals with MASLD
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Part of Journal of Crohn's & Colitis, p. 1962-1967, 2023
- DOI for Inflammatory Bowel Disease Is not Linked to a Higher Rate of Adverse Events in Colonoscopy -a Nationwide Population-based Study in Sweden
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Part of Scandinavian Journal of Gastroenterology, p. 1131-1138, 2023
- DOI for Diverticulosis is not associated with altered gut microbiota nor is it predictive of future diverticulitis: a population-based colonoscopy study
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Impact on follow-up strategies in patients with primary sclerosing cholangitis
Part of Liver international, p. 127-138, 2023
- DOI for Impact on follow-up strategies in patients with primary sclerosing cholangitis
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Part of Upsala Journal of Medical Sciences, 2023
- DOI for High iNOS and IL-1β immunoreactivity are features of colitis-associated colorectal cancer tumors, but fail to predict 5-year survival
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Part of Translational Vision Science & Technology, 2023
- DOI for The Retinal Nerve Fiber Layer Thickness Is Associated with Systemic Neurodegeneration in Long-Term Type 1 Diabetes
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Experiences in implementing immunopsychiatry in real life
Part of Journal of Affective Disorders Reports, 2023
- DOI for Experiences in implementing immunopsychiatry in real life
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Part of ESC Heart Failure, 2023
- DOI for Acyl ghrelin increases cardiac output while preserving right ventricular-pulmonary arterial coupling in heart failure
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Part of Journal of Clinical Medicine, 2023
- DOI for Opioids in the Treatment of Chronic Idiopathic Diarrhea in Humans: A Systematic Review and Treatment Guideline
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Part of PLoS Pathogens, 2023
- DOI for Trophozoite fitness dictates the intestinal epithelial cell response to Giardia intestinalis infection
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Part of European Journal of Heart Failure, p. 2093-2095, 2023
- DOI for Acyl ghrelin infusion increases circulating growth hormone in patients with heart failure and reduced ejection fraction
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Part of PLOS ONE, 2023
- DOI for Feeling safe or falling through the cracks – Patients’ experiences of healthcare in cirrhosis illness: A qualitative study
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Inflammatory bowel disease and asthma: Results from the RHINE study
Part of Respiratory Medicine, 2023
- DOI for Inflammatory bowel disease and asthma: Results from the RHINE study
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The progression of doxorubicin-induced intestinal mucositis in rats
Part of Naunyn-Schmiedeberg's Archives of Pharmacology, p. 247-260, 2023
- DOI for The progression of doxorubicin-induced intestinal mucositis in rats
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Part of Journal of Hepatology, p. 592-604, 2023
- DOI for An individual patient data meta-analysis to determine cut-offs for and confounders of NAFLD-fibrosis staging with magnetic resonance elastography
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Part of Clinical and Translational Gastroenterology, 2023
Part of European Heart Journal, 2023
- DOI for Acyl ghrelin improves cardiac function in heart failure and increases fractional shortening in cardiomyocytes without calcium mobilization
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Part of Oral surgery, oral medicine, oral pathology and oral radiology, p. 691-702, 2023
- DOI for Oral manifestations and dental considerations of patients with hereditary hemorrhagic telangiectasia: a scoping review
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FODMAPs: Do they really affect IBS symptoms?
Part of Frontiers in Medicine, 2023
- DOI for FODMAPs: Do they really affect IBS symptoms?
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Part of Nutrients, 2023
- DOI for Effects of FODMAPs and Gluten on Gut Microbiota and Their Association with the Metabolome in Irritable Bowel Syndrome: A Double-Blind, Randomized, Cross-Over Intervention Study
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Part of American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2023
Part of Journal of Ethnopharmacology, 2023
- DOI for Detection and isolation of intestinal muscle relaxant substances from the root of Taverniera abyssinica A. Rich
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Part of European Journal of Gastroenterology and Hepathology, p. 288-293, 2023
DIgestive COmplications in DIabetes: the DICODI population study
Part of Scandinavian Journal of Gastroenterology, p. 3-6, 2023
- DOI for DIgestive COmplications in DIabetes: the DICODI population study
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