Publications from the Preclinical PET-MRI Platform

Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts

Mortensen, Anja; Berglund, Hanna; Jha, Preeti; Stenman, Adam et al.

Part of Molecular Cancer Therapeutics, p. 753-762, 2025

• DOI for Dual-Nuclide Biodistribution and Therapeutic Evaluation of a Novel Antibody-Based Radiopharmaceutical in Anaplastic Thyroid Cancer Xenografts
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Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model

Wilske, Frida; Eriksson, Olof; Amini, Rose-Marie; Estrada, Sergio et al.

Part of Intensive Care Medicine Experimental, 2025

• DOI for Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model
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Targeting mutant p53: Evaluation of novel anti-p53^R175H monoclonal antibodies as diagnostic tools

Spiegelberg, Diana; Hwang, Le-Ann; Pua, Khian Hong; Kumar, Sashwini Chandra et al.

Part of Scientific Reports, 2025

• DOI for Targeting mutant p53: Evaluation of novel anti-p53^R175H monoclonal antibodies as diagnostic tools
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Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging

Xiong, Mengfei; Dahlén, Amelia; Roshanbin, Sahar; Wik, Elin et al.

Part of Journal of Neurochemistry, p. 2601-2610, 2024

• DOI for Antibody engagement with amyloid‐beta does not inhibit [¹¹C]PiB binding for PET imaging
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Noninvasive PET Detection of CD69-Positive Immune Cells Before Signs of Clinical Disease in Inflammatory Arthritis

Puuvuori, Emmi; Shen, Yunbing; Hulsart-Billström, Gry; Mitran, Bogdan et al.

Part of Journal of Nuclear Medicine, p. 294-299, 2024

• DOI for Noninvasive PET Detection of CD69-Positive Immune Cells Before Signs of Clinical Disease in Inflammatory Arthritis

PET imaging of GABA_A receptors in pancreatic islets by [¹¹C]flumazenil

Maloum-Rami, Faïza; Cheung, Pierre; Antoni, Gunnar; Jin, Zhe et al.

Part of EJNMMI Research, 2024

• DOI for PET imaging of GABA_A receptors in pancreatic islets by [¹¹C]flumazenil
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Radiation dosimetry of para-chloro-2-[¹⁸F]fluoroethyl-etomidate: a PET tracer for adrenocortical imaging

Silins, Isabella; Moreno, Adrian; Wall, Anders; Aigbirhio, Franklin et al.

Part of EJNMMI Research, 2024

• DOI for Radiation dosimetry of para-chloro-2-[¹⁸F]fluoroethyl-etomidate: a PET tracer for adrenocortical imaging
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Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences

Velikyan, Irina; Bossart, Martin; Haack, Torsten; Laitinen, Iina et al.

Part of Pharmaceuticals, 2023

• DOI for Imaging of the Glucose-Dependent Insulinotropic Polypeptide Receptor Using a Novel Radiolabeled Peptide Rationally Designed Based on Endogenous GIP and Synthetic Exendin-4 Sequences
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Nanostructured Ag-Bioglass Implant Coatings with Antibacterial and Osteogenic Activity

Geissel, Felix J.; Platania, Varvara; De Berardinis, Niccoló; Skjöldebrand, Charlotte et al.

Part of Advanced Materials Interfaces, 2023

• DOI for Nanostructured Ag-Bioglass Implant Coatings with Antibacterial and Osteogenic Activity
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PET imaging of neutrophil elastase with ¹¹C-GW457427 in Acute Respiratory Distress Syndrome in pigs

Puuvuori, Emmi; Chiodaroli, Elena; Estrada, Sergio; Cheung, Pierre et al.

Part of Journal of Nuclear Medicine, p. 423-429, 2023

• DOI for PET imaging of neutrophil elastase with ¹¹C-GW457427 in Acute Respiratory Distress Syndrome in pigs

Synaptic density in aging mice measured by [18F]SynVesT-1 PET

Xiong, Mengfei; Roshanbin, Sahar; Sehlin, Dag; Hansen, Hanne D. et al.

Part of NeuroImage, 2023

• DOI for Synaptic density in aging mice measured by [18F]SynVesT-1 PET
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E-Cigarette Aerosol Deposition and Disposition of [C-11]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations

Wall, Anders; Roslin, Sara; Borg, Beatrice; McDermott, Simon et al.

Part of Pharmaceuticals, 2022

• DOI for E-Cigarette Aerosol Deposition and Disposition of [C-11]Nicotine Using Positron Emission Tomography: A Comparison of Nicotine Uptake in Lungs and Brain Using Two Different Nicotine Formulations
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Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study

Wechalekar, Ashutosh; Antoni, Gunnar; Al Azzam, Wasfi; Bergstrom, Mats et al.

Part of BMC Cardiovascular Disorders, 2022

• DOI for Pharmacodynamic evaluation and safety assessment of treatment with antibodies to serum amyloid P component in patients with cardiac amyloidosis: an open-label Phase 2 study and an adjunctive immuno-PET imaging study
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Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase

Estrada, Sergio; Elgland, Mathias; Selvaraju, Ram Kumar; Mani, Kevin et al.

Part of Nuclear Medicine and Biology, p. 62-71, 2022

• DOI for Preclinical evaluation of [C-11]GW457427 as a tracer for neutrophil elastase
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¹⁸F-Radiolabeling and Preliminary Evaluation of a HSP₉₀ ligand

Nordeman, Patrik; Jayendra, Z. P.; Briard, E.; Li, Su-Chen et al.

Part of European Journal of Pharmaceutical Sciences, 2021

• DOI for ¹⁸F-Radiolabeling and Preliminary Evaluation of a HSP₉₀ ligand

A comparative study on Suzuki‐type 11 C‐methylation of aromatic organoboranes performed in two reaction media

Rokka, Johanna; Nordeman, Patrik; Bergman, Sara; Eriksson, Jonas

Part of Journal of labelled compounds & radiopharmaceuticals, p. 447-455, 2021

• DOI for A comparative study on Suzuki‐type 11 C‐methylation of aromatic organoboranes performed in two reaction media
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Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69

Persson, Jonas; Puuvuori, Emmi; Zhang, Bo; Velikyan, Irina et al.

Part of Scientific Reports, 2021

• DOI for Discovery, optimization and biodistribution of an Affibody molecule for imaging of CD69
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Longitudinal Assessment of ¹¹C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes

Espes, Daniel; Carlsson, Per-Ola; Selvaraju, Ram Kumar; Rosestedt, Maria et al.

Part of Diabetes, p. 966-975, 2021

• DOI for Longitudinal Assessment of ¹¹C-5-Hydroxytryptophan Uptake in Pancreas After Debut of Type 1 Diabetes

News ways of understanding the complex biology of diabetes using PET

Eriksson, Olof; Långström, Bengt; Antoni, Gunnar

Part of Nuclear Medicine and Biology, p. 65-71, 2021

• DOI for News ways of understanding the complex biology of diabetes using PET

PET Imaging of GPR44 by Antagonist [C-11]MK-7246 in Pigs

Cheung, Pierre; Zhang, Bo; Puuvuori, Emmi; Estrada, Sergio et al.

Part of Biomedicines, 2021

• DOI for PET Imaging of GPR44 by Antagonist [C-11]MK-7246 in Pigs
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Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1

Rosestedt, Maria; Velikyan, Irina; Rosenström, Ulrika; Estrada, Sergio et al.

Part of Nuclear Medicine and Biology, p. 54-62, 2021

• DOI for Radiolabelling and positron emission tomography imaging of a high-affinity peptide binder to collagen type 1
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Tau aggregation and increased neuroinflammation in athletes after sports-related concussions and in traumatic brain injury patients – A PET/MR study

Marklund, Niklas; Vedung, Fredrik; Lubberink, Mark; Tegner, Yelverton et al.

Part of NeuroImage, 2021

• DOI for Tau aggregation and increased neuroinflammation in athletes after sports-related concussions and in traumatic brain injury patients – A PET/MR study
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Theranostic Approach in Breast Cancer A Treasured Tailor for Future Oncology

Jokar, Narges; Velikyan, Irina; Ahmadzadehfar, Hojjat; Rekabpour, Seyed Javad et al.

Part of Clinical Nuclear Medicine, 2021

• DOI for Theranostic Approach in Breast Cancer A Treasured Tailor for Future Oncology

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

Syvänen, Stina; Fang, Xiaotian T.; Faresjö, Rebecca; Rokka, Johanna et al.

Part of ACS Chemical Neuroscience, p. 4460-4468, 2020

• DOI for Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
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Phosphodiesterase 10A levels are related to striatal function in schizophrenia: a combined positron emission tomography and functional magnetic resonance imaging study

Persson, Jonas; Szalisznyo, Krisztina; Antoni, Gunnar; Wall, Anders et al.

Part of European Archives of Psychiatry and Clinical Neuroscience, p. 451-459, 2020

• DOI for Phosphodiesterase 10A levels are related to striatal function in schizophrenia: a combined positron emission tomography and functional magnetic resonance imaging study
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Quantification of aromatase binding in the female human brain using [¹¹ C]cetrozole positron emission tomography.

Jonasson, My; Nordeman, Patrik; Eriksson, Jonas; Wilking, Helena et al.

Part of Journal of Neuroscience Research, p. 2208-2218, 2020

• DOI for Quantification of aromatase binding in the female human brain using [¹¹ C]cetrozole positron emission tomography.
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High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

Fang, Xiaotian T.; Hultqvist, Greta; Meier, Silvio R.; Antoni, Gunnar et al.

Part of NeuroImage, p. 881-888, 2019

• DOI for High detection sensitivity with antibody-based PET radioligand for amyloid beta in brain

Improved synthesis of SV2A targeting radiotracer [11C]UCB-J

Rokka, Johanna; Schlein, Eva; Eriksson, Jonas

Part of EJNMMI Radiopharmacy and Chemistry, 2019

• DOI for Improved synthesis of SV2A targeting radiotracer [11C]UCB-J
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Synaptic vesicle protein 2A as a potential biomarker in synaptopathies

Heurling, Kerstin; Ashton, Nicholas J; Leuzy, Antoine; Zimmer, Eduardo R et al.

Part of Molecular and Cellular Neuroscience, p. 34-42, 2019

• DOI for Synaptic vesicle protein 2A as a potential biomarker in synaptopathies
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Synthesis and initial preclinical evaluation of the CRTH2 antagonist [C-11] MK-7246

Eriksson, Jonas; Roy, Tamal; Sawadjoon, Supaporn; Bachmann, Kim et al.

Part of Journal of Labelled Compounds and Pharmaceuticals, 2019

Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass

Eriksson, Jonas; Roy, Tamal; Sawadjoon, Supaporn; Bachmann, Kim et al.

Part of Nuclear Medicine and Biology, p. 1-10, 2019

• DOI for Synthesis and preclinical evaluation of the CRTH2 antagonist [¹¹C]MK-7246 as a novel PET tracer and potential surrogate marker for pancreatic beta-cell mass
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Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease

Olsen, Malin; Aguilar, Ximena; Sehlin, Dag; Fang, Xiaotian T. et al.

Part of Molecular Imaging and Biology, p. 605-614, 2018

• DOI for Astroglial Responses to Amyloid-Beta Progression in a Mouse Model of Alzheimer's Disease
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In Vivo Visualization of beta-Cells by Targeting of GPR44

Eriksson, Olof; Johnström, Peter; Cselenyi, Zsolt; Jahan, Mahabuba et al.

Part of Diabetes, p. 182-192, 2018

• DOI for In Vivo Visualization of beta-Cells by Targeting of GPR44

Non-invasive tri-modal visualisation via PET/SPECT/μCT of recombinant human bone morphogenetic protein-2 retention and associated bone regeneration: A proof of concept

Hulsart Billström, Gry; Selvaraju, Ramkumar; Estrada, Sergio; Lubberink, Mark et al.

Part of Journal of Controlled Release, p. 178-186, 2018

• DOI for Non-invasive tri-modal visualisation via PET/SPECT/μCT of recombinant human bone morphogenetic protein-2 retention and associated bone regeneration: A proof of concept
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Phase 0, Including Microdosing Approaches: Applying the Three Rs and Increasing the Efficiency of Human Drug Development

Burt, Tal; Vuong, Le Thuy; Baker, Elizabeth; Young, Graeme C. et al.

Part of ATLA (Alternatives to Laboratory Animals), p. 335-346, 2018

Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model

Mitran, Bogdan; Güler, Rezan; Roche, Francis P.; Lindström, Elin et al.

Part of Theranostics, p. 4462-4476, 2018

• DOI for Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model
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The development of a GPR44 targeting radioligand [¹¹C]AZ12204657 for in vivo assessment of beta cell mass.

Jahan, Mahabuba; Johnström, Peter; Selvaraju, Ramkumar; Svedberg, Marie et al.

Part of EJNMMI Research, 2018

• DOI for The development of a GPR44 targeting radioligand [¹¹C]AZ12204657 for in vivo assessment of beta cell mass.
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Blood Flow Quantitation by Positron Emission Tomography During Selective Antegrade Cerebral Perfusion

Tovedal, Thomas; Lubberink, Mark; Morell, Arvid; Estrada, Sergio et al.

Part of Annals of Thoracic Surgery, p. 610-616, 2017

• DOI for Blood Flow Quantitation by Positron Emission Tomography During Selective Antegrade Cerebral Perfusion

Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Fang, Xiaotian T.; Eriksson, Jonas; Antoni, Gunnar; Yngve, Ulrika et al.

Part of Neuropharmacology, p. 293-300, 2017

• DOI for Brain mGluR5 in mice with amyloid beta pathology studied with in vivo [(11)C]ABP688 PET imaging and ex vivo immunoblotting

Palladium-mediated C-11-carbonylations using aryl halides and cyanamide

Nordeman, Patrik; Chow, Shiao Y.; Odell, A. F.; Antoni, Gunnar et al.

Part of Organic and biomolecular chemistry, p. 4875-4881, 2017

• DOI for Palladium-mediated C-11-carbonylations using aryl halides and cyanamide

Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4

Eriksson, Olof; Rosenström, Ulrika; Selvaraju, Ram Kumar; Eriksson, Barbro et al.

Part of Acta Diabetologica, p. 1039-1045, 2017

• DOI for Species differences in pancreatic binding of DO3A-VS-Cys40-Exendin4
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C-11 and F-18 Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates

Nordeman, Patrik; Johansson, Leif B. G.; Back, Marcus; Estrada, Sergio et al.

Part of ACS Medicinal Chemistry Letters, p. 368-373, 2016

• DOI for C-11 and F-18 Radiolabeling of Tetra- and Pentathiophenes as PET-Ligands for Amyloid Protein Aggregates

[C-11]UCB-A, a novel PET tracer for synaptic vesicle protein 2 A

Estrada, Sergio; Lubberink, Mark; Thibblin, Alf; Sprycha, Margareta et al.

Part of Nuclear Medicine and Biology, p. 325-332, 2016

• DOI for [C-11]UCB-A, a novel PET tracer for synaptic vesicle protein 2 A

Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma

Haylock, Anna-Karin; Spiegelberg, Diana; Mortensen, Anja C.; Selvaraju, Ram K. et al.

Part of International journal of oncology, p. 461-470, 2016

• DOI for Evaluation of a novel type of imaging probe based on a recombinant bivalent mini-antibody construct for detection of CD44v6-expressing squamous cell carcinoma
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Feasibility of Affibody Molecule-Based PNA-Mediated Radionuclide Pretargeting of Malignant Tumors

Honarvar, Hadis; Westerlund, Kristina; Altai, Mohamed; Sandström, Mattias et al.

Part of Theranostics, p. 93-103, 2016

• DOI for Feasibility of Affibody Molecule-Based PNA-Mediated Radionuclide Pretargeting of Malignant Tumors
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Feasibility of affibody-based bioorthogonal chemistry-mediated radionuclide pretargeting

Altai, Mohamed; Perols, Anna; Tsourma, Maria; Mitran, Bogdan et al.

Part of Journal of Nuclear Medicine, p. 431-436, 2016

• DOI for Feasibility of affibody-based bioorthogonal chemistry-mediated radionuclide pretargeting

Ga-68/PET imaging and quantification of fibrosis using peptide-based tracers

Velikyan, Irina; Rosenström, Ulrika; Eriksson, Olof; Antoni, Gunnar

Part of European Journal of Nuclear Medicine and Molecular Imaging, 2016

Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.

Spiegelberg, Diana; Mortensen, Anja C; Selvaraju, Ram K; Eriksson, Olof et al.

Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 974-982, 2016

• DOI for Molecular imaging of EGFR and CD44v6 for prediction and response monitoring of HSP90 inhibition in an in vivo squamous cell carcinoma model.
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Tracer kinetic analysis of (S)-18F-THK5117 as a PET tracer for assessing tau pathology.

Jonasson, My; Wall, Anders; Chiotis, Konstantinos; Saint-Aubert, Laure et al.

Part of Journal of Nuclear Medicine, p. 574-581, 2016

• DOI for Tracer kinetic analysis of (S)-18F-THK5117 as a PET tracer for assessing tau pathology.

ADAPT, a novel scaffold protein-based probe for radionuclide imaging of molecular targets that are expressed in disseminated cancers

Garousi, Javad; Lindbo, Sarah; Nilvebrant, Johan; Åstrand, Mikael et al.

Part of Cancer Research, p. 4364-4371, 2015

• DOI for ADAPT, a novel scaffold protein-based probe for radionuclide imaging of molecular targets that are expressed in disseminated cancers