Our publications

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie et al.

Part of Neurotherapeutics, p. 1588-1602, 2022

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• DOI for A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
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A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses

Morrison, Jamie I.; Metzendorf, Nicole G.; Rofo, Fadi; Petrovic, Alex et al.

Part of Journal of Neurochemistry, p. 413-425, 2023

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• DOI for A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses
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Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Rofo, Fadi; Metzendorf, Nicole; Saubi, Cristina; Suominen, Laura et al.

Part of Alzheimer's Research & Therapy, 2022

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• DOI for Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
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Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.

Sehlin, Dag; Stocki, Pawel; Gustavsson, Tobias; Hultqvist, Greta et al.

Part of The FASEB Journal, p. 13272-13283, 2020

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• DOI for Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.
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Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells

Fang, Xiaotian T.; Sehlin, Dag; Lannfelt, Lars; Syvänen, Stina et al.

Part of Biological Procedures Online, 2017

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• DOI for Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
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Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Rofo, Fadi; Yilmaz, Canan Ugur; Metzendorf, Nicole G.; Gustavsson, Tobias et al.

Part of Theranostics, p. 789-804, 2021

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• DOI for Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
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Evolution of the p53-MDM2 pathway

Åberg, Emma; Saccoccia, Fulvio; Grabherr, Manfred; Ore, Wai Ying Josefin et al.

Part of BMC Evolutionary Biology, 2017

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• DOI for Evolution of the p53-MDM2 pathway
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Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

de la Rosa, Andres; Metzendorf, Nicole G.; Morrison, Jamie; Faresjö, Rebecca et al.

Part of Scientific Reports, 2022

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• DOI for Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3
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Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates

Petersen, Inga; Ali, Muhammad Ilyas; Petrovic, Alex; Ytterberg, A. Jimmy et al.

Part of mAbs, 2023

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• DOI for Multivalent design of the monoclonal SynO2 antibody improves binding strength to soluble α-Synuclein aggregates
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Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken et al.

Part of Translational Neurodegeneration, 2021

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• DOI for Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
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Standardized Preclinical In Vitro Blood-Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways

Morrison, Jamie; Petrovic, Alex; Metzendorf, Nicole G.; Rofo, Fadi et al.

Part of Molecular Pharmaceutics, p. 1564-1576, 2023

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• DOI for Standardized Preclinical In Vitro Blood-Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways
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Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

Rofo, Fadi; Sandbaumhüter, Friederike A.; Chourlia, Aikaterini; Metzendorf, Nicole G. et al.

Part of ACS Chemical Neuroscience, p. 2529-2541, 2021

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• DOI for Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
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