Medical Epidemiology
Our main research concern diseases and conditions in the ageing population, including fragility fractures, cardiovascular diseases and cancer, but we are involved in other areas of epidemiological research as well.
The Medical Epidemiology research group is based at the EpiHub (map), an office and network for epidemiological research within the the Disciplinary domain of Medicine and Pharmacy at Uppsala University. This facilitates fruitful interaction with different research groups aiming to jointly build a long term foundation for advanced epidemiological research.
Seminars
Our main research concern diseases and conditions in the ageing population, including fragility fractures, cardiovascular diseases and cancer, but we are involved in other areas of epidemiological research as well. We combine traditional epidemiological methods with modern causal inference methods in observational studies and perform randomised intervention studies. Find out more about our research by browsing through our publication list below.
SIMPLER
Karl Michaëlsson, head of Medical Epidemiology, is also director for the national research infrastructure SIMPLER, Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (simpler4health.se) and much of our research is based on the cohorts included in SIMPLER. Since the end of 2018 the infrastructure is managed by a consortium consisting of Uppsala University, Karolinska Institutet, Chalmers University of Technology and Örebro University in collaboration with the County Councils in Uppsala, Västmanland and Örebro County.
The infrastructure's mission is to provide national and international researchers with data for studies on how dietary and lifestyle factors and genetics affect our health, especially during the latter part of life. The knowledge can for example be used to develop recommendations on diet and lifestyle, develop new markers fore easier and more accurate diagnosis of chronic diseases and their precursors and to develop new individualized treatments.
Funding
The research group has received funding from the Swedish Research Council (VR), the Swedish Research Council for Health, Working Life and Welfare (FORTE), the Swedish Heart-Lung Foundation, the Swedish Cancer Society, Hjärnfonden, and ALF.
Seminars in Medical Epidemiology
The seminars are open to PhD students and post doc researchers working in the field of medical epidemiology at Uppsala University. In a friendly atmosphere we discuss around different methodological topics with the aim to gain a deeper knowledge on topics in medical epidemiology.
Seminars can be held by researchers, PhD students or invited speakers. Active participation by participants is required and discussion material will be distributed before each seminar. Seminars are most commonly held on zoom or as hybrid meetings. Because the seminars are interactive, you need a functioning headset and webcam to participate.
The scheduled seminars are shown below. For most seminars, no registration is needed. However, you do need to sign up to the email list to get the information on how to connect to the seminar. You manage your own email list subscription and unsubscription: https://lists.uu.se/sympa/subscribe/surgsci-episeminars
Approximately one week before each seminar, an email with additional information (zoom link) and reading material will be circulated via the email list.
Suggestions for topics or presentations of own epidemiology-related results or questions are encouraged and can be sent to the course leader.
The seminars are given one of the seminar series within the research training courses at the Disciplinary domain of medicine and pharmacy, Uppsala university. Active participation in 10 seminars qualifies for 1 credit (hp).
Senior researchers are welcome to join the seminars but will be asked to “keep mainly in the background” since the main focus will be to facilitate discussion amongst the PhD students.
Course leader: Liisa Byberg, professor of medical epidemiology, Medical Epidemiology, Department of Surgical Sciences, Uppsala University (liisa.byberg@uu.se)
No formal examination; credits given based on attendance. PhD students will receive 1 credit (hp) for 10 seminars attended. Do not forget to state your name, affiliation, and whether you are a PhD student, postdoc (etc.) in the zoom chat or sign the attendance list circulated at the seminar.
Scheduled seminars, autumn 2024
All seminars are on Zoom, from 1-2 pm, unless otherwise stated. Dates are fixed, topics may change.
Wednesday, 11 September 2024
- Causal diagrams: introduction and a case example. Causal diagrams are more frequently being used in epidemiology. We often use them in the seminar series to illustrate, discuss, and understand epidemiological issues including confounding and selection bias. In this seminar, we give an introduction to causal diagrams for those who are unfamiliar with the concept and provide a refresher and an applied example for those who have used causal diagrams in the past. We base the discussions on the paper “Using Causal Diagrams to Improve the Design and Interpretation of Medical Research” by Etminan et al. This seminar is hosted by Liisa Byberg.
Wednesday, 25 September 2024
- Gabriel Baldanzi: Measurement errors. How can measurement errors affect my results? What is the difference between measurement error and misclassification? Can we address these issues in our analyses? Join us for this epidemiology seminar on measurement error. We will use DAGs to discuss the different types of measurement errors. Prepare by reflecting on whether your exposure, outcome, or covariates have some measurement error. We will use the article by Innes et al. to kick off the discussion. https://academic-oup-com.ezproxy.its.uu.se/epirev/article/43/1/94/6401584
Tuesday, 1 October 2024
- In this week’s seminar, we will provide an introduction to sibling comparison designs. Elena Extrand, PhD student at the Department of Surgical Sciences, will give a brief introduction and we will together discuss the advantages of sibling comparison designs and what kinds of research questions they can help address. The following article by Obel et al. will be used to guide the discussion: Is maternal smoking during pregnancy a risk factor for hyperkinetic disorder? - Findings from a sibling design. This seminar will provide the foundation for next week’s discussion on the limitations of sibling comparison designs. Participants who want a broad overview of sibling comparison designs are also welcome to read this commentary: https://pubmed.ncbi.nlm.nih.gov/21450688/.
Wednesday, 9 October 2024, on Zoom and in person at BMC, Room A1:111a.
- Thomas Frisell, Karolinska Institutet. Sibling comparison designs are increasingly utilized in epidemiology to address confounding factors shared between siblings, such as socioeconomic or genetic influences. In this seminar, we will explore limitations and biases that can arise when using these designs. How should we interpret the results of sibling design studies? In which circumstances should we use sibling designs? Thomas Frisell will discuss these questions and more in this seminar. Please prepare by reading his article: Sibling Comparison Designs: Bias from Non-Shared Confounders and Measurement Error.
Wednesday, 30 October 2024
- Charlson’s comorbidity index
Wednesday, 13 November 2024
- Anna Aronsson: New measures of comorbidity
Wednesday, 27 November 2024
- Topic to be determined
Wednesday, 11 December 2024
- Topic to be determined
Group members
Publications
Part of Environmental Science and Technology, p. 1036-1047, 2024
Part of Cell Death Discovery, 2024
Part of Journal of Autoimmunity, 2024
Part of Cancer Causes and Control, p. 367-376, 2024
Part of European Journal of Nutrition, 2024
Digestive System Diseases, Genetic Risk, and Incident Dementia: A Prospective Cohort Study
Part of American Journal of Preventive Medicine, p. 516-525, 2024
Part of BMC Medicine, 2024
- DOI for Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
- Download full text (pdf) of Genetic investigation into the broad health implications of caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
Part of EBioMedicine, 2024
Part of American Journal of Epidemiology, p. 96-106, 2024
- DOI for Hypothetical 22-Year Intervention With the Dietary Approaches to Stop Hypertension and Risk of Heart Failure in a General Population
- Download full text (pdf) of Hypothetical 22-Year Intervention With the Dietary Approaches to Stop Hypertension and Risk of Heart Failure in a General Population
Part of EBioMedicine, 2024
Proteomic insights into modifiable risk of venous thromboembolism and cardiovascular comorbidities
Part of Journal of Thrombosis and Haemostasis, p. 738-748, 2024
Part of The journals of gerontology. Series A, Biological sciences and medical sciences, 2024
Healthy lifestyle and cancer survival: A multinational cohort study
Part of International Journal of Cancer, p. 1709-1718, 2024
Design, Methods, and Participation in Riksmaten Young Children—A Swedish National Dietary Survey
Part of Current Developments in Nutrition, 2024
Part of Diabetologia, 2024
DNA methylation and stroke prognosis: an epigenome-wide association study
Part of Clinical Epigenetics, 2024
Part of Stroke, p. 1582-1591, 2024
Part of American Journal of Clinical Nutrition, p. 187-195, 2024
- DOI for Substitutions of saturated fat intakes with other macronutrients and foods and risk of NAFLD cirrhosis and all-cause hepatocellular carcinoma: a prospective cohort study
- Download full text (pdf) of Substitutions of saturated fat intakes with other macronutrients and foods and risk of NAFLD cirrhosis and all-cause hepatocellular carcinoma: a prospective cohort study
The Fate of Phosphate: Assessing Dietary Intake and Urinary Excretion in Swedish Adolescents
Part of Current Developments in Nutrition, 2024
Cardiopulmonary exercise testing and body composition.
Part of ERJ open research, 2024
Part of The Bone & Joint Journal, p. 705-712, 2024
- DOI for Decompression alone or decompression with fusion for lumbar spinal stenosis: five-year clinical results from a randomized clinical trial
- Download full text (pdf) of Decompression alone or decompression with fusion for lumbar spinal stenosis: five-year clinical results from a randomized clinical trial
Part of Journal of Cachexia, Sarcopenia and Muscle, 2024
Part of Nutrition Journal, 2024
- DOI for Validation of an web-based dietary assessment tool (RiksmatenFlex) against doubly labelled water and 24 h dietary recalls in pregnant women
- Download full text (pdf) of Validation of an web-based dietary assessment tool (RiksmatenFlex) against doubly labelled water and 24 h dietary recalls in pregnant women
Time trends of the association of body mass index with mortality in 3.5 million young Swedish adults
Part of Annals of Epidemiology, p. 23-32, 2024
Part of BMC Public Health, 2024
- DOI for Short, frequent physical activity breaks improve working memory while preserving cerebral blood flow in adolescents during prolonged sitting - AbbaH teen, a randomized crossover trial
- Download full text (pdf) of Short, frequent physical activity breaks improve working memory while preserving cerebral blood flow in adolescents during prolonged sitting - AbbaH teen, a randomized crossover trial
Part of The Journal of Nutrition, Health & Aging, 2024
Part of Scientific Reports, 2024
Cohort profile: The Obesity and Disease Development Sweden (ODDS) study, a pooled cohort
Part of BMJ Open, p. 1-15, 2024
Eggs - a scoping review for Nordic Nutrition Recommendations 2023
Part of Food & Nutrition Research, 2024
Markers of imminent myocardial infarction
Part of Nature Cardiovascular Research, p. 130-139, 2024
Part of The Lancet Diabetes and Endocrinology, p. 619-630, 2024
- DOI for Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 197 million adults with 100 000 incident cases from 31 cohorts in 20 countries
- Download full text (pdf) of Meat consumption and incident type 2 diabetes: an individual-participant federated meta-analysis of 197 million adults with 100 000 incident cases from 31 cohorts in 20 countries
Part of npj Science of Food, 2024
Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease
Part of Clinical Gastroenterology and Hepatology, p. 398-4050000, 2023
Part of EBioMedicine, 2023
Part of EBioMedicine, 2023
Part of Clinical Physiology and Functional Imaging, p. 120-127, 2023
Part of Alimentary Pharmacology and Therapeutics, p. 399-408, 2023
Federated analyses of multiple data sources in drug safety studies
Part of Pharmacoepidemiology and Drug Safety, p. 279-286, 2023
Part of Acta Paediatrica, p. 1011-1018, 2023
Part of Alimentary Pharmacology and Therapeutics, p. 475-485, 2023
Part of Diabetologia, p. 800-812, 2023
Part of American Journal of Gastroenterology, p. 511-522, 2023
- DOI for The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study
- Download full text (pdf) of The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study
Part of Cancer Epidemiology, Biomarkers and Prevention, p. 809-817, 2023
- DOI for Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
- Download full text (pdf) of Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis
Part of Journal of the Endocrine Society, 2023
Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study
Part of Frontiers in Medicine, 2023
Ultra-processed food intake and incident venous thromboembolism risk: Prospective cohort study
Part of Clinical Nutrition, p. 1268-1275, 2023
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Part of Clinical Proteomics, 2023
Part of BMC Medicine, 2023
Part of Cancer Epidemiology, Biomarkers and Prevention, p. 1048-1060, 2023
Part of Diabetes Care, p. 828-835, 2023