Ophthalmology

Photo: Elin Eriksson
The ophthalmology research group runs research projects in several subspecialties within ophthalmology. The research is primarily clinical and patient based.
Research on retinal diseases
The research on retinal diseases is based, among other things, on data from the national quality registry, the Swedish Macula Register. The aim is to investigate prognostic factors in the treatment of macular oedema caused by diabetes, and to study medical outcomes following treatment of macular oedema caused by retinal vein occlusion.
The research on retinal diseases also investigates the retinal cell layers using optical coherence tomography (OCT) in individuals with various neurological diseases. The aim is to identify OCT biomarkers for specific neurological diseases.
Research is also being conducted on the evaluation of hereditary retinal dystrophies. The aim is, through assessment with electroretinogram (ERG) and genetic testing, to improve prognostication and habilitation in these diseases in both adults and children.
Research in paediatric ophthalmology
The overall research aim in paediatric ophthalmology is to provide new knowledge about how visual and ocular function develop over time in preterm children and in children who have undergone surgery for craniosynostosis, and to design optimal ophthalmic follow-up for these children. In paediatric ophthalmology, research is also conducted at national level through the Swedish quality registry for retinopathy of prematurity (ROP) (SWEDROP). The research concerns the prevalence of ROP and its treatment, as well as follow-up up to preschool age. Furthermore, the group investigates how methods such as OCT and ERG can facilitate the evaluation of disorders of the visual pathways and retinal diseases in children.
Research on visual and ocular function in children who have had idiopathic intracranial hypertension and brain tumours is carried out in collaboration with paediatricians.
Research on glaucoma
Glaucoma research aims to diagnose the disease at an early stage and to detect progression. The group has several ongoing projects. Using OCT, a new deep learning-based algorithm has been developed. The method is being applied in healthy individuals to build normative data. The algorithm is also being compared with established methods used to make a diagnosis and to assess disease progression. The aim is to analyse whether the method is superior and more precise for diagnosing glaucoma, as well as for follow-up and assessment of progression. Parts of the projects are conducted in collaboration with the KTH Royal Institute of Technology in Stockholm.
In addition, a study on so-called normal-tension glaucoma is ongoing in collaboration with ophthalmologists in Switzerland.
Research in oculoplastic surgery
In oculoplastic surgery, studies are underway on how to measure intraorbital pressure using the least invasive procedures possible in patients with severe burns involving the face and eyes. A further study is investigating different surgical techniques in eyelid surgery.
Research in cataract surgery
A study is underway on learning progression in cataract surgery using a virtual simulator. The aim is to evaluate whether a cataract surgery simulator can help improve training in cataract surgery, and to assess whether the method can enhance surgical competence and reduce complications during real-life operations.
Collaborations
The ophthalmology research group collaborates with other units at the Department of Surgical Sciences, such as Plastic Surgery and Radiology. We also collaborate with the Department of Women’s and Children’s Health, the Department of Medical Sciences (Neurology and Internal Medicine), and the Department of Psychology. In addition, we collaborate with other universities in Sweden within the framework of our research based on national quality registries.
Teaching
The research group is responsible for undergraduate education in ophthalmology:
- The Medical Programme, with a total of just over 200 students per year
- The Biomedicine Programme, including one course per year with a total of 50 students
The unit is also responsible for organising courses within the Swedish national specialist training (ST) programme in:
- Physiological optics
- Paediatric ophthalmology and strabismus
History
The ophthalmology unit was founded by Professor Alvar Gullstrand, who was the first Professor of Ophthalmology at Uppsala University, appointed in 1894. In 1911, Alvar Gullstrand was awarded the Nobel Prize in Physiology or Medicine for his work on the optics of the eye. In 1914, he was appointed to a personal professorship in physical and physiological optics. Professor emeritus Albert Alm, in close collaboration with the Uppsala-based company Pharmacia Ophthalmics, led the clinical development of latanoprost, the first molecule in a new generation of intraocular pressure-lowering drugs, which is now a market leader in many parts of the world. Professor emerita Gerd Holmström was one of the founders of the Swedish registry for retinopathy of prematurity (SWEDROP). Findings from Gerd Holmström’s research group have contributed to international protocols for clinical follow-up of retinopathy of prematurity.om