Endocrine Surgery
![Operation i endokrinkirurgi. Fotograf Mikael Wallerstedt](/images/200.59b846bf18bcc057d9a1260/1699966647054/endokrinkirurgi%20-%20per%20hellman%201932x828px.jpg)
Photo: Mikael Wallerstedt
The Endocrine Surgery Research Group studies the genetics, diagnostics and treatment of endocrine tumors.
The Endocrine Surgical Research Group runs studies of genetics, diagnosis and treatment of endocrine tumours, in order to identify genes involved in tumour development and progression, and to ultimately provide possibilities for new treatment. We have always included translational studies in our work. In clinical studies genetic changes are related to the disease course of individual tumours, with the overall aim to improve diagnosis and treatment in patients with endocrine tumour disease. We are also studying indications for surgery, survival benefits and optimization of surgery from different perspectives.
Research
Our aims
Endocrine tumours are of special interest in tumour biology because of a common extended disease course, and often presence of only few specific genetic changes, which can be related to variable tumour biology. For many endocrine tumours histopathology can often not distinguish tumours with more malignant biological features, and there is a general hope that genetic differences will provide better means of discrimination. Genetic studies are expected to become of great importance for the clinical management by predicting prognosis, and genetic defects may be used as targets for new treatment. The overall aim of the studies is to identify tumour genes and other prognostic markers of importance for the development and progression of endocrine tumours, reveal gene changes with new technology, and investigate new possibilities of treatment against tumour progression.
Other research, more clinical, lines are the studies of treatment of liver metastases in small intestinal as well as pancreatic NETs, to pinpoint the surgical indication and the efficacy of surgical treatment. Also non-surgical treatment is scrutinized as an option. In thyroid surgery postoperative hypoparathyroidism has been displayed as a far more important and frequently occurring complication than previously expected. The novel analogue 18F-CETO for PET has been developed by us, and is now established for adrenocortical disease. Further studies with 18F-CETO-PET/CT is ongoing for further clarification of its role especially in adrenocortical cancer and primary aldosteronism.
Collaboration
Collaboration is continuously running with other groups within Academic Hospital: Uppsala Centre of Excellence for Endocrine Tumors. We have a national certificate to perform highly specialized care in patients with advanced small intestinal NETs, all pancreatic NETs, adrenal tumours, and carcinoid heart disease.
Collaboration is also ongoing in Sweden with other certified NET centers (Gothenburg, Lund, Stockholm) and internationally with Groeningen, Harvard in Boston, Melbourne, Cambridge, Oxford and Sydney.
As an overall resource we have access to >3000 specimens and blood samples from patients operated for endocrine tumours during >20 years. The samples, stored at Uppsala Biobank, have being used in many previous studies and is a valuable and important source in our studies.
Some selected publications
- Daskalakis K, Karakatsanis A, Hessman O, Stuart HC, Welin S, Tiensuu Janson E, et al. Association of a Prophylactic surgical approach to Stage IV Small Intestinal Neuroendocrine Tumors with Survival. JAMA Oncology [Internet]. 2018;4(2):183–9.
- Backman S, Bajic D, Crona J, Hellman P, Skogseid B, Stålberg P. Whole genome sequencing of apparently mutation-negative MEN1 patients. European Journal of Endocrinology [Internet]. 2020;182(1):35–45.
- Annebäck M, McHale Sjödin E, Hellman P, Stålberg P, Norlén O. Preoperative prophylactic active vitamin D to streamline total thyroidectomy. BJS Open [Internet]. 2022;6(3).
- Silins I, Sundin A, Lubberink M, O’Sullivan L, Gurnell M, Aigbirhio F, et al. First-in-human evaluation of [18F]CETO : a novel tracer for adrenocortical tumours. European Journal of Nuclear Medicine and Molecular Imaging [Internet]. 2023;50(2):398–409.
- Kjaer J, Clancy TE, Thornell A, Andersson N, Hellman P, Crona J, et al. Benefit of Primary Tumor Resection in Stage IV, Grade 1 and 2, Pancreatic Neuroendocrine Tumors : A Propensity-Score Matched Cohort Study. Annals of Surgery Open [Internet]. 2022;3(1).
- Barazeghi E, Hellman P, Norlén O, Westin G, Stålberg P. EZH2 presents a therapeutic target for neuroendocrine tumors of the small intestine. Scientific Reports [Internet]. 2021;11.
- Backman S, Åkerström T, Maharjan R, Cupisti K, Willenberg HS, Hellman P, et al. RNA Sequencing Provides Novel Insights into the Transcriptome of Aldosterone Producing Adenomas. Scientific Reports [Internet]. 2019;9.
- Annebäck M, Hedberg J, Almquist M, Stålberg P, Norlén O. Risk of Permanent Hypoparathyroidism After Total Thyroidectomy for Benign Disease : A Nationwide Population-based Cohort Study From Sweden. Annals of Surgery [Internet]. 2021;274(6):e1202–8.
- Kjaer J, Smith S, Hellman P, Stålberg P, Crona J, Welin S, et al. Overall Survival in Patients with Stage IV Pan-NET Eligible for Liver Transplantation. World Journal of Surgery [Internet]. 2023;47:340–7.
Group members
Publications
Part of Breast, 2024
- DOI for Association of clinicopathologic variables and patient preference with the choice of surgical treatment for early-stage breast cancer: A registry-based study
- Download full text (pdf) of Association of clinicopathologic variables and patient preference with the choice of surgical treatment for early-stage breast cancer: A registry-based study
Part of British Journal of Surgery, 2024
- DOI for Validating the risk of hypoparathyroidism after total thyroidectomy in a population-based cohort: plea for improved follow-up
- Download full text (pdf) of Validating the risk of hypoparathyroidism after total thyroidectomy in a population-based cohort: plea for improved follow-up
Part of International Journal of Surgery, p. 176-182, 2024
- DOI for Effect of mode of delivery of patient reported outcomes in patients with breast disease: a randomised controlled trial
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Part of British Journal of Surgery, 2024
- DOI for Magnetically guided surgery after primary systemic therapy for breast cancer: implications for enhanced axillary mapping
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Part of Endocrine-Related Cancer, 2024
Part of British Journal of Surgery, 2024
Part of Scandinavian Journal of Gastroenterology, p. 503-511, 2024
- DOI for The role of endoscopist adenoma detection rate in in sex differences in colonoscopy findings: cross-sectional analysis of the SCREESCO randomized controlled trial
- Download full text (pdf) of The role of endoscopist adenoma detection rate in in sex differences in colonoscopy findings: cross-sectional analysis of the SCREESCO randomized controlled trial
Part of Clinical and Translational Radiation Oncology, 2024
- DOI for Postmastectomy radiation therapy in breast cancer patients with micrometastatic disease in sentinel node dissection: A cohort study and meta-analysis
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Part of British Journal of Surgery, 2024
Carl Blomqvist, Nordic network builder in oncology (1951-2023)
Part of Acta Oncologica, p. 3-3, 2024
- DOI for Carl Blomqvist, Nordic network builder in oncology (1951-2023)
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EUSOMA quality indicators for non-metastatic breast cancer: An update
Part of European Journal of Cancer, 2024
First-in-human evaluation of [18F]CETO: a novel tracer for adrenocortical tumours
Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 398-409, 2023
- DOI for First-in-human evaluation of [18F]CETO: a novel tracer for adrenocortical tumours
- Download full text (pdf) of First-in-human evaluation of [18F]CETO: a novel tracer for adrenocortical tumours
Pancreatic Neuroendocrine Tumors: Surgical Treatment and Follow-up
2023
Hypoparathyroidism after thyroid surgery- rates, risks, prevention and consequences
2023
Part of Cancers, 2023
- DOI for Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)
- Download full text (pdf) of Localization Techniques for Non-Palpable Breast Lesions: Current Status, Knowledge Gaps, and Rationale for the MELODY Study (EUBREAST-4/iBRA-NET, NCT 05559411)
Overall Survival in Patients with Stage IV Pan-NET Eligible for Liver Transplantation
Part of World Journal of Surgery, p. 340-347, 2023
- DOI for Overall Survival in Patients with Stage IV Pan-NET Eligible for Liver Transplantation
- Download full text (pdf) of Overall Survival in Patients with Stage IV Pan-NET Eligible for Liver Transplantation
Short term outcomes after robot assisted and open cystectomy- A nation-wide population-based study
Part of European Journal of Surgical Oncology, p. 868-874, 2023
- DOI for Short term outcomes after robot assisted and open cystectomy- A nation-wide population-based study
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Part of European Journal of Surgical Oncology, p. 716-723, 2023
- DOI for Comprehending the impact of #Breastcancer, #Breastsurgery and related hashtags on Twitter: A content and social network cross-sectional analysis #Breastcancer#Breastsurgery
- Download full text (pdf) of Comprehending the impact of #Breastcancer, #Breastsurgery and related hashtags on Twitter: A content and social network cross-sectional analysis #Breastcancer#Breastsurgery
Metabolically (un)healthy obesity and risk of obesity-related cancers: a pooled study
Part of Journal of the National Cancer Institute, p. 456-467, 2023
- DOI for Metabolically (un)healthy obesity and risk of obesity-related cancers: a pooled study
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Part of World Journal of Surgery, p. 1084-1085, 2023
Smoking and Risk of Prostate Cancer and Prostate Cancer Death: A Pooled Study
Part of European Urology, p. 422-431, 2023
- DOI for Smoking and Risk of Prostate Cancer and Prostate Cancer Death: A Pooled Study
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Part of European Journal of Surgical Oncology, p. 60-67, 2023
- DOI for Effect of standardised surgical assessment and shared decision-making on morbidity and patient satisfaction after breast conserving therapy: A cross-sectional study
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Part of JAMA Network Open, 2023
- DOI for Outcomes of Different Quality of Life Assessment Modalities After Breast Cancer Therapy: A Network Meta-analysis
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Keeping a Breast with Social Media: "Le Marteau Sans Maitre?"
Part of Breast Care, p. 179-181, 2023
Part of Breast Care, p. 209-212, 2023
Part of British Journal of Surgery, p. 410-419, 2023
- DOI for Evolution and refinement of magnetically guided sentinel lymph node detection in breast cancer: meta-analysis
- Download full text (pdf) of Evolution and refinement of magnetically guided sentinel lymph node detection in breast cancer: meta-analysis
Part of Journal of Oncology, p. 9527920, 2023
Part of Acta Oncologica, p. 1045-1051, 2023
- DOI for Outcome of different radiotherapy strategies after breast conserving surgery in patients with ductal carcinoma in situ (DCIS)
- Download full text (pdf) of Outcome of different radiotherapy strategies after breast conserving surgery in patients with ductal carcinoma in situ (DCIS)
Part of PLOS ONE, 2023
- DOI for Preoperative upper tract invasive diagnostic modalities are associated with intravesical recurrence following surgery for upper tract urothelial carcinoma: A population-based study
- Download full text (pdf) of Preoperative upper tract invasive diagnostic modalities are associated with intravesical recurrence following surgery for upper tract urothelial carcinoma: A population-based study
Part of Cancer Medicine, p. 13856-13864, 2023
- DOI for Latent heterogeneity of muscle-invasive bladder cancer in patient characteristics and survival: A population-based nation-wide study in the Bladder Cancer Data Base Sweden (BladderBaSe)
- Download full text (pdf) of Latent heterogeneity of muscle-invasive bladder cancer in patient characteristics and survival: A population-based nation-wide study in the Bladder Cancer Data Base Sweden (BladderBaSe)
Part of British Journal of Surgery, p. 966-972, 2023
- DOI for Chest wall perforator flaps for breast reconstruction: international survey on attitudes and training needs
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Part of Upsala Journal of Medical Sciences, 2023
- DOI for High iNOS and IL-1β immunoreactivity are features of colitis-associated colorectal cancer tumors, but fail to predict 5-year survival
- Download full text (pdf) of High iNOS and IL-1β immunoreactivity are features of colitis-associated colorectal cancer tumors, but fail to predict 5-year survival
Magnetic Seed vs Guidewire Breast Cancer Localization With Magnetic Lymph Node Detection
Part of JAMA Surgery, 2023
Part of Journal of neuroendocrinology, 2023
- DOI for Improved health‐related quality of life during peptide receptor radionuclide therapy in patients with neuroendocrine tumours
- Download full text (pdf) of Improved health‐related quality of life during peptide receptor radionuclide therapy in patients with neuroendocrine tumours
Part of The Lancet Oncology, p. 187-194, 2023
Angiosarcoma in the breast: a population-based cohort from Sweden
Part of British Journal of Surgery, p. 1850-1856, 2023
Part of Journal of the National Cancer Institute, p. 38-46, 2022
- DOI for Antibiotics Use and Subsequent Risk of Colorectal Cancer: A Swedish Nationwide Population-Based Study
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Part of Scandinavian journal of urology, p. 14-18, 2022
- DOI for Bladder cancer recurrence in papillary urothelial neoplasm of low malignant potential (PUNLMP) compared to G1 WHO 1999: a population-based study
- Download full text (pdf) of Bladder cancer recurrence in papillary urothelial neoplasm of low malignant potential (PUNLMP) compared to G1 WHO 1999: a population-based study
Part of Cancer Epidemiology, Biomarkers and Prevention, p. 1483-1491, 2022
Part of Scandinavian journal of urology, p. 27-33, 2022
- DOI for Risk of bladder cancer death in patients younger than 50 with non-muscle-invasive and muscle-invasive bladder cancer
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Part of European Urology Open Science, p. 81-87, 2022
- DOI for Changes in Characteristics of Men with Lethal Prostate Cancer During the Past 25 Years: Description of Population-based Deaths
- Download full text (pdf) of Changes in Characteristics of Men with Lethal Prostate Cancer During the Past 25 Years: Description of Population-based Deaths
Part of European Journal of Surgical Oncology, p. 1503-1509, 2022
Part of Glycobiology, p. 518-528, 2022
- DOI for A dominant negative splice variant of the heparan sulfate biosynthesis enzyme NDST1 reduces heparan sulfate sulfation
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Prospective Evaluation of Complications and Associated Risk Factors in Breast Cancer Surgery
Part of Journal of Oncology, 2022
- DOI for Prospective Evaluation of Complications and Associated Risk Factors in Breast Cancer Surgery
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Improved adrenocortical PET imaging
2022
No self-evident interpretation of a randomized study
Part of Scandinavian journal of urology, p. 12-13, 2022
Part of Annals of Surgical Oncology, p. 6456-6457, 2022
Part of Annals of Surgical Oncology, p. 6440-6453, 2022
Part of Annals of Surgery Open, 2022
- DOI for Benefit of Primary Tumor Resection in Stage IV, Grade 1 and 2, Pancreatic Neuroendocrine Tumors: A Propensity-Score Matched Cohort Study
- Download full text (pdf) of Benefit of Primary Tumor Resection in Stage IV, Grade 1 and 2, Pancreatic Neuroendocrine Tumors: A Propensity-Score Matched Cohort Study
Preoperative prophylactic active vitamin D to streamline total thyroidectomy
Part of BJS Open, 2022
- DOI for Preoperative prophylactic active vitamin D to streamline total thyroidectomy
- Download full text (pdf) of Preoperative prophylactic active vitamin D to streamline total thyroidectomy