Otorhinolaryngology and Head and Neck Surgery

Research group leader Linda Marklund. Photo: Mikael Wallerstedt
The head and neck area is one of the most complex parts when it comes to anatomy and function.
The head and neck area is one of the most complex parts when it comes to anatomy and function. The area includes many vital structures that affect our quality of life such as sensory organs for hearing, balance, smell and taste, as well as breathing, swallowing, voice and facial mimicry and sensory. These functions can be affected both by diseases and by the treatment.
Research in the field of Otorhinolaryngology and Head and Neck surgery includes basic research that strives for increased understanding of organ anatomy and function as well as clinical treatment studies. The basic purpose is to increase knowledge about diseases and their course to improve treatment for the individual patient. These pages present an overview of the various research areas and projects that are ongoing at the Unit for Ear, Nose and Throat Diseases, Head and Neck Surgery.
Research fields
Group members
Publications
Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
Part of Scientific Reports, 2025
- DOI for Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
- Download full text (pdf) of Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
Part of STAR Protocols, 2025
- DOI for Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry
- Download full text (pdf) of Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry
Part of JPRAS Open, p. 22-33, 2025
- DOI for Exploring the relationship between the level of facial nerve injury and surgical outcome: Application of a new anatomical classification system in a limited cohort undergoing marginal mandibular nerve reconstruction
- Download full text (pdf) of Exploring the relationship between the level of facial nerve injury and surgical outcome: Application of a new anatomical classification system in a limited cohort undergoing marginal mandibular nerve reconstruction
World-wide survey on the treatment of peripheral vestibular disorders
Part of Frontiers in Neurology, 2025
- DOI for World-wide survey on the treatment of peripheral vestibular disorders
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Part of Frontiers in Oncology, 2025
- DOI for Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy
- Download full text (pdf) of Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy
Part of Acta Neurochirurgica, 2025
- DOI for Complications following endoscopic transsphenoidal surgery for pituitary adenoma-special focus on intrasellar pressure
- Download full text (pdf) of Complications following endoscopic transsphenoidal surgery for pituitary adenoma-special focus on intrasellar pressure
2025
Machine learning explainability for survival outcome in head and neck squamous cell carcinoma
Part of International Journal of Medical Informatics, 2025
- DOI for Machine learning explainability for survival outcome in head and neck squamous cell carcinoma
- Download full text (pdf) of Machine learning explainability for survival outcome in head and neck squamous cell carcinoma
Part of International Journal of Pediatric Otorhinolaryngology, 2024
- DOI for Estimated prevalence of permanent hearing loss among newborns and 6-year-olds: An evaluation of the three auditory screenings in Uppsala
- Download full text (pdf) of Estimated prevalence of permanent hearing loss among newborns and 6-year-olds: An evaluation of the three auditory screenings in Uppsala
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Part of Nature Communications, 2024
- DOI for Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
- Download full text (pdf) of Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Vestibular schwannoma: Clinical, Epidemiological and Biochemical perspectives
2024
Inner ear proteomics and barriers: Clinical and experimental findings
2024
Part of Plastic and reconstructive surgery (1963), 2024
Part of Oral Oncology, 2024
- DOI for Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival
- Download full text (pdf) of Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival
Systemic inflammation and prognostic markers in patients with head and neck cancer
2024
Immuno-surveillance and protection of the human cochlea
Part of Frontiers in Neurology, 2024
- DOI for Immuno-surveillance and protection of the human cochlea
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Part of PLOS ONE, 2024
- DOI for Six-month mortality has decreased for patients with curative treatment intent for head and neck cancer in Sweden
- Download full text (pdf) of Six-month mortality has decreased for patients with curative treatment intent for head and neck cancer in Sweden
Part of BMC Cancer, 2024
- DOI for The effect of internet-administered support (carer eSupport) on preparedness for caregiving in informal caregivers of patients with head and neck cancer compared with support as usual: a study protocol for a randomized controlled trial
- Download full text (pdf) of The effect of internet-administered support (carer eSupport) on preparedness for caregiving in informal caregivers of patients with head and neck cancer compared with support as usual: a study protocol for a randomized controlled trial
Fall-related injury among patients with vestibular schwannoma
Part of PLOS ONE, 2024
- DOI for Fall-related injury among patients with vestibular schwannoma
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Part of Digital Health and Informatics Innovations for Sustainable Health Care Systems, p. 751-755, 2024
- DOI for A Qualitative Study with Informal Caregivers and Healthcare Professionals for Individuals with Head and Neck Cancer on the Usage of AI Chatbots
- Download full text (pdf) of A Qualitative Study with Informal Caregivers and Healthcare Professionals for Individuals with Head and Neck Cancer on the Usage of AI Chatbots
Part of Scientific Reports, 2024
- DOI for Hearing loss and its association with the proteome of perilymph, cerebrospinal fluid, and tumor tissue in patients with vestibular schwannoma
- Download full text (pdf) of Hearing loss and its association with the proteome of perilymph, cerebrospinal fluid, and tumor tissue in patients with vestibular schwannoma
Liquid Metal-Based High-Density Interconnect Technology for Stretchable Printed Circuits
Part of Advanced Functional Materials, 2024
- DOI for Liquid Metal-Based High-Density Interconnect Technology for Stretchable Printed Circuits
- Download full text (pdf) of Liquid Metal-Based High-Density Interconnect Technology for Stretchable Printed Circuits
Part of Nature Communications, 2024
- DOI for Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists
- Download full text (pdf) of Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists
Part of European Journal of Cancer, 2024
Part of Journal of Anatomy, p. 271-288, 2024
- DOI for Microanatomy of the human tunnel of Corti structures and cochlear partition-tonotopic variations and transcellular signaling
- Download full text (pdf) of Microanatomy of the human tunnel of Corti structures and cochlear partition-tonotopic variations and transcellular signaling
Part of Frontiers in Immunology, 2024
- DOI for Prognostic value of T regulatory cells and immune checkpoints expression in tumor-draining lymph nodes for oral squamous cell carcinoma
- Download full text (pdf) of Prognostic value of T regulatory cells and immune checkpoints expression in tumor-draining lymph nodes for oral squamous cell carcinoma
Part of iScience, 2024
- DOI for MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors
- Download full text (pdf) of MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors
Cochlear implantation and partial deafness: A retrospective review on processor programming
Part of Acta Oto-Laryngologica, p. 355-361, 2024
- DOI for Cochlear implantation and partial deafness: A retrospective review on processor programming
- Download full text (pdf) of Cochlear implantation and partial deafness: A retrospective review on processor programming
Part of Acta Oto-Laryngologica, p. 552-557, 2024
- DOI for Do different types of cochlear implant electrode influence hearing preservation and speech perception?
- Download full text (pdf) of Do different types of cochlear implant electrode influence hearing preservation and speech perception?
Morphologic Analysis of the Scala Tympani Using Synchrotron: Implications for Cochlear Implantation.
Part of The Laryngoscope, p. 2889-2897, 2024
- DOI for Morphologic Analysis of the Scala Tympani Using Synchrotron: Implications for Cochlear Implantation.
- Download full text (pdf) of Morphologic Analysis of the Scala Tympani Using Synchrotron: Implications for Cochlear Implantation.
A novel therapeutic pathway to the human cochlear nerve
Part of Scientific Reports, 2024
- DOI for A novel therapeutic pathway to the human cochlear nerve
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Part of Frontiers in Cell and Developmental Biology, 2024
- DOI for First photon-counting detector computed tomography in the living crocodile: a 3D-Imaging study with special reference to amphibious hearing
- Download full text (pdf) of First photon-counting detector computed tomography in the living crocodile: a 3D-Imaging study with special reference to amphibious hearing
Part of Clinical Otolaryngology, p. 660-669, 2024
- DOI for Hearing Outcomes After Ossiculoplasty With Bone or Titanium Prostheses—A Nationwide Register-Based Study
- Download full text (pdf) of Hearing Outcomes After Ossiculoplasty With Bone or Titanium Prostheses—A Nationwide Register-Based Study
Part of Cochlear Implants International, p. 316-333, 2024
Expression of Neurotrophins and Its Receptors During Fetal Development in the Human Cochlea
Part of International Journal of Molecular Sciences, 2024
- DOI for Expression of Neurotrophins and Its Receptors During Fetal Development in the Human Cochlea
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Middle Ear Biofilm and Sudden Deafness: A Light and Transmission Electron Microscopy Study
Part of Frontiers in Neurology, 2024
- DOI for Middle Ear Biofilm and Sudden Deafness: A Light and Transmission Electron Microscopy Study
- Download full text (pdf) of Middle Ear Biofilm and Sudden Deafness: A Light and Transmission Electron Microscopy Study
Test-retest reliability of the urban outdoor situated phoneme (SiP) test
Part of International Journal of Audiology, p. 859-866, 2024
- DOI for Test-retest reliability of the urban outdoor situated phoneme (SiP) test
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Part of Supportive Care in Cancer, 2024
- DOI for Mapping the impact of malnutrition as defined by the Global Leadership Initiative on Malnutrition and nutrition impact symptoms on the possibility of returning to work after treatment for head and neck cancer
- Download full text (pdf) of Mapping the impact of malnutrition as defined by the Global Leadership Initiative on Malnutrition and nutrition impact symptoms on the possibility of returning to work after treatment for head and neck cancer
Part of Western Journal of Nursing Research, p. 790-798, 2024
- DOI for Swedish Translation and Cultural Adaptation of the Head and Neck Patient Symptom Checklist: An Instrument to Screen for Nutrition Impact Symptoms in Clinical Practice and Research
- Download full text (pdf) of Swedish Translation and Cultural Adaptation of the Head and Neck Patient Symptom Checklist: An Instrument to Screen for Nutrition Impact Symptoms in Clinical Practice and Research
Part of Head and Neck, p. 808-818, 2024
- DOI for Pretreatment fat‐free mass index correlates with early death in patients with head and neck squamous cell carcinoma
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Part of Head and Neck, p. 2422-2431, 2024
- DOI for Prognostic value of bone marrow and tumor 18F‐FDG uptake on PET/CT in patients with oropharyngeal cancer and the interplay between inflammation and FDG uptake
- Download full text (pdf) of Prognostic value of bone marrow and tumor 18F‐FDG uptake on PET/CT in patients with oropharyngeal cancer and the interplay between inflammation and FDG uptake
Synchrotron Phase-Contrast Imaging and Cochlear Otosclerosis: A Case Report
Part of Audiology & neuro-otology, p. 487-499, 2024
- DOI for Synchrotron Phase-Contrast Imaging and Cochlear Otosclerosis: A Case Report
- Download full text (pdf) of Synchrotron Phase-Contrast Imaging and Cochlear Otosclerosis: A Case Report
Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations
Part of Cancers, 2023
- DOI for Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations
- Download full text (pdf) of Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations
Part of International Journal of Molecular Sciences, 2023
- DOI for Loco-Regional Control and Sustained Difference in Serum Immune Protein Expression in Patients Treated for p16-Positive and p16-Negative Head and Neck Squamous Cell Carcinoma
- Download full text (pdf) of Loco-Regional Control and Sustained Difference in Serum Immune Protein Expression in Patients Treated for p16-Positive and p16-Negative Head and Neck Squamous Cell Carcinoma
Do Patients Aged 85 Years and above Benefit from Their Cochlear Implants?
Part of Audiology Research, p. 96-106, 2023
- DOI for Do Patients Aged 85 Years and above Benefit from Their Cochlear Implants?
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Part of Frontiers in Cell and Developmental Biology, 2023
- DOI for The ultrastructure of a stria vascularis in the auditory organ of the cuban crocodile (Crocodylus rhombifer)
- Download full text (pdf) of The ultrastructure of a stria vascularis in the auditory organ of the cuban crocodile (Crocodylus rhombifer)
Part of The Lancet Oncology, p. 239-251, 2023
- DOI for Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis
- Download full text (pdf) of Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis
Factors that affect quality of life for older people with head and neck cancer: A systematic review
Part of European Journal of Oncology Nursing, 2023
- DOI for Factors that affect quality of life for older people with head and neck cancer: A systematic review
- Download full text (pdf) of Factors that affect quality of life for older people with head and neck cancer: A systematic review
Part of Scientific Reports, 2023
- DOI for Transcriptomics unravels molecular changes associated with cilia and COVID-19 in chronic rhinosinusitis with nasal polyps
- Download full text (pdf) of Transcriptomics unravels molecular changes associated with cilia and COVID-19 in chronic rhinosinusitis with nasal polyps
Part of Journal of Clinical Sleep Medicine (JCSM), p. 573-579, 2023