Öron-, näs- och halskirurgi

Forskargruppsledare Linda Marklund. Foto: Mikael Wallerstedt
Huvud-halsområdet är ett av kroppens mest komplexa områden när det kommer till anatomi och funktion.
Huvud-halsområdet omfattar många vitala strukturer som påverkar vår livskvalitet såsom sinnesorgan för hörsel, balans, lukt och smak, och andning, röst, svälj- och tuggfunktioner samt även ansiktets mimik och sensorisk. Halsen inbegriper även rösten som är ett viktigt instrument i den mänskliga kommunikationen. Dessa funktioner kan påverkas av såväl sjukdomar samt den behandling som ges.
Forskningen inom detta område inbegriper såväl grundforskning som strävar till ökad förståelse för organs anatomi och funktion som kliniska behandlingsstudier. Det grundläggande syftet är att öka kunskapen om sjukdomar och deras förlopp för att kunna förbättra behandlingen för den enskilde patienten.
På dessa sidor presenteras en överblick av de olika forskningsområden och projekt som pågår just nu.
Pågående forskning:
Gruppmedlemmar
Publikationer
Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
Ingår i Scientific Reports, 2025
- DOI för Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
- Ladda ner fulltext (pdf) av Targeting mutant p53: Evaluation of novel anti-p53R175H monoclonal antibodies as diagnostic tools
Ingår i STAR Protocols, 2025
- DOI för Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry
- Ladda ner fulltext (pdf) av Protocol for in vivo immune cell analysis in subcutaneous murine tumor models using advanced flow cytometry
Ingår i JPRAS Open, s. 22-33, 2025
- DOI för Exploring the relationship between the level of facial nerve injury and surgical outcome: Application of a new anatomical classification system in a limited cohort undergoing marginal mandibular nerve reconstruction
- Ladda ner fulltext (pdf) av Exploring the relationship between the level of facial nerve injury and surgical outcome: Application of a new anatomical classification system in a limited cohort undergoing marginal mandibular nerve reconstruction
World-wide survey on the treatment of peripheral vestibular disorders
Ingår i Frontiers in Neurology, 2025
- DOI för World-wide survey on the treatment of peripheral vestibular disorders
- Ladda ner fulltext (pdf) av World-wide survey on the treatment of peripheral vestibular disorders
Ingår i Frontiers in Oncology, 2025
- DOI för Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy
- Ladda ner fulltext (pdf) av Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy
Ingår i Acta Neurochirurgica, 2025
- DOI för Complications following endoscopic transsphenoidal surgery for pituitary adenoma-special focus on intrasellar pressure
- Ladda ner fulltext (pdf) av Complications following endoscopic transsphenoidal surgery for pituitary adenoma-special focus on intrasellar pressure
2025
Machine learning explainability for survival outcome in head and neck squamous cell carcinoma
Ingår i International Journal of Medical Informatics, 2025
- DOI för Machine learning explainability for survival outcome in head and neck squamous cell carcinoma
- Ladda ner fulltext (pdf) av Machine learning explainability for survival outcome in head and neck squamous cell carcinoma
Distinct Tissue-Dependent Composition and Gene Expression of Human Fetal Innate Lymphoid Cells
Ingår i European Journal of Immunology, 2025
- DOI för Distinct Tissue-Dependent Composition and Gene Expression of Human Fetal Innate Lymphoid Cells
- Ladda ner fulltext (pdf) av Distinct Tissue-Dependent Composition and Gene Expression of Human Fetal Innate Lymphoid Cells
Ingår i Audiology Research, 2025
- DOI för Intraoperative Assessment of Cochlear Nerve Function During Cochlear Implantation Using the Auditory Nerve Test Stimulator
- Ladda ner fulltext (pdf) av Intraoperative Assessment of Cochlear Nerve Function During Cochlear Implantation Using the Auditory Nerve Test Stimulator
Ingår i International Journal of Pediatric Otorhinolaryngology, 2024
- DOI för Estimated prevalence of permanent hearing loss among newborns and 6-year-olds: An evaluation of the three auditory screenings in Uppsala
- Ladda ner fulltext (pdf) av Estimated prevalence of permanent hearing loss among newborns and 6-year-olds: An evaluation of the three auditory screenings in Uppsala
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Ingår i Nature Communications, 2024
- DOI för Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
- Ladda ner fulltext (pdf) av Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Vestibular schwannoma: Clinical, Epidemiological and Biochemical perspectives
2024
Inner ear proteomics and barriers: Clinical and experimental findings
2024
Ingår i Plastic and reconstructive surgery (1963), 2024
Ingår i Oral Oncology, 2024
- DOI för Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival
- Ladda ner fulltext (pdf) av Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival
Systemic inflammation and prognostic markers in patients with head and neck cancer
2024
Immuno-surveillance and protection of the human cochlea
Ingår i Frontiers in Neurology, 2024
- DOI för Immuno-surveillance and protection of the human cochlea
- Ladda ner fulltext (pdf) av Immuno-surveillance and protection of the human cochlea
Ingår i PLOS ONE, 2024
- DOI för Six-month mortality has decreased for patients with curative treatment intent for head and neck cancer in Sweden
- Ladda ner fulltext (pdf) av Six-month mortality has decreased for patients with curative treatment intent for head and neck cancer in Sweden
Ingår i BMC Cancer, 2024
- DOI för The effect of internet-administered support (carer eSupport) on preparedness for caregiving in informal caregivers of patients with head and neck cancer compared with support as usual: a study protocol for a randomized controlled trial
- Ladda ner fulltext (pdf) av The effect of internet-administered support (carer eSupport) on preparedness for caregiving in informal caregivers of patients with head and neck cancer compared with support as usual: a study protocol for a randomized controlled trial
Fall-related injury among patients with vestibular schwannoma
Ingår i PLOS ONE, 2024
- DOI för Fall-related injury among patients with vestibular schwannoma
- Ladda ner fulltext (pdf) av Fall-related injury among patients with vestibular schwannoma
Ingår i Digital Health and Informatics Innovations for Sustainable Health Care Systems, s. 751-755, 2024
- DOI för A Qualitative Study with Informal Caregivers and Healthcare Professionals for Individuals with Head and Neck Cancer on the Usage of AI Chatbots
- Ladda ner fulltext (pdf) av A Qualitative Study with Informal Caregivers and Healthcare Professionals for Individuals with Head and Neck Cancer on the Usage of AI Chatbots
Ingår i Scientific Reports, 2024
- DOI för Hearing loss and its association with the proteome of perilymph, cerebrospinal fluid, and tumor tissue in patients with vestibular schwannoma
- Ladda ner fulltext (pdf) av Hearing loss and its association with the proteome of perilymph, cerebrospinal fluid, and tumor tissue in patients with vestibular schwannoma
Liquid Metal-Based High-Density Interconnect Technology for Stretchable Printed Circuits
Ingår i Advanced Functional Materials, 2024
- DOI för Liquid Metal-Based High-Density Interconnect Technology for Stretchable Printed Circuits
- Ladda ner fulltext (pdf) av Liquid Metal-Based High-Density Interconnect Technology for Stretchable Printed Circuits
Ingår i Nature Communications, 2024
- DOI för Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists
- Ladda ner fulltext (pdf) av Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists
Ingår i European Journal of Cancer, 2024
Ingår i Journal of Anatomy, s. 271-288, 2024
- DOI för Microanatomy of the human tunnel of Corti structures and cochlear partition-tonotopic variations and transcellular signaling
- Ladda ner fulltext (pdf) av Microanatomy of the human tunnel of Corti structures and cochlear partition-tonotopic variations and transcellular signaling
Ingår i Frontiers in Immunology, 2024
- DOI för Prognostic value of T regulatory cells and immune checkpoints expression in tumor-draining lymph nodes for oral squamous cell carcinoma
- Ladda ner fulltext (pdf) av Prognostic value of T regulatory cells and immune checkpoints expression in tumor-draining lymph nodes for oral squamous cell carcinoma
Ingår i iScience, 2024
- DOI för MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors
- Ladda ner fulltext (pdf) av MDM2/MDMX inhibition by Sulanemadlin synergizes with anti-Programmed Death 1 immunotherapy in wild-type p53 tumors
Cochlear implantation and partial deafness: A retrospective review on processor programming
Ingår i Acta Oto-Laryngologica, s. 355-361, 2024
- DOI för Cochlear implantation and partial deafness: A retrospective review on processor programming
- Ladda ner fulltext (pdf) av Cochlear implantation and partial deafness: A retrospective review on processor programming
Ingår i Acta Oto-Laryngologica, s. 552-557, 2024
- DOI för Do different types of cochlear implant electrode influence hearing preservation and speech perception?
- Ladda ner fulltext (pdf) av Do different types of cochlear implant electrode influence hearing preservation and speech perception?
Morphologic Analysis of the Scala Tympani Using Synchrotron: Implications for Cochlear Implantation.
Ingår i The Laryngoscope, s. 2889-2897, 2024
- DOI för Morphologic Analysis of the Scala Tympani Using Synchrotron: Implications for Cochlear Implantation.
- Ladda ner fulltext (pdf) av Morphologic Analysis of the Scala Tympani Using Synchrotron: Implications for Cochlear Implantation.
A novel therapeutic pathway to the human cochlear nerve
Ingår i Scientific Reports, 2024
- DOI för A novel therapeutic pathway to the human cochlear nerve
- Ladda ner fulltext (pdf) av A novel therapeutic pathway to the human cochlear nerve
Ingår i Frontiers in Cell and Developmental Biology, 2024
- DOI för First photon-counting detector computed tomography in the living crocodile: a 3D-Imaging study with special reference to amphibious hearing
- Ladda ner fulltext (pdf) av First photon-counting detector computed tomography in the living crocodile: a 3D-Imaging study with special reference to amphibious hearing
Ingår i Clinical Otolaryngology, s. 660-669, 2024
- DOI för Hearing Outcomes After Ossiculoplasty With Bone or Titanium Prostheses—A Nationwide Register-Based Study
- Ladda ner fulltext (pdf) av Hearing Outcomes After Ossiculoplasty With Bone or Titanium Prostheses—A Nationwide Register-Based Study
Ingår i Cochlear Implants International, s. 316-333, 2024
Expression of Neurotrophins and Its Receptors During Fetal Development in the Human Cochlea
Ingår i International Journal of Molecular Sciences, 2024
- DOI för Expression of Neurotrophins and Its Receptors During Fetal Development in the Human Cochlea
- Ladda ner fulltext (pdf) av Expression of Neurotrophins and Its Receptors During Fetal Development in the Human Cochlea
Middle Ear Biofilm and Sudden Deafness: A Light and Transmission Electron Microscopy Study
Ingår i Frontiers in Neurology, 2024
- DOI för Middle Ear Biofilm and Sudden Deafness: A Light and Transmission Electron Microscopy Study
- Ladda ner fulltext (pdf) av Middle Ear Biofilm and Sudden Deafness: A Light and Transmission Electron Microscopy Study
Test-retest reliability of the urban outdoor situated phoneme (SiP) test
Ingår i International Journal of Audiology, s. 859-866, 2024
- DOI för Test-retest reliability of the urban outdoor situated phoneme (SiP) test
- Ladda ner fulltext (pdf) av Test-retest reliability of the urban outdoor situated phoneme (SiP) test
Ingår i Supportive Care in Cancer, 2024
- DOI för Mapping the impact of malnutrition as defined by the Global Leadership Initiative on Malnutrition and nutrition impact symptoms on the possibility of returning to work after treatment for head and neck cancer
- Ladda ner fulltext (pdf) av Mapping the impact of malnutrition as defined by the Global Leadership Initiative on Malnutrition and nutrition impact symptoms on the possibility of returning to work after treatment for head and neck cancer
Ingår i Western Journal of Nursing Research, s. 790-798, 2024
- DOI för Swedish Translation and Cultural Adaptation of the Head and Neck Patient Symptom Checklist: An Instrument to Screen for Nutrition Impact Symptoms in Clinical Practice and Research
- Ladda ner fulltext (pdf) av Swedish Translation and Cultural Adaptation of the Head and Neck Patient Symptom Checklist: An Instrument to Screen for Nutrition Impact Symptoms in Clinical Practice and Research
Ingår i Head and Neck, s. 808-818, 2024
- DOI för Pretreatment fat‐free mass index correlates with early death in patients with head and neck squamous cell carcinoma
- Ladda ner fulltext (pdf) av Pretreatment fat‐free mass index correlates with early death in patients with head and neck squamous cell carcinoma
Ingår i Head and Neck, s. 2422-2431, 2024
- DOI för Prognostic value of bone marrow and tumor 18F‐FDG uptake on PET/CT in patients with oropharyngeal cancer and the interplay between inflammation and FDG uptake
- Ladda ner fulltext (pdf) av Prognostic value of bone marrow and tumor 18F‐FDG uptake on PET/CT in patients with oropharyngeal cancer and the interplay between inflammation and FDG uptake
Synchrotron Phase-Contrast Imaging and Cochlear Otosclerosis: A Case Report
Ingår i Audiology & neuro-otology, s. 487-499, 2024
- DOI för Synchrotron Phase-Contrast Imaging and Cochlear Otosclerosis: A Case Report
- Ladda ner fulltext (pdf) av Synchrotron Phase-Contrast Imaging and Cochlear Otosclerosis: A Case Report
Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations
Ingår i Cancers, 2023
- DOI för Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations
- Ladda ner fulltext (pdf) av Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations
Ingår i International Journal of Molecular Sciences, 2023
- DOI för Loco-Regional Control and Sustained Difference in Serum Immune Protein Expression in Patients Treated for p16-Positive and p16-Negative Head and Neck Squamous Cell Carcinoma
- Ladda ner fulltext (pdf) av Loco-Regional Control and Sustained Difference in Serum Immune Protein Expression in Patients Treated for p16-Positive and p16-Negative Head and Neck Squamous Cell Carcinoma
Do Patients Aged 85 Years and above Benefit from Their Cochlear Implants?
Ingår i Audiology Research, s. 96-106, 2023
- DOI för Do Patients Aged 85 Years and above Benefit from Their Cochlear Implants?
- Ladda ner fulltext (pdf) av Do Patients Aged 85 Years and above Benefit from Their Cochlear Implants?
Ingår i Frontiers in Cell and Developmental Biology, 2023
- DOI för The ultrastructure of a stria vascularis in the auditory organ of the cuban crocodile (Crocodylus rhombifer)
- Ladda ner fulltext (pdf) av The ultrastructure of a stria vascularis in the auditory organ of the cuban crocodile (Crocodylus rhombifer)
Ingår i The Lancet Oncology, s. 239-251, 2023
- DOI för Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis
- Ladda ner fulltext (pdf) av Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis
Factors that affect quality of life for older people with head and neck cancer: A systematic review
Ingår i European Journal of Oncology Nursing, 2023
- DOI för Factors that affect quality of life for older people with head and neck cancer: A systematic review
- Ladda ner fulltext (pdf) av Factors that affect quality of life for older people with head and neck cancer: A systematic review