Anaesthesiology and Intensive Care Medicine

Photo: Mikael Wallerstedt

The research group is investigating, among other things, how circulation, breathing and the nervous system are affected and can be maintained after trauma.

Research projects:

Cardiac arrest-neuroprotection
Sepsis
Cardiothoracic anesthesia and intensive care, clinical and experimental research
Lung function in anaesthesia and intensive care
Paediatric anesthesia and perioperative medicine
The AKI group: Anesthesia, Kidney and Intensive Care

Group members

Research leader: Sten Rubertsson

Group members: Akram Abawi, Björn Ahlström, Anders Albåge, Mustafa Ali, Jimmy Almström, Hanna Andersson, Erebouni Arakelian, Kai Arnell, Anna Aronsson, Henrik Arthursson, Sana Asif, Sylvia Augustini, Anna Bandert, Lovisa Bark, Annelie Barrueta, Reka Bencze, Elisabeth Berghäll, Kristin Jóna Bjarnadóttir, Ivan Blokhin, Hans Blomberg, Erik Bruno, Sara Bûlow, Bram Burger, Lennart Christiansson, Jan Colldén, Lucian Covaciu, Sebastian de Brun, Konstantin Dirscherl, Arash Emami, Henrik Engquist, Joakim Engström, Mats Eriksson, Mikael Eriksson, Stephan Filipowski, Diddi Fors, Carley Fowler, Stephanie Franzén, Filip Fredén, Jennifer Fridman, Robert Frithiof, Peter Frykholm, Sarah Galien, Rolf Gedeborg, Anna Gradin, Peter Halvorsen, Katja Hanslin, Solveig Helgadottir, Edit Herczeghne, Anders Holmström, Bernhard Holzgraefe, Johan Hylander, Eva-Britt Hysing, Mikael Janiec, Lars Janson, Odin Joensen, Jakob Johansson, Lina Jonikaite, Torbjörn Karlsson, Rafael Kawati, Daniela Kietzmann, Anna Klaucane, Ann Kvarnström, Rickard Lagedal, Aleksandra Larina, Alexander Larsson, Anders Larsson, Ing-Marie Larsson, Ulrica Lennborn, Fredrik Lennmyr, Michael Lichtwarck-Aschoff, Chun-Yu Lin, Erik Lindgren, Miklós Lipcsey, Patrik Lundström, Tomas Luther, Daniel Löfving, Michael Marks-Hultström, Francisco Martinez, Ali-Reza Modiri, Eyla Mohlin, Maria Molnar, Rasmus Mossberg, Johan Mälberg, Sandra Nihlén, Manja Nilsson, Silvia Nyholm, Erik Näslund, David Ohlen, Alexander Otterbeck, Niccolo Pedrotti, Mariangela Pellegrini, Gaetano Perchiazzi, Emma Pontén, Bahareh Razmand, Thomas Renlund, Jacob Rosén, Christian Rylander, Paul Saretok, Petter Schiller, Eva Schmidtke, Egidijus Semenas, Magnus von Seth, Aruna Sharma, Hari Shanker Sharma, Oscar Simonson, Anna-Karin Smekal, David Smekal, Mark Solomon Mlamba, Karl Stattin, Fredrik Stiger, Kalle Stoorhöök, Gunnar Strandberg, Pernilla Sundqvist, Robert Sütterlin, Ewa Söderberg, Elin Söderman, Micael Taavo, Hanna Tegnér, Jyrki Tenhunen, Emma Thoren, Thomas Tovedal, Martin Tovedal, Sven Uhlig, Ewa Wallin, Johann Valtysson, Jaap van der Heijden, Wojciech Weigl, Anna Welander, Joanna Wessbergh, Arne Wessén, Hannes Widing, Lars Wiklund, Frenne Wåhlin, Björn Zarén, Henrik Zetterström, Frank Zoerner, Emma Ågren, Sara Åkerman

Publications

10th Anniversary of Biomedicines—Biomarkers in Pain

Eriksson, Mats; Larsson, Anders

MDPI, 2023
- DOI for 10th Anniversary of Biomedicines—Biomarkers in Pain
- Download full text (pdf) of 10th Anniversary of Biomedicines—Biomarkers in Pain
10th Clinical Trials on Alzheimer's Disease (CTAD), Boston MA, USA, November 1-4, 2017

Sharma, Hari Shanker; Skaper, Stephen D.; Sharma, Aruna

Part of CNS & Neurological Disorders, p. 1134-1137, 2017
- DOI for 10th Clinical Trials on Alzheimer's Disease (CTAD), Boston MA, USA, November 1-4, 2017
11th International Conference on Neuroprotective Agents, Wendake, Quebec City, Quebec, Canada, Sept 30-Oct 3, 2012

Sharma, Hari Shanker; Sharma, Aruna; Skaper, Stephen

Part of CNS & Neurological Disorders, p. 951-952, 2012
12th International Congress on Neuroprotective Agents (ICNA), Charlottesville, VA, USA September 28, 2014-Ocobert 01, 2014

Sharma, Hari Shanker; Skaper, Stephen D.; Sharma, Aruna

Part of CNS & Neurological Disorders, p. 1308-1309, 2014
- DOI for 12th International Congress on Neuroprotective Agents (ICNA), Charlottesville, VA, USA September 28, 2014-Ocobert 01, 2014
14th International Congress on Amino Acids, Peptides and Proteins, Vienna, Austria, August 3-7, 2015

Sharma, Hari S.; Skaper, Stephen D.; Sharma, Aruna

Part of CNS & Neurological Disorders, p. 644-645, 2016
- DOI for 14th International Congress on Amino Acids, Peptides and Proteins, Vienna, Austria, August 3-7, 2015
181st Annual Meeting of the American Association for the Advancement of Science (AAAS), San Jose Convention Center, San Jose, CA, USA February 12-16, 2015

Sharma, Hari Shanker; Skaper, Stephen D.; Sharma, Aruna

Part of CNS & Neurological Disorders, p. 434-436, 2015
183rd American Association for the Advancement of Science Annual Meeting, Boston MA, USA Feb 16-20, 2017 "Serving Society through Science Policy"

Sharma, Hari S.; Skaper, Stephen D.; Sharma, Aruna

Part of CNS & Neurological Disorders, p. 965-968, 2017
- DOI for 183rd American Association for the Advancement of Science Annual Meeting, Boston MA, USA Feb 16-20, 2017 "Serving Society through Science Policy"
184th American Association for the Advancement of Science Annual Meeting, Austin TX, USA Feb. 15-19, 2018

Sharma, Hari Shanker; Skaper, Stephen D.; Sharma, Aruna

Part of CNS & Neurological Disorders, p. 240-242, 2018
- DOI for 184th American Association for the Advancement of Science Annual Meeting, Austin TX, USA Feb. 15-19, 2018
2018 Yearbook of Neurorestoratology

Huang, Hongyun; Sharma, Hari Shanker; Chen, Lin; Saberi, Hooshang et al.

Part of JOURNAL OF NEURORESTORATOLOGY, p. 8-17, 2019
- DOI for 2018 Yearbook of Neurorestoratology
24-Hour ambulatory blood pressure associates inversely with prostaglandin F-2 alpha, interleukin-6 and F-2-isoprostane formation in a Swedish population of older men

Helmersson-Karlqvist, Johanna; Björklund-Bodegard, Kristina; Larsson, Anders; Basu, Samar

Part of International Journal of Clinical and Experimental Medicine, p. 145-153, 2012
3-Bromofascaplysin is a prospective chemical compound for developing new chemotherapy agents in glioblastoma treatment

Lyakhova, Irina; Piatkova, Mariia; Khotimchenko, Yuri; Zhidkov, Maxim et al.

Part of Novel therapeutic advances in glioblastoma, p. 325-343, Elsevier BV, 2020
- DOI for 3-Bromofascaplysin is a prospective chemical compound for developing new chemotherapy agents in glioblastoma treatment
5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology

Sharma, Aruna; Castellani, Rudy J.; Smith, Mark A.; Muresanu, Dafin Fior et al.

Part of New Therapeutic Strategies for Brain Edema and Cell Injury, p. 1-44, Elsevier, 2019
- DOI for 5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology
5th Annual Global College of Neuroprotection and Neuroregeneration

Sharma, Hari Shanker

Part of Expert review of neurotherapeutics, p. 881-7, 2008
- DOI for 5th Annual Global College of Neuroprotection and Neuroregeneration
5th International Conference on Nanotek & Expo, Nov 16-18, 2015, San Antonio TX, USA

Sharma, Hari Shanker; Sharma, Aruna

Part of CNS & Neurological Disorders, p. 265-266, 2016
- DOI for 5th International Conference on Nanotek & Expo, Nov 16-18, 2015, San Antonio TX, USA
6th Clinical Trials on Alzheimer's Disease (CTAD) Conference, Nov 14-16, 2013, The Westin San Diego Gaslamp Quarter Hotel, San Diego, CA, USA

Sharma, Hari Shanker; Sharma, Aruna; Skaper, Stephen D.

Part of CNS & Neurological Disorders, p. 187-190, 2014
6th Global College of Neuroprotection and Neuroregeneration, annual meeting

Sharma, Hari Shanker; Sharma, Aruna

Part of Expert review of neurotherapeutics, p. 941-947, 2009
- DOI for 6th Global College of Neuroprotection and Neuroregeneration, annual meeting
7th Clinical Trials on Alzheimer's Disease Annual Conference, Philadelphia, PA, USA Nov 20-22, 2014

Sharma, Hari Shanker; Skaper, Stephen D.; Sharma, Aruna

Part of CNS & Neurological Disorders, p. 7-10, 2015
- DOI for 7th Clinical Trials on Alzheimer's Disease Annual Conference, Philadelphia, PA, USA Nov 20-22, 2014
8th Clinical Trials on Alzheimer Disease (CTAD), Barcelona, Spain November 5-7, 2015

Sharma, Hari S.; Skaper, Stephen D.; Sharma, Aruna

Part of CNS & Neurological Disorders, p. 375-377, 2016
- DOI for 8th Clinical Trials on Alzheimer Disease (CTAD), Barcelona, Spain November 5-7, 2015
A Cannabinoid Receptor Type 1 (CB1R) Agonist Enhances the Developmental Neurotoxicity of Acetaminophen (Paracetamol)

Philippot, Gaetan; Hallgren, Stefan; Gordh, Torsten; Fredriksson, Anders et al.

Part of Toxicological Sciences, p. 203-212, 2018
- DOI for A Cannabinoid Receptor Type 1 (CB1R) Agonist Enhances the Developmental Neurotoxicity of Acetaminophen (Paracetamol)
- Download full text (pdf) of A Cannabinoid Receptor Type 1 (CB1R) Agonist Enhances the Developmental Neurotoxicity of Acetaminophen (Paracetamol)
A clinical study of high-dose urokinase for the treatment of the patients with hypertension induced ventricular hemorrhage

He, Chao; Yang, Gang; Zhao, Ming; Wu, Qilin et al.

Part of Brain protection strategies and nanomedicine, p. 349-355, Elsevier BV, 2021
- DOI for A clinical study of high-dose urokinase for the treatment of the patients with hypertension induced ventricular hemorrhage
A combination of tumor necrosis factor-α and neuronal nitric oxide synthase antibodies applied topically over the traumatized spinal cord enhances neuroprotection and functional recovery in the rat

Sharma, Hari Shanker

Part of Annals of the New York Academy of Sciences, p. 175-185, 2010
- DOI for A combination of tumor necrosis factor-α and neuronal nitric oxide synthase antibodies applied topically over the traumatized spinal cord enhances neuroprotection and functional recovery in the rat
A Comparison between Endostatin and Conventional Biomarkers on 30-Day Mortality and Renal Replacement Therapy in Unselected Intensive Care Patients

Ruge, Toralph; Larsson, Anders; Lipcsey, Miklós; Tydén, Jonas et al.

Part of Biomedicines, 2021
- DOI for A Comparison between Endostatin and Conventional Biomarkers on 30-Day Mortality and Renal Replacement Therapy in Unselected Intensive Care Patients
- Download full text (pdf) of A Comparison between Endostatin and Conventional Biomarkers on 30-Day Mortality and Renal Replacement Therapy in Unselected Intensive Care Patients
A comparison between PEEP titration methods in a porcine ARDS model

Pino, Fabio; Ball, Lorenzo; Scaramuzzo, Gaetano; Pinol Ribas, Miquel et al.

Part of Acta Anaesthesiologica Scandinavica, p. 1024-1025, 2017
A comparison of auditory evoked potentials and spectral EEG in the ability to detect marked sevoflurane concentration alterations and clinical events

Enlund, Mats; Jansson, Per

Part of Upsala Journal of Medical Sciences, Supplement, p. 221-229, 2007
- DOI for A comparison of auditory evoked potentials and spectral EEG in the ability to detect marked sevoflurane concentration alterations and clinical events
A comparison of impact of comorbidities and demographics on 60-day mortality in ICU patients with COVID-19, sepsis and acute respiratory distress syndrome

Ahlström, Björn; Frithiof, Robert; Larsson, Ing-Marie; Strandberg, Gunnar et al.

Part of Scientific Reports, 2022
- DOI for A comparison of impact of comorbidities and demographics on 60-day mortality in ICU patients with COVID-19, sepsis and acute respiratory distress syndrome
- Download full text (pdf) of A comparison of impact of comorbidities and demographics on 60-day mortality in ICU patients with COVID-19, sepsis and acute respiratory distress syndrome
A comparison of three doses of sufentanil in combination withbupivacaine-adrenaline in continuous epidural analgesia during labour.

Eriksson, SL; Frykholm, Peter; Stenlund, PM; Olofsson, C

Part of Acta Anaesthesiol. Scand., p. 919, 2000
A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention

Jung, Christian; Wernly, Bernhard; Muessig, Johanna M.; Kelm, Malte et al.

Part of Journal of critical care, p. 141-148, 2019
- DOI for A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention
A drug comorbidity index to predict mortality in men with castration resistant prostate cancer

Fallara, Giuseppe; Gedeborg, Rolf; Bill-Axelson, Anna; Garmo, Hans et al.

Part of PLOS ONE, 2021
- DOI for A drug comorbidity index to predict mortality in men with castration resistant prostate cancer
- Download full text (pdf) of A drug comorbidity index to predict mortality in men with castration resistant prostate cancer
A European survey of nosocomial infection control and hospital-acquired pneumonia prevention practices

Ricard, Jean-Damien; Conti, Giorgio; Boucherie, Maud; Hormann, Christoph et al.

Part of Journal of Infection, p. 285-291, 2012
- DOI for A European survey of nosocomial infection control and hospital-acquired pneumonia prevention practices
A first update on mapping the human genetic architecture of COVID-19

Pathak, Gita A.; Frithiof, Robert; Hultström, Michael; Lipcsey, Miklós et al.

Part of Nature, 2022
- DOI for A first update on mapping the human genetic architecture of COVID-19
- Download full text (pdf) of A first update on mapping the human genetic architecture of COVID-19
A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021

Wulf Hanson, Sarah; Abbafati, Cristiana; Aerts, Joachim G; Al-Aly, Ziyad et al.

2022
- DOI for A global systematic analysis of the occurrence, severity, and recovery pattern of long COVID in 2020 and 2021
A history of nordic anesthesia

Stromskag, Kjell Erik; Brock-Utne, Johan G.; Eklund, Jan; Holmdahl, Martin H:son

Part of The Wondrous Story of Anesthesia, p. 417-428, Springer-Verlag New York, 2014
- DOI for A history of nordic anesthesia
A journey to a new stable state-further development of the postoperative recovery concept from day surgical perspective: a qualitative study

Nilsson, Ulrica; Jaensson, Maria; Hugelius, Karin; Arakelian, Erebouni et al.

Part of BMJ Open, 2020
- DOI for A journey to a new stable state-further development of the postoperative recovery concept from day surgical perspective: a qualitative study
- Download full text (pdf) of A journey to a new stable state-further development of the postoperative recovery concept from day surgical perspective: a qualitative study
A metabolic threshold of irreversible ischemia demonstrated by PET in amiddle cerebral artery occlusion-reperfusion primate model.

Frykholm, Peter; Andersson, JL; Valtysson, Johann; Silander, HC et al.

Part of Acta Neurol Scand, p. 18, 2000
A model-based source separation algorithm for lung perfusion imaging using electrical impedance tomography

Hentze, Benjamin; Muders, Thomas; Antink, Christoph Hoog; Putensen, Christian et al.

Part of Physiological Measurement, 2021
- DOI for A model-based source separation algorithm for lung perfusion imaging using electrical impedance tomography
- Download full text (pdf) of A model-based source separation algorithm for lung perfusion imaging using electrical impedance tomography
A modified breathing pattern improves the performance of a continuous capnodynamic method for estimation of effective pulmonary blood flow

Hällsjö Sander, Caroline; Sigmundsson, Thorir; Hallbäck, Magnus; Suarez-Sipmann, Fernando et al.

Part of Journal of clinical monitoring and computing, p. 717-725, 2017
- DOI for A modified breathing pattern improves the performance of a continuous capnodynamic method for estimation of effective pulmonary blood flow
A modified Glenn shunt improves haemodynamics in acute right ventricular failure in an experimental model

Vikholm, Per; Schiller, Petter; Johansson, Jakob; Hellgren, Laila

Part of European Journal of Cardio-Thoracic Surgery, p. 612-618, 2013
- DOI for A modified Glenn shunt improves haemodynamics in acute right ventricular failure in an experimental model
A Multicenter Randomized Trial Comparing a Mechanical CPR Algorithm Using LUCAS Versus Manual CPR in Out-of-Hospital Cardiac Arrest Patients-Per Protocol Analysis of the LINC Study

Rubertsson, Sten; Lindgren, Erik; Östlund, Ollie; Herlitz, Johan et al.

Part of Circulation, p. 2719-2719, 2013
A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients

Lind, Anne-Li; Yu, Di; Freyhult, Eva; Bodolea, Constantin et al.

Part of PLOS ONE, 2016
- DOI for A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients
- Download full text (pdf) of A Multiplex Protein Panel Applied to Cerebrospinal Fluid Reveals Three New Biomarker Candidates in ALS but None in Neuropathic Pain Patients
A nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disorders

Mossberg, Rasmus; Ahlström, Björn; Lipcsey, Miklós

Part of Scientific Reports, 2024
- DOI for A nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disorders
- Download full text (pdf) of A nationwide cohort study on the association between intensive care treatments and mental distress linked psychiatric disorders
A nationwide postal questionnaire survey: the presence of airway guidelines in anaesthesia department in Sweden

Knudsen, Kati; Pöder, Ulrika; Högman, Marieann; Larsson, Anders et al.

Part of BMC Anesthesiology, p. 25, 2014
- DOI for A nationwide postal questionnaire survey: the presence of airway guidelines in anaesthesia department in Sweden
- Download full text (pdf) of A nationwide postal questionnaire survey: the presence of airway guidelines in anaesthesia department in Sweden
A nationwide study of the long-term prevalence of dementia and its risk factors in the Swedish intensive care cohort

Ahlström, Björn; Larsson, Ing-Marie; Strandberg, Gunnar; Lipcsey, Miklós

Part of Critical Care, 2020
- DOI for A nationwide study of the long-term prevalence of dementia and its risk factors in the Swedish intensive care cohort
- Download full text (pdf) of A nationwide study of the long-term prevalence of dementia and its risk factors in the Swedish intensive care cohort
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

Zhou, Sirui; Butler-Laporte, Guillaume; Nakanishi, Tomoko; Morrison, David R. et al.

Part of Nature Medicine, p. 659-667, 2021
- DOI for A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity
A networking and publishing tool for pain researchers and pain clinicians in the Nordic countries

Breivik, Harald; Gordh, Torsten; Kalso, Eija; Jensen, Troels S. et al.

Part of Scandinavian Journal of Pain, p. 1-2, 2010
- DOI for A networking and publishing tool for pain researchers and pain clinicians in the Nordic countries
A New Antioxidant Compound H-290/51 Attenuates Nanoparticle Induced Neurotoxicity and Enhances Neurorepair in Hyperthermia

Sharma, Hari Shanker; Sharma, Aruna; Hussain, Saber; Schlager, John et al.

Part of Brain Edema XIV, p. 351-357, 2010
- DOI for A New Antioxidant Compound H-290/51 Attenuates Nanoparticle Induced Neurotoxicity and Enhances Neurorepair in Hyperthermia
A new device för administration of nasal CPAP in the newborn

Moa, Gunnar; Nilsson, Kjell; Zetterström, Henrik; Jonsson, Lars O

Part of Critical Care Medicine, p. 1238-1242, 1988
A new device to reduce inhalational agent expenditure

Enlund, Mats; Lambert, H; Wiklund, Lars

Part of Anest Analg, p. 201, 2000
A new device to reduce the consumption of a halogenated anaesthetic agent.

Enlund, Mats; Wiklund, Lars; Lambert, H

Part of Anaesthesia, p. 429, 2001
A new method of intrathecal PO2, PCO2, and pH measurements for continuous monitoring of spinal cord ischemia during thoracic aortic clamping in pigs

Christiansson, Lennart; Hellberg, Anders; Koga, Itaru; Thelin, Stefan et al.

Part of Surgery, p. 571-576, 2000
- DOI for A new method of intrathecal PO2, PCO2, and pH measurements for continuous monitoring of spinal cord ischemia during thoracic aortic clamping in pigs
A new nomogram facilitating adequate haemodilution

Zetterström, Henrik; Wiklund, Lars

Part of Acta Anaesthesiologica Scandinavica, p. 300-304, 1986