Mariangela Pellegrini

Specialist physician at Department of Surgical Sciences; Anaesthesiology and Intensive Care

E-mail:
mariangela.pellegrini@uu.se
Visiting address:
Akademiska sjukhuset, ingång 70, 1tr
751 85 Uppsala
Postal address:
Akademiska sjukhuset, ingång 70, 1tr
751 85 UPPSALA

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Short presentation

Mariangela Pellegrini is a Consultant in Intensive Care at Uppsala University Hospital and Associate Professor at Uppsala University.

Her research focuses on respiratory mechanics and mechanical ventilation in critically ill patients, combining clinical and translational approaches with advanced lung imaging and quantitative physiology.

Keywords

  • respiratory mechanics
  • acute respiratory distress syndrome
  • mechanical ventilation
  • synchrotron radiation computed tomography
  • translational research
  • clinical research
  • intensive care
  • lung
  • physiology
  • lung imaging
  • computed tomography
  • acute respiratory failure

Biography

Mariangela Pellegrini is a Consultant in Intensive Care at Uppsala University Hospital and an Associate Professor (Docent) at the Department of Surgical Sciences, Uppsala University.

She obtained her PhD in 2019 with a thesis on the modulation of expiration during mechanical ventilation. Following a postdoctoral period in Toronto, she has developed a translational research profile at the interface of physiology, imaging, and critical care medicine.

Her work integrates experimental and clinical approaches to better understand respiratory function in acute illness. She has particular expertise in lung imaging, respiratory mechanics, and quantitative analysis of physiological signals, and has contributed to methodological development in these areas.

She supervises doctoral students and is actively building an independent research line aimed at improving personalized ventilation strategies in acute respiratory failure.

Research

Her research focuses on respiratory mechanics and ventilatory management in critically ill patients, particularly in acute respiratory distress syndrome (ARDS). She investigates mechanisms of ventilator-induced and patient self-inflicted lung injury, as well as strategies to optimize lung-protective ventilation.

Her work combines advanced imaging techniques, including CT-based and functional approaches, with detailed analysis of respiratory signals to characterize lung heterogeneity, ventilation–perfusion relationships, and recruitability.

A central goal of her research is to develop individualized, physiology-based ventilation strategies that can be translated into clinical practice to improve patient outcomes.

Mariangela Pellegrini

Publications

Recent publications

All publications

Articles in journal

Articles, review/survey

Chapters in book

Comprehensive doctoral thesis

Conference papers

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