Mariangela Pellegrini
Specialistläkare vid Institutionen för kirurgiska vetenskaper; Anestesiologi och intensivvård
- E-post:
- mariangela.pellegrini@uu.se
- Besöksadress:
- Akademiska sjukhuset, ingång 70, 1tr
751 85 Uppsala - Postadress:
- Akademiska sjukhuset, ingång 70, 1tr
751 85 UPPSALA
Kort presentation
Mariangela Pellegrini är överläkare inom intensivvård vid Akademiska sjukhuset och docent vid Uppsala universitet.
Hennes forskning fokuserar på respirationsmekanik och ventilatorbehandling hos kritiskt sjuka patienter, med en kombination av kliniska och translationella metoder samt avancerad lungavbildning och kvantitativ fysiologi.
Nyckelord
- respiratory mechanics
- acute respiratory distress syndrome
- mechanical ventilation
- synchrotron radiation computed tomography
- translational research
- clinical research
- intensive care
- lung
- physiology
- lung imaging
- computed tomography
- acute respiratory failure
Biografi
Mariangela Pellegrini är överläkare inom intensivvård vid Akademiska sjukhuset och docent vid Institutionen för kirurgiska vetenskaper, Uppsala universitet.
Hon disputerade 2019 med en avhandling om modulering av exspiration under mekanisk ventilation. Efter en postdoktoral vistelse i Toronto har hon utvecklat en translationell forskningsprofil i gränslandet mellan fysiologi, bilddiagnostik och intensivvård.
Hennes arbete integrerar experimentella och kliniska metoder för att öka förståelsen av respirationsfysiologi vid kritisk sjukdom. Hon har särskild kompetens inom lungavbildning, respirationsmekanik och kvantitativ analys av fysiologiska signaler, och har bidragit till metodutveckling inom dessa områden.
Hon handleder doktorander och arbetar aktivt med att etablera en självständig forskningslinje med fokus på individualiserad ventilatorbehandling vid akut respiratorisk svikt.
Forskning
Hennes forskning är inriktad på respirationsmekanik och ventilatorbehandling hos kritiskt sjuka patienter, särskilt vid akut respiratorisk svikt och ARDS. Hon studerar mekanismer bakom ventilatorinducerad och patientorsakad lungskada samt strategier för lungprotektiv ventilation.
Arbetet kombinerar avancerade avbildningstekniker, inklusive CT-baserade och funktionella metoder, med detaljerad analys av respiratoriska signaler för att karakterisera lungans heterogenitet, ventilation–perfusionsfördelning och rekryterbarhet.
Ett övergripande mål är att utveckla individualiserade, fysiologibaserade ventilationsstrategier som kan implementeras i klinisk praxis för att förbättra patientutfall.

Publikationer
Senaste publikationer
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Ingår i Thrombosis Research, 2026
- DOI för Heparin formulation and thromboprophylaxis intensity in critically ill patients: Results from the ESICM UNITE registry
- Ladda ner fulltext (pdf) av Heparin formulation and thromboprophylaxis intensity in critically ill patients: Results from the ESICM UNITE registry
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Ingår i Intensive Care Medicine, s. 406-407, 2026
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Ingår i Journal of applied physiology, s. 764-777, 2026
- DOI för Global versus regional effects of PEEP on recruitment and strain: insights from preclinical and clinical studies
- Ladda ner fulltext (pdf) av Global versus regional effects of PEEP on recruitment and strain: insights from preclinical and clinical studies
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Ingår i Intensive Care Medicine Experimental, 2026
- DOI för Characterizing heterogeneity and subphenotyping acute respiratory distress syndrome with computed tomography
- Ladda ner fulltext (pdf) av Characterizing heterogeneity and subphenotyping acute respiratory distress syndrome with computed tomography
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Ingår i Intensive Care Medicine Experimental, 2025
- DOI för Personalized mechanical ventilation guided by lung ultrasound in patients with ARDS: a pilot phase of a randomized clinical trial
- Ladda ner fulltext (pdf) av Personalized mechanical ventilation guided by lung ultrasound in patients with ARDS: a pilot phase of a randomized clinical trial
Alla publikationer
Artiklar i tidskrift
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Ingår i Thrombosis Research, 2026
- DOI för Heparin formulation and thromboprophylaxis intensity in critically ill patients: Results from the ESICM UNITE registry
- Ladda ner fulltext (pdf) av Heparin formulation and thromboprophylaxis intensity in critically ill patients: Results from the ESICM UNITE registry
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Ingår i Intensive Care Medicine, s. 406-407, 2026
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Ingår i Journal of applied physiology, s. 764-777, 2026
- DOI för Global versus regional effects of PEEP on recruitment and strain: insights from preclinical and clinical studies
- Ladda ner fulltext (pdf) av Global versus regional effects of PEEP on recruitment and strain: insights from preclinical and clinical studies
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Ingår i Intensive Care Medicine Experimental, 2025
- DOI för Personalized mechanical ventilation guided by lung ultrasound in patients with ARDS: a pilot phase of a randomized clinical trial
- Ladda ner fulltext (pdf) av Personalized mechanical ventilation guided by lung ultrasound in patients with ARDS: a pilot phase of a randomized clinical trial
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Pathophysiology and clinical applications of PEEP in acute brain injury
Ingår i Intensive Care Medicine, s. 2104-2116, 2025
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Ingår i Intensive Care Medicine Experimental, 2025
- DOI för The focal index: a quantitative approach to morphological sub-phenotyping of COVID-19 patients with acute respiratory distress syndrome: a pilot study
- Ladda ner fulltext (pdf) av The focal index: a quantitative approach to morphological sub-phenotyping of COVID-19 patients with acute respiratory distress syndrome: a pilot study
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Ingår i ANAESTHESIA CRITICAL CARE & PAIN MEDICINE, 2025
- DOI för Evaluating early mobilisation in critically ill COVID-19 patients: Secondary analysis from the ESICM UNITE-COVID-II multicentre observational study
- Ladda ner fulltext (pdf) av Evaluating early mobilisation in critically ill COVID-19 patients: Secondary analysis from the ESICM UNITE-COVID-II multicentre observational study
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Ingår i Intensive Care Medicine Experimental, 2025
- DOI för Intracranial response to positive end-expiratory pressure is influenced by lung recruitability and gas distribution during mechanical ventilation in acute brain injury patients: a proof-of-concept physiological study
- Ladda ner fulltext (pdf) av Intracranial response to positive end-expiratory pressure is influenced by lung recruitability and gas distribution during mechanical ventilation in acute brain injury patients: a proof-of-concept physiological study
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Individualized PEEP can improve both pulmonary hemodynamics and lung function in acute lung injury
Ingår i Critical Care, 2025
- DOI för Individualized PEEP can improve both pulmonary hemodynamics and lung function in acute lung injury
- Ladda ner fulltext (pdf) av Individualized PEEP can improve both pulmonary hemodynamics and lung function in acute lung injury
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Novel lung imaging techniques: new experimental insights in acute respiratory failure
Ingår i Intensive Care Medicine Experimental, 2025
- DOI för Novel lung imaging techniques: new experimental insights in acute respiratory failure
- Ladda ner fulltext (pdf) av Novel lung imaging techniques: new experimental insights in acute respiratory failure
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Lung impedance changes during awake prone positioning in COVID-19: A non-randomized cross-over study
Ingår i PLOS ONE, 2024
- DOI för Lung impedance changes during awake prone positioning in COVID-19: A non-randomized cross-over study
- Ladda ner fulltext (pdf) av Lung impedance changes during awake prone positioning in COVID-19: A non-randomized cross-over study
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Ingår i Journal of clinical monitoring and computing, s. 1269-1280, 2024
- DOI för Imitating the respiratory activity of the brain stem by using artificial neural networks: exploratory study on an animal model of lactic acidosis and proof of concept
- Ladda ner fulltext (pdf) av Imitating the respiratory activity of the brain stem by using artificial neural networks: exploratory study on an animal model of lactic acidosis and proof of concept
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Ingår i Annals of Intensive Care, 2024
- DOI för Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study
- Ladda ner fulltext (pdf) av Impact of airway closure and lung collapse on inhaled nitric oxide effect in acute lung injury: an experimental study
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How to protect the diaphragm and the lung with diaphragm neurostimulation
Ingår i Current Opinion in Critical Care, s. 70-77, 2024
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Finding the optimal tidal volume in acute respiratory distress syndrome
Ingår i Intensive Care Medicine, s. 1154-1156, 2024
- DOI för Finding the optimal tidal volume in acute respiratory distress syndrome
- Ladda ner fulltext (pdf) av Finding the optimal tidal volume in acute respiratory distress syndrome
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Ingår i Intensive care medicine experimental, 2024
- DOI för Clinical implementation of advanced respiratory monitoring with esophageal pressure and electrical impedance tomography: results from an international survey and focus group discussion.
- Ladda ner fulltext (pdf) av Clinical implementation of advanced respiratory monitoring with esophageal pressure and electrical impedance tomography: results from an international survey and focus group discussion.
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Ingår i Intensive Care Medicine Experimental, 2024
- DOI för Positive end-expiratory pressure limits inspiratory effort through modulation of the effort-to-drive ratio: an experimental crossover study
- Ladda ner fulltext (pdf) av Positive end-expiratory pressure limits inspiratory effort through modulation of the effort-to-drive ratio: an experimental crossover study
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Ingår i Intensive Care Medicine Experimental, 2024
- DOI för Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury: an experimental study
- Ladda ner fulltext (pdf) av Regional distribution of mechanical strain and macrophage-associated lung inflammation after ventilator-induced lung injury: an experimental study
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Ingår i Frontiers in Physiology, 2024
- DOI för Body mass index is associated with pulmonary gas and blood distribution mismatch in COVID-19 acute respiratory failure: A physiological study
- Ladda ner fulltext (pdf) av Body mass index is associated with pulmonary gas and blood distribution mismatch in COVID-19 acute respiratory failure: A physiological study
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Ingår i Intensive Care Medicine, s. 727-759, 2023
- DOI för ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies
- Ladda ner fulltext (pdf) av ESICM guidelines on acute respiratory distress syndrome: definition, phenotyping and respiratory support strategies
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Ingår i Annals of Intensive Care, 2023
- DOI för Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study
- Ladda ner fulltext (pdf) av Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study
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Ingår i Journal of critical care, 2022
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Ingår i Critical Care, 2022
- DOI för Limitations of the ARDS criteria during high-flow oxygen or non-invasive ventilation: evidence from critically ill COVID-19 patients
- Ladda ner fulltext (pdf) av Limitations of the ARDS criteria during high-flow oxygen or non-invasive ventilation: evidence from critically ill COVID-19 patients
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Chest dual-energy CT to assess the effects of steroids on lung function in severe COVID-19 patients
Ingår i Critical Care, 2022
- DOI för Chest dual-energy CT to assess the effects of steroids on lung function in severe COVID-19 patients
- Ladda ner fulltext (pdf) av Chest dual-energy CT to assess the effects of steroids on lung function in severe COVID-19 patients
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Ingår i Intensive Care Medicine, s. 690-705, 2022
- DOI för Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study
- Ladda ner fulltext (pdf) av Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study
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Ingår i Frontiers in Physiology, 2021
- DOI för Inspiratory Efforts, Positive End-Expiratory Pressure, and External Resistances Influence Intraparenchymal Gas Redistribution in Mechanically Ventilated Injured Lungs
- Ladda ner fulltext (pdf) av Inspiratory Efforts, Positive End-Expiratory Pressure, and External Resistances Influence Intraparenchymal Gas Redistribution in Mechanically Ventilated Injured Lungs
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Ingår i Critical Care, 2021
- DOI för A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomography
- Ladda ner fulltext (pdf) av A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomography
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Expiratory Resistances Prevent Expiratory Diaphragm Contraction, Flow Limitation, and Lung Collapse
Ingår i American Journal of Respiratory and Critical Care Medicine, s. 1218-1229, 2020
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Ingår i Best Practice & Research, s. 561-567, 2020
- DOI för The use of positive end expiratory pressure in patients affected by COVID-19: Time to reconsider the relation between morphology and physiology
- Ladda ner fulltext (pdf) av The use of positive end expiratory pressure in patients affected by COVID-19: Time to reconsider the relation between morphology and physiology
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Ingår i Frontiers in Physiology, 2019
- DOI för The Effects of Positive End-Expiratory Pressure on Transpulmonary Pressure and Recruitment-Derecruitment During Neurally Adjusted Ventilator Assist: A Continuous Computed Tomography Study in an Animal Model of Acute Respiratory Distress Syndrome
- Ladda ner fulltext (pdf) av The Effects of Positive End-Expiratory Pressure on Transpulmonary Pressure and Recruitment-Derecruitment During Neurally Adjusted Ventilator Assist: A Continuous Computed Tomography Study in an Animal Model of Acute Respiratory Distress Syndrome
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Ingår i Frontiers in Physiology, 2019
- DOI för Regional Behavior of Airspaces During Positive Pressure Reduction Assessed by Synchrotron Radiation Computed Tomography
- Ladda ner fulltext (pdf) av Regional Behavior of Airspaces During Positive Pressure Reduction Assessed by Synchrotron Radiation Computed Tomography
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Ingår i Journal of Clinical Medicine, 2019
- DOI för The Effect of Positive End-Expiratory Pressure on Lung Micromechanics Assessed by Synchrotron Radiation Computed Tomography in an Animal Model of ARDS
- Ladda ner fulltext (pdf) av The Effect of Positive End-Expiratory Pressure on Lung Micromechanics Assessed by Synchrotron Radiation Computed Tomography in an Animal Model of ARDS
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Expiratory Resistances Prevent Expiratory Diaphragm Contraction, Flow Limitation, and Lung Collapse
Ingår i Intensive Care Medicine Experimental, 2019
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Individual Airway Closure Characterized In Vivo by Phase-Contrast CT Imaging in Injured Rabbit Lung
Ingår i Critical Care Medicine, 2019
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2018
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Ingår i American Journal of Respiratory and Critical Care Medicine, 2018
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Onset and Magnitude of Pendelluft During Spontaneous Breathing Depend on Lung Volume
Ingår i American Journal of Respiratory and Critical Care Medicine, 2018
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Ingår i Acta Anaesthesiologica Scandinavica, s. 94-104, 2018
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Ingår i Critical Care Medicine, s. 687-694, 2017
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The Diaphragm Acts as a Brake During Expiration to Prevent Lung Collapse
Ingår i American Journal of Respiratory and Critical Care Medicine, s. 1608-1616, 2017
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Ingår i Medical and Biological Engineering and Computing, s. 1819-1828, 2017
- DOI för Robustness of two different methods of monitoring respiratory system compliance during mechanical ventilation.
- Ladda ner fulltext (pdf) av Robustness of two different methods of monitoring respiratory system compliance during mechanical ventilation.
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Ingår i Journal of clinical monitoring and computing, s. 551-559, 2017
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Expiratory Diaphragm Activity Reduces Atelectasis Formation
Ingår i American Journal of Respiratory and Critical Care Medicine, 2016
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Effects of superimposed tissue weight on regional compliance of injured lungs
Ingår i Respiratory Physiology & Neurobiology, s. 16-24, 2016
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Ingår i American Journal of Respiratory and Critical Care Medicine, 2016
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Ingår i American Journal of Respiratory and Critical Care Medicine, 2015
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Ingår i American Journal of Respiratory and Critical Care Medicine, 2015
Artiklar, forskningsöversikt
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Ingår i Intensive Care Medicine Experimental, 2026
- DOI för Characterizing heterogeneity and subphenotyping acute respiratory distress syndrome with computed tomography
- Ladda ner fulltext (pdf) av Characterizing heterogeneity and subphenotyping acute respiratory distress syndrome with computed tomography
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Ingår i Critical Care, 2024
- DOI för Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions
- Ladda ner fulltext (pdf) av Electrical impedance tomography monitoring in adult ICU patients: state-of-the-art, recommendations for standardized acquisition, processing, and clinical use, and future directions
Doktorsavhandlingar, sammanläggning
Kapitel i böcker, delar av antologi
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Principles and Management of ARDS
Ingår i Best 2022 Clinical Cases in Intensive Care Medicine, s. 181-194, Springer, 2023
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Ingår i Best 2022 Clinical Cases in Intensive Care Medicine, s. 249-262, Springer, 2023