Orthopedics and Hand Surgery

Photo: Mikael Wallerstedt
Orthopaedics examines damage and diseases that affect musculoskeletal organs. Orthopaedic injuries can be caused by trauma, some orthopaedic diseases are degenerative and diagnostics, treatment and rehabilitation of congenital conditions is also a large area.
A trauma can result in fractures and soft tissue damage. Within orthopaedics, we treat life-threatening injuries that are the result of traffic accidents or falls from a height, often defined as “high-energy injuries”. Orthopaedic trauma also includes the more common falling injuries – those that primarily affect children and the elderly and are often referred to as “low-energy injuries”.
Degenerative diseases make up a large area of orthopaedics and include osteoarthritis – joint disease – and tissue-related pain in the neck, back and extremities. More unusual conditions of the musculoskeletal system, such as infections, tumours and congenital diseases may also require knowledge of orthopaedics. Inflammatory joint diseases such as rheumatoid arthritis may also require orthopaedic treatment. Orthopaedics also assess and treat strain injuries that often are the result of occupational or sports injuries.
Changes to the orthopaedic disease panorama
Orthopaedic injury and diseases affect people of all ages. However, low-energy and degenerative changes mainly affect older individuals. As the average life expectancy in Sweden has doubled over the past 200 years, so has the number of elderly in society. Thanks to an active lifestyle well into old age, there are many more injuries and wear that are a direct consequence of sport or other physical activities. The changing social demographics and shift towards more active lifestyles has resulted in an increase of individuals with orthopaedic ailments – and this trend is expected to increase.

Photo: Mikael Wallerstedt
Orthopaedic research
Historically, research in orthopaedics and hand surgery has led to fantastic and clearly noticeable results for large patient groups. For example, take artificial joints, fracture surgery or re-attachment of fingers that have been cut off. Two generations ago, these treatments were more science fiction than fact.
Our research aims to continually improve diagnosis and treatment of patients affected by the injuries and diseases mentioned above, and to systematically evaluate new treatment methods. Our unit conducts research in several areas, from trauma and osteoarthritis to paediatric orthopaedics and hand surgery. We use diverse methods, depending on the topic. Everything from translational research on cultivated cells or animals, clinical studies on patients to large-scale epidemiological research on extensive patient groups.
These pages present an overview of the various research projects ongoing at the unit for orthopaedics and hand surgery. Fortunately enough, we are a very active unit with many enthusiastic doctoral students and senior research group leaders. In recent years we have produced many exciting research results, which have received a lot of media attention.
Group members
Publications
Pain in idiopathic scoliosis not associated with known genetic variants for pain
Part of Pain Reports, 2025
- DOI for Pain in idiopathic scoliosis not associated with known genetic variants for pain
- Download full text (pdf) of Pain in idiopathic scoliosis not associated with known genetic variants for pain
Part of eClinicalMedicine, 2025
- DOI for Possible factors influencing on the effect of minimally invasive sacroiliac joint fusion: a call for further research and discussion
- Download full text (pdf) of Possible factors influencing on the effect of minimally invasive sacroiliac joint fusion: a call for further research and discussion
Surgically treated degenerative cervical spine diseases in twins.
Part of European spine journal, 2025
Part of Journal of Physical Activity and Health, 2025
Part of Frontiers in Microbiology, 2025
- DOI for Never mind the bug: no differences in infection-free survival after periprosthetic joint infections with Staphylococcus aureus, Coagulase-negative Staphylococcus, or Streptococcus
- Download full text (pdf) of Never mind the bug: no differences in infection-free survival after periprosthetic joint infections with Staphylococcus aureus, Coagulase-negative Staphylococcus, or Streptococcus
Ionic silver coating of orthopedic implants may impair osteogenic differentiation and mineralization
Part of Experimental and Therapeutic Medicine, 2025
- DOI for Ionic silver coating of orthopedic implants may impair osteogenic differentiation and mineralization
- Download full text (pdf) of Ionic silver coating of orthopedic implants may impair osteogenic differentiation and mineralization
Part of Acta Orthopaedica, p. 94-101, 2025
- DOI for Mortality and reoperations following treatment of acetabular fractures in patients ≥ 70 years: a retrospective cohort study of 247 patients
- Download full text (pdf) of Mortality and reoperations following treatment of acetabular fractures in patients ≥ 70 years: a retrospective cohort study of 247 patients
Part of Acta Orthopaedica, p. 26-32, 2025
- DOI for 1-year data on patient-reported outcome is enough after surgery for degenerative cervical myelopathy: a cohort study from the Swedish Spine register
- Download full text (pdf) of 1-year data on patient-reported outcome is enough after surgery for degenerative cervical myelopathy: a cohort study from the Swedish Spine register
Is 18F-fluoride PET/CT an Accurate Tool to Diagnose Loosening After Total Joint Arthroplasty?
Part of Clinical Orthopaedics and Related Research, p. 415-428, 2025
- DOI for Is 18F-fluoride PET/CT an Accurate Tool to Diagnose Loosening After Total Joint Arthroplasty?
- Download full text (pdf) of Is 18F-fluoride PET/CT an Accurate Tool to Diagnose Loosening After Total Joint Arthroplasty?
Part of 3D Printing in Medicine, 2025
- DOI for Trabecular-bone mimicking osteoconductive collagen scaffolds: An optimized 3D printing approach using freeform reversible embedding of suspended hydrogels
- Download full text (pdf) of Trabecular-bone mimicking osteoconductive collagen scaffolds: An optimized 3D printing approach using freeform reversible embedding of suspended hydrogels
Part of Neurosurgery, p. 881-891, 2025
Part of Clinical Epidemiology, p. 167-176, 2025
- DOI for Interaction Between Multimorbidity and Hip Fracture Surgery Leads to Excess Risk of Infection: A Danish Registry-Based Cohort Study of 92,599 Patients With Hip Fracture
- Download full text (pdf) of Interaction Between Multimorbidity and Hip Fracture Surgery Leads to Excess Risk of Infection: A Danish Registry-Based Cohort Study of 92,599 Patients With Hip Fracture
Part of Acta Orthopaedica, p. 176-181, 2025
- DOI for Correlation between a real-time bioparticle detection device and a traditional microbiological active air sampler monitoring air quality in an operating room during elective arthroplasty surgery: a prospective feasibility study
- Download full text (pdf) of Correlation between a real-time bioparticle detection device and a traditional microbiological active air sampler monitoring air quality in an operating room during elective arthroplasty surgery: a prospective feasibility study
Part of Acta Orthopaedica, p. 142-150, 2025
- DOI for Incidence of constrained condylar and hinged knee implants and mid- to long-term survivorship: a register- based study from the Nordic Arthroplasty Register Association (NARA)
- Download full text (pdf) of Incidence of constrained condylar and hinged knee implants and mid- to long-term survivorship: a register- based study from the Nordic Arthroplasty Register Association (NARA)
Part of Foot and Ankle Surgery, p. 208-213, 2025
- DOI for Favorable change in patient-reported outcomes following peroneus longus to brevis tendon transfer and lateral ankle ligament reconstruction
- Download full text (pdf) of Favorable change in patient-reported outcomes following peroneus longus to brevis tendon transfer and lateral ankle ligament reconstruction
Part of Acta Neurochirurgica, 2025
- DOI for Image quality assessment in spine surgery: a comparison of intraoperative CBCT and postoperative MDCT
- Download full text (pdf) of Image quality assessment in spine surgery: a comparison of intraoperative CBCT and postoperative MDCT
Part of Brain Sciences, 2025
- DOI for Hypoglossal Nerve Palsy Following Cervical Spine Surgery: Two Case Reports and a Systematic Review of the Literature
- Download full text (pdf) of Hypoglossal Nerve Palsy Following Cervical Spine Surgery: Two Case Reports and a Systematic Review of the Literature
Part of Global Spine Journal, p. 136-142, 2025
- DOI for Can Survival Scoring Systems for Spinal Metastases be Used to Predict Postoperative Neurologic Recovery?: A Retrospective Study on 204 Patients With Thoracolumbar Metastases Treated at a Tertiary Center
- Download full text (pdf) of Can Survival Scoring Systems for Spinal Metastases be Used to Predict Postoperative Neurologic Recovery?: A Retrospective Study on 204 Patients With Thoracolumbar Metastases Treated at a Tertiary Center
Part of Journal of Pediatric Orthopaedics, p. 274-280, 2025
- DOI for An International Consensus on Evaluation and Management of Idiopathic Genu Valgum: A Modified Delphi Survey
- Download full text (pdf) of An International Consensus on Evaluation and Management of Idiopathic Genu Valgum: A Modified Delphi Survey
Conservative or surgical management of orbital schwannomas: a population-based case series
Part of Acta Neurochirurgica, 2024
- DOI for Conservative or surgical management of orbital schwannomas: a population-based case series
- Download full text (pdf) of Conservative or surgical management of orbital schwannomas: a population-based case series
Association of genetic variation in COL11A1 with adolescent idiopathic scoliosis
Part of eLIFE, 2024
- DOI for Association of genetic variation in COL11A1 with adolescent idiopathic scoliosis
- Download full text (pdf) of Association of genetic variation in COL11A1 with adolescent idiopathic scoliosis
Part of Spine, 2024
Part of Bone & Joint Open, p. 87-93, 2024
- DOI for Reoperation-free survival after hip screws or hip arthroplasty for undisplaced femoral neck fractures in the elderly: a nationwide population-based cohort study of 3,909 patients
- Download full text (pdf) of Reoperation-free survival after hip screws or hip arthroplasty for undisplaced femoral neck fractures in the elderly: a nationwide population-based cohort study of 3,909 patients
Part of Musculoskeletal Care, 2024
- DOI for Swedish musculoskeletal researchers view on a collaborative network and future research priorities in Swedish healthcare
- Download full text (pdf) of Swedish musculoskeletal researchers view on a collaborative network and future research priorities in Swedish healthcare
Part of JAMA Network Open, 2024
- DOI for Nighttime Bracing or Exercise in Moderate-Grade Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial
- Download full text (pdf) of Nighttime Bracing or Exercise in Moderate-Grade Adolescent Idiopathic Scoliosis: A Randomized Clinical Trial
Two years of neurosurgical intraoperative MRI in Sweden - evaluation of use and costs
Part of Acta Neurochirurgica, 2024
- DOI for Two years of neurosurgical intraoperative MRI in Sweden - evaluation of use and costs
- Download full text (pdf) of Two years of neurosurgical intraoperative MRI in Sweden - evaluation of use and costs
Part of Acta Orthopaedica, p. 20-24, 2024
- DOI for Assessment of the sacroiliac joint with computed tomography motion analysis: a diagnostic study of 12 patients
- Download full text (pdf) of Assessment of the sacroiliac joint with computed tomography motion analysis: a diagnostic study of 12 patients
Part of Acta Orthopaedica, p. 12-18, 2024
- DOI for Spinal surgery and the risk of reoperation after total hip arthroplasty: a cohort study based on Swedish spine and hip arthroplasty registers
- Download full text (pdf) of Spinal surgery and the risk of reoperation after total hip arthroplasty: a cohort study based on Swedish spine and hip arthroplasty registers
Part of Cancers, 2024
- DOI for Long-Term Functional Outcomes Following Surgical Treatment of Spinal Schwannomas: A Population-Based Cohort Study
- Download full text (pdf) of Long-Term Functional Outcomes Following Surgical Treatment of Spinal Schwannomas: A Population-Based Cohort Study
Part of Acta Orthopaedica, p. 92-98, 2024
- DOI for Lumbar degeneration and quality of life in patients with lumbar disc herniation: a case-control long-term follow-up study
- Download full text (pdf) of Lumbar degeneration and quality of life in patients with lumbar disc herniation: a case-control long-term follow-up study
Part of Journal of Clinical Medicine, 2024
- DOI for Concentrations of Cobalt, Chromium and Titanium and Immunological Changes after Primary Total Knee Arthroplasty - A Cohort Study with an 18-Year Follow-Up
- Download full text (pdf) of Concentrations of Cobalt, Chromium and Titanium and Immunological Changes after Primary Total Knee Arthroplasty - A Cohort Study with an 18-Year Follow-Up
Part of eClinicalMedicine, 2024
- DOI for The effect of minimally invasive sacroiliac joint fusion compared to sham operation: a double-blind randomized-controlled trial
- Download full text (pdf) of The effect of minimally invasive sacroiliac joint fusion compared to sham operation: a double-blind randomized-controlled trial
Part of Pain Reports, 2024
- DOI for Back morphology and walking patterns mean 13.8 years after surgery for lumbar disk herniation in adolescents
- Download full text (pdf) of Back morphology and walking patterns mean 13.8 years after surgery for lumbar disk herniation in adolescents
Part of Neurosurgical Focus, 2024
Part of Acta Orthopaedica, p. 152-156, 2024
- DOI for ChatGPT-4 generates orthopedic discharge documents faster than humans maintaining comparable quality: a pilot study of 6 cases
- Download full text (pdf) of ChatGPT-4 generates orthopedic discharge documents faster than humans maintaining comparable quality: a pilot study of 6 cases
Reliability of thoracolumbar burst fracture classification in the Swedish Fracture Register
Part of BMC Musculoskeletal Disorders, 2024
- DOI for Reliability of thoracolumbar burst fracture classification in the Swedish Fracture Register
- Download full text (pdf) of Reliability of thoracolumbar burst fracture classification in the Swedish Fracture Register
Part of European spine journal, p. 1205-1212, 2024
- DOI for Comparison of the patient-derived modified Japanese Orthopaedic Association scale and the European myelopathy score
- Download full text (pdf) of Comparison of the patient-derived modified Japanese Orthopaedic Association scale and the European myelopathy score
Dysphagia, health-related quality of life, and return to work after occipitocervical fixation
Part of Acta Neurochirurgica, 2024
- DOI for Dysphagia, health-related quality of life, and return to work after occipitocervical fixation
- Download full text (pdf) of Dysphagia, health-related quality of life, and return to work after occipitocervical fixation
Extended reality in cranial and spinal neurosurgery: a bibliometric analysis
Part of Acta Neurochirurgica, 2024
- DOI for Extended reality in cranial and spinal neurosurgery: a bibliometric analysis
- Download full text (pdf) of Extended reality in cranial and spinal neurosurgery: a bibliometric analysis
Part of Injury, 2024
- DOI for Surgical and non-surgical treatment for fully displaced lateral clavicle fractures have similar outcomes: An observational register study of 113 patients
- Download full text (pdf) of Surgical and non-surgical treatment for fully displaced lateral clavicle fractures have similar outcomes: An observational register study of 113 patients
Part of European spine journal, p. 739-745, 2024
- DOI for Growing rods in meningomyelocele lead to increased risk for complications in comparison with fusion; a retrospective study of 30 patients treated for at the University Hospital of Uppsala
- Download full text (pdf) of Growing rods in meningomyelocele lead to increased risk for complications in comparison with fusion; a retrospective study of 30 patients treated for at the University Hospital of Uppsala
Part of Acta Orthopaedica, p. 206-211, 2024
- DOI for Risk of conversion to total knee arthroplasty after surgically treated tibial plateau fractures: an observational cohort study of 439 patients
- Download full text (pdf) of Risk of conversion to total knee arthroplasty after surgically treated tibial plateau fractures: an observational cohort study of 439 patients
Optical Methods for Brain Tumor Detection: A Systematic Review
Part of Journal of Clinical Medicine, 2024
- DOI for Optical Methods for Brain Tumor Detection: A Systematic Review
- Download full text (pdf) of Optical Methods for Brain Tumor Detection: A Systematic Review
Part of Acta Orthopaedica, p. 212-218, 2024
- DOI for Patients with more complex ankle fractures are associated with poorer patient-reported outcome: an observational study of 11,733 patients from the Swedish Fracture Register
- Download full text (pdf) of Patients with more complex ankle fractures are associated with poorer patient-reported outcome: an observational study of 11,733 patients from the Swedish Fracture Register
Spontaneous spinal cord infarction: a systematic review
Part of BMJ NEUROLOGY OPEN, 2024
- DOI for Spontaneous spinal cord infarction: a systematic review
- Download full text (pdf) of Spontaneous spinal cord infarction: a systematic review
Part of Acta Orthopaedica, p. 284-289, 2024
- DOI for Patient-reported outcomes after minimally invasive sacro-iliac joint surgery: a cohort study based on the Swedish Spine Registry
- Download full text (pdf) of Patient-reported outcomes after minimally invasive sacro-iliac joint surgery: a cohort study based on the Swedish Spine Registry
Part of Archives of Physical Medicine and Rehabilitation, p. 1069-1075, 2024
- DOI for The Effect of Concomitant Spinal Cord Injury on Postoperative Health-related Quality of Life After Traumatic Subaxial Cervical Spine Injuries: A Nationwide Registry Study
- Download full text (pdf) of The Effect of Concomitant Spinal Cord Injury on Postoperative Health-related Quality of Life After Traumatic Subaxial Cervical Spine Injuries: A Nationwide Registry Study
ChatGPT can yield valuable responses in the context of orthopaedic trauma surgery
Part of Journal of Experimental Orthopaedics, 2024
- DOI for ChatGPT can yield valuable responses in the context of orthopaedic trauma surgery
- Download full text (pdf) of ChatGPT can yield valuable responses in the context of orthopaedic trauma surgery
Part of Acta Neurochirurgica, 2024
- DOI for Safety of anterior cervical corpectomy and fusion (ACCF) for the treatment of subaxial cervical spine injuries, a single center comparative matched analysis
- Download full text (pdf) of Safety of anterior cervical corpectomy and fusion (ACCF) for the treatment of subaxial cervical spine injuries, a single center comparative matched analysis
Part of Injury, 2024
- DOI for Epidemiology and patient-reported measurement outcome of pelvic fractures in children and adolescents: A population-based cohort study from the Swedish fracture register
- Download full text (pdf) of Epidemiology and patient-reported measurement outcome of pelvic fractures in children and adolescents: A population-based cohort study from the Swedish fracture register