Pancreatic NETs

Several previous studies have investigated gene changes associated with pancreatic NETs. In a collaborative effort with Yale University we showed early that mutations in YY1 was present in approximately 40% of insulinomas. Further work includes characterization of DAXX mutations and expression. Further analyses of genetic derangements in multiple endocrine neoplasia type 1 (MEN1) are also performed. A local work within the Centre of Excellence is investigating the genetic evolution of pancreatic NETs, as well as genetic effects of chemotherapy treatment.

We have studied the effect of liver surgery for metastases of pancreatic NET, and the overall survival benefit in case of metastasized disease.