Clinical and translational research in pediatric oncology
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By increasing our understanding of the clinical, biological, and psychosocial aspects of childhood neurological diseases and childhood cancer, the research group Pediatric oncological and neurological research works to improve the quality of life for children and adolescents with these diseases and their families.
The research performed within our research group spans from experimental studies using molecular biological techniques to behavioral research aiming to help children and their families better cope with demanding treatments. We collaborate nationally and internationally, both leading and participating in different research projects. We work especially tightly together with research group Pediatric oncological and neurological research with whom we have several collaborative projects. Read more about our main fields of research and projects and our research group.
Special resources at UU
Protein beam therapy
The Skandion Clinic in Uppsala started in 2015 and is a national, and even Nordic, resource and entails a significant expansion of the therapeutic arsenal for children with cancer. Protein beam therapy enables the irradiation field to be precisely controlled, thereby limiting damage to nearby healthy tissues. The establishment of Skandion Clinic provides increased possibilities for radiation therapy for younger patients, where treatment is otherwise restrictive due to the risks for serious late complications, particularly in the brain.
Biobanks
There are two biobanks connected to Uppsala with a particular focus on childhood cancer and neuropediatrics: The Nordic biobank for childhood leukemia (Frost main responsible, Palle et al.) and the Swedish childhood tumour biobank (Ljungman clinical leader and chairman of the board). Learn more about both biobanks on the Swedish Childhood Cancer Fund's website (in Swedish only).
Research funders
We would like to warmly thank our funders, collaborators, and all patients and their parents who enable our research work, including for example the Swedish Childhood Cancer Fund, Gillbergska Stiftelsen, Lions Cancerforskningsfond Mellansverige Uppsala-Örebro, Mary Bevés Stiftelse, and Region Uppsala.
Group members
Publications
Part of Acta Paediatrica, 2025
- DOI for Challenges and Considerations in Manipulating Oral Dosage Forms in Paediatric Healthcare Settings: A Narrative Review
- Download full text (pdf) of Challenges and Considerations in Manipulating Oral Dosage Forms in Paediatric Healthcare Settings: A Narrative Review
European standard clinical practice recommendations for paediatric high-grade gliomas
Part of EJC Paediatric Oncology, 2025
- DOI for European standard clinical practice recommendations for paediatric high-grade gliomas
- Download full text (pdf) of European standard clinical practice recommendations for paediatric high-grade gliomas
Part of Journal of Pharmaceutical Sciences, 2025
- DOI for Exploring Industry Stakeholder Perspectives on a Clinical Testbed for Evaluating the Handling of Protein Drugs in Hospitals
- Download full text (pdf) of Exploring Industry Stakeholder Perspectives on a Clinical Testbed for Evaluating the Handling of Protein Drugs in Hospitals
Healthcare professionals' attitudes to animal assisted activity with dogs in paediatric care
Part of Complementary Therapies in Clinical Practice, 2025
- DOI for Healthcare professionals' attitudes to animal assisted activity with dogs in paediatric care
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Part of Disability and Rehabilitation, 2025
- DOI for Long-term outcome and rehabilitation needs after acquired brain injury in children and adolescents: an evaluation in a Swedish cohort
- Download full text (pdf) of Long-term outcome and rehabilitation needs after acquired brain injury in children and adolescents: an evaluation in a Swedish cohort
Part of Critical reviews in oncology/hematology, 2025
- DOI for Pharmacogenomics in pediatric oncology patients with solid tumors related to chemotherapy-induced toxicity: A systematic review
- Download full text (pdf) of Pharmacogenomics in pediatric oncology patients with solid tumors related to chemotherapy-induced toxicity: A systematic review
Part of Journal of Pharmaceutical Sciences, p. 1142-1151, 2025
- DOI for Pneumatic tube transport of trastuzumab in IV bags -effect of headspace and surfactant on subvisible particle formation
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Part of Drug Safety, p. 375-388, 2025
- DOI for Prenatal and Early Childhood Exposure to Proton Pump Inhibitors and Antibiotics and the Risk of Childhood Cancer: A Nationwide Population-Based Cohort Study
- Download full text (pdf) of Prenatal and Early Childhood Exposure to Proton Pump Inhibitors and Antibiotics and the Risk of Childhood Cancer: A Nationwide Population-Based Cohort Study
Part of Cancer Medicine, 2025
- DOI for Prognostic factors in patients with localized and metastatic alveolar rhabdomyosarcoma: A report from two studies and two registries of the Cooperative Weichteilsarkom Studiengruppe CWS
- Download full text (pdf) of Prognostic factors in patients with localized and metastatic alveolar rhabdomyosarcoma: A report from two studies and two registries of the Cooperative Weichteilsarkom Studiengruppe CWS
Part of European Journal of Oncology Nursing, 2025
Part of European Journal of Oncology Nursing, 2025
- DOI for Siblings' lived experiences of transitions between hospital and home in paediatric oncology: A qualitative study
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Part of BMC Public Health, 2025
- DOI for Young people's proposals for tackling everyday challenges in order to improve mental health: a qualitative comparison study based on different socioeconomic neighborhoods
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Part of Journal of Adolescent Research, p. 3-29, 2024
- DOI for A Clash of Sexual Gender Norms and Understandings: A Qualitative Study of Homosexual, Bisexual, Transgender, and Queer Adolescents’ Experiences in Junior High Schools
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Part of JMIR Serious Games, 2024
- DOI for Acceptability of a Serious Game About Proton Radiotherapy Designed for Children Aged 5 to 14 Years and Its Potential Impact on Perceived Anxiety: Feasibility and Randomized Controlled Pilot Trial
- Download full text (pdf) of Acceptability of a Serious Game About Proton Radiotherapy Designed for Children Aged 5 to 14 Years and Its Potential Impact on Perceived Anxiety: Feasibility and Randomized Controlled Pilot Trial
Part of Pharmaceutics, 2024
- DOI for Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets
- Download full text (pdf) of Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets
Part of BMJ Open, 2024
- DOI for Children's participation in the development, use and evaluation of support interventions for children of a parent diagnosed with cancer: a scoping review protocol
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Part of BMJ Paediatrics Open, 2024
- DOI for Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial
- Download full text (pdf) of Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial
Part of BMJ Paediatrics Open, 2024
- DOI for Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial
- Download full text (pdf) of Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial
Part of European Journal of Integrative Medicine, 2024
- DOI for Comparing the use of colored Trace Images in Kids' Books with passive distractions to decrease pain and fear during cannulation in children: A randomized clinical trial
- Download full text (pdf) of Comparing the use of colored Trace Images in Kids' Books with passive distractions to decrease pain and fear during cannulation in children: A randomized clinical trial
Part of European Journal of Pediatrics, p. 113-122, 2024
- DOI for Comparison of trace image colors for kids-book with two active distractions in reducing pain and fear of children during the venipuncture procedure
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Conceptualizing adolescents' everyday stressors to underscore areas for support
Part of Frontiers in Education, 2024
- DOI for Conceptualizing adolescents' everyday stressors to underscore areas for support
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Part of JBMR Plus, 2024
- DOI for Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
- Download full text (pdf) of Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
Part of The Lancet Regional Health, 2024
- DOI for Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors: a nationwide, prospective Swedish study
- Download full text (pdf) of Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors: a nationwide, prospective Swedish study
Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
Part of Cancers, 2024
- DOI for Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
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Part of Acta Psychologica, 2024
- DOI for Exploring the relationship between depressive symptoms, problematic smartphone use, and cumulative risk factors in nursing students: A cross sectional study
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Part of Children & society, p. 228-244, 2024
- DOI for Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
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Part of International Journal for Quality in Health Care, 2024
- DOI for How are we handling protein drugs in hospitals?: A Human Factors and Systems Engineering Approach to compare two hospitals and suggest a best practice
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Part of Journal of Pharmaceutical Sciences, p. 2055-2064, 2024
- DOI for Impact of Post Manufacturing Handling of Protein-Based Biologic Drugs on Product Quality and User Centricity
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Part of Frontiers in Oncology, 2024
- DOI for Implementing data on targeted therapy from the INFORM registry platform for children with relapsed cancer in Sweden
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Part of Nature Communications, 2024
- DOI for In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity
- Download full text (pdf) of In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity
Part of Cancer Research Communications, p. 2553-2564, 2024
- DOI for Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis
- Download full text (pdf) of Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis
Part of Genes, Chromosomes and Cancer, 2024
- DOI for Loss of Chromosome Y in Neuroblastoma Is Associated With High-Risk Disease, 11q-Deletion, and Telomere Maintenance
- Download full text (pdf) of Loss of Chromosome Y in Neuroblastoma Is Associated With High-Risk Disease, 11q-Deletion, and Telomere Maintenance
Part of eClinicalMedicine, 2024
- DOI for Maintenance therapy with trofosfamide, idarubicin and etoposide in patients with rhabdomyosarcoma and other high-risk soft tissue sarcomas (CWS-2007-HR): a multicentre, open-label, randomised controlled phase 3 trial
- Download full text (pdf) of Maintenance therapy with trofosfamide, idarubicin and etoposide in patients with rhabdomyosarcoma and other high-risk soft tissue sarcomas (CWS-2007-HR): a multicentre, open-label, randomised controlled phase 3 trial
Nursing interventions for pediatric patients with cancer and their families: A scoping review
Part of International Journal of Nursing Studies, 2024
- DOI for Nursing interventions for pediatric patients with cancer and their families: A scoping review
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Part of International Journal of Pharmaceutics, 2024
- DOI for Off-the-shelf medication transformed: Custom-dosed metoprolol tartrate tablets via semisolid extrusion additive manufacturing and the perception of this technique in a hospital context
- Download full text (pdf) of Off-the-shelf medication transformed: Custom-dosed metoprolol tartrate tablets via semisolid extrusion additive manufacturing and the perception of this technique in a hospital context
Part of American Journal of Case Reports, 2024
- DOI for Pediatric Soft Tissue Sarcoma in Limb-Girdle Muscular Dystrophy: Molecular Findings and Clinical Implications
- Download full text (pdf) of Pediatric Soft Tissue Sarcoma in Limb-Girdle Muscular Dystrophy: Molecular Findings and Clinical Implications
Part of Pediatric Blood & Cancer, 2024
- DOI for Radiotherapy and long-term sequelae in pediatric patients with parameningeal rhabdomyosarcoma: Results of two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry
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Part of Clinical Nutrition, p. 1696-1705, 2024
- DOI for Safe and efficient practice of parenteral nutrition in neonates and children aged 0-18 years - The role of licensed multi-chamber bags
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School children's perceptions about being offered the HPV vaccination: A focus group study
Part of Acta Paediatrica, p. 1672-1678, 2024
- DOI for School children's perceptions about being offered the HPV vaccination: A focus group study
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Part of 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology in Vienna, Austria, 2024
Part of Pediatric Blood & Cancer, 2024
- DOI for Significance of fusion status, Oberlin risk factors, local and maintenance treatment in pediatric and adolescent patients with metastatic rhabdomyosarcoma: Data of the European Soft Tissue Sarcoma Registry SoTiSaR
- Download full text (pdf) of Significance of fusion status, Oberlin risk factors, local and maintenance treatment in pediatric and adolescent patients with metastatic rhabdomyosarcoma: Data of the European Soft Tissue Sarcoma Registry SoTiSaR
Part of Neuro-Oncology Advances, 2024
- DOI for The potential of liquid biopsy for detection of the KIAA1549-BRAF fusion in circulating tumor DNA from children with pilocytic astrocytoma
- Download full text (pdf) of The potential of liquid biopsy for detection of the KIAA1549-BRAF fusion in circulating tumor DNA from children with pilocytic astrocytoma
Part of Health Expectations, 2024
- DOI for Translation, cultural adaptation and validation of a patient-reported experience measure for children
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Part of Acta Paediatrica, p. 2398-2405, 2024
- DOI for Unpredictable supplementation of vitamin D to infants in the neonatal intensive care unit: An experimental study
- Download full text (pdf) of Unpredictable supplementation of vitamin D to infants in the neonatal intensive care unit: An experimental study
Part of Pielegniarstwo XXI wieku / Nursing in the 21st Century, p. 264-272, 2023
- DOI for A systematic review and meta-analysis of the effect of art-based psychological distraction on school-aged children's pain and anxiety during painful procedures
- Download full text (pdf) of A systematic review and meta-analysis of the effect of art-based psychological distraction on school-aged children's pain and anxiety during painful procedures
Alleviating anxiety in children with cancer facing radiotherapy: The creation of a serious game
2023
Children's interaction with a dog when having Animal Assisted Activity in paediatric hospital care
Part of Complementary Therapies in Clinical Practice, 2023
- DOI for Children's interaction with a dog when having Animal Assisted Activity in paediatric hospital care
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2023
Diagnostic Yield From a Nationwide Implementation of Precision Medicine for all Children With Cancer
Part of JCO PRECISION ONCOLOGY, 2023
- DOI for Diagnostic Yield From a Nationwide Implementation of Precision Medicine for all Children With Cancer
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Part of Journal of Pharmaceutical Sciences, p. 2799-2810, 2023
- DOI for Examination of the Protein Drug Supply Chain in a Swedish University Hospital: Focus on Handling Risks and Mitigation Measures
- Download full text (pdf) of Examination of the Protein Drug Supply Chain in a Swedish University Hospital: Focus on Handling Risks and Mitigation Measures