Clinical and translational research in pediatric oncology
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By increasing our understanding of the clinical, biological, and psychosocial aspects of childhood neurological diseases and childhood cancer, the research group Pediatric oncological and neurological research works to improve the quality of life for children and adolescents with these diseases and their families.
The research performed within our research group spans from experimental studies using molecular biological techniques to behavioral research aiming to help children and their families better cope with demanding treatments. We collaborate nationally and internationally, both leading and participating in different research projects. We work especially tightly together with research group Pediatric oncological and neurological research with whom we have several collaborative projects. Read more about our main fields of research and projects and our research group.
Special resources at UU
Protein beam therapy
The Skandion Clinic in Uppsala started in 2015 and is a national, and even Nordic, resource and entails a significant expansion of the therapeutic arsenal for children with cancer. Protein beam therapy enables the irradiation field to be precisely controlled, thereby limiting damage to nearby healthy tissues. The establishment of Skandion Clinic provides increased possibilities for radiation therapy for younger patients, where treatment is otherwise restrictive due to the risks for serious late complications, particularly in the brain.
Biobanks
There are two biobanks connected to Uppsala with a particular focus on childhood cancer and neuropediatrics: The Nordic biobank for childhood leukemia (Frost main responsible, Palle et al.) and the Swedish childhood tumour biobank (Ljungman clinical leader and chairman of the board). Learn more about both biobanks on the Swedish Childhood Cancer Fund's website (in Swedish only).
Research funders
We would like to warmly thank our funders, collaborators, and all patients and their parents who enable our research work, including for example the Swedish Childhood Cancer Fund, Gillbergska Stiftelsen, Lions Cancerforskningsfond Mellansverige Uppsala-Örebro, Mary Bevés Stiftelse, and Region Uppsala.
Group members
Publications
Part of Journal of Pharmaceutical Sciences, 2025
Part of Cancer Medicine, 2025
- DOI for Prognostic factors in patients with localized and metastatic alveolar rhabdomyosarcoma: A report from two studies and two registries of the Cooperative Weichteilsarkom Studiengruppe CWS
- Download full text (pdf) of Prognostic factors in patients with localized and metastatic alveolar rhabdomyosarcoma: A report from two studies and two registries of the Cooperative Weichteilsarkom Studiengruppe CWS
Part of Journal of Adolescent Research, p. 3-29, 2024
- DOI for A Clash of Sexual Gender Norms and Understandings: A Qualitative Study of Homosexual, Bisexual, Transgender, and Queer Adolescents’ Experiences in Junior High Schools
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Part of JMIR Serious Games, 2024
- DOI for Acceptability of a Serious Game About Proton Radiotherapy Designed for Children Aged 5 to 14 Years and Its Potential Impact on Perceived Anxiety: Feasibility and Randomized Controlled Pilot Trial
- Download full text (pdf) of Acceptability of a Serious Game About Proton Radiotherapy Designed for Children Aged 5 to 14 Years and Its Potential Impact on Perceived Anxiety: Feasibility and Randomized Controlled Pilot Trial
Part of Pharmaceutics, 2024
- DOI for Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets
- Download full text (pdf) of Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets
Part of BMJ Open, 2024
- DOI for Children's participation in the development, use and evaluation of support interventions for children of a parent diagnosed with cancer: a scoping review protocol
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Part of European Journal of Integrative Medicine, 2024
- DOI for Comparing the use of colored Trace Images in Kids' Books with passive distractions to decrease pain and fear during cannulation in children: A randomized clinical trial
- Download full text (pdf) of Comparing the use of colored Trace Images in Kids' Books with passive distractions to decrease pain and fear during cannulation in children: A randomized clinical trial
Part of European Journal of Pediatrics, p. 113-122, 2024
- DOI for Comparison of trace image colors for kids-book with two active distractions in reducing pain and fear of children during the venipuncture procedure
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Conceptualizing adolescents' everyday stressors to underscore areas for support
Part of Frontiers in Education, 2024
- DOI for Conceptualizing adolescents' everyday stressors to underscore areas for support
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Part of JBMR Plus, 2024
- DOI for Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
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Part of The Lancet Regional Health, 2024
- DOI for Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors: a nationwide, prospective Swedish study
- Download full text (pdf) of Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors: a nationwide, prospective Swedish study
Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
Part of Cancers, 2024
- DOI for Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
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Part of Acta Psychologica, 2024
- DOI for Exploring the relationship between depressive symptoms, problematic smartphone use, and cumulative risk factors in nursing students: A cross sectional study
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Part of Children & society, p. 228-244, 2024
- DOI for Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
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Part of International Journal for Quality in Health Care, 2024
- DOI for How are we handling protein drugs in hospitals?: A Human Factors and Systems Engineering Approach to compare two hospitals and suggest a best practice
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Part of Journal of Pharmaceutical Sciences, p. 2055-2064, 2024
- DOI for Impact of Post Manufacturing Handling of Protein-Based Biologic Drugs on Product Quality and User Centricity
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Part of Frontiers in Oncology, 2024
- DOI for Implementing data on targeted therapy from the INFORM registry platform for children with relapsed cancer in Sweden
- Download full text (pdf) of Implementing data on targeted therapy from the INFORM registry platform for children with relapsed cancer in Sweden
Part of Nature Communications, 2024
- DOI for In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity
- Download full text (pdf) of In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity
Part of Cancer Research Communications, p. 2553-2564, 2024
- DOI for Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis
- Download full text (pdf) of Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis
Part of Genes, Chromosomes and Cancer, 2024
- DOI for Loss of Chromosome Y in Neuroblastoma Is Associated With High-Risk Disease, 11q-Deletion, and Telomere Maintenance
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Nursing interventions for pediatric patients with cancer and their families: A scoping review
Part of International Journal of Nursing Studies, 2024
- DOI for Nursing interventions for pediatric patients with cancer and their families: A scoping review
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Part of International Journal of Pharmaceutics, 2024
- DOI for Off-the-shelf medication transformed: Custom-dosed metoprolol tartrate tablets via semisolid extrusion additive manufacturing and the perception of this technique in a hospital context
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Part of International Journal of Pharmaceutics, 2024
Part of American Journal of Case Reports, 2024
- DOI for Pediatric Soft Tissue Sarcoma in Limb-Girdle Muscular Dystrophy: Molecular Findings and Clinical Implications
- Download full text (pdf) of Pediatric Soft Tissue Sarcoma in Limb-Girdle Muscular Dystrophy: Molecular Findings and Clinical Implications
Part of Pediatric Blood & Cancer, 2024
- DOI for Radiotherapy and long-term sequelae in pediatric patients with parameningeal rhabdomyosarcoma: Results of two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry
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Part of Clinical Nutrition, p. 1696-1705, 2024
- DOI for Safe and efficient practice of parenteral nutrition in neonates and children aged 0-18 years - The role of licensed multi-chamber bags
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School children's perceptions about being offered the HPV vaccination: A focus group study
Part of Acta Paediatrica, 2024
- DOI for School children's perceptions about being offered the HPV vaccination: A focus group study
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Part of 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology in Vienna, Austria, 2024
Part of Pediatric Blood & Cancer, 2024
- DOI for Significance of fusion status, Oberlin risk factors, local and maintenance treatment in pediatric and adolescent patients with metastatic rhabdomyosarcoma: Data of the European Soft Tissue Sarcoma Registry SoTiSaR
- Download full text (pdf) of Significance of fusion status, Oberlin risk factors, local and maintenance treatment in pediatric and adolescent patients with metastatic rhabdomyosarcoma: Data of the European Soft Tissue Sarcoma Registry SoTiSaR
Part of Health Expectations, 2024
- DOI for Translation, cultural adaptation and validation of a patient-reported experience measure for children
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Part of Pielegniarstwo XXI wieku / Nursing in the 21st Century, p. 264-272, 2023
- DOI for A systematic review and meta-analysis of the effect of art-based psychological distraction on school-aged children's pain and anxiety during painful procedures
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Alleviating anxiety in children with cancer facing radiotherapy: The creation of a serious game
2023
Children's interaction with a dog when having Animal Assisted Activity in paediatric hospital care
Part of Complementary Therapies in Clinical Practice, 2023
- DOI for Children's interaction with a dog when having Animal Assisted Activity in paediatric hospital care
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2023
Diagnostic Yield From a Nationwide Implementation of Precision Medicine for all Children With Cancer
Part of JCO PRECISION ONCOLOGY, 2023
- DOI for Diagnostic Yield From a Nationwide Implementation of Precision Medicine for all Children With Cancer
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Part of Journal of Pharmaceutical Sciences, p. 2799-2810, 2023
- DOI for Examination of the Protein Drug Supply Chain in a Swedish University Hospital: Focus on Handling Risks and Mitigation Measures
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Part of Nursing Open, p. 630-640, 2023
- DOI for Factors associated with posttraumatic growth among spouses of women diagnosed with gynaecological cancer: A cross-sectional study
- Download full text (pdf) of Factors associated with posttraumatic growth among spouses of women diagnosed with gynaecological cancer: A cross-sectional study
Part of Cancer Medicine, p. 6148-6160, 2023
- DOI for Losing a child to adolescent cancer: A register‐based cohort study of psychotropic medication use in bereaved parents
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Neurocognition and mean radiotherapy dose to vulnerable brain structures: new organs at risk?
Part of Radiation Oncology, 2023
- DOI for Neurocognition and mean radiotherapy dose to vulnerable brain structures: new organs at risk?
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Part of Journal of Pediatric Hematology/Oncology Nursing, p. 178-187, 2023
- DOI for Nurses' Perceptions of the Impact of a National Educational Program in Pediatric Oncology Nursing: A Cross-Sectional Evaluation
- Download full text (pdf) of Nurses' Perceptions of the Impact of a National Educational Program in Pediatric Oncology Nursing: A Cross-Sectional Evaluation
Part of JBI Evidence Synthesis, p. 1903-1909, 2023
Pain in pediatric oncology: A Swedish nationwide follow-up study among nurses and physicians
Part of Acta Paediatrica, 2023
Part of Radiography, p. 95-100, 2023
- DOI for Parents' experiences of having their children take part in participatory action research creating a serious game about radiotherapy
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Part of Cancers, 2023
- DOI for Pediatric Patients with Stage IV Rhabdomyosarcoma Significantly Benefit from Long-Term Maintenance Therapy: Results of the CWS-IV 2002 and the CWS DOK IV 2004-Trials
- Download full text (pdf) of Pediatric Patients with Stage IV Rhabdomyosarcoma Significantly Benefit from Long-Term Maintenance Therapy: Results of the CWS-IV 2002 and the CWS DOK IV 2004-Trials
Part of Journal of Cancer Research and Clinical Oncology, p. 1717-1731, 2023
- DOI for Pre-operative radiotherapy is associated with superior local relapse-free survival in advanced synovial sarcoma
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Part of Acta Paediatrica, p. 2560-2562, 2023
- DOI for Preparing paediatric medicines by dissolving tablets and extracting a portion may compromise dosing accuracy
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Part of Medical Oncology, 2023
- DOI for Randomized cross-over study investigating the tolerability and side effects of an intra-oral air-cooling device compared to ice in healthy volunteers
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Reference standards for follicular density in ovarian cortex from birth to sexual maturity
Part of Reproductive BioMedicine Online, 2023
- DOI for Reference standards for follicular density in ovarian cortex from birth to sexual maturity
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Part of Pediatric Blood & Cancer, 2023
- DOI for Second-line treatment of pediatric patients with relapsed rhabdomyosarcoma adapted to initial risk stratification: Data of the European Soft Tissue Sarcoma Registry (SoTiSaR)
- Download full text (pdf) of Second-line treatment of pediatric patients with relapsed rhabdomyosarcoma adapted to initial risk stratification: Data of the European Soft Tissue Sarcoma Registry (SoTiSaR)
Part of Clinical Epigenetics, 2023
- DOI for Supratentorial CNS-PNETs in children; a Swedish population-based study with molecular re-evaluation and long-term follow-up
- Download full text (pdf) of Supratentorial CNS-PNETs in children; a Swedish population-based study with molecular re-evaluation and long-term follow-up