Barnonkologisk klinisk och translationell forskning
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Genom att öka förståelse för kliniska, biologiska, och psykosociala aspekter av barncancer arbetar forskargruppen Barnonkologisk klinisk och translationell forskning på att förbättra livskvalitet för barn och ungdomar med cancer och deras familjer.
Bredden är stor på den forskning som sker inom vår forskargrupp, från experimentell forskning med molekylärbiologiska tekniker till beteendevetenskaplig forskning som syftar till att hjälpa barn och familjer att bättre klara den krävande behandlingen. Vi samarbetar nationellt och internationellt både med att leda och samverka i olika forskningsprojekt. Vi arbetar särskilt tätt ihop med forskargruppen Barnonkologisk och neurologisk forskning som vi har flera gemensamma projekt med.
Särskilda resurser vid Uppsala universitet
Protonstrålning
Skandionkliniken i Uppsala som startade 2015 är en nationell, och även nordisk, resurs som har medfört en viktig utökning av den barnonkologiska behandlingsarsenalen. Protonbehandling gör att strålfälten kan avgränsas med stor precision. Tillkomsten av Skandionkliniken ger även utökade möjligheter till strålbehandling i de lägre åldrarna, där man för närvarande är restriktiv på grund av risker för allvarliga sena komplikationer, framför allt i hjärnan.
Biobanker
Det finns två biobanker med koppling till Uppsala som är särskilt inriktad mot barnonkologi och barnneurologi: Nordisk biobank för barnleukemi (Frost huvudansvarig, Palle et al.) och Barntumörbanken (Ljungman klinisk ledare och ordförande för styrgruppen). Läs mer om både biobanker på Barncancerfondens webbsida.
Finansiärer
Vi vill rikta ett varmt tack till våra finansiärer, samverkanspartner, och alla patienter och deras familjer som möjliggör vårt forskningsarbete, bland annat
Barncancerfonden, Cancerfonden, Gillbergska Stiftelsen, Mary Bevés Stiftelse, och Region Uppsala.
Gruppmedlemmar
Publikationer
Ingår i Acta Paediatrica, 2025
- DOI för Challenges and Considerations in Manipulating Oral Dosage Forms in Paediatric Healthcare Settings: A Narrative Review
- Ladda ner fulltext (pdf) av Challenges and Considerations in Manipulating Oral Dosage Forms in Paediatric Healthcare Settings: A Narrative Review
European standard clinical practice recommendations for paediatric high-grade gliomas
Ingår i EJC Paediatric Oncology, 2025
- DOI för European standard clinical practice recommendations for paediatric high-grade gliomas
- Ladda ner fulltext (pdf) av European standard clinical practice recommendations for paediatric high-grade gliomas
Ingår i Journal of Pharmaceutical Sciences, 2025
- DOI för Exploring Industry Stakeholder Perspectives on a Clinical Testbed for Evaluating the Handling of Protein Drugs in Hospitals
- Ladda ner fulltext (pdf) av Exploring Industry Stakeholder Perspectives on a Clinical Testbed for Evaluating the Handling of Protein Drugs in Hospitals
Healthcare professionals' attitudes to animal assisted activity with dogs in paediatric care
Ingår i Complementary Therapies in Clinical Practice, 2025
- DOI för Healthcare professionals' attitudes to animal assisted activity with dogs in paediatric care
- Ladda ner fulltext (pdf) av Healthcare professionals' attitudes to animal assisted activity with dogs in paediatric care
Ingår i Disability and Rehabilitation, 2025
- DOI för Long-term outcome and rehabilitation needs after acquired brain injury in children and adolescents: an evaluation in a Swedish cohort
- Ladda ner fulltext (pdf) av Long-term outcome and rehabilitation needs after acquired brain injury in children and adolescents: an evaluation in a Swedish cohort
Ingår i Critical reviews in oncology/hematology, 2025
- DOI för Pharmacogenomics in pediatric oncology patients with solid tumors related to chemotherapy-induced toxicity: A systematic review
- Ladda ner fulltext (pdf) av Pharmacogenomics in pediatric oncology patients with solid tumors related to chemotherapy-induced toxicity: A systematic review
Ingår i Journal of Pharmaceutical Sciences, s. 1142-1151, 2025
- DOI för Pneumatic tube transport of trastuzumab in IV bags -effect of headspace and surfactant on subvisible particle formation
- Ladda ner fulltext (pdf) av Pneumatic tube transport of trastuzumab in IV bags -effect of headspace and surfactant on subvisible particle formation
Ingår i Drug Safety, s. 375-388, 2025
- DOI för Prenatal and Early Childhood Exposure to Proton Pump Inhibitors and Antibiotics and the Risk of Childhood Cancer: A Nationwide Population-Based Cohort Study
- Ladda ner fulltext (pdf) av Prenatal and Early Childhood Exposure to Proton Pump Inhibitors and Antibiotics and the Risk of Childhood Cancer: A Nationwide Population-Based Cohort Study
Ingår i Cancer Medicine, 2025
- DOI för Prognostic factors in patients with localized and metastatic alveolar rhabdomyosarcoma: A report from two studies and two registries of the Cooperative Weichteilsarkom Studiengruppe CWS
- Ladda ner fulltext (pdf) av Prognostic factors in patients with localized and metastatic alveolar rhabdomyosarcoma: A report from two studies and two registries of the Cooperative Weichteilsarkom Studiengruppe CWS
Ingår i European Journal of Oncology Nursing, 2025
Ingår i European Journal of Oncology Nursing, 2025
- DOI för Siblings' lived experiences of transitions between hospital and home in paediatric oncology: A qualitative study
- Ladda ner fulltext (pdf) av Siblings' lived experiences of transitions between hospital and home in paediatric oncology: A qualitative study
Ingår i BMC Public Health, 2025
- DOI för Young people's proposals for tackling everyday challenges in order to improve mental health: a qualitative comparison study based on different socioeconomic neighborhoods
- Ladda ner fulltext (pdf) av Young people's proposals for tackling everyday challenges in order to improve mental health: a qualitative comparison study based on different socioeconomic neighborhoods
Ingår i Journal of Adolescent Research, s. 3-29, 2024
- DOI för A Clash of Sexual Gender Norms and Understandings: A Qualitative Study of Homosexual, Bisexual, Transgender, and Queer Adolescents’ Experiences in Junior High Schools
- Ladda ner fulltext (pdf) av A Clash of Sexual Gender Norms and Understandings: A Qualitative Study of Homosexual, Bisexual, Transgender, and Queer Adolescents’ Experiences in Junior High Schools
Ingår i JMIR Serious Games, 2024
- DOI för Acceptability of a Serious Game About Proton Radiotherapy Designed for Children Aged 5 to 14 Years and Its Potential Impact on Perceived Anxiety: Feasibility and Randomized Controlled Pilot Trial
- Ladda ner fulltext (pdf) av Acceptability of a Serious Game About Proton Radiotherapy Designed for Children Aged 5 to 14 Years and Its Potential Impact on Perceived Anxiety: Feasibility and Randomized Controlled Pilot Trial
Ingår i Pharmaceutics, 2024
- DOI för Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets
- Ladda ner fulltext (pdf) av Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets
Ingår i BMJ Open, 2024
- DOI för Children's participation in the development, use and evaluation of support interventions for children of a parent diagnosed with cancer: a scoping review protocol
- Ladda ner fulltext (pdf) av Children's participation in the development, use and evaluation of support interventions for children of a parent diagnosed with cancer: a scoping review protocol
Ingår i BMJ Paediatrics Open, 2024
- DOI för Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial
- Ladda ner fulltext (pdf) av Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial
Ingår i BMJ Paediatrics Open, 2024
- DOI för Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial
- Ladda ner fulltext (pdf) av Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial
Ingår i European Journal of Integrative Medicine, 2024
- DOI för Comparing the use of colored Trace Images in Kids' Books with passive distractions to decrease pain and fear during cannulation in children: A randomized clinical trial
- Ladda ner fulltext (pdf) av Comparing the use of colored Trace Images in Kids' Books with passive distractions to decrease pain and fear during cannulation in children: A randomized clinical trial
Ingår i European Journal of Pediatrics, s. 113-122, 2024
- DOI för Comparison of trace image colors for kids-book with two active distractions in reducing pain and fear of children during the venipuncture procedure
- Ladda ner fulltext (pdf) av Comparison of trace image colors for kids-book with two active distractions in reducing pain and fear of children during the venipuncture procedure
Conceptualizing adolescents' everyday stressors to underscore areas for support
Ingår i Frontiers in Education, 2024
- DOI för Conceptualizing adolescents' everyday stressors to underscore areas for support
- Ladda ner fulltext (pdf) av Conceptualizing adolescents' everyday stressors to underscore areas for support
Ingår i JBMR Plus, 2024
- DOI för Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
- Ladda ner fulltext (pdf) av Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
Ingår i The Lancet Regional Health, 2024
- DOI för Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors: a nationwide, prospective Swedish study
- Ladda ner fulltext (pdf) av Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors: a nationwide, prospective Swedish study
Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
Ingår i Cancers, 2024
- DOI för Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
- Ladda ner fulltext (pdf) av Drivers Underlying Metastasis and Relapse in Medulloblastoma and Targeting Strategies
Ingår i Acta Psychologica, 2024
- DOI för Exploring the relationship between depressive symptoms, problematic smartphone use, and cumulative risk factors in nursing students: A cross sectional study
- Ladda ner fulltext (pdf) av Exploring the relationship between depressive symptoms, problematic smartphone use, and cumulative risk factors in nursing students: A cross sectional study
Ingår i Children & society, s. 228-244, 2024
- DOI för Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
- Ladda ner fulltext (pdf) av Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
Ingår i International Journal for Quality in Health Care, 2024
- DOI för How are we handling protein drugs in hospitals?: A Human Factors and Systems Engineering Approach to compare two hospitals and suggest a best practice
- Ladda ner fulltext (pdf) av How are we handling protein drugs in hospitals?: A Human Factors and Systems Engineering Approach to compare two hospitals and suggest a best practice
Ingår i Journal of Pharmaceutical Sciences, s. 2055-2064, 2024
- DOI för Impact of Post Manufacturing Handling of Protein-Based Biologic Drugs on Product Quality and User Centricity
- Ladda ner fulltext (pdf) av Impact of Post Manufacturing Handling of Protein-Based Biologic Drugs on Product Quality and User Centricity
Ingår i Frontiers in Oncology, 2024
- DOI för Implementing data on targeted therapy from the INFORM registry platform for children with relapsed cancer in Sweden
- Ladda ner fulltext (pdf) av Implementing data on targeted therapy from the INFORM registry platform for children with relapsed cancer in Sweden
Ingår i Nature Communications, 2024
- DOI för In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity
- Ladda ner fulltext (pdf) av In-depth analysis of transcriptomes in ovarian cortical follicles from children and adults reveals interfollicular heterogeneity
Ingår i Cancer Research Communications, s. 2553-2564, 2024
- DOI för Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis
- Ladda ner fulltext (pdf) av Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis
Ingår i Genes, Chromosomes and Cancer, 2024
- DOI för Loss of Chromosome Y in Neuroblastoma Is Associated With High-Risk Disease, 11q-Deletion, and Telomere Maintenance
- Ladda ner fulltext (pdf) av Loss of Chromosome Y in Neuroblastoma Is Associated With High-Risk Disease, 11q-Deletion, and Telomere Maintenance
Ingår i eClinicalMedicine, 2024
- DOI för Maintenance therapy with trofosfamide, idarubicin and etoposide in patients with rhabdomyosarcoma and other high-risk soft tissue sarcomas (CWS-2007-HR): a multicentre, open-label, randomised controlled phase 3 trial
- Ladda ner fulltext (pdf) av Maintenance therapy with trofosfamide, idarubicin and etoposide in patients with rhabdomyosarcoma and other high-risk soft tissue sarcomas (CWS-2007-HR): a multicentre, open-label, randomised controlled phase 3 trial
Nursing interventions for pediatric patients with cancer and their families: A scoping review
Ingår i International Journal of Nursing Studies, 2024
- DOI för Nursing interventions for pediatric patients with cancer and their families: A scoping review
- Ladda ner fulltext (pdf) av Nursing interventions for pediatric patients with cancer and their families: A scoping review
Ingår i International Journal of Pharmaceutics, 2024
- DOI för Off-the-shelf medication transformed: Custom-dosed metoprolol tartrate tablets via semisolid extrusion additive manufacturing and the perception of this technique in a hospital context
- Ladda ner fulltext (pdf) av Off-the-shelf medication transformed: Custom-dosed metoprolol tartrate tablets via semisolid extrusion additive manufacturing and the perception of this technique in a hospital context
Ingår i American Journal of Case Reports, 2024
- DOI för Pediatric Soft Tissue Sarcoma in Limb-Girdle Muscular Dystrophy: Molecular Findings and Clinical Implications
- Ladda ner fulltext (pdf) av Pediatric Soft Tissue Sarcoma in Limb-Girdle Muscular Dystrophy: Molecular Findings and Clinical Implications
Ingår i Pediatric Blood & Cancer, 2024
- DOI för Radiotherapy and long-term sequelae in pediatric patients with parameningeal rhabdomyosarcoma: Results of two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry
- Ladda ner fulltext (pdf) av Radiotherapy and long-term sequelae in pediatric patients with parameningeal rhabdomyosarcoma: Results of two Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry
Ingår i Clinical Nutrition, s. 1696-1705, 2024
- DOI för Safe and efficient practice of parenteral nutrition in neonates and children aged 0-18 years - The role of licensed multi-chamber bags
- Ladda ner fulltext (pdf) av Safe and efficient practice of parenteral nutrition in neonates and children aged 0-18 years - The role of licensed multi-chamber bags
School children's perceptions about being offered the HPV vaccination: A focus group study
Ingår i Acta Paediatrica, s. 1672-1678, 2024
- DOI för School children's perceptions about being offered the HPV vaccination: A focus group study
- Ladda ner fulltext (pdf) av School children's perceptions about being offered the HPV vaccination: A focus group study
Ingår i 14th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology in Vienna, Austria, 2024
Ingår i Pediatric Blood & Cancer, 2024
- DOI för Significance of fusion status, Oberlin risk factors, local and maintenance treatment in pediatric and adolescent patients with metastatic rhabdomyosarcoma: Data of the European Soft Tissue Sarcoma Registry SoTiSaR
- Ladda ner fulltext (pdf) av Significance of fusion status, Oberlin risk factors, local and maintenance treatment in pediatric and adolescent patients with metastatic rhabdomyosarcoma: Data of the European Soft Tissue Sarcoma Registry SoTiSaR
Ingår i Neuro-Oncology Advances, 2024
- DOI för The potential of liquid biopsy for detection of the KIAA1549-BRAF fusion in circulating tumor DNA from children with pilocytic astrocytoma
- Ladda ner fulltext (pdf) av The potential of liquid biopsy for detection of the KIAA1549-BRAF fusion in circulating tumor DNA from children with pilocytic astrocytoma
Ingår i Health Expectations, 2024
- DOI för Translation, cultural adaptation and validation of a patient-reported experience measure for children
- Ladda ner fulltext (pdf) av Translation, cultural adaptation and validation of a patient-reported experience measure for children
Ingår i Acta Paediatrica, s. 2398-2405, 2024
- DOI för Unpredictable supplementation of vitamin D to infants in the neonatal intensive care unit: An experimental study
- Ladda ner fulltext (pdf) av Unpredictable supplementation of vitamin D to infants in the neonatal intensive care unit: An experimental study
Ingår i Pielegniarstwo XXI wieku / Nursing in the 21st Century, s. 264-272, 2023
- DOI för A systematic review and meta-analysis of the effect of art-based psychological distraction on school-aged children's pain and anxiety during painful procedures
- Ladda ner fulltext (pdf) av A systematic review and meta-analysis of the effect of art-based psychological distraction on school-aged children's pain and anxiety during painful procedures
Alleviating anxiety in children with cancer facing radiotherapy: The creation of a serious game
2023
Children's interaction with a dog when having Animal Assisted Activity in paediatric hospital care
Ingår i Complementary Therapies in Clinical Practice, 2023
- DOI för Children's interaction with a dog when having Animal Assisted Activity in paediatric hospital care
- Ladda ner fulltext (pdf) av Children's interaction with a dog when having Animal Assisted Activity in paediatric hospital care
2023
Diagnostic Yield From a Nationwide Implementation of Precision Medicine for all Children With Cancer
Ingår i JCO PRECISION ONCOLOGY, 2023
- DOI för Diagnostic Yield From a Nationwide Implementation of Precision Medicine for all Children With Cancer
- Ladda ner fulltext (pdf) av Diagnostic Yield From a Nationwide Implementation of Precision Medicine for all Children With Cancer
Ingår i Journal of Pharmaceutical Sciences, s. 2799-2810, 2023
- DOI för Examination of the Protein Drug Supply Chain in a Swedish University Hospital: Focus on Handling Risks and Mitigation Measures
- Ladda ner fulltext (pdf) av Examination of the Protein Drug Supply Chain in a Swedish University Hospital: Focus on Handling Risks and Mitigation Measures