Pediatric oncological and neurological research
By increasing our understanding of the clinical, biological, and psychosocial aspects of childhood neurological diseases and childhood cancer, the research group Pediatric oncological and neurological research works to improve the quality of life for children and adolescents with these diseases and their families.
The research performed within our research group spans from experimental studies using molecular biological techniques to behavioral research aiming to help children and their families better cope with demanding treatments. We collaborate nationally and internationally, both leading and participating in different research projects. We work especially tightly together with research group Pediatric oncology research with a special focus on side effects with whom we have several collaborative projects.
Special resources at UU
Protein beam therapy
The Skandion Clinic in Uppsala started in 2015 and is a national, and even Nordic, resource and entails a significant expansion of the therapeutic arsenal for children with cancer. Protein beam therapy enables the irradiation field to be precisely controlled, thereby limiting damage to nearby healthy tissues. The establishment of Skandion Clinic provides increased possibilities for radiation therapy for younger patients, where treatment is otherwise restrictive due to the risks for serious late complications, particularly in the brain.
Biobanks
There are two biobanks connected to Uppsala with a particular focus on childhood cancer and neuropediatrics: The Nordic biobank for childhood leukemia (Frost main responsible, Palle et al.) and the Swedish childhood tumour biobank (Ljungman clinical leader and chairman of the board). Learn more about both biobanks on the Swedish Childhood Cancer Fund's website (in Swedish only).
Research funders
We would like to warmly thank our funders, collaborators, and all patients and their parents who enable our research work, including for example the Swedish Childhood Cancer Fund, Gillbergska Stiftelsen, Lions Cancerforskningsfond Mellansverige Uppsala-Örebro, Mary Bevés Stiftelse, Insamlingsstiftelsen för Prader-Willi forskning, and Region Uppsala.
Group members
Publications
Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
Part of NAR Genomics and Bioinformatics, 2024
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Part of Clinical Epigenetics, 2024
Part of Pediatric Blood & Cancer, 2024
Part of Children & society, p. 228-244, 2024
- DOI for Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
- Download full text (pdf) of Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor
Part of Neuro-Oncology, p. 362-373, 2024
Part of Journal of Clinical Oncology, p. 2174-2185, 2024
Part of International Journal of Molecular Sciences, 2024
- DOI for Bone Marrow-Suppressive Treatment in Children Is Associated with Diminished IFN-γ Response from T Cells upon Polyclonal and Varicella Zoster Virus Peptide Stimulation
- Download full text (pdf) of Bone Marrow-Suppressive Treatment in Children Is Associated with Diminished IFN-γ Response from T Cells upon Polyclonal and Varicella Zoster Virus Peptide Stimulation
Part of HemaSphere, 2024
- DOI for Parents' perception of treatment-related toxicity in children treated according to the NOPHO ALL2008 protocol for acute lymphoblastic leukemia
- Download full text (pdf) of Parents' perception of treatment-related toxicity in children treated according to the NOPHO ALL2008 protocol for acute lymphoblastic leukemia
Part of JBMR Plus, 2024
Part of Haematologica, p. 2873-2883, 2024
- DOI for Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 protocol
- Download full text (pdf) of Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 protocol
Part of Early Human Development, 2024
Part of Pediatric Blood & Cancer, 2024
- DOI for Quality of life in children and adolescents after treatment for acute lymphoblastic leukemia according to the NOPHO ALL2008 protocol
- Download full text (pdf) of Quality of life in children and adolescents after treatment for acute lymphoblastic leukemia according to the NOPHO ALL2008 protocol
Part of Haematologica, p. 2846-2853, 2024
- DOI for Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
- Download full text (pdf) of Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
Intensive care in children with non-Hodgkin lymphoma in Sweden
Part of Acta Paediatrica, p. 1974-1976, 2024
Part of Vaccines, 2023
Part of Acta Paediatrica, p. 742-752, 2023
Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden
Part of Journal of cancer survivorship, p. 1072-1081, 2023
Part of British Journal of Haematology, p. 384-392, 2023
- DOI for The prognostic impact of IKZF1 deletions and UKALL genetic classifiers in paediatric B-cell precursor acute lymphoblastic leukaemia treated according to NOPHO 2008 protocols
- Download full text (pdf) of The prognostic impact of IKZF1 deletions and UKALL genetic classifiers in paediatric B-cell precursor acute lymphoblastic leukaemia treated according to NOPHO 2008 protocols
Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia
Part of British Journal of Haematology, p. 757-765, 2023
Part of Journal of Lipid Research, 2023
Part of Nursing Open, p. 630-640, 2023
Part of The Pharmacogenomics Journal, p. 105-111, 2023
- DOI for DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship?
- Download full text (pdf) of DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship?
Part of Cancers, 2023
- DOI for Simultaneous Ultra-Sensitive Detection of Structural and Single Nucleotide Variants Using Multiplex Droplet Digital PCR in Liquid Biopsies from Children with Medulloblastoma
- Download full text (pdf) of Simultaneous Ultra-Sensitive Detection of Structural and Single Nucleotide Variants Using Multiplex Droplet Digital PCR in Liquid Biopsies from Children with Medulloblastoma
Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
Part of npj Precision Oncology, 2023
Part of Cancer Medicine, p. 7459-7469, 2023
Patterns of smartphone usage associated with depressive symptoms in nursing students
Part of Frontiers in Psychiatry, 2023
Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia
Part of Genes, Chromosomes and Cancer, p. 597-606, 2023
Part of Acta Oncologica, p. 1723-1731, 2023
Part of HemaSphere, 2023
Early disc degeneration in radiotherapy-treated childhood brain tumor survivors
Part of BMC Musculoskeletal Disorders, 2023
Parental experiences of the informed consent process in randomized clinical trials-A Nordic study
Part of Pediatric Blood & Cancer, 2023
Part of Pediatric Transplantation, 2023
Perceptions of health among school-aged children living in socially vulnerable areas in Sweden
Part of Frontiers in Public Health, 2023
Part of Child's Nervous System, p. 1479-1485, 2022
Part of Supportive Care in Cancer, p. 1901-1902, 2022
Part of Pediatric Blood & Cancer, 2022
- DOI for Does minimal central nervous system involvement in childhood acute lymphoblastic leukemia increase the risk for central nervous system toxicity?
- Download full text (pdf) of Does minimal central nervous system involvement in childhood acute lymphoblastic leukemia increase the risk for central nervous system toxicity?
COVID-19 seroprevalence and clinical picture in Swedish pediatric oncology and hematology patients
Part of Pediatric Blood & Cancer, 2022
Part of Leukemia and Lymphoma, p. 2311-2320, 2022
- DOI for Familial platelet disorder due to germline exonic deletions in RUNX1: a diagnostic challenge with distinct alterations of the transcript isoform equilibrium
- Download full text (pdf) of Familial platelet disorder due to germline exonic deletions in RUNX1: a diagnostic challenge with distinct alterations of the transcript isoform equilibrium
High need for intensive care in paediatric acute myeloid leukaemia: A population-based study
Part of Acta Paediatrica, p. 2235-2241, 2022
Part of Pediatric Blood & Cancer, 2022
- DOI for Prospective registration of symptoms and times to diagnosis in children and adolescents with central nervous system tumors: A study of the Swedish Childhood Cancer Registry
- Download full text (pdf) of Prospective registration of symptoms and times to diagnosis in children and adolescents with central nervous system tumors: A study of the Swedish Childhood Cancer Registry
Part of Expert Review of Anticancer Therapy, p. 1183-1196, 2022
Part of PLOS ONE, 2022
- DOI for Pre- and postdiagnosis growth failure, adult short stature, and untreated growth hormone deficiency in radiotherapy-treated long-term survivors of childhood brain tumor
- Download full text (pdf) of Pre- and postdiagnosis growth failure, adult short stature, and untreated growth hormone deficiency in radiotherapy-treated long-term survivors of childhood brain tumor
Part of British Journal of Haematology, p. 1032-1040, 2022
Part of Belitung Nursing Journal, p. 213-221, 2022
- DOI for Effectiveness of art-based distraction in reducing pain and anxiety of hospitalized children during cannulation procedure: A randomized controlled trial
- Download full text (pdf) of Effectiveness of art-based distraction in reducing pain and anxiety of hospitalized children during cannulation procedure: A randomized controlled trial
Part of Complementary Therapies in Clinical Practice, 2022
Obesity as a predictor of treatment-related toxicity in children with acute lymphoblastic leukaemia
Part of British Journal of Haematology, p. 1239-1247, 2022
The human cathelicidin hCAP-18 in serum of children with haemato-oncological diseases
Part of British Journal of Haematology, p. 1023-1031, 2022
Part of International Journal of Cancer, p. 406-419, 2022
A somatic UBA2 variant preceded ETV6-RUNX1 in the concordant BCP-ALL of monozygotic twins
Part of Blood Advances, p. 2275-2289, 2022
Part of Blood, p. 3159-3165, 2022