Pediatric oncological and neurological research
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By increasing our understanding of the clinical, biological, and psychosocial aspects of childhood neurological diseases and childhood cancer, the research group Pediatric oncological and neurological research works to improve the quality of life for children and adolescents with these diseases and their families.
The research performed within our research group spans from experimental studies using molecular biological techniques to behavioral research aiming to help children and their families better cope with demanding treatments. We collaborate nationally and internationally, both leading and participating in different research projects. We work especially tightly together with research group Pediatric oncology research with a special focus on side effects with whom we have several collaborative projects.
Special resources at UU
Protein beam therapy
The Skandion Clinic in Uppsala started in 2015 and is a national, and even Nordic, resource and entails a significant expansion of the therapeutic arsenal for children with cancer. Protein beam therapy enables the irradiation field to be precisely controlled, thereby limiting damage to nearby healthy tissues. The establishment of Skandion Clinic provides increased possibilities for radiation therapy for younger patients, where treatment is otherwise restrictive due to the risks for serious late complications, particularly in the brain.
Biobanks
There are two biobanks connected to Uppsala with a particular focus on childhood cancer and neuropediatrics: The Nordic biobank for childhood leukemia (Frost main responsible, Palle et al.) and the Swedish childhood tumour biobank (Ljungman clinical leader and chairman of the board). Learn more about both biobanks on the Swedish Childhood Cancer Fund's website (in Swedish only).
Research funders
We would like to warmly thank our funders, collaborators, and all patients and their parents who enable our research work, including for example the Swedish Childhood Cancer Fund, Gillbergska Stiftelsen, Lions Cancerforskningsfond Mellansverige Uppsala-Örebro, Mary Bevés Stiftelse, Insamlingsstiftelsen för Prader-Willi forskning, and Region Uppsala.
Group members
Publications
Part of Radiography, 2026
- DOI for Children's experiences of coping with proton radiotherapy: A mixed-method study at a Swedish nationwide clinic
- Download full text (pdf) of Children's experiences of coping with proton radiotherapy: A mixed-method study at a Swedish nationwide clinic
Part of Pediatric Neurology, p. 134-140, 2026
- DOI for The Lack of Broad Multidisciplinary Assessments in Children and Adolescents With Newly Diagnosed Idiopathic Intracranial Hypertension
- Download full text (pdf) of The Lack of Broad Multidisciplinary Assessments in Children and Adolescents With Newly Diagnosed Idiopathic Intracranial Hypertension
Part of Acta Paediatrica, p. 697-705, 2026
- DOI for Overall Good Quality of Life Reported by Survivors of Childhood Hodgkin Lymphoma in Sweden and Finland
- Download full text (pdf) of Overall Good Quality of Life Reported by Survivors of Childhood Hodgkin Lymphoma in Sweden and Finland
Part of International Breastfeeding Journal, 2026
- DOI for Mothers' experiences of support during a structured breastfeeding support programme in antenatal care: a lifeworld hermeneutic study.
- Download full text (pdf) of Mothers' experiences of support during a structured breastfeeding support programme in antenatal care: a lifeworld hermeneutic study.
Part of Pediatric Blood & Cancer, 2026
- DOI for Early Toxicity in Childhood Acute Lymphoblastic Leukemia: A Comparison of NOPHO ALL2008 and ALLTogether Protocols in Sweden
- Download full text (pdf) of Early Toxicity in Childhood Acute Lymphoblastic Leukemia: A Comparison of NOPHO ALL2008 and ALLTogether Protocols in Sweden
Part of JMIR Formative Research, 2026
- DOI for Process Evaluation of Interdisciplinary Experiences During the Development of a Serious Game About Radiotherapy for Children: Qualitative Interview Study
- Download full text (pdf) of Process Evaluation of Interdisciplinary Experiences During the Development of a Serious Game About Radiotherapy for Children: Qualitative Interview Study
An integrative molecular map of pediatric B-cell precursor acute lymphoblastic leukemia
Part of Communications Medicine, 2026
- DOI for An integrative molecular map of pediatric B-cell precursor acute lymphoblastic leukemia
- Download full text (pdf) of An integrative molecular map of pediatric B-cell precursor acute lymphoblastic leukemia
Part of Pediatric Blood & Cancer, 2026
- DOI for Infectious Complications During Early Treatment of Childhood Acute Lymphoblastic Leukemia-A Comparison Between the ALLTogether and NOPHO ALL-2008 Protocols
- Download full text (pdf) of Infectious Complications During Early Treatment of Childhood Acute Lymphoblastic Leukemia-A Comparison Between the ALLTogether and NOPHO ALL-2008 Protocols
Part of European Journal of Oncology Nursing, 2025
Part of International Journal of Cancer, p. 1347-1357, 2025
- DOI for Educational outcomes school year nine in children treated for acute lymphoblastic leukemia: A nationwide registry‐based study from Sweden
- Download full text (pdf) of Educational outcomes school year nine in children treated for acute lymphoblastic leukemia: A nationwide registry‐based study from Sweden
Part of Frontiers in Immunology, 2025
- DOI for The quantity and quality of B-cell immunity against SARS-CoV-2 in children with cancer and hematological diseases
- Download full text (pdf) of The quantity and quality of B-cell immunity against SARS-CoV-2 in children with cancer and hematological diseases
Quality of life after treatment for childhood Hodgkin lymphoma in Sweden and Finland
2025
Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients
Part of HemaSphere, 2025
- DOI for Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients
- Download full text (pdf) of Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients
Part of Acta Paediatrica, 2025
- DOI for Systematic follow‐ups were not associated with reduced acute ventriculoperitoneal shunt dysfunction in infancy
- Download full text (pdf) of Systematic follow‐ups were not associated with reduced acute ventriculoperitoneal shunt dysfunction in infancy
2025
Part of Studies in Health Technology and Informatics, p. 929-933, 2025
Part of European Journal of Oncology Nursing, p. 102780-102780, 2025
Part of BMC Public Health, 2025
Part of European Journal of Oncology Nursing, p. 102853-102853, 2025
Healthcare professionals’ attitudes to animal assisted activity with dogs in paediatric care
Part of Complementary Therapies in Clinical Practice, p. 101952-101952, 2025
Risk Factors for Traumatic Lumbar Puncture in Children With ALL
Part of Acta Paediatrica, p. 2713-2715, 2025
- DOI for Risk Factors for Traumatic Lumbar Puncture in Children With ALL
- Download full text (pdf) of Risk Factors for Traumatic Lumbar Puncture in Children With ALL
Part of British Journal of Haematology, p. 1454-1463, 2025
- DOI for Characteristics and prognosis of paediatric normal karyotype acute myeloid leukaemia: A NOPHO-DBH AML study
- Download full text (pdf) of Characteristics and prognosis of paediatric normal karyotype acute myeloid leukaemia: A NOPHO-DBH AML study
Part of Disability and Rehabilitation, p. 4467-4475, 2025
- DOI for Long-term outcome and rehabilitation needs after acquired brain injury in children and adolescents: an evaluation in a Swedish cohort
- Download full text (pdf) of Long-term outcome and rehabilitation needs after acquired brain injury in children and adolescents: an evaluation in a Swedish cohort
School Nurses’ Experiences of the School-Based HPV Vaccination Program – A Decade Later
Part of Journal of School Nursing, 2025
- DOI for School Nurses’ Experiences of the School-Based HPV Vaccination Program – A Decade Later
- Download full text (pdf) of School Nurses’ Experiences of the School-Based HPV Vaccination Program – A Decade Later
Part of Thrombosis Research, 2025
- DOI for Venous thromboembolism in children with Hodgkin lymphoma: A population-based study in Sweden, Finland, and Denmark
- Download full text (pdf) of Venous thromboembolism in children with Hodgkin lymphoma: A population-based study in Sweden, Finland, and Denmark
Part of British Journal of Haematology, p. 1920-1929, 2025
- DOI for Early prediction of subsequent peg-asparaginase inactivation in acute lymphoblastic leukaemia patients-A NOPHO ALL2008 study
- Download full text (pdf) of Early prediction of subsequent peg-asparaginase inactivation in acute lymphoblastic leukaemia patients-A NOPHO ALL2008 study
Part of JMIR Pediatrics and Parenting, 2025
- DOI for Perspectives on Swedish Regulations for Online Record Access Among Adolescents With Serious Health Issues and Their Parents: Mixed Methods Study
- Download full text (pdf) of Perspectives on Swedish Regulations for Online Record Access Among Adolescents With Serious Health Issues and Their Parents: Mixed Methods Study
Part of BMC Health Services Research, 2025
- DOI for Pediatric oncology healthcare professionals’ attitudes to and awareness of regulations for minors’ and guardians’ online record access: A mixed-methods study in Sweden
- Download full text (pdf) of Pediatric oncology healthcare professionals’ attitudes to and awareness of regulations for minors’ and guardians’ online record access: A mixed-methods study in Sweden
Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
Part of NAR Genomics and Bioinformatics, 2024
- DOI for Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
- Download full text (pdf) of Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
Part of Pediatric Blood & Cancer, 2024
- DOI for Educational and occupational outcomes in Swedish children treated for sarcomas: A nationwide registry-based study
- Download full text (pdf) of Educational and occupational outcomes in Swedish children treated for sarcomas: A nationwide registry-based study
Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor
Part of Neuro-Oncology, p. 362-373, 2024
Part of Journal of Clinical Oncology, p. 2174-2185, 2024
Part of International Journal of Molecular Sciences, 2024
- DOI for Bone Marrow-Suppressive Treatment in Children Is Associated with Diminished IFN-γ Response from T Cells upon Polyclonal and Varicella Zoster Virus Peptide Stimulation
- Download full text (pdf) of Bone Marrow-Suppressive Treatment in Children Is Associated with Diminished IFN-γ Response from T Cells upon Polyclonal and Varicella Zoster Virus Peptide Stimulation
Part of HemaSphere, 2024
- DOI for Parents' perception of treatment-related toxicity in children treated according to the NOPHO ALL2008 protocol for acute lymphoblastic leukemia
- Download full text (pdf) of Parents' perception of treatment-related toxicity in children treated according to the NOPHO ALL2008 protocol for acute lymphoblastic leukemia
Part of Early Human Development, 2024
- DOI for Neonatal therapeutic hypothermia in a regional swedish cohort: Adherence to guidelines, transport and outcomes
- Download full text (pdf) of Neonatal therapeutic hypothermia in a regional swedish cohort: Adherence to guidelines, transport and outcomes
Part of Pediatric Blood & Cancer, 2024
- DOI for Quality of life in children and adolescents after treatment for acute lymphoblastic leukemia according to the NOPHO ALL2008 protocol
- Download full text (pdf) of Quality of life in children and adolescents after treatment for acute lymphoblastic leukemia according to the NOPHO ALL2008 protocol
Intensive care in children with non-Hodgkin lymphoma in Sweden
Part of Acta Paediatrica, p. 1974-1976, 2024
- DOI for Intensive care in children with non-Hodgkin lymphoma in Sweden
- Download full text (pdf) of Intensive care in children with non-Hodgkin lymphoma in Sweden
Part of Acta Paediatrica, p. 2676-2678, 2024
- DOI for Haemostasis during early treatment of childhood acute lymphoblastic leukaemia with the ALLTogether protocol
- Download full text (pdf) of Haemostasis during early treatment of childhood acute lymphoblastic leukaemia with the ALLTogether protocol
Part of British Journal of Haematology, p. 1450-1459, 2024
- DOI for Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy-An observational Ponte di Legno Toxicity Working Group Study
- Download full text (pdf) of Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy-An observational Ponte di Legno Toxicity Working Group Study
Part of Acta Paediatrica, p. 2398-2405, 2024
- DOI for Unpredictable supplementation of vitamin D to infants in the neonatal intensive care unit: An experimental study
- Download full text (pdf) of Unpredictable supplementation of vitamin D to infants in the neonatal intensive care unit: An experimental study
Part of Children & society, p. 228-244, 2024
- DOI for Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
- Download full text (pdf) of Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
Part of Brain Injury, p. 151-159, 2024
- DOI for Further recommendations of the International Paediatric Brain Injury Society (IPBIS) for the post-acute rehabilitation of children with acquired brain injury
- Download full text (pdf) of Further recommendations of the International Paediatric Brain Injury Society (IPBIS) for the post-acute rehabilitation of children with acquired brain injury
Part of Pediatric Blood & Cancer, 2024
- DOI for Symptomatic osteonecrosis in children treated for Hodgkin lymphoma: A population‐based study in Sweden, Finland, and Denmark
- Download full text (pdf) of Symptomatic osteonecrosis in children treated for Hodgkin lymphoma: A population‐based study in Sweden, Finland, and Denmark
Radiological follow‐up of osteonecrosis lesions in children and adolescents with Hodgkin lymphoma
Part of British Journal of Haematology, p. 1460-1468, 2024
- DOI for Radiological follow‐up of osteonecrosis lesions in children and adolescents with Hodgkin lymphoma
- Download full text (pdf) of Radiological follow‐up of osteonecrosis lesions in children and adolescents with Hodgkin lymphoma
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Part of Clinical Epigenetics, 2024
- DOI for Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
- Download full text (pdf) of Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Part of Haematologica, p. 2846-2853, 2024
- DOI for Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
- Download full text (pdf) of Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
Part of Haematologica, p. 2873-2883, 2024
- DOI for Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 protocol
- Download full text (pdf) of Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 protocol
Part of JBMR Plus, 2024
- DOI for Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
- Download full text (pdf) of Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
Part of Acta Paediatrica, p. 742-752, 2023
- DOI for Predictive value of Bayley-III Motor Index for later motor difficulties in children born extremely preterm
- Download full text (pdf) of Predictive value of Bayley-III Motor Index for later motor difficulties in children born extremely preterm
Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden
Part of Journal of cancer survivorship, p. 1072-1081, 2023
- DOI for Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden
- Download full text (pdf) of Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden

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