Pediatric oncological and neurological research
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By increasing our understanding of the clinical, biological, and psychosocial aspects of childhood neurological diseases and childhood cancer, the research group Pediatric oncological and neurological research works to improve the quality of life for children and adolescents with these diseases and their families.
The research performed within our research group spans from experimental studies using molecular biological techniques to behavioral research aiming to help children and their families better cope with demanding treatments. We collaborate nationally and internationally, both leading and participating in different research projects. We work especially tightly together with research group Pediatric oncology research with a special focus on side effects with whom we have several collaborative projects.
Special resources at UU
Protein beam therapy
The Skandion Clinic in Uppsala started in 2015 and is a national, and even Nordic, resource and entails a significant expansion of the therapeutic arsenal for children with cancer. Protein beam therapy enables the irradiation field to be precisely controlled, thereby limiting damage to nearby healthy tissues. The establishment of Skandion Clinic provides increased possibilities for radiation therapy for younger patients, where treatment is otherwise restrictive due to the risks for serious late complications, particularly in the brain.
Biobanks
There are two biobanks connected to Uppsala with a particular focus on childhood cancer and neuropediatrics: The Nordic biobank for childhood leukemia (Frost main responsible, Palle et al.) and the Swedish childhood tumour biobank (Ljungman clinical leader and chairman of the board). Learn more about both biobanks on the Swedish Childhood Cancer Fund's website (in Swedish only).
Research funders
We would like to warmly thank our funders, collaborators, and all patients and their parents who enable our research work, including for example the Swedish Childhood Cancer Fund, Gillbergska Stiftelsen, Lions Cancerforskningsfond Mellansverige Uppsala-Örebro, Mary Bevés Stiftelse, Insamlingsstiftelsen för Prader-Willi forskning, and Region Uppsala.
Group members
Publications
Part of Disability and Rehabilitation, 2025
- DOI for Long-term outcome and rehabilitation needs after acquired brain injury in children and adolescents: an evaluation in a Swedish cohort
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Part of European Journal of Oncology Nursing, 2025
Part of JMIR Pediatrics and Parenting, 2025
- DOI for Perspectives on Swedish Regulations for Online Record Access Among Adolescents With Serious Health Issues and Their Parents: Mixed Methods Study
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Part of Thrombosis Research, 2025
- DOI for Venous thromboembolism in children with Hodgkin lymphoma - A population-based study in Sweden, Finland, and Denmark
- Download full text (pdf) of Venous thromboembolism in children with Hodgkin lymphoma - A population-based study in Sweden, Finland, and Denmark
Part of International Journal of Cancer, p. 1347-1357, 2025
- DOI for Educational outcomes school year nine in children treated for acute lymphoblastic leukemia: A nationwide registry‐based study from Sweden
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Part of Studies in Health Technology and Informatics, p. 929-933, 2025
Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
Part of NAR Genomics and Bioinformatics, 2024
- DOI for Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
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Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Part of Clinical Epigenetics, 2024
- DOI for Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
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Part of Pediatric Blood & Cancer, 2024
- DOI for Educational and occupational outcomes in Swedish children treated for sarcomas: A nationwide registry-based study
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Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor
Part of Neuro-Oncology, p. 362-373, 2024
Part of Journal of Clinical Oncology, p. 2174-2185, 2024
Part of International Journal of Molecular Sciences, 2024
- DOI for Bone Marrow-Suppressive Treatment in Children Is Associated with Diminished IFN-γ Response from T Cells upon Polyclonal and Varicella Zoster Virus Peptide Stimulation
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Part of HemaSphere, 2024
- DOI for Parents' perception of treatment-related toxicity in children treated according to the NOPHO ALL2008 protocol for acute lymphoblastic leukemia
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Part of JBMR Plus, 2024
- DOI for Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
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Part of Haematologica, p. 2873-2883, 2024
- DOI for Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 protocol
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Part of Early Human Development, 2024
- DOI for Neonatal therapeutic hypothermia in a regional swedish cohort: Adherence to guidelines, transport and outcomes
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Part of Pediatric Blood & Cancer, 2024
- DOI for Quality of life in children and adolescents after treatment for acute lymphoblastic leukemia according to the NOPHO ALL2008 protocol
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Part of Haematologica, p. 2846-2853, 2024
- DOI for Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
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Radiological follow‐up of osteonecrosis lesions in children and adolescents with Hodgkin lymphoma
Part of British Journal of Haematology, p. 1460-1468, 2024
- DOI for Radiological follow‐up of osteonecrosis lesions in children and adolescents with Hodgkin lymphoma
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Intensive care in children with non-Hodgkin lymphoma in Sweden
Part of Acta Paediatrica, p. 1974-1976, 2024
- DOI for Intensive care in children with non-Hodgkin lymphoma in Sweden
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Part of Acta Paediatrica, p. 2676-2678, 2024
- DOI for Haemostasis during early treatment of childhood acute lymphoblastic leukaemia with the ALLTogether protocol
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Part of British Journal of Haematology, p. 1450-1459, 2024
- DOI for Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy-An observational Ponte di Legno Toxicity Working Group Study
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Part of Acta Paediatrica, p. 2398-2405, 2024
- DOI for Unpredictable supplementation of vitamin D to infants in the neonatal intensive care unit: An experimental study
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Part of Children & society, p. 228-244, 2024
- DOI for Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
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Part of Brain Injury, p. 151-159, 2024
- DOI for Further recommendations of the International Paediatric Brain Injury Society (IPBIS) for the post-acute rehabilitation of children with acquired brain injury
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Part of Acta Paediatrica, 2024
- DOI for Systematic follow‐ups were not associated with reduced acute ventriculoperitoneal shunt dysfunction in infancy
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Part of Pediatric Blood & Cancer, 2024
- DOI for Symptomatic osteonecrosis in children treated for Hodgkin lymphoma: A population‐based study in Sweden, Finland, and Denmark
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Part of BMJ Paediatrics Open, 2024
- DOI for Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial
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Part of Acta Paediatrica, p. 742-752, 2023
- DOI for Predictive value of Bayley-III Motor Index for later motor difficulties in children born extremely preterm
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Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden
Part of Journal of cancer survivorship, p. 1072-1081, 2023
- DOI for Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden
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Part of British Journal of Haematology, p. 384-392, 2023
- DOI for The prognostic impact of IKZF1 deletions and UKALL genetic classifiers in paediatric B-cell precursor acute lymphoblastic leukaemia treated according to NOPHO 2008 protocols
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Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia
Part of British Journal of Haematology, p. 757-765, 2023
- DOI for Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia
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Part of Nursing Open, p. 630-640, 2023
- DOI for Factors associated with posttraumatic growth among spouses of women diagnosed with gynaecological cancer: A cross-sectional study
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Part of The Pharmacogenomics Journal, p. 105-111, 2023
- DOI for DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship?
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Part of Cancers, 2023
- DOI for Simultaneous Ultra-Sensitive Detection of Structural and Single Nucleotide Variants Using Multiplex Droplet Digital PCR in Liquid Biopsies from Children with Medulloblastoma
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Part of Cancer Medicine, p. 7459-7469, 2023
- DOI for Occupational outcomes after high-grade or low-grade brain tumors in childhood: A Swedish, nationwide, registry-based study
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Patterns of smartphone usage associated with depressive symptoms in nursing students
Part of Frontiers in Psychiatry, 2023
- DOI for Patterns of smartphone usage associated with depressive symptoms in nursing students
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Part of Acta Oncologica, p. 1723-1731, 2023
- DOI for Impact of body mass index on outcome and treatment-related toxicity in young adults with acute lymphoblastic leukemia
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Part of HemaSphere, 2023
- DOI for Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial
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Early disc degeneration in radiotherapy-treated childhood brain tumor survivors
Part of BMC Musculoskeletal Disorders, 2023
- DOI for Early disc degeneration in radiotherapy-treated childhood brain tumor survivors
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Parental experiences of the informed consent process in randomized clinical trials-A Nordic study
Part of Pediatric Blood & Cancer, 2023
- DOI for Parental experiences of the informed consent process in randomized clinical trials-A Nordic study
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Part of Pediatric Transplantation, 2023
- DOI for A retrospective case-control study of gastrostomy use in children undergoing hematopoietic cell transplantation
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Perceptions of health among school-aged children living in socially vulnerable areas in Sweden
Part of Frontiers in Public Health, 2023
- DOI for Perceptions of health among school-aged children living in socially vulnerable areas in Sweden
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Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
Part of npj Precision Oncology, 2023
- DOI for Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
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Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia
Part of Genes, Chromosomes and Cancer, p. 597-606, 2023
- DOI for Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia
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Part of Journal of Lipid Research, 2023
- DOI for The atypical sphingolipid SPB 18:1(14Z);O2 is a biomarker for DEGS1 related hypomyelinating leukodystrophy
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Part of Vaccines, 2023
- DOI for Barriers in the School-Based Pan-Gender HPV Vaccination Program in Sweden: Healthcare Providers' Perspective
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Part of Child's Nervous System, p. 1479-1485, 2022
Part of Supportive Care in Cancer, p. 1901-1902, 2022
Part of Pediatric Blood & Cancer, 2022
- DOI for Does minimal central nervous system involvement in childhood acute lymphoblastic leukemia increase the risk for central nervous system toxicity?
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