Petra Marttila

NAD kinase essentiality in cancer: in real life, it is all about folates

Marttila, Petra; Meiser, Johannes

Part of Nature Metabolism, p. 1103-1105, 2025

• DOI for NAD kinase essentiality in cancer: in real life, it is all about folates

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

Zhang, Si Min; Paulin, Cynthia B. J.; Shu, Huazhang; Yagüe-Capilla, Miriam et al.

Part of iScience, 2024

• DOI for Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
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The one‐carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

Marttila, Petra; Bonagas, Nadilly; Chalkiadaki, Christina; Stigsdotter, Hannah et al.

Part of Molecular Oncology, p. 2179-2195, 2024

• DOI for The one‐carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation
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Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL

Largeot, Anne; Klapp, Vanessa; Viry, Elodie; Gonder, Susanne et al.

Part of Blood, p. 3166-3183, 2023

• DOI for Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL
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Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

Green, Alanna C.; Marttila, Petra; Kiweler, Nicole; Chalkiadaki, Christina et al.

Part of Nature Metabolism, p. 642-659, 2023

• DOI for Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
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NAD kinase essentiality in cancer: in real life, it is all about folates

Marttila, Petra; Meiser, Johannes

Part of Nature Metabolism, p. 1103-1105, 2025

• DOI for NAD kinase essentiality in cancer: in real life, it is all about folates

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

Zhang, Si Min; Paulin, Cynthia B. J.; Shu, Huazhang; Yagüe-Capilla, Miriam et al.

Part of iScience, 2024

• DOI for Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
• Download full text (pdf) of Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

The one‐carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

Marttila, Petra; Bonagas, Nadilly; Chalkiadaki, Christina; Stigsdotter, Hannah et al.

Part of Molecular Oncology, p. 2179-2195, 2024

• DOI for The one‐carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation
• Download full text (pdf) of The one‐carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL

Largeot, Anne; Klapp, Vanessa; Viry, Elodie; Gonder, Susanne et al.

Part of Blood, p. 3166-3183, 2023

• DOI for Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL
• Download full text (pdf) of Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as therapeutic strategy in CLL

Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells

Green, Alanna C.; Marttila, Petra; Kiweler, Nicole; Chalkiadaki, Christina et al.

Part of Nature Metabolism, p. 642-659, 2023

• DOI for Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
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Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

Michel, Maurice; Benítez-Buelga, Carlos; Calvo, Patricia A.; Hanna, Bishoy M. F. et al.

Part of Science, p. 1471-1476, 2022

• DOI for Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, Nadilly; Gustafsson, Nina M. S.; Henriksson, Martin; Marttila, Petra et al.

Part of Nature Cancer, p. 156, 2022

• DOI for Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress
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MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells

Karsten, Stella; Fiskesund, Roland; Zhang, Xing-Mei; Marttila, Petra et al.

Part of Cell Death and Differentiation, p. 246-261, 2021

• DOI for MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

Škerlová, Jana; Unterlass, Judith; Göttmann, Mona; Marttila, Petra et al.

Part of Journal of Biological Chemistry, p. 11656-11668, 2020

• DOI for Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target
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Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

Gustafsson, Nina M. S.; Färnegårdh, Katarina; Bonagas, Nadilly; Huguet Ninou, Anna et al.

Part of Nature Communications, 2018

• DOI for Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination
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Bis-(2-ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster

Cao, Hao; Wiemerslage, Lyle; Marttila, Petra S. K.; Williams, Michael J. et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 309-316, 2016

• DOI for Bis-(2-ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster

Bis‐(2‐ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster

Cao, Hao; Wiemerslage, Lyle; Marttila, Petra; Williams, Michael J. et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 309-316, 2016

• DOI for Bis‐(2‐ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster