Barnonkologisk och neurologisk forskning
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Genom att öka förståelse för kliniska, biologiska, och psykosociala aspekter av barnneurologiska sjukdomar och barncancer, arbetar forskargruppen Barnonkologisk och neurologisk forskning på att förbättra livskvalitet för barn och ungdomar med dessa sjukdomar och deras familjer.
Bredden är stor på den forskning som sker inom vår forskargrupp, från experimentell forskning med molekylärbiologiska tekniker till beteendevetenskaplig forskning som syftar till att hjälpa barn och familjer att bättre klara den krävande behandlingen. Vi samarbetar både nationellt och internationellt med att leda och samverka i olika forskningsprojekt. Vi arbetar särskilt tätt ihop med forskargruppen Barnonkologisk klinisk och translationell forskning som vi har flera gemensamma projekt med.
Särskilda resurser vid Uppsala universitet
Protonstrålning
Skandionkliniken i Uppsala som startade 2015 är en nationell, och även nordisk, resurs som har medfört en viktig utökning av den barnonkologiska behandlingsarsenalen. Protonbehandling gör att strålfälten kan avgränsas med stor precision. Tillkomsten av Skandionkliniken ger även utökade möjligheter till strålbehandling i de lägre åldrarna, där man för närvarande är restriktiv på grund av risker för allvarliga sena komplikationer, framför allt i hjärnan.
Biobanker
Det finns två biobanker med koppling till Uppsala som är särskilt inriktad mot barnonkologi och barnneurologi: Nordisk biobank för barnleukemi (Frost huvudansvarig, Palle et al.) och Barntumörbanken (Ljungman klinisk ledare och ordförande för styrgruppen). Läs mer om både biobanker på Barncancerfondens webbsida.
Finansiärer
Vi vill rikta ett varmt tack till våra finansiärer, samverkanspartner, och alla patienter och deras familjer som möjliggör vårt forskningsarbete, bland annat Barncancerfonden, Gillbergska Stiftelsen, Lions Cancerforskningsfond Mellansverige Uppsala-Örebro, Mary Bevés Stiftelse, Insamlingsstiftelsen för Prader-Willi forskning och Region Uppsala.
Gruppmedlemmar
Publikationer
Ingår i Disability and Rehabilitation, 2025
- DOI för Long-term outcome and rehabilitation needs after acquired brain injury in children and adolescents: an evaluation in a Swedish cohort
- Ladda ner fulltext (pdf) av Long-term outcome and rehabilitation needs after acquired brain injury in children and adolescents: an evaluation in a Swedish cohort
Ingår i European Journal of Oncology Nursing, 2025
Ingår i JMIR Pediatrics and Parenting, 2025
- DOI för Perspectives on Swedish Regulations for Online Record Access Among Adolescents With Serious Health Issues and Their Parents: Mixed Methods Study
- Ladda ner fulltext (pdf) av Perspectives on Swedish Regulations for Online Record Access Among Adolescents With Serious Health Issues and Their Parents: Mixed Methods Study
Ingår i Thrombosis Research, 2025
- DOI för Venous thromboembolism in children with Hodgkin lymphoma - A population-based study in Sweden, Finland, and Denmark
- Ladda ner fulltext (pdf) av Venous thromboembolism in children with Hodgkin lymphoma - A population-based study in Sweden, Finland, and Denmark
Ingår i International Journal of Cancer, s. 1347-1357, 2025
- DOI för Educational outcomes school year nine in children treated for acute lymphoblastic leukemia: A nationwide registry‐based study from Sweden
- Ladda ner fulltext (pdf) av Educational outcomes school year nine in children treated for acute lymphoblastic leukemia: A nationwide registry‐based study from Sweden
Ingår i Studies in Health Technology and Informatics, s. 929-933, 2025
Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
Ingår i NAR Genomics and Bioinformatics, 2024
- DOI för Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
- Ladda ner fulltext (pdf) av Comparison of high-throughput single-cell RNA-seq methods for ex vivo drug screening
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Ingår i Clinical Epigenetics, 2024
- DOI för Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
- Ladda ner fulltext (pdf) av Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Ingår i Pediatric Blood & Cancer, 2024
- DOI för Educational and occupational outcomes in Swedish children treated for sarcomas: A nationwide registry-based study
- Ladda ner fulltext (pdf) av Educational and occupational outcomes in Swedish children treated for sarcomas: A nationwide registry-based study
Radiotherapy-induced vascular cognitive impairment 20 years after childhood brain tumor
Ingår i Neuro-Oncology, s. 362-373, 2024
Ingår i Journal of Clinical Oncology, s. 2174-2185, 2024
Ingår i International Journal of Molecular Sciences, 2024
- DOI för Bone Marrow-Suppressive Treatment in Children Is Associated with Diminished IFN-γ Response from T Cells upon Polyclonal and Varicella Zoster Virus Peptide Stimulation
- Ladda ner fulltext (pdf) av Bone Marrow-Suppressive Treatment in Children Is Associated with Diminished IFN-γ Response from T Cells upon Polyclonal and Varicella Zoster Virus Peptide Stimulation
Ingår i HemaSphere, 2024
- DOI för Parents' perception of treatment-related toxicity in children treated according to the NOPHO ALL2008 protocol for acute lymphoblastic leukemia
- Ladda ner fulltext (pdf) av Parents' perception of treatment-related toxicity in children treated according to the NOPHO ALL2008 protocol for acute lymphoblastic leukemia
Ingår i JBMR Plus, 2024
- DOI för Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
- Ladda ner fulltext (pdf) av Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
Ingår i Haematologica, s. 2873-2883, 2024
- DOI för Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 protocol
- Ladda ner fulltext (pdf) av Management of hyperleukocytosis in pediatric acute myeloid leukemia using immediate chemotherapy without leukapheresis: results from the NOPHO-DBH AML 2012 protocol
Ingår i Early Human Development, 2024
- DOI för Neonatal therapeutic hypothermia in a regional swedish cohort: Adherence to guidelines, transport and outcomes
- Ladda ner fulltext (pdf) av Neonatal therapeutic hypothermia in a regional swedish cohort: Adherence to guidelines, transport and outcomes
Ingår i Pediatric Blood & Cancer, 2024
- DOI för Quality of life in children and adolescents after treatment for acute lymphoblastic leukemia according to the NOPHO ALL2008 protocol
- Ladda ner fulltext (pdf) av Quality of life in children and adolescents after treatment for acute lymphoblastic leukemia according to the NOPHO ALL2008 protocol
Ingår i Haematologica, s. 2846-2853, 2024
- DOI för Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
- Ladda ner fulltext (pdf) av Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study
Radiological follow‐up of osteonecrosis lesions in children and adolescents with Hodgkin lymphoma
Ingår i British Journal of Haematology, s. 1460-1468, 2024
- DOI för Radiological follow‐up of osteonecrosis lesions in children and adolescents with Hodgkin lymphoma
- Ladda ner fulltext (pdf) av Radiological follow‐up of osteonecrosis lesions in children and adolescents with Hodgkin lymphoma
Intensive care in children with non-Hodgkin lymphoma in Sweden
Ingår i Acta Paediatrica, s. 1974-1976, 2024
- DOI för Intensive care in children with non-Hodgkin lymphoma in Sweden
- Ladda ner fulltext (pdf) av Intensive care in children with non-Hodgkin lymphoma in Sweden
Ingår i Acta Paediatrica, s. 2676-2678, 2024
- DOI för Haemostasis during early treatment of childhood acute lymphoblastic leukaemia with the ALLTogether protocol
- Ladda ner fulltext (pdf) av Haemostasis during early treatment of childhood acute lymphoblastic leukaemia with the ALLTogether protocol
Ingår i British Journal of Haematology, s. 1450-1459, 2024
- DOI för Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy-An observational Ponte di Legno Toxicity Working Group Study
- Ladda ner fulltext (pdf) av Severe steroid-related neuropsychiatric symptoms during paediatric acute lymphoblastic leukaemia therapy-An observational Ponte di Legno Toxicity Working Group Study
Ingår i Acta Paediatrica, s. 2398-2405, 2024
- DOI för Unpredictable supplementation of vitamin D to infants in the neonatal intensive care unit: An experimental study
- Ladda ner fulltext (pdf) av Unpredictable supplementation of vitamin D to infants in the neonatal intensive care unit: An experimental study
Ingår i Children & society, s. 228-244, 2024
- DOI för Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
- Ladda ner fulltext (pdf) av Exploring young people's experiences of race, gender and socioeconomic status in relation to everyday challenges: A focus group study
Ingår i Brain Injury, s. 151-159, 2024
- DOI för Further recommendations of the International Paediatric Brain Injury Society (IPBIS) for the post-acute rehabilitation of children with acquired brain injury
- Ladda ner fulltext (pdf) av Further recommendations of the International Paediatric Brain Injury Society (IPBIS) for the post-acute rehabilitation of children with acquired brain injury
Ingår i Acta Paediatrica, 2024
- DOI för Systematic follow‐ups were not associated with reduced acute ventriculoperitoneal shunt dysfunction in infancy
- Ladda ner fulltext (pdf) av Systematic follow‐ups were not associated with reduced acute ventriculoperitoneal shunt dysfunction in infancy
Ingår i Pediatric Blood & Cancer, 2024
- DOI för Symptomatic osteonecrosis in children treated for Hodgkin lymphoma: A population‐based study in Sweden, Finland, and Denmark
- Ladda ner fulltext (pdf) av Symptomatic osteonecrosis in children treated for Hodgkin lymphoma: A population‐based study in Sweden, Finland, and Denmark
Ingår i BMJ Paediatrics Open, 2024
- DOI för Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial
- Ladda ner fulltext (pdf) av Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial
Ingår i Acta Paediatrica, s. 742-752, 2023
- DOI för Predictive value of Bayley-III Motor Index for later motor difficulties in children born extremely preterm
- Ladda ner fulltext (pdf) av Predictive value of Bayley-III Motor Index for later motor difficulties in children born extremely preterm
Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden
Ingår i Journal of cancer survivorship, s. 1072-1081, 2023
- DOI för Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden
- Ladda ner fulltext (pdf) av Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden
Ingår i British Journal of Haematology, s. 384-392, 2023
- DOI för The prognostic impact of IKZF1 deletions and UKALL genetic classifiers in paediatric B-cell precursor acute lymphoblastic leukaemia treated according to NOPHO 2008 protocols
- Ladda ner fulltext (pdf) av The prognostic impact of IKZF1 deletions and UKALL genetic classifiers in paediatric B-cell precursor acute lymphoblastic leukaemia treated according to NOPHO 2008 protocols
Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia
Ingår i British Journal of Haematology, s. 757-765, 2023
- DOI för Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia
- Ladda ner fulltext (pdf) av Characteristics and outcome of primary resistant disease in paediatric acute myeloid leukaemia
Ingår i Nursing Open, s. 630-640, 2023
- DOI för Factors associated with posttraumatic growth among spouses of women diagnosed with gynaecological cancer: A cross-sectional study
- Ladda ner fulltext (pdf) av Factors associated with posttraumatic growth among spouses of women diagnosed with gynaecological cancer: A cross-sectional study
Ingår i The Pharmacogenomics Journal, s. 105-111, 2023
- DOI för DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship?
- Ladda ner fulltext (pdf) av DNA polymerase gamma variants and hepatotoxicity during maintenance therapy of childhood acute lymphoblastic leukemia: is there a causal relationship?
Ingår i Cancers, 2023
- DOI för Simultaneous Ultra-Sensitive Detection of Structural and Single Nucleotide Variants Using Multiplex Droplet Digital PCR in Liquid Biopsies from Children with Medulloblastoma
- Ladda ner fulltext (pdf) av Simultaneous Ultra-Sensitive Detection of Structural and Single Nucleotide Variants Using Multiplex Droplet Digital PCR in Liquid Biopsies from Children with Medulloblastoma
Ingår i Cancer Medicine, s. 7459-7469, 2023
- DOI för Occupational outcomes after high-grade or low-grade brain tumors in childhood: A Swedish, nationwide, registry-based study
- Ladda ner fulltext (pdf) av Occupational outcomes after high-grade or low-grade brain tumors in childhood: A Swedish, nationwide, registry-based study
Patterns of smartphone usage associated with depressive symptoms in nursing students
Ingår i Frontiers in Psychiatry, 2023
- DOI för Patterns of smartphone usage associated with depressive symptoms in nursing students
- Ladda ner fulltext (pdf) av Patterns of smartphone usage associated with depressive symptoms in nursing students
Ingår i Acta Oncologica, s. 1723-1731, 2023
- DOI för Impact of body mass index on outcome and treatment-related toxicity in young adults with acute lymphoblastic leukemia
- Ladda ner fulltext (pdf) av Impact of body mass index on outcome and treatment-related toxicity in young adults with acute lymphoblastic leukemia
Ingår i HemaSphere, 2023
- DOI för Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial
- Ladda ner fulltext (pdf) av Genetic Subtypes and Outcome of Patients Aged 1 to 45 Years Old With Acute Lymphoblastic Leukemia in the NOPHO ALL2008 Trial
Early disc degeneration in radiotherapy-treated childhood brain tumor survivors
Ingår i BMC Musculoskeletal Disorders, 2023
- DOI för Early disc degeneration in radiotherapy-treated childhood brain tumor survivors
- Ladda ner fulltext (pdf) av Early disc degeneration in radiotherapy-treated childhood brain tumor survivors
Parental experiences of the informed consent process in randomized clinical trials-A Nordic study
Ingår i Pediatric Blood & Cancer, 2023
- DOI för Parental experiences of the informed consent process in randomized clinical trials-A Nordic study
- Ladda ner fulltext (pdf) av Parental experiences of the informed consent process in randomized clinical trials-A Nordic study
Ingår i Pediatric Transplantation, 2023
- DOI för A retrospective case-control study of gastrostomy use in children undergoing hematopoietic cell transplantation
- Ladda ner fulltext (pdf) av A retrospective case-control study of gastrostomy use in children undergoing hematopoietic cell transplantation
Perceptions of health among school-aged children living in socially vulnerable areas in Sweden
Ingår i Frontiers in Public Health, 2023
- DOI för Perceptions of health among school-aged children living in socially vulnerable areas in Sweden
- Ladda ner fulltext (pdf) av Perceptions of health among school-aged children living in socially vulnerable areas in Sweden
Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
Ingår i npj Precision Oncology, 2023
- DOI för Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
- Ladda ner fulltext (pdf) av Multimodal classification of molecular subtypes in pediatric acute lymphoblastic leukemia
Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia
Ingår i Genes, Chromosomes and Cancer, s. 597-606, 2023
- DOI för Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia
- Ladda ner fulltext (pdf) av Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia
Ingår i Journal of Lipid Research, 2023
- DOI för The atypical sphingolipid SPB 18:1(14Z);O2 is a biomarker for DEGS1 related hypomyelinating leukodystrophy
- Ladda ner fulltext (pdf) av The atypical sphingolipid SPB 18:1(14Z);O2 is a biomarker for DEGS1 related hypomyelinating leukodystrophy
Ingår i Vaccines, 2023
- DOI för Barriers in the School-Based Pan-Gender HPV Vaccination Program in Sweden: Healthcare Providers' Perspective
- Ladda ner fulltext (pdf) av Barriers in the School-Based Pan-Gender HPV Vaccination Program in Sweden: Healthcare Providers' Perspective
Ingår i European Journal of Pediatrics, s. 113-122, 2023
- DOI för Comparison of trace image colors for kids-book with two active distractions in reducing pain and fear of children during the venipuncture procedure
- Ladda ner fulltext (pdf) av Comparison of trace image colors for kids-book with two active distractions in reducing pain and fear of children during the venipuncture procedure
Ingår i Child's Nervous System, s. 1479-1485, 2022
Ingår i Supportive Care in Cancer, s. 1901-1902, 2022