Våra aktuella publikationer

Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort.

Smekal, Anna-Karin; Swartling, Maria; Furebring, Mia; Giske, Christian G et al.

Ingår i Journal of Antimicrobial Chemotherapy, 2025

• DOI för Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort.

Development and Validation of an Instrument to Assess Quality and Completeness of Medication-Related Discharge Documentation

Bertilsson, Emma; Östman, Victoria; Cam, Henrik; Franzon, Kristin et al.

Ingår i Journal of Evaluation In Clinical Practice, 2025

• DOI för Development and Validation of an Instrument to Assess Quality and Completeness of Medication-Related Discharge Documentation

Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)

O'Jeanson, Amaury; Ioannidis, Konstantinos; Nielsen, Elisabet I.; Galani, Lamprini et al.

Ingår i International Journal of Antimicrobial Agents, 2025

• DOI för Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)
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Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis

Bahnasawy, Salma M.; Ahmed, Hifza; Zeitlinger, Markus; Friberg, Lena E. et al.

Ingår i International Journal of Antimicrobial Agents, 2025

• DOI för Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis
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Model-informed precision dosing of vancomycin in clinical practice: an intervention development study

Swartling, Maria; Hamberg, Anna-Karin; Furebring, Mia; Tängdén, Thomas et al.

Ingår i International Journal of Clinical Pharmacy, s. 178-186, 2025

• DOI för Model-informed precision dosing of vancomycin in clinical practice: an intervention development study
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An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae

Zhao, Chenyan; van den Berg, Sanne; Wang, Zhigang; Olsson, Anna et al.

Ingår i International Journal of Antimicrobial Agents, 2025

• DOI för An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae
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A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime

O'Jeanson, Amaury; Nielsen, Elisabet I.; Friberg, Lena E.

Ingår i JAC - Antimicrobial Resistance, 2025

• DOI för A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime
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From exploration to intervention: Enhancing medication communication at hospital discharge

Cam, Henrik

2025

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Physiology-informed pharmacometric models for bacterial infections

Bahnasawy, Salma

2025

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First dose target attainment with extended infusion regimens of piperacillin and meropenem

Beijer, Gustaf; Swartling, Maria; Nielsen, Elisabet I.; Breuer, Olof et al.

Ingår i Critical Care, 2025

• DOI för First dose target attainment with extended infusion regimens of piperacillin and meropenem
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Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients

Smekal, Anna-Karin; Swartling, Maria; Nielsen, Elisabet I.; Furebring, Mia et al.

Ingår i Scientific Reports, 2025

• DOI för Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients
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Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Cam, Henrik; Gillespie, Ulrika; Kälvemark Sporrong, Sofia; Nielsen, Elisabet I. et al.

Ingår i Research in Social and Administrative Pharmacy, s. 216-217, 2024

• DOI för Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units

Damgaard, Tobias; Woksepp, Hanna; Brudin, Lars; Bonnedahl, Jonas et al.

Ingår i Infectious Diseases, s. 451-459, 2024

• DOI för Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units
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Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Zhao, Chenyan; Kristoffersson, Anders N.; Khan, David D.; Lagerbäck, Pernilla et al.

Ingår i Scientific Reports, 2024

• DOI för Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model
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Recommended dosages of analgesic and sedative drugs in intensive care result in a low incidence of potentially toxic blood concentrations

Lennborn, Ulrica; Johansson, Anna; Lindgren, Erik; Nielsen, Elisabet I. et al.

Ingår i Upsala Journal of Medical Sciences, 2024

• DOI för Recommended dosages of analgesic and sedative drugs in intensive care result in a low incidence of potentially toxic blood concentrations
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Exploring communication challenges during hospital discharge of older patients: insights from healthcare professionals' perspectives

Cam, Henrik; Wennlöf, Björn; Gillespie, Ulrika; Franzon, Kristin et al.

Ingår i Exploring communication challenges during hospital discharge of older patients: insights from healthcare professionals' perspectives, s. 261, 2024

• DOI för Exploring communication challenges during hospital discharge of older patients: insights from healthcare professionals' perspectives

Model-informed antibiotic dose individualisation in clinical practice

Swartling, Maria

2024

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Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project

Melander, Erik; Nielsen, Elisabet I.; Lindqvist, Annika; Hovd, Markus et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, 2024

• DOI för Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project
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Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe

Skrede, Silje; Bogavac-Stanojevic, Natasa; Dreesen, Erwin; Nielsen, Elisabet et al.

Ingår i Basic & Clinical Pharmacology & Toxicology, s. 556-560, 2024

• DOI för Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe
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PK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs

Saporta, Raphaël; Nielsen, Elisabet I.; Hansen, Jon U.; Liepinsh, Edgars et al.

Ingår i International Journal of Antimicrobial Agents, 2024

• DOI för PK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs
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Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study

O'Jeanson, Amaury; Nielsen, Elisabet I.; Friberg, Lena E.

Ingår i Journal of Antimicrobial Chemotherapy, 2024

• DOI för Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study
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Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics

Bahnasawy, Salma M.; Parrott, Neil J.; Gijsen, Matthias; Spriet, Isabel et al.

Ingår i International Journal of Antimicrobial Agents, 2024

• DOI för Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics
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'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge

Cam, Henrik; Franzon, Kristin; Kälvemark Sporrong, Sofia; Kempen, Thomas Gerardus Hendrik et al.

Ingår i Health Expectations, 2024

• DOI för 'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge
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Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus

Saporta, Raphaël; Nielsen, Elisabet I.; Menetrey, Annick; Cameron, David R et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 3150-3159, 2024

• DOI för Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus
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Evaluation of the completeness of patients’ medication reports and discharge summaries at discharge from two wards at Uppsala University hospital

Östman, Victoria

2023

Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial

Kempen, Thomas; Hedman, Anton N.; Hadziosmanovic, Nermin; Lindner, Karl‐Johan et al.

Ingår i British Journal of Clinical Pharmacology, s. 1575-1587, 2023

• DOI för Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
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Quantifying effects of antimicrobial drug combinations by modelling and simulation

Zhao, Chenyan

2023

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Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: agreement with in silico predictions.

Olsson, Anna; Malmberg, Christer; Zhao, Chenyan; Friberg, Lena et al.

Ingår i Journal of Antimicrobial Chemotherapy, 2023

• DOI för Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: agreement with in silico predictions.

Persistent SARS-CoV-2 infection in patients with B-cell deficiency: a case series of successful antiviral treatment of four patients

Faxén, Lisa; Edvinsson, Marie

Ingår i Upsala Journal of Medical Sciences, 2023

• DOI för Persistent SARS-CoV-2 infection in patients with B-cell deficiency: a case series of successful antiviral treatment of four patients
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Drug-related readmissions in older hospitalized adults: External validation and updating of OPERAM DRA prediction tool

Snijders, Birgitta M. G.; Kempen, Thomas; Aubert, Carole E.; Koek, Huiberdina L. et al.

Ingår i Journal of The American Geriatrics Society, s. 3848-3856, 2023

• DOI för Drug-related readmissions in older hospitalized adults: External validation and updating of OPERAM DRA prediction tool
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Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies

Thorsted, Anders; Pham, Anh Duc; Friberg, Lena E.; Nielsen, Elisabet I.

Ingår i CPT, s. 1972-1987, 2023

• DOI för Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies
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Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions

Olsson, Anna; Malmberg, Christer; Zhao, Chenyan; Friberg, Lena et al.

Ingår i Journal of Antimicrobial Chemotherapy, 2023

• DOI för Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions
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Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time

Swartling, Maria; Tängdén, Thomas; Lipcsey, Miklós; Jönsson, Siv et al.

Ingår i International Journal of Antimicrobial Agents, 2023

• DOI för Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time
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Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

Bahnasawy, Salma M.; Skorup, Paul; Hanslin, Katja; Friberg, Lena et al.

Ingår i Cytokine, 2023

• DOI för Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli
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The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views

Cam, Henrik; Wennlöf, Björn; Gillespie, Ulrika; Franzon, Kristin et al.

Ingår i BMC Health Services Research, 2023

• DOI för The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views
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Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden

Sulku, Johanna; Janson, Christer; Melhus, Håkan; Ställberg, Björn et al.

Ingår i Respiratory Medicine, 2022

• DOI för Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
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Research priorities towards precision antibiotic therapy to improve patient care

Bulman, Zackery P.; Wicha, Sebastian G.; Nielsen, Elisabet I.; Lenhard, Justin R. et al.

Ingår i LANCET MICROBE, 2022

• DOI för Research priorities towards precision antibiotic therapy to improve patient care
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Drug-related emergency department visits in older patients: an applicability and reliability study of an existing assessment tool

Kempen, Thomas Gerardus Hendrik; Hedman, Anton; Gillespie, Ulrika

Ingår i International Journal of Clinical Pharmacy, s. 1078-1082, 2022

• DOI för Drug-related emergency department visits in older patients: an applicability and reliability study of an existing assessment tool
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An Emotion-driven Approach to Hospital Physicians' Work-Related User Experience

Golay, Diane; Sving, Celina; Cajander, Åsa

Ingår i Proceedings 10th Nordic Conference on Human-Computer Interaction - NordiCHI '22, 2022

• DOI för An Emotion-driven Approach to Hospital Physicians' Work-Related User Experience

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Brem, Jürgen; Panduwawala, Tharindi; Hansen, Jon Ulf; Hewitt, Joanne et al.

Ingår i Nature Chemistry, s. 15-24, 2022

• DOI för Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Population pharmacokinetics of cefotaxime in intensive care patients

Swartling, Maria; Smekal, Anna-Karin; Furebring, Mia; Lipcsey, Miklós et al.

Ingår i European Journal of Clinical Pharmacology, s. 251-258, 2022

• DOI för Population pharmacokinetics of cefotaxime in intensive care patients
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Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose

Zhao, Chenyan; Chirkova, Anna; Rosenborg, Staffan; Palma Villar, Rodrigo et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 2718-2728, 2022

• DOI för Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose
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Inclusion of pharmacy students in an interprofessional training ward placement for health care students in Sweden

Balgård, Matts; Dobric, Srebrenka; Karlsson, Lina; Klaren, Lena et al.

2021

Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

Maarbjerg, Sabine F.; Thorsted, Anders; Friberg, Lena; Nielsen, Elisabet I. et al.

Ingår i Cancer Reports, 2021

• DOI för Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever
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Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial

Kempen, Thomas; Bertilsson, Maria; Hadziosmanovic, Nermin; Lindner, Karl-Johan et al.

Ingår i JAMA Network Open, 2021

• DOI för Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
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Quantitation of seven sedative and analgesic drugs in whole blood from intensive care patients using liquid chromatography mass spectrometry

Johansson, Anna; Ahlner, Johan; Lennborn, Ulrica; Nielsen, Elisabet I. et al.

Ingår i TOXICOLOGIE ANALYTIQUE ET CLINIQUE, s. 327-337, 2021

• DOI för Quantitation of seven sedative and analgesic drugs in whole blood from intensive care patients using liquid chromatography mass spectrometry

From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic

Wicha, Sebastian G.; Martson, Anne-Grete; Nielsen, Elisabet I.; Koch, Birgit C. P. et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 928-941, 2021

• DOI för From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic

Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations

Sulku, Johanna; Bröms, Kristina; Högman, Marieann; Janson, Christer et al.

Ingår i npj Primary Care Respiratory Medicine, 2021

• DOI för Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
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Assessment of requests for medication-related follow-up after hospital discharge, and the relation to unplanned hospital revisits, in older patients: a multicentre retrospective chart review

Cam, Henrik; Kempen, Thomas Gerardus Hendrik; Eriksson, Helena; Abdulreda, Kanar et al.

Ingår i BMC Geriatrics, 2021

• DOI för Assessment of requests for medication-related follow-up after hospital discharge, and the relation to unplanned hospital revisits, in older patients: a multicentre retrospective chart review
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A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Kristoffersson, Anders N.; Bissantz, Caterina; Okujava, Rusudan; Haldimann, Andreas et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 400-408, 2020

• DOI för A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime.

Thorsted, Anders; Tano, Eva; Kaivonen, Kia; Sjölin, Jan et al.

Ingår i Antimicrobial Agents and Chemotherapy, 2020

• DOI för Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime.
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Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Abrantes, João A.; Solms, Alexander; Garmann, Dirk; Nielsen, Elisabet I. et al.

Ingår i Haematologica, s. 1443-1453, 2020

• DOI för Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients
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Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

Thorsted, Anders; Nielsen, Elisabet I.; Friberg, Lena

Ingår i International Journal of Antimicrobial Agents, 2020

• DOI för Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients

Kempen, Thomas; Kälvemark, Amanda; Sawires, Maria; Stewart, Derek et al.

Ingår i European Journal of Clinical Pharmacology, s. 775-784, 2020

• DOI för Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients
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Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments

Wistrand-Yuen, Pikkei; Olsson, Anna; Skarp, Kari Pekka; Friberg, Lena et al.

Ingår i Clinical Microbiology and Infection, s. 1214-1221, 2020

• DOI för Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments
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Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments

Olsson, Anna; Wistrand-Yuen, Pikkei; Nielsen, Elisabet I.; Friberg, Lena et al.

Ingår i Antimicrobial Agents and Chemotherapy, 2020

• DOI för Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments
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Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism

Senek, Marina; Nyholm, Dag; Nielsen, Elisabet I.

Ingår i Scientific Reports, 2020

• DOI för Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism
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Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data

Zhao, Chenyan; Wistrand-Yuen, Pikkei; Lagerbäck, Pernilla; Tängdén, Thomas et al.

Ingår i International Journal of Antimicrobial Agents, 2020

• DOI för Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data
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Comprehensive medication reviews by ward-based pharmacists in Swedish hospitals: What does the patient have to say?

Kempen, Thomas Gerardus Hendrik; Kälvemark, Amanda; Gillespie, Ulrika; Stewart, Derek

Ingår i Journal of Evaluation In Clinical Practice, s. 149-157, 2020

• DOI för Comprehensive medication reviews by ward-based pharmacists in Swedish hospitals: What does the patient have to say?

Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.

Kempen, Thomas; Cam, Henrik; Kälvemark, Amanda; Lindner, Karl-Johan et al.

Ingår i Journal of Clinical Pharmacy and Therapeutics, s. 1021-1029, 2020

• DOI för Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
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