Our recent publications

Development and Validation of an Instrument to Assess Quality and Completeness of Medication-Related Discharge Documentation

Bertilsson, Emma; Östman, Victoria; Cam, Henrik; Franzon, Kristin et al.

Part of Journal of Evaluation In Clinical Practice, 2025

• DOI for Development and Validation of an Instrument to Assess Quality and Completeness of Medication-Related Discharge Documentation

Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)

O'Jeanson, Amaury; Ioannidis, Konstantinos; Nielsen, Elisabet I.; Galani, Lamprini et al.

Part of International Journal of Antimicrobial Agents, 2025

• DOI for Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)
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Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis

Bahnasawy, Salma M.; Ahmed, Hifza; Zeitlinger, Markus; Friberg, Lena E. et al.

Part of International Journal of Antimicrobial Agents, 2025

• DOI for Plasma effects on bacterial time-kill dynamics: Insights from a PK/PD modelling analysis
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Model-informed precision dosing of vancomycin in clinical practice: an intervention development study

Swartling, Maria; Hamberg, Anna-Karin; Furebring, Mia; Tängdén, Thomas et al.

Part of International Journal of Clinical Pharmacy, p. 178-186, 2025

• DOI for Model-informed precision dosing of vancomycin in clinical practice: an intervention development study
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An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae

Zhao, Chenyan; van den Berg, Sanne; Wang, Zhigang; Olsson, Anna et al.

Part of International Journal of Antimicrobial Agents, 2025

• DOI for An integrative and translational PKPD modelling approach to explore the combined effect of polymyxin B and minocycline against Klebsiella pneumoniae
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A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime

O'Jeanson, Amaury; Nielsen, Elisabet I.; Friberg, Lena E.

Part of JAC - Antimicrobial Resistance, 2025

• DOI for A model-based evaluation of the pharmacokinetics-pharmacodynamics (PKPD) of avibactam in combination with ceftazidime
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From exploration to intervention: Enhancing medication communication at hospital discharge

Cam, Henrik

2025

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Physiology-informed pharmacometric models for bacterial infections

Bahnasawy, Salma

2025

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First dose target attainment with extended infusion regimens of piperacillin and meropenem

Beijer, Gustaf; Swartling, Maria; Nielsen, Elisabet I.; Breuer, Olof et al.

Part of Critical Care, 2025

• DOI for First dose target attainment with extended infusion regimens of piperacillin and meropenem
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Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients

Smekal, Anna-Karin; Swartling, Maria; Nielsen, Elisabet I.; Furebring, Mia et al.

Part of Scientific Reports, 2025

• DOI for Utilizing gentamicin concentrations to estimate glomerular filtration rate in intensive care unit patients
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Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort.

Smekal, Anna-Karin; Swartling, Maria; Furebring, Mia; Giske, Christian G et al.

Part of Journal of Antimicrobial Chemotherapy, p. 876-884, 2025

• DOI for Short, extended and continuous infusion of β-lactams: predicted impact on target attainment and risk for toxicity in an ICU patient cohort.

Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Cam, Henrik; Gillespie, Ulrika; Kälvemark Sporrong, Sofia; Nielsen, Elisabet I. et al.

Part of Research in Social and Administrative Pharmacy, p. 216-217, 2024

• DOI for Failure to Involve Older Hospitalised Patients in Medication Decisions: A Change of Approach is Called For

Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units

Damgaard, Tobias; Woksepp, Hanna; Brudin, Lars; Bonnedahl, Jonas et al.

Part of Infectious Diseases, p. 451-459, 2024

• DOI for Estimated glomerular filtration rate as a tool for early identification of patients with insufficient exposure to beta-lactam antibiotics in intensive care units
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Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model

Zhao, Chenyan; Kristoffersson, Anders N.; Khan, David D.; Lagerbäck, Pernilla et al.

Part of Scientific Reports, 2024

• DOI for Quantifying combined effects of colistin and ciprofloxacin against Escherichia coli in an in silico pharmacokinetic-pharmacodynamic model
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Recommended dosages of analgesic and sedative drugs in intensive care result in a low incidence of potentially toxic blood concentrations

Lennborn, Ulrica; Johansson, Anna; Lindgren, Erik; Nielsen, Elisabet I. et al.

Part of Upsala Journal of Medical Sciences, 2024

• DOI for Recommended dosages of analgesic and sedative drugs in intensive care result in a low incidence of potentially toxic blood concentrations
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Exploring communication challenges during hospital discharge of older patients: insights from healthcare professionals' perspectives

Cam, Henrik; Wennlöf, Björn; Gillespie, Ulrika; Franzon, Kristin et al.

Part of Exploring communication challenges during hospital discharge of older patients: insights from healthcare professionals' perspectives, p. 261, 2024

• DOI for Exploring communication challenges during hospital discharge of older patients: insights from healthcare professionals' perspectives

Model-informed antibiotic dose individualisation in clinical practice

Swartling, Maria

2024

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Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project

Melander, Erik; Nielsen, Elisabet I.; Lindqvist, Annika; Hovd, Markus et al.

Part of Basic & Clinical Pharmacology & Toxicology, 2024

• DOI for Population pharmacokinetic modelling of cetirizine concentrations in human breast milk: A contribution from the ConcePTION project
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Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe

Skrede, Silje; Bogavac-Stanojevic, Natasa; Dreesen, Erwin; Nielsen, Elisabet et al.

Part of Basic & Clinical Pharmacology & Toxicology, p. 556-560, 2024

• DOI for Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe
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PK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs

Saporta, Raphaël; Nielsen, Elisabet I.; Hansen, Jon U.; Liepinsh, Edgars et al.

Part of International Journal of Antimicrobial Agents, 2024

• DOI for PK/PD modelling and simulation of longitudinal meropenem in vivo effects against Escherichia coli and Klebsiella pneumoniae strains with high MICs
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Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study

O'Jeanson, Amaury; Nielsen, Elisabet I.; Friberg, Lena E.

Part of Journal of Antimicrobial Chemotherapy, 2024

• DOI for Therapeutic drug monitoring (TDM) of β-lactam/β-lactamase inhibitor (BL/BLI) drug combinations: insights from a pharmacometric simulation study
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Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics

Bahnasawy, Salma M.; Parrott, Neil J.; Gijsen, Matthias; Spriet, Isabel et al.

Part of International Journal of Antimicrobial Agents, 2024

• DOI for Physiologically-based pharmacokinetic modelling in sepsis: A tool to elucidate how pathophysiology affects meropenem pharmacokinetics
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'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge

Cam, Henrik; Franzon, Kristin; Kälvemark Sporrong, Sofia; Kempen, Thomas Gerardus Hendrik et al.

Part of Health Expectations, 2024

• DOI for 'You're Just Thinking About Going Home': Exploring Person-Centred Medication Communication With Older Patients at Hospital Discharge
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Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus

Saporta, Raphaël; Nielsen, Elisabet I.; Menetrey, Annick; Cameron, David R et al.

Part of Journal of Antimicrobial Chemotherapy, p. 3150-3159, 2024

• DOI for Model-based translation of results from in vitro to in vivo experiments for afabicin activity against Staphylococcus aureus
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Evaluation of the completeness of patients’ medication reports and discharge summaries at discharge from two wards at Uppsala University hospital

Östman, Victoria

2023

Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial

Kempen, Thomas; Hedman, Anton N.; Hadziosmanovic, Nermin; Lindner, Karl‐Johan et al.

Part of British Journal of Clinical Pharmacology, p. 1575-1587, 2023

• DOI for Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
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Quantifying effects of antimicrobial drug combinations by modelling and simulation

Zhao, Chenyan

2023

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Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: agreement with in silico predictions.

Olsson, Anna; Malmberg, Christer; Zhao, Chenyan; Friberg, Lena et al.

Part of Journal of Antimicrobial Chemotherapy, 2023

• DOI for Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: agreement with in silico predictions.

Persistent SARS-CoV-2 infection in patients with B-cell deficiency: a case series of successful antiviral treatment of four patients

Faxén, Lisa; Edvinsson, Marie

Part of Upsala Journal of Medical Sciences, 2023

• DOI for Persistent SARS-CoV-2 infection in patients with B-cell deficiency: a case series of successful antiviral treatment of four patients
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Drug-related readmissions in older hospitalized adults: External validation and updating of OPERAM DRA prediction tool

Snijders, Birgitta M. G.; Kempen, Thomas; Aubert, Carole E.; Koek, Huiberdina L. et al.

Part of Journal of The American Geriatrics Society, p. 3848-3856, 2023

• DOI for Drug-related readmissions in older hospitalized adults: External validation and updating of OPERAM DRA prediction tool
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Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies

Thorsted, Anders; Pham, Anh Duc; Friberg, Lena E.; Nielsen, Elisabet I.

Part of CPT, p. 1972-1987, 2023

• DOI for Model‐based assessment of neutrophil‐mediated phagocytosis and digestion of bacteria across in vitro and in vivo studies
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Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions

Olsson, Anna; Malmberg, Christer; Zhao, Chenyan; Friberg, Lena et al.

Part of Journal of Antimicrobial Chemotherapy, 2023

• DOI for Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: high agreement with in silico predictions
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Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time

Swartling, Maria; Tängdén, Thomas; Lipcsey, Miklós; Jönsson, Siv et al.

Part of International Journal of Antimicrobial Agents, 2023

• DOI for Therapeutic drug monitoring of vancomycin and meropenem: Illustration of the impact of inaccurate information in dose administration time
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Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli

Bahnasawy, Salma M.; Skorup, Paul; Hanslin, Katja; Friberg, Lena et al.

Part of Cytokine, 2023

• DOI for Predicting cytokine kinetics during sepsis; a modelling framework from a porcine sepsis model with live Escherichia coli
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The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views

Cam, Henrik; Wennlöf, Björn; Gillespie, Ulrika; Franzon, Kristin et al.

Part of BMC Health Services Research, 2023

• DOI for The complexities of communication at hospital discharge of older patients: a qualitative study of healthcare professionals' views
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Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden

Sulku, Johanna; Janson, Christer; Melhus, Håkan; Ställberg, Björn et al.

Part of Respiratory Medicine, 2022

• DOI for Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
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Research priorities towards precision antibiotic therapy to improve patient care

Bulman, Zackery P.; Wicha, Sebastian G.; Nielsen, Elisabet I.; Lenhard, Justin R. et al.

Part of LANCET MICROBE, 2022

• DOI for Research priorities towards precision antibiotic therapy to improve patient care
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Drug-related emergency department visits in older patients: an applicability and reliability study of an existing assessment tool

Kempen, Thomas Gerardus Hendrik; Hedman, Anton; Gillespie, Ulrika

Part of International Journal of Clinical Pharmacy, p. 1078-1082, 2022

• DOI for Drug-related emergency department visits in older patients: an applicability and reliability study of an existing assessment tool
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An Emotion-driven Approach to Hospital Physicians' Work-Related User Experience

Golay, Diane; Sving, Celina; Cajander, Åsa

Part of Proceedings 10th Nordic Conference on Human-Computer Interaction - NordiCHI '22, 2022

• DOI for An Emotion-driven Approach to Hospital Physicians' Work-Related User Experience

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Brem, Jürgen; Panduwawala, Tharindi; Hansen, Jon Ulf; Hewitt, Joanne et al.

Part of Nature Chemistry, p. 15-24, 2022

• DOI for Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors

Population pharmacokinetics of cefotaxime in intensive care patients

Swartling, Maria; Smekal, Anna-Karin; Furebring, Mia; Lipcsey, Miklós et al.

Part of European Journal of Clinical Pharmacology, p. 251-258, 2022

• DOI for Population pharmacokinetics of cefotaxime in intensive care patients
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Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose

Zhao, Chenyan; Chirkova, Anna; Rosenborg, Staffan; Palma Villar, Rodrigo et al.

Part of Journal of Antimicrobial Chemotherapy, p. 2718-2728, 2022

• DOI for Population pharmacokinetics of apramycin from first-in-human plasma and urine data to support prediction of efficacious dose
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Inclusion of pharmacy students in an interprofessional training ward placement for health care students in Sweden

Balgård, Matts; Dobric, Srebrenka; Karlsson, Lina; Klaren, Lena et al.

2021

Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever

Maarbjerg, Sabine F.; Thorsted, Anders; Friberg, Lena; Nielsen, Elisabet I. et al.

Part of Cancer Reports, 2021

• DOI for Continuous infusion of piperacillin‐tazobactam significantly improves target attainment in children with cancer and fever
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Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial

Kempen, Thomas; Bertilsson, Maria; Hadziosmanovic, Nermin; Lindner, Karl-Johan et al.

Part of JAMA Network Open, 2021

• DOI for Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
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Quantitation of seven sedative and analgesic drugs in whole blood from intensive care patients using liquid chromatography mass spectrometry

Johansson, Anna; Ahlner, Johan; Lennborn, Ulrica; Nielsen, Elisabet I. et al.

Part of TOXICOLOGIE ANALYTIQUE ET CLINIQUE, p. 327-337, 2021

• DOI for Quantitation of seven sedative and analgesic drugs in whole blood from intensive care patients using liquid chromatography mass spectrometry

From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic

Wicha, Sebastian G.; Martson, Anne-Grete; Nielsen, Elisabet I.; Koch, Birgit C. P. et al.

Part of Clinical Pharmacology and Therapeutics, p. 928-941, 2021

• DOI for From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic

Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations

Sulku, Johanna; Bröms, Kristina; Högman, Marieann; Janson, Christer et al.

Part of npj Primary Care Respiratory Medicine, 2021

• DOI for Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
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Assessment of requests for medication-related follow-up after hospital discharge, and the relation to unplanned hospital revisits, in older patients: a multicentre retrospective chart review

Cam, Henrik; Kempen, Thomas Gerardus Hendrik; Eriksson, Helena; Abdulreda, Kanar et al.

Part of BMC Geriatrics, 2021

• DOI for Assessment of requests for medication-related follow-up after hospital discharge, and the relation to unplanned hospital revisits, in older patients: a multicentre retrospective chart review
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A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Kristoffersson, Anders N.; Bissantz, Caterina; Okujava, Rusudan; Haldimann, Andreas et al.

Part of Journal of Antimicrobial Chemotherapy, p. 400-408, 2020

• DOI for A novel mechanism-based pharmacokinetic-pharmacodynamic (PKPD) model describing ceftazidime/avibactam efficacy against β-lactamase-producing Gram-negative bacteria

Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime.

Thorsted, Anders; Tano, Eva; Kaivonen, Kia; Sjölin, Jan et al.

Part of Antimicrobial Agents and Chemotherapy, 2020

• DOI for Extension of Pharmacokinetic/Pharmacodynamic Time-Kill Studies To Include Lipopolysaccharide/Endotoxin Release from Escherichia coli Exposed to Cefuroxime.
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Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients

Abrantes, João A.; Solms, Alexander; Garmann, Dirk; Nielsen, Elisabet I. et al.

Part of Haematologica, p. 1443-1453, 2020

• DOI for Relationship between factor VIII activity, bleeds and individual characteristics in severe hemophilia A patients
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Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

Thorsted, Anders; Nielsen, Elisabet I.; Friberg, Lena

Part of International Journal of Antimicrobial Agents, 2020

• DOI for Pharmacodynamics of immune response biomarkers of interest for evaluation of treatment effects in bacterial infections

Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients

Kempen, Thomas; Kälvemark, Amanda; Sawires, Maria; Stewart, Derek et al.

Part of European Journal of Clinical Pharmacology, p. 775-784, 2020

• DOI for Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients
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Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments

Wistrand-Yuen, Pikkei; Olsson, Anna; Skarp, Kari Pekka; Friberg, Lena et al.

Part of Clinical Microbiology and Infection, p. 1214-1221, 2020

• DOI for Evaluation of polymyxin B in combination with 13 other antibiotics against carbapenemase-producing Klebsiella pneumoniae in time-lapse microscopy and time-kill experiments
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Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments

Olsson, Anna; Wistrand-Yuen, Pikkei; Nielsen, Elisabet I.; Friberg, Lena et al.

Part of Antimicrobial Agents and Chemotherapy, 2020

• DOI for Efficacy of Antibiotic Combinations against Multidrug-Resistant Pseudomonas aeruginosa in Automated Time-Lapse Microscopy and Static Time-Kill Experiments
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Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism

Senek, Marina; Nyholm, Dag; Nielsen, Elisabet I.

Part of Scientific Reports, 2020

• DOI for Population pharmacokinetics of levodopa gel infusion in Parkinson's disease: effects of entacapone infusion and genetic polymorphism
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Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data

Zhao, Chenyan; Wistrand-Yuen, Pikkei; Lagerbäck, Pernilla; Tängdén, Thomas et al.

Part of International Journal of Antimicrobial Agents, 2020

• DOI for Combination of polymyxin B and minocycline against multidrug-resistant Klebsiella pneumoniae: interaction quantified by pharmacokinetic/pharmacodynamic modelling from in vitro data
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Comprehensive medication reviews by ward-based pharmacists in Swedish hospitals: What does the patient have to say?

Kempen, Thomas Gerardus Hendrik; Kälvemark, Amanda; Gillespie, Ulrika; Stewart, Derek

Part of Journal of Evaluation In Clinical Practice, p. 149-157, 2020

• DOI for Comprehensive medication reviews by ward-based pharmacists in Swedish hospitals: What does the patient have to say?

Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.

Kempen, Thomas; Cam, Henrik; Kälvemark, Amanda; Lindner, Karl-Johan et al.

Part of Journal of Clinical Pharmacy and Therapeutics, p. 1021-1029, 2020

• DOI for Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
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