Kardiologi

Hjärt-kärlsjukdom är den vanligaste dödsorsaken globalt och medför stort lidande och höga kostnader för individ och samhälle. Under mer än 25 år har kardiologsektionens forskningsgrupp varit ledande inom forskning och utveckling kring bland annat kranskärlsjukdom och antitrombotisk behandling och inom biomarkörforskning.
Beskrivning av vår forskning
Vi har studerat metoder att optimera vård och medicinering, utan att samtidigt öka risken för komplikationer. Under senare år har gruppen även drivit framgångsrika studier och projekt inom klaffsjukdomar och studier av strokeförebyggande behandling vid förmaksflimmer. Forskningen omfattar hela spektret från cellbiologisk forskning till registerbaserade randomiserade kliniska studier (R-RCT) och inkluderar ofta randomiserade kliniska prövningar med patienter och kontrollpersoner från många olika länder.
Vårt mål är att förbättra behandling och omhändertagande av den enskilda patienten och vi bedriver forsknngsprojekt inom följande områden:
- Sjukdomsförekomst och sjukdomsmekanismer genom epidemiologiska register- och kohortstudierstudier, patofysiologiska studier samt diagnos, riskbedömning och individualiserad behandling.
- Biomarkörstudier genom bilddiagnostikstudier (s.k. imaging) samt utvärdering av nya (och gamla) terapier.
- Internationella läkemedelsprövningar genom oberoende register randomiserade kliniska prövningar, observationella register- och kohortstudier samt implementation av nya terapier.
- Observationella registerstudier.
Gruppmedlemmar
Publikationer
Ingår i Trials, 2025
- DOI för Large simple randomized controlled trials – from drugs to medical devices: lessons from recent experience
- Ladda ner fulltext (pdf) av Large simple randomized controlled trials – from drugs to medical devices: lessons from recent experience
Ingår i International Journal of Cardiology, 2025
- DOI för Lipoproteins and lipoprotein lipid composition are associated with stages of dysglycemia and subclinical coronary atherosclerosis
- Ladda ner fulltext (pdf) av Lipoproteins and lipoprotein lipid composition are associated with stages of dysglycemia and subclinical coronary atherosclerosis
2024 EACTS Guidelines on perioperative medication in adult cardiac surgery
Ingår i European Journal of Cardio-Thoracic Surgery, 2025
Asundexian versus Apixaban in Patients with Atrial Fibrillation.
Ingår i New England Journal of Medicine, s. 23-32, 2025
Ingår i BMJ Open, 2025
- DOI för Completion of registration of risk factor variables during telephone vs on-site follow-up after myocardial infarction: a nationwide observational study in 101 199 patients from contemporary clinical practice in Sweden
- Ladda ner fulltext (pdf) av Completion of registration of risk factor variables during telephone vs on-site follow-up after myocardial infarction: a nationwide observational study in 101 199 patients from contemporary clinical practice in Sweden
Ingår i European Heart Journal - Quality of Care and Clinical Outcomes, s. 723-736, 2024
Ischemic Stroke in Adults With Congenital Heart Disease: Cumulative Incidence and Associated Factors
Ingår i Journal of the American Heart Association, 2024
Neurofilament Light Chain and Risk of Stroke in Patients With Atrial Fibrillation
Ingår i Circulation, s. 1090-1100, 2024
Ingår i Journal of the American Heart Association, 2024
Symptoms during pregnancy in primiparous women with congenital heart disease
Ingår i Scandinavian Cardiovascular Journal, 2024
- DOI för Symptoms during pregnancy in primiparous women with congenital heart disease
- Ladda ner fulltext (pdf) av Symptoms during pregnancy in primiparous women with congenital heart disease
Unwrapping phase contrast MRI by iterative graph cuts
Ingår i Magnetic Resonance in Medicine, s. 1484-1495, 2024
Ingår i Journal of the American Heart Association, 2024
- DOI för Self-Report Tool for Identification of Individuals With Coronary Atherosclerosis: The Swedish CardioPulmonary BioImage Study
- Ladda ner fulltext (pdf) av Self-Report Tool for Identification of Individuals With Coronary Atherosclerosis: The Swedish CardioPulmonary BioImage Study
Ingår i European Heart Journal - Quality of Care and Clinical Outcomes, 2024
Ingår i European Heart Journal - Quality of Care and Clinical Outcomes, s. 386-390, 2024
Ingår i Structural Heart, 2024
- DOI för Characteristics and Outcomes of Patients Receiving a Second Rescue Valve During Transcatheter Aortic Valve Implantation
- Ladda ner fulltext (pdf) av Characteristics and Outcomes of Patients Receiving a Second Rescue Valve During Transcatheter Aortic Valve Implantation
Ingår i Annals of the American Thoracic Society, s. 1678-1687, 2024
- DOI för Chronic Airflow Limitation, Emphysema and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-Aged Population
- Ladda ner fulltext (pdf) av Chronic Airflow Limitation, Emphysema and Impaired Diffusing Capacity in Relation to Smoking Habits in a Swedish Middle-Aged Population
Limb Outcomes With Ticagrelor Plus Aspirin in Patients With Diabetes Mellitus and Atherosclerosis
Ingår i Journal of the American College of Cardiology, s. 1627-1636, 2024
FFR-Guided Complete or Culprit-Only PCI in Patients with Myocardial Infarction
Ingår i New England Journal of Medicine, s. 1481-1492, 2024
Ingår i EuroIntervention, s. 1370-1379, 2024
Ingår i Open heart, 2024
- DOI för Pregnancy complications and long-term risk of cardiovascular events in women with structural heart disease
- Ladda ner fulltext (pdf) av Pregnancy complications and long-term risk of cardiovascular events in women with structural heart disease
Ingår i Acta Obstetricia et Gynecologica Scandinavica, s. 970-979, 2024
- DOI för Biomarkers associated with cardiovascular disease in women with spontaneous preterm birth: A case-control study
- Ladda ner fulltext (pdf) av Biomarkers associated with cardiovascular disease in women with spontaneous preterm birth: A case-control study
Kommentar zu den Leitlinien 2023 der ESC zur infektiösen Endokarditis
Ingår i KARDIOLOGIE, s. 447-457, 2024
Temporal biomarker concentration patterns during the early course of acute coronary syndrome
Ingår i Clinical Chemistry and Laboratory Medicine, s. 1167-1176, 2024
- DOI för Temporal biomarker concentration patterns during the early course of acute coronary syndrome
- Ladda ner fulltext (pdf) av Temporal biomarker concentration patterns during the early course of acute coronary syndrome
Ingår i European Heart Journal, s. 559-562, 2024
- DOI för Cardiovascular medications, high-sensitivity cardiac troponin T concentrations, and long-term outcome in non-ST segment elevation acute coronary syndrome
- Ladda ner fulltext (pdf) av Cardiovascular medications, high-sensitivity cardiac troponin T concentrations, and long-term outcome in non-ST segment elevation acute coronary syndrome
Ingår i British Journal of Haematology, s. 1740-1751, 2024
Ingår i European Journal of Epidemiology, s. 35-49, 2024
- DOI för Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
- Ladda ner fulltext (pdf) av Pulmonary function and atherosclerosis in the general population: causal associations and clinical implications
Ingår i American Heart Journal, s. 1-10, 2024
- DOI för Rationale and design of INFINITY-SWEDEHEART: A registry-based randomized clinical trial comparing clinical outcomes of the sirolimus-eluting DynamX bioadaptor to the zotarolimus-eluting Resolute Onyx stent
- Ladda ner fulltext (pdf) av Rationale and design of INFINITY-SWEDEHEART: A registry-based randomized clinical trial comparing clinical outcomes of the sirolimus-eluting DynamX bioadaptor to the zotarolimus-eluting Resolute Onyx stent
Ingår i The Lancet, s. 1750-1759, 2024
Obituary: Arthur E. Weyman, 1941-2024
Ingår i European Heart Journal Cardiovascular Imaging, s. 1183-1185, 2024
Ingår i Open heart, 2024
- DOI för Major bleeding in patients with atrial fibrillation treated with apixaban versus warfarin in combination with amiodarone: nationwide cohort study
- Ladda ner fulltext (pdf) av Major bleeding in patients with atrial fibrillation treated with apixaban versus warfarin in combination with amiodarone: nationwide cohort study
Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts.
Ingår i Scientific Reports, s. 8933, 2024
Ingår i Circulation, 2024
Ingår i Circulation, s. 1065-1086, 2024
Ingår i European Heart Journal - Cardiovascular Pharmacotherapy, s. 614-645, 2024
Ingår i Journal of the American Heart Association, 2024
- DOI för Repeated Measurement of the Novel Atrial Biomarker BMP10 (Bone Morphogenetic Protein 10) Refines Risk Stratification in Anticoagulated Patients With Atrial Fibrillation: Insights From the ARISTOTLE Trial
- Ladda ner fulltext (pdf) av Repeated Measurement of the Novel Atrial Biomarker BMP10 (Bone Morphogenetic Protein 10) Refines Risk Stratification in Anticoagulated Patients With Atrial Fibrillation: Insights From the ARISTOTLE Trial
Cardiac rehabilitation registries around the globe: current status and future needs
Ingår i European Journal of Preventive Cardiology, 2024
- DOI för Cardiac rehabilitation registries around the globe: current status and future needs
- Ladda ner fulltext (pdf) av Cardiac rehabilitation registries around the globe: current status and future needs
Ingår i Journal of the American Heart Association, 2024
- DOI för Major Adverse Cardiovascular Events Following Coronary Artery Stenting by History of Hypertensive Disorder of Pregnancy
- Ladda ner fulltext (pdf) av Major Adverse Cardiovascular Events Following Coronary Artery Stenting by History of Hypertensive Disorder of Pregnancy
Ingår i JMIR Formative Research, 2024
Ingår i Journal of the American College of Cardiology, s. 1528-1540, 2024
Ingår i American Journal of Cardiology, s. 118-124, 2024
Ingår i JACC. Advances, s. 101088, 2024
Life's Essential 8 is inversely associated with high-sensitivity C-reactive protein
Ingår i Scientific Reports, 2024
- DOI för Life's Essential 8 is inversely associated with high-sensitivity C-reactive protein
- Ladda ner fulltext (pdf) av Life's Essential 8 is inversely associated with high-sensitivity C-reactive protein
Ingår i Contemporary Clinical Trials Communications, 2024
- DOI för Patients' experiences of clinical trial participation involving a product remotely assessing study drug adherence
- Ladda ner fulltext (pdf) av Patients' experiences of clinical trial participation involving a product remotely assessing study drug adherence
Ingår i British Journal of Sports Medicine, 2024
- DOI för Physical fitness in male adolescents and atherosclerosis in middle age: a population-based cohort study
- Ladda ner fulltext (pdf) av Physical fitness in male adolescents and atherosclerosis in middle age: a population-based cohort study
Breastfeeding in primiparous women with congenital heart disease: a register study
Ingår i International Breastfeeding Journal, 2024
- DOI för Breastfeeding in primiparous women with congenital heart disease: a register study
- Ladda ner fulltext (pdf) av Breastfeeding in primiparous women with congenital heart disease: a register study
Ingår i Scandinavian Cardiovascular Journal, 2024
- DOI för Self-rated health in primiparous women with congenital heart disease before, during and after pregnancy: A register study
- Ladda ner fulltext (pdf) av Self-rated health in primiparous women with congenital heart disease before, during and after pregnancy: A register study
Ingår i European Heart Journal Open, 2024
Ingår i Journal of the American Heart Association, 2024
- DOI för Abbreviated Versus Standard Dual Antiplatelet Therapy Times After Percutaneous Coronary Intervention in Patients With High Bleeding Risk With Acute Coronary Syndrome: Insights From the SWEDEHEART Registry
- Ladda ner fulltext (pdf) av Abbreviated Versus Standard Dual Antiplatelet Therapy Times After Percutaneous Coronary Intervention in Patients With High Bleeding Risk With Acute Coronary Syndrome: Insights From the SWEDEHEART Registry
Dapagliflozin in Myocardial Infarction without Diabetes or Heart Failure.
Ingår i NEJM evidence, 2024
Dapagliflozin in patients with myocardial infarction without diabetes or prior heart failure
Ingår i European Heart Journal - Cardiovascular Pharmacotherapy, s. 91-92, 2024
- DOI för Dapagliflozin in patients with myocardial infarction without diabetes or prior heart failure