Kardiologi

Hjärt-kärlsjukdom är den vanligaste dödsorsaken globalt och medför stort lidande och höga kostnader för individ och samhälle. Under mer än 25 år har kardiologsektionens forskningsgrupp varit ledande inom forskning och utveckling kring bland annat kranskärlsjukdom och antitrombotisk behandling och inom biomarkörforskning.
Beskrivning av vår forskning
Vi har studerat metoder att optimera vård och medicinering, utan att samtidigt öka risken för komplikationer. Under senare år har gruppen även drivit framgångsrika studier och projekt inom klaffsjukdomar och studier av strokeförebyggande behandling vid förmaksflimmer. Forskningen omfattar hela spektret från cellbiologisk forskning till registerbaserade randomiserade kliniska studier (R-RCT) och inkluderar ofta randomiserade kliniska prövningar med patienter och kontrollpersoner från många olika länder.
Vårt mål är att förbättra behandling och omhändertagande av den enskilda patienten och vi bedriver forsknngsprojekt inom följande områden:
- Sjukdomsförekomst och sjukdomsmekanismer genom epidemiologiska register- och kohortstudierstudier, patofysiologiska studier samt diagnos, riskbedömning och individualiserad behandling.
- Biomarkörstudier genom bilddiagnostikstudier (s.k. imaging) samt utvärdering av nya (och gamla) terapier.
- Internationella läkemedelsprövningar genom oberoende register randomiserade kliniska prövningar, observationella register- och kohortstudier samt implementation av nya terapier.
- Observationella registerstudier.
Gruppmedlemmar
Publikationer
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DOAC score among patients receiving Vitamin K antagonists
Ingår i American Heart Journal, 2026
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Heterogeneity of Treatment Effect of DOACs vs Warfarin in Atrial Fibrillation
Ingår i JACC: Advances, 2026
- DOI för Heterogeneity of Treatment Effect of DOACs vs Warfarin in Atrial Fibrillation
- Ladda ner fulltext (pdf) av Heterogeneity of Treatment Effect of DOACs vs Warfarin in Atrial Fibrillation
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Ingår i JACC: Advances, 2026
- DOI för Outcomes With Warfarin in Atrial Fibrillation: Individual Patient Data Analysis From Four Randomized Trials
- Ladda ner fulltext (pdf) av Outcomes With Warfarin in Atrial Fibrillation: Individual Patient Data Analysis From Four Randomized Trials
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Ingår i Circulation, s. 567-575, 2026
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Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
Ingår i JACC: Advances, 2026
- DOI för Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
- Ladda ner fulltext (pdf) av Standardized Mortality Ratio and Long-Term Stroke Incidence After PFO Closure: A Register Study
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Ingår i Scientific Reports, 2026
- DOI för Comparison of two analytical platforms for quantification of neuroglial biomarkers in blood samples: a single molecule array and an electrochemiluminescence assay
- Ladda ner fulltext (pdf) av Comparison of two analytical platforms for quantification of neuroglial biomarkers in blood samples: a single molecule array and an electrochemiluminescence assay
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Coronary Computed Tomography Angiography in Prediction of First Coronary Events
Ingår i Journal of the American Medical Association (JAMA), s. 245-254, 2026
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Optimizing lipoprotein(a) testing for immediate clinical impact in primary prevention
Ingår i Atherosclerosis, 2026
- DOI för Optimizing lipoprotein(a) testing for immediate clinical impact in primary prevention
- Ladda ner fulltext (pdf) av Optimizing lipoprotein(a) testing for immediate clinical impact in primary prevention
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First quinquennium completed: highlights from EHJ Open 2025
Ingår i European Heart Journal Open, 2026
- DOI för First quinquennium completed: highlights from EHJ Open 2025
- Ladda ner fulltext (pdf) av First quinquennium completed: highlights from EHJ Open 2025
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Ingår i Pharmacoepidemiology and Drug Safety, 2026
- DOI för Methodological Challenges of Emulating a Target Trial to Assess Effectiveness of Timing of PCSK9 Inhibitor Treatment Initiation Post Myocardial Infarction
- Ladda ner fulltext (pdf) av Methodological Challenges of Emulating a Target Trial to Assess Effectiveness of Timing of PCSK9 Inhibitor Treatment Initiation Post Myocardial Infarction
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Sexual functioning after the age of 40 in adults with moderate or severe congenital heart disease
Ingår i International Journal of Cardiology Congenital Heart Disease, 2026
- DOI för Sexual functioning after the age of 40 in adults with moderate or severe congenital heart disease
- Ladda ner fulltext (pdf) av Sexual functioning after the age of 40 in adults with moderate or severe congenital heart disease
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Ingår i Scandinavian Cardiovascular Journal, 2026
- DOI för A novel risk score based on exercise capacity to predict prognosis in adults with congenital heart disease
- Ladda ner fulltext (pdf) av A novel risk score based on exercise capacity to predict prognosis in adults with congenital heart disease
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Ingår i Clinical Chemistry, s. 488-502, 2026
- DOI för Establishing Reference Values in Healthy Participants for the Cardiac Troponin T High-Sensitivity Gen 6 Assay: REF-TSIX Global Reference Study
- Ladda ner fulltext (pdf) av Establishing Reference Values in Healthy Participants for the Cardiac Troponin T High-Sensitivity Gen 6 Assay: REF-TSIX Global Reference Study
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Ingår i CIRCULATION-POPULATION HEALTH AND OUTCOMES, 2026
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The plasma protein profile of left ventricular diastolic function
Ingår i Scientific Reports, 2026
- DOI för The plasma protein profile of left ventricular diastolic function
- Ladda ner fulltext (pdf) av The plasma protein profile of left ventricular diastolic function
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Predictors of depressed left-ventricular ejection fraction after acute myocardial infarction
Ingår i International Journal of Cardiology, 2026
- DOI för Predictors of depressed left-ventricular ejection fraction after acute myocardial infarction
- Ladda ner fulltext (pdf) av Predictors of depressed left-ventricular ejection fraction after acute myocardial infarction
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Exercise-induced cardiac troponin release: do we need to worry?
Ingår i European Heart Journal, s. 315-317, 2026
- DOI för Exercise-induced cardiac troponin release: do we need to worry?
- Ladda ner fulltext (pdf) av Exercise-induced cardiac troponin release: do we need to worry?
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Ingår i European Stroke Journal, 2026
- DOI för Early versus delayed DOAC after ischaemic stroke in atrial fibrillation: 1-year outcomes in the TIMING study and in concurrent practice
- Ladda ner fulltext (pdf) av Early versus delayed DOAC after ischaemic stroke in atrial fibrillation: 1-year outcomes in the TIMING study and in concurrent practice
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Ingår i European Heart Journal Open, 2026
- DOI för Cost-effectiveness analysis of transcatheter aortic valve implantation for asymptomatic severe aortic stenosis across nine European countries
- Ladda ner fulltext (pdf) av Cost-effectiveness analysis of transcatheter aortic valve implantation for asymptomatic severe aortic stenosis across nine European countries
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Ingår i Journal of Internal Medicine, s. 467-480, 2026
- DOI för The Swedish CArdioPulmonary bioImage Study re-examination: Rationale, design, methods, and management of incidental findings
- Ladda ner fulltext (pdf) av The Swedish CArdioPulmonary bioImage Study re-examination: Rationale, design, methods, and management of incidental findings
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Ingår i Journal of Hypertension, s. 346-353, 2026
- DOI för Systolic inter-arm blood pressure difference and subclinical atherosclerosis: a population-based cohort study of 29 921 individuals
- Ladda ner fulltext (pdf) av Systolic inter-arm blood pressure difference and subclinical atherosclerosis: a population-based cohort study of 29 921 individuals
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Ingår i CJC OPEN, s. 550-556, 2026
- DOI för Outcomes of No-Touch Vs Conventionally Harvested Saphenous Veins for Coronary Artery Bypass Surgery Individual Patient Data Meta-Analysis Protocol
- Ladda ner fulltext (pdf) av Outcomes of No-Touch Vs Conventionally Harvested Saphenous Veins for Coronary Artery Bypass Surgery Individual Patient Data Meta-Analysis Protocol
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Ingår i Cell Stem Cell, s. 1324-1338, 2026
- DOI för Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis
- Ladda ner fulltext (pdf) av Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis
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Ingår i ESC Heart Failure, 2026
- DOI för An integrated Biobank in the Swedish Heart Failure Registry-clinomics, proteomics, transcriptomics and genomics
- Ladda ner fulltext (pdf) av An integrated Biobank in the Swedish Heart Failure Registry-clinomics, proteomics, transcriptomics and genomics
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Dynamics of long-term adherence to lipid-lowering therapy in patients after myocardial infarction
Ingår i European Journal of Clinical Pharmacology, 2026
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Ingår i Open heart, 2026
- DOI för Symptom burden and secondary prevention in patients with left ventricular systolic dysfunction after acute myocardial infarction: a nationwide register-based study in Sweden
- Ladda ner fulltext (pdf) av Symptom burden and secondary prevention in patients with left ventricular systolic dysfunction after acute myocardial infarction: a nationwide register-based study in Sweden
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Ingår i Open heart, 2026
- DOI för Physical fitness after myocardial infarction compared with clinical reference values: a SWEDEHEART registry study
- Ladda ner fulltext (pdf) av Physical fitness after myocardial infarction compared with clinical reference values: a SWEDEHEART registry study
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Ingår i HUMAN-ANIMAL INTERACTIONS, 2026
- DOI för Associations between dog and cat ownership, social integration, mental health and physical activity: A cross-sectional study from the SCAPIS population
- Ladda ner fulltext (pdf) av Associations between dog and cat ownership, social integration, mental health and physical activity: A cross-sectional study from the SCAPIS population
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Ingår i American Journal of Preventive Medicine, 2026
- DOI för Associations of adolescent BMI and physical fitness with cardiovascular health in middle age: a population-based prospective study of Swedish men
- Ladda ner fulltext (pdf) av Associations of adolescent BMI and physical fitness with cardiovascular health in middle age: a population-based prospective study of Swedish men
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Ingår i Journal of Thrombosis and Haemostasis, s. 399-407, 2026
- DOI för Evaluation of the updated ABC-AF-bleeding score 2.0 in patients with atrial fibrillation treated with a direct oral anticoagulant or warfarin
- Ladda ner fulltext (pdf) av Evaluation of the updated ABC-AF-bleeding score 2.0 in patients with atrial fibrillation treated with a direct oral anticoagulant or warfarin
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How to Make Medical Device Registry Data Fit for Purpose: A Response to Recent Commentaries
Ingår i International Journal of Health Policy and Management, 2026
- DOI för How to Make Medical Device Registry Data Fit for Purpose: A Response to Recent Commentaries
- Ladda ner fulltext (pdf) av How to Make Medical Device Registry Data Fit for Purpose: A Response to Recent Commentaries
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Realizing the full potential of registry-based randomized controlled trials
Ingår i Journal of Clinical Epidemiology, 2026
- DOI för Realizing the full potential of registry-based randomized controlled trials
- Ladda ner fulltext (pdf) av Realizing the full potential of registry-based randomized controlled trials
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Ingår i Journal of Nuclear Cardiology, 2026
- DOI för Evaluation of Gd-DOTA as a marker for myocardial blood flow using 68Ga-DOTA and 15O-water positron emission tomography
- Ladda ner fulltext (pdf) av Evaluation of Gd-DOTA as a marker for myocardial blood flow using 68Ga-DOTA and 15O-water positron emission tomography
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Ingår i Ultraschall in der Medizin, s. 149-159, 2026
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Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome
Ingår i Cell, s. 3339-+, 2026
- DOI för Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome
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Beta-Blockers after Myocardial Infarction with Normal Ejection Fraction
Ingår i New England Journal of Medicine, s. 540-550, 2026
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Ingår i Journal of Investigative Dermatology, 2026
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Ingår i Heart, s. 761-770, 2026
- DOI för Risk and protective factors for stroke and transient ischaemic attack in patients with atrial fibrillation: an umbrella review of meta-analyses
- Ladda ner fulltext (pdf) av Risk and protective factors for stroke and transient ischaemic attack in patients with atrial fibrillation: an umbrella review of meta-analyses
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Ingår i Journal of the American Heart Association, 2026
- DOI för Randomized Controlled Trial of Internet-Delivered Cognitive Behavioral Therapy After Myocardial Infarction With Nonobstructive Coronary Arteries or Takotsubo Syndrome
- Ladda ner fulltext (pdf) av Randomized Controlled Trial of Internet-Delivered Cognitive Behavioral Therapy After Myocardial Infarction With Nonobstructive Coronary Arteries or Takotsubo Syndrome
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Ingår i Scientific Reports, 2026
- DOI för Growth differentiation factor-15 improves long-term mortality risk prediction beyond the GRACE 2.0 score after acute coronary syndrome
- Ladda ner fulltext (pdf) av Growth differentiation factor-15 improves long-term mortality risk prediction beyond the GRACE 2.0 score after acute coronary syndrome
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Ingår i European Journal of Radiology, 2026
- DOI för Improved coronary CT angiography image quality using photon-counting detector CT in SCAPIS reexamination: scan protocol and comparative analysis
- Ladda ner fulltext (pdf) av Improved coronary CT angiography image quality using photon-counting detector CT in SCAPIS reexamination: scan protocol and comparative analysis
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Ingår i American Heart Journal Plus: Cardiology Research and Practice, 2026
- DOI för Health related quality of life and cardiac symptoms following admission for suspected MINOCA: A post-hoc analysis of the MINOCA-BAT randomized clinical trial
- Ladda ner fulltext (pdf) av Health related quality of life and cardiac symptoms following admission for suspected MINOCA: A post-hoc analysis of the MINOCA-BAT randomized clinical trial
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Ingår i Clinical Biochemistry, 2026
- DOI för Change in cardiac troponin T to differentiate acute from chronic myocardial injury in the Emergency Department
- Ladda ner fulltext (pdf) av Change in cardiac troponin T to differentiate acute from chronic myocardial injury in the Emergency Department
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Cardiomyopathies: Nationwide Trends in Prevalence, Incidence, and Mortality (2004-2023)
Ingår i Journal of the American College of Cardiology, s. 1087-1090, 2026
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Lipoprotein(a) cascade screening in coronary artery disease
Ingår i Atherosclerosis, 2026
- DOI för Lipoprotein(a) cascade screening in coronary artery disease
- Ladda ner fulltext (pdf) av Lipoprotein(a) cascade screening in coronary artery disease
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Ingår i Circulation, 2026
- DOI för One-Year Outcomes of the MODULAR ATP Trial: A Novel Leadless Pacemaker in Wireless Communication With a Subcutaneous Implantable Cardioverter Defibrillator
- Ladda ner fulltext (pdf) av One-Year Outcomes of the MODULAR ATP Trial: A Novel Leadless Pacemaker in Wireless Communication With a Subcutaneous Implantable Cardioverter Defibrillator
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Ingår i Circulation. Cardiovascular Interventions, 2026
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Ingår i Annals of Clinical Biochemistry, s. 308-318, 2026
- DOI för NT-proBNP and its correlation to left ventricular ejection fraction and heart failure - the DEMONSTRATE database.
- Ladda ner fulltext (pdf) av NT-proBNP and its correlation to left ventricular ejection fraction and heart failure - the DEMONSTRATE database.
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Ingår i International Journal of Cardiology, 2026
- DOI för Person-centred care in congenital heart disease: Intercountry variation in patient-reported experiences across 32 countries.
- Ladda ner fulltext (pdf) av Person-centred care in congenital heart disease: Intercountry variation in patient-reported experiences across 32 countries.
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Long-term outcome in adults with a previous Ross operation: a cohort study
Ingår i Open heart, 2026
- DOI för Long-term outcome in adults with a previous Ross operation: a cohort study
- Ladda ner fulltext (pdf) av Long-term outcome in adults with a previous Ross operation: a cohort study