Klinisk farmakogenomik och osteoporos

Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigation

Michaëlsson, Karl; Zheng, Rui; Baron, John A.; Fall, Tove et al.

Ingår i EBioMedicine, 2025

• DOI för Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigation
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Identification of risk factors for adverse drug reactions in a pharmacovigilance database

Attelind, Sofia; Eriksson, Niclas; Sundstroem, A.; Wadelius, Mia et al.

Ingår i Pharmacoepidemiology and Drug Safety, 2024

• DOI för Identification of risk factors for adverse drug reactions in a pharmacovigilance database

Dapagliflozin in Myocardial Infarction without Diabetes or Heart Failure.

James, Stefan; Erlinge, David; Storey, Robert F; McGuire, Darren K et al.

Ingår i NEJM evidence, 2024

• DOI för Dapagliflozin in Myocardial Infarction without Diabetes or Heart Failure.

Meta-analysis of ACE inhibitor-induced angioedema identifies novel risk locus

Mathey, Carina M.; Maj, Carlo; Eriksson, Niclas; Krebs, Kristi et al.

Ingår i Journal of Allergy and Clinical Immunology, s. 1073-1082, 2024

• DOI för Meta-analysis of ACE inhibitor-induced angioedema identifies novel risk locus

Non-fermented and fermented milk intake in relation to risk of ischemic heart disease and to circulating cardiometabolic proteins in swedish women and men: Two prospective longitudinal cohort studies with 100,775 participants

Michaëlsson, Karl; Warensjö Lemming, Eva; Larsson, Susanna C.; Höijer, Jonas et al.

Ingår i BMC Medicine, 2024

• DOI för Non-fermented and fermented milk intake in relation to risk of ischemic heart disease and to circulating cardiometabolic proteins in swedish women and men: Two prospective longitudinal cohort studies with 100,775 participants
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Precision Diagnostics in Myeloid Malignancies: Development and Validation of a National Capture‐Based Gene Panel

Orsmark‐Pietras, Christina; Lyander, Anna; Ladenvall, Claes; Hallström, Björn et al.

Ingår i Genes, Chromosomes and Cancer, 2024

• DOI för Precision Diagnostics in Myeloid Malignancies: Development and Validation of a National Capture‐Based Gene Panel
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Intensive early and sustained lowering of non-high-density lipoprotein cholesterol after myocardial infarction and prognosis: the SWEDEHEART registry

Schubert, Jessica; Leosdottir, Margrét; Lindahl, Bertil; Westerbergh, Johan et al.

Ingår i European Heart Journal, s. 4204-4215, 2024

• DOI för Intensive early and sustained lowering of non-high-density lipoprotein cholesterol after myocardial infarction and prognosis: the SWEDEHEART registry
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Autoantibodies to protein S may explain rare cases of coagulopathy following COVID-19 vaccination

Yalcinkaya, Ahmet; Cavalli, Marco; Aranda-Guillén, Maribel; Cederholm, Axel et al.

Ingår i Scientific Reports, 2024

• DOI för Autoantibodies to protein S may explain rare cases of coagulopathy following COVID-19 vaccination
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No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines

Yalcinkaya, Ahmet; Cavalli, Marco; Cederholm, Axel; Aranda-Guillen, Maribel et al.

Ingår i NPJ VACCINES, 2024

• DOI för No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines
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Pulmonary embolism after SARS-CoV-2 vaccination

Zethelius, Björn; Attelind, Sofia; Westman, Gabriel; Ljung, Rickard et al.

Ingår i Vaccine: X, 2024

• DOI för Pulmonary embolism after SARS-CoV-2 vaccination
• Ladda ner fulltext (pdf) av Pulmonary embolism after SARS-CoV-2 vaccination

Gene-based association analysis of a large patient cohort provides insights into genetics of atypical femur fractures

Zhou, Wei; Ås, Joel; Shore-Lorenti, Catherine; Nguyen, Hanh H. et al.

Ingår i Journal of Bone and Mineral Research, s. 1315-1326, 2024

• DOI för Gene-based association analysis of a large patient cohort provides insights into genetics of atypical femur fractures
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Genomic Analysis of Adverse Drug Reactions

Ås, Joel

2024

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Whole genome case-control study of central nervous system toxicity due to antimicrobial drugs

Ås, Joel; Bertulyte, Ilma; Norgren, Nina; Johansson, Anna et al.

Ingår i PLOS ONE, 2024

• DOI för Whole genome case-control study of central nervous system toxicity due to antimicrobial drugs
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Identification of risk factors for adverse drug reactions in a pharmacovigilance database

Attelind, Sofia; Eriksson, Niclas; Sundström, Anders; Wadelius, Mia et al.

Ingår i Pharmacoepidemiology and Drug Safety, s. 1431-1438, 2023

• DOI för Identification of risk factors for adverse drug reactions in a pharmacovigilance database
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Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial

Kempen, Thomas; Hedman, Anton N.; Hadziosmanovic, Nermin; Lindner, Karl‐Johan et al.

Ingår i British Journal of Clinical Pharmacology, s. 1575-1587, 2023

• DOI för Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
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Vitamin D and bone metabolism in Graves’ disease: a prospective study

Khamisi, Selwan; Lundqvist, Martin H.; Rasmusson, Annica J.; Edén Engström, Britt et al.

Ingår i Journal of Endocrinological Investigation, s. 425-433, 2023

• DOI för Vitamin D and bone metabolism in Graves’ disease: a prospective study
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Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Ollila, Hanna M.; Sharon, Eilon; Lin, Ling; Sinnott-Armstrong, Nasa et al.

Ingår i Nature Communications, 2023

• DOI för Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
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Elevated low-density lipoprotein cholesterol: An inverse marker of morbidity and mortality in patients with myocardial infarction

Schubert, Jessica; Lindahl, Bertil; Melhus, Håkan; Renlund, Henrik et al.

Ingår i Journal of Internal Medicine, s. 616-627, 2023

• DOI för Elevated low-density lipoprotein cholesterol: An inverse marker of morbidity and mortality in patients with myocardial infarction
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Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Zhao, Jing Hua; Stacey, David; Eriksson, Niclas; Macdonald-Dunlop, Erin et al.

Ingår i Nature Immunology, s. 1960, 2023

• DOI för Author Correction: Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events

Attelind, Sofia; Hallberg, Pär; Wadelius, Mia; Hamberg, Anna-Karin et al.

Ingår i Frontiers in Genetics, 2022

• DOI för Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events
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General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children

Bouazza, Naim; Dokoumetzidis, Aristides; Knibbe, Catherijne A. J.; de Wildt, Saskia N. et al.

Ingår i British Journal of Clinical Pharmacology, s. 4985-4996, 2022

• DOI för General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children

Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate

Cavalli, Marco; Eriksson, Niclas; Karlsson Sundbaum, Johanna; Wallenberg, Matilda et al.

Ingår i Pharmacogenomics (London), s. 813-820, 2022

• DOI för Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate
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The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms

Cooper-DeHoff, Rhonda M.; Niemi, Mikko; Ramsey, Laura B.; Luzum, Jasmine A. et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 1007-1021, 2022

• DOI för The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms

Implementing precision medicine in a regionally organized healthcare system in Sweden.

Fioretos, Thoas; Wirta, Valtteri; Cavelier, Lucia; Berglund, Eva et al.

Ingår i Nature Medicine, s. 1980-1982, 2022

• DOI för Implementing precision medicine in a regionally organized healthcare system in Sweden.

Mast cell chymase has a negative impact on human osteoblasts

Lind, Thomas; Melo, Fabio R.; Gustafson, Ann-Marie; Sundqvist, Anders et al.

Ingår i Matrix Biology, s. 1-19, 2022

• DOI för Mast cell chymase has a negative impact on human osteoblasts
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Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes

Mathey, Carina M; Maj, Carlo; Scheer, Annika B; Fazaal, Julia et al.

Ingår i Frontiers in Genetics, 2022

• DOI för Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes
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Chapter 73: Pharmacogenetics

McMillin, Gwendolyn A; Wadelius, Mia; Pratt, Victoria M

Ingår i Tietz Textbook of Laboratory Medicine, 7th Edition, Elsevier, 2022

The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design

Michaelsson, Madeleine; Yuan, Shuai; Melhus, Håkan; Baron, John A. et al.

Ingår i BMC Medicine, 2022

• DOI för The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
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Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden

Sulku, Johanna; Janson, Christer; Melhus, Håkan; Ställberg, Björn et al.

Ingår i Respiratory Medicine, 2022

• DOI för Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
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HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease

Ås, Joel; Bertulyte, Ilma; Eriksson, Niclas; Magnusson, Patrik K. E. et al.

Ingår i Clinical and Translational Science, s. 1249-1256, 2022

• DOI för HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease
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Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Byrgazov, Konstantin; Lind, Thomas; Rasmusson, Annica J.; Andersson, Claes et al.

Ingår i Bone Reports, 2021

• DOI för Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Farmakogenomik – individuell anpassning av läkemedel och dos: [Pharmacogenomics - a cornerstone of Precision Medicine. Genomic Medicine Sweden analyses genotypes associated with serious drug toxicity or therapeutic failure]

Eliasson, Erik; Wadelius, Mia

Ingår i Läkartidningen, 2021

Technological readiness and implementation of genomic-driven precision medicine for complex diseases

Franks, P. W.; Melén, E.; Friedman, M.; Sundström, Johan et al.

Ingår i Journal of Internal Medicine, s. 602-620, 2021

• DOI för Technological readiness and implementation of genomic-driven precision medicine for complex diseases
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Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors

Ghouse, Jonas; Ahlberg, Gustav; Andreasen, Laura; Banasi, Karina et al.

Ingår i Journal of the American College of Cardiology, s. 696-709, 2021

• DOI för Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors

Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate

Karlsson Sundbaum, Johanna; Baecklund, Eva; Eriksson, Niclas; Kohnke, Hugo et al.

Ingår i Pharmacogenomics (London), s. 973-982, 2021

• DOI för Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate
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Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial

Kempen, Thomas; Bertilsson, Maria; Hadziosmanovic, Nermin; Lindner, Karl-Johan et al.

Ingår i JAMA Network Open, 2021

• DOI för Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
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Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis

Mahmoodi, Bakhtawar K.; Eriksson, Niclas; Vos, Gerrit J. A.; Meijer, Karina et al.

Ingår i Journal of the American Heart Association, 2021

• DOI för Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis
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Type 2 diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Elderly Swedish Men and Women: Supplementary material

Mitchell, Adam; Fall, Tove; Melhus, Håkan; Lind, Lars et al.

2021

Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years

Mitchell, Adam; Fall, Tove; Melhus, Håkan; Lind, Lars et al.

Ingår i Journal of Clinical Endocrinology and Metabolism, s. 2840-2854, 2021

• DOI för Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years
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Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?

Mitchell, Adam; Fall, Tove; Melhus, Håkan; Wolk, Alicja et al.

Ingår i International Journal of Epidemiology, s. 234-244, 2021

• DOI för Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?
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Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study

Mitchell, Adam; Larsson, Susanna C.; Fall, Tove; Melhus, Håkan et al.

Ingår i Diabetologia, s. 1348-1357, 2021

• DOI för Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study
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Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens

Nicoletti, Paola; Devarbhavi, Harshad; Goel, Ashish; Venkatesan, Radha et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 1125-1135, 2021

• DOI för Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens
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Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema

Pall, Amalie Hartvig; Rasmussen, Eva Rye; Wadelius, Mia

Ingår i Pharmacogenomics (London), s. 319-321, 2021

• DOI för Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema

Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study

Schubert, Jessica; Lindahl, Bertil; Melhus, Håkan; Renlund, Henrik et al.

Ingår i European Heart Journal, s. 243-252, 2021

• DOI för Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study
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Fördelaktigt med genetisk analys före behandling med 5-fluorouracil: Utvärdering tyder på mindre biverkningar och kostnadsbesparing för sjukvården: [New recommendation on pharmacogenetic screening prior to 5-fluorouracil based cancer treatment - Swedish experience indicates less adverse effects and healthcare cost savings]

Schultz, Alice; Kohnke, Hugo; Wadelius, Mia; Nygren, Peter

Ingår i Läkartidningen, 2021

Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations

Sulku, Johanna; Bröms, Kristina; Högman, Marieann; Janson, Christer et al.

Ingår i npj Primary Care Respiratory Medicine, 2021

• DOI för Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
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High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis

Cismaru, Anca Liliana; Grimm, Livia; Rudin, Deborah; Ibanez, Luisa et al.

Ingår i Frontiers in Genetics, 2020

• DOI för High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis
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Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations

Cismaru, Anca Liliana; Rudin, Deborah; Ibanez, Luisa; Liakoni, Evangelia et al.

Ingår i Genes, 2020

• DOI för Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations
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SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions

Hallberg, Pär; Yue, Qun-Ying; Eliasson, Erik; Melhus, Håkan et al.

Ingår i The Pharmacogenomics Journal, s. 579-585, 2020

• DOI för SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions
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MTHFR, TYMS and SLCO1B1 polymorphisms and adverse liver effects of methotrexate in rheumatoid arthritis

Karlsson Sundbaum, Johanna; Baecklund, Eva; Eriksson, Niclas; Hallberg, Pär et al.

Ingår i Pharmacogenomics (London), s. 337-346, 2020

• DOI för MTHFR, TYMS and SLCO1B1 polymorphisms and adverse liver effects of methotrexate in rheumatoid arthritis