Klinisk farmakogenomik och osteoporos

Identification of risk factors for adverse drug reactions in a pharmacovigilance database

Attelind, Sofia; Eriksson, Niclas; Sundstroem, A.; Wadelius, Mia et al.

Ingår i Pharmacoepidemiology and Drug Safety, 2024

• DOI för Identification of risk factors for adverse drug reactions in a pharmacovigilance database

Meta-analysis of ACE inhibitor-induced angioedema identifies novel risk locus

Mathey, Carina M.; Maj, Carlo; Eriksson, Niclas; Krebs, Kristi et al.

Ingår i Journal of Allergy and Clinical Immunology, s. 1073-1082, 2024

• DOI för Meta-analysis of ACE inhibitor-induced angioedema identifies novel risk locus

Precision Diagnostics in Myeloid Malignancies: Development and Validation of a National Capture‐Based Gene Panel

Orsmark‐Pietras, Christina; Lyander, Anna; Ladenvall, Claes; Hallström, Björn et al.

Ingår i Genes, Chromosomes and Cancer, 2024

• DOI för Precision Diagnostics in Myeloid Malignancies: Development and Validation of a National Capture‐Based Gene Panel

No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines

Yalcinkaya, Ahmet; Cavalli, Marco; Cederholm, Axel; Aranda-Guillen, Maribel et al.

Ingår i NPJ VACCINES, 2024

• DOI för No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines
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Gene-based association analysis of a large patient cohort provides insights into genetics of atypical femur fractures

Zhou, Wei; Ås, Joel; Shore-Lorenti, Catherine; Nguyen, Hanh H. et al.

Ingår i Journal of Bone and Mineral Research, s. 1315-1326, 2024

• DOI för Gene-based association analysis of a large patient cohort provides insights into genetics of atypical femur fractures
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Genomic Analysis of Adverse Drug Reactions

Ås, Joel

2024

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Whole genome case-control study of central nervous system toxicity due to antimicrobial drugs

Ås, Joel; Bertulyte, Ilma; Norgren, Nina; Johansson, Anna et al.

Ingår i PLOS ONE, 2024

• DOI för Whole genome case-control study of central nervous system toxicity due to antimicrobial drugs
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Identification of risk factors for adverse drug reactions in a pharmacovigilance database

Attelind, Sofia; Eriksson, Niclas; Sundstroem, Anders; Wadelius, Mia et al.

Ingår i Pharmacoepidemiology and Drug Safety, s. 1431-1438, 2023

• DOI för Identification of risk factors for adverse drug reactions in a pharmacovigilance database
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Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial

Kempen, Thomas; Hedman, Anton N.; Hadziosmanovic, Nermin; Lindner, Karl‐Johan et al.

Ingår i British Journal of Clinical Pharmacology, s. 1575-1587, 2023

• DOI för Risk factors for and preventability of drug‐related hospital revisits in older patients: A post‐hoc analysis of a randomized clinical trial
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Vitamin D and bone metabolism in Graves’ disease: a prospective study

Khamisi, Selwan; Lundqvist, Martin H.; Rasmusson, Annica J.; Edén Engström, Britt et al.

Ingår i Journal of Endocrinological Investigation, s. 425-433, 2023

• DOI för Vitamin D and bone metabolism in Graves’ disease: a prospective study
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Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

Ollila, Hanna M.; Sharon, Eilon; Lin, Ling; Sinnott-Armstrong, Nasa et al.

Ingår i Nature Communications, 2023

• DOI för Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy
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Elevated low-density lipoprotein cholesterol: An inverse marker of morbidity and mortality in patients with myocardial infarction

Schubert, Jessica; Lindahl, Bertil; Melhus, Håkan; Renlund, Henrik et al.

Ingår i Journal of Internal Medicine, s. 616-627, 2023

• DOI för Elevated low-density lipoprotein cholesterol: An inverse marker of morbidity and mortality in patients with myocardial infarction
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Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events

Attelind, Sofia; Hallberg, Pär; Wadelius, Mia; Hamberg, Anna-Karin et al.

Ingår i Frontiers in Genetics, 2022

• DOI för Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic events
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General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children

Bouazza, Naim; Dokoumetzidis, Aristides; Knibbe, Catherijne A. J.; de Wildt, Saskia N. et al.

Ingår i British Journal of Clinical Pharmacology, s. 4985-4996, 2022

• DOI för General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children

Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty

Brüggemann, Anders; Eriksson, Niclas; Michaëlsson, Karl; Hailer, Nils

Ingår i Journal of Bone and Joint Surgery, s. 610-620, 2022

• DOI för Risk of Revision After Arthroplasty Associated withSpecific Gene Loci: A Genomewide Association Study of Single-Nucleotide Polymorphisms in 1,130 TwinsTreated with Arthroplasty
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Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate

Cavalli, Marco; Eriksson, Niclas; Karlsson Sundbaum, Johanna; Wallenberg, Matilda et al.

Ingår i Pharmacogenomics (London), s. 813-820, 2022

• DOI för Genome-wide association study of liver enzyme elevation in an extended cohort of rheumatoid arthritis patients starting low-dose methotrexate
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The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms

Cooper-DeHoff, Rhonda M.; Niemi, Mikko; Ramsey, Laura B.; Luzum, Jasmine A. et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 1007-1021, 2022

• DOI för The Clinical Pharmacogenetics Implementation Consortium Guideline for SLCO1B1, ABCG2, and CYP2C9 genotypes and Statin-Associated Musculoskeletal Symptoms

Implementing precision medicine in a regionally organized healthcare system in Sweden.

Fioretos, Thoas; Wirta, Valtteri; Cavelier, Lucia; Berglund, Eva et al.

Ingår i Nature Medicine, s. 1980-1982, 2022

• DOI för Implementing precision medicine in a regionally organized healthcare system in Sweden.

Mast cell chymase has a negative impact on human osteoblasts

Lind, Thomas; Melo, Fabio R.; Gustafson, Ann-Marie; Sundqvist, Anders et al.

Ingår i Matrix Biology, s. 1-19, 2022

• DOI för Mast cell chymase has a negative impact on human osteoblasts
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Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes

Mathey, Carina M; Maj, Carlo; Scheer, Annika B; Fazaal, Julia et al.

Ingår i Frontiers in Genetics, 2022

• DOI för Molecular Genetic Screening in Patients With ACE Inhibitor/Angiotensin Receptor Blocker-Induced Angioedema to Explore the Role of Hereditary Angioedema Genes
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Chapter 73: Pharmacogenetics

McMillin, Gwendolyn A; Wadelius, Mia; Pratt, Victoria M

Ingår i Tietz Textbook of Laboratory Medicine, 7th Edition, Elsevier, 2022

The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design

Michaelsson, Madeleine; Yuan, Shuai; Melhus, Håkan; Baron, John A. et al.

Ingår i BMC Medicine, 2022

• DOI för The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample Mendelian randomization design
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Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden

Sulku, Johanna; Janson, Christer; Melhus, Håkan; Ställberg, Björn et al.

Ingår i Respiratory Medicine, 2022

• DOI för Changes in critical inhaler technique errors in inhaled COPD treatment: A one-year follow-up study in Sweden
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HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease

Ås, Joel; Bertulyte, Ilma; Eriksson, Niclas; Magnusson, Patrik K. E. et al.

Ingår i Clinical and Translational Science, s. 1249-1256, 2022

• DOI för HLA variants associated with azathioprine-induced pancreatitis in patients with Crohn's disease
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Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Byrgazov, Konstantin; Lind, Thomas; Rasmusson, Annica J.; Andersson, Claes et al.

Ingår i Bone Reports, 2021

• DOI för Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Farmakogenomik – individuell anpassning av läkemedel och dos: [Pharmacogenomics - a cornerstone of Precision Medicine. Genomic Medicine Sweden analyses genotypes associated with serious drug toxicity or therapeutic failure]

Eliasson, Erik; Wadelius, Mia

Ingår i Läkartidningen, 2021

Technological readiness and implementation of genomic-driven precision medicine for complex diseases

Franks, P. W.; Melén, E.; Friedman, M.; Sundström, Johan et al.

Ingår i Journal of Internal Medicine, s. 602-620, 2021

• DOI för Technological readiness and implementation of genomic-driven precision medicine for complex diseases
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Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors

Ghouse, Jonas; Ahlberg, Gustav; Andreasen, Laura; Banasi, Karina et al.

Ingår i Journal of the American College of Cardiology, s. 696-709, 2021

• DOI för Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors

Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate

Karlsson Sundbaum, Johanna; Baecklund, Eva; Eriksson, Niclas; Kohnke, Hugo et al.

Ingår i Pharmacogenomics (London), s. 973-982, 2021

• DOI för Genome-wide association study of liver enzyme elevation in rheumatoid arthritis patients starting methotrexate
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Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial

Kempen, Thomas; Bertilsson, Maria; Hadziosmanovic, Nermin; Lindner, Karl-Johan et al.

Ingår i JAMA Network Open, 2021

• DOI för Effects of Hospital-Based Comprehensive Medication Reviews Including Postdischarge Follow-up on Older Patients' Use of Health Care: A Cluster Randomized Clinical Trial
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Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis

Mahmoodi, Bakhtawar K.; Eriksson, Niclas; Vos, Gerrit J. A.; Meijer, Karina et al.

Ingår i Journal of the American Heart Association, 2021

• DOI för Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis
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Type 2 diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Elderly Swedish Men and Women: Supplementary material

Mitchell, Adam; Fall, Tove; Melhus, Håkan; Lind, Lars et al.

2021

Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years

Mitchell, Adam; Fall, Tove; Melhus, Håkan; Lind, Lars et al.

Ingår i Journal of Clinical Endocrinology and Metabolism, s. 2840-2854, 2021

• DOI för Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years
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Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?

Mitchell, Adam; Fall, Tove; Melhus, Håkan; Wolk, Alicja et al.

Ingår i International Journal of Epidemiology, s. 234-244, 2021

• DOI för Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?
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Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study

Mitchell, Adam; Larsson, Susanna C.; Fall, Tove; Melhus, Håkan et al.

Ingår i Diabetologia, s. 1348-1357, 2021

• DOI för Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study
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Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens

Nicoletti, Paola; Devarbhavi, Harshad; Goel, Ashish; Venkatesan, Radha et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 1125-1135, 2021

• DOI för Genetic Risk Factors in Drug-Induced Liver Injury Due to Isoniazid-Containing Antituberculosis Drug Regimens
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Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema

Pall, Amalie Hartvig; Rasmussen, Eva Rye; Wadelius, Mia

Ingår i Pharmacogenomics (London), s. 319-321, 2021

• DOI för Pharmacogenetics of angiotensin-converting enzyme inhibitor-induced angioedema

Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study

Schubert, Jessica; Lindahl, Bertil; Melhus, Håkan; Renlund, Henrik et al.

Ingår i European Heart Journal, s. 243-252, 2021

• DOI för Low-density lipoprotein cholesterol reduction and statin intensity in myocardial infarction patients and major adverse outcomes: a Swedish nationwide cohort study
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Fördelaktigt med genetisk analys före behandling med 5-fluorouracil: Utvärdering tyder på mindre biverkningar och kostnadsbesparing för sjukvården: [New recommendation on pharmacogenetic screening prior to 5-fluorouracil based cancer treatment - Swedish experience indicates less adverse effects and healthcare cost savings]

Schultz, Alice; Kohnke, Hugo; Wadelius, Mia; Nygren, Peter

Ingår i Läkartidningen, 2021

Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations

Sulku, Johanna; Bröms, Kristina; Högman, Marieann; Janson, Christer et al.

Ingår i npj Primary Care Respiratory Medicine, 2021

• DOI för Critical inhaler technique errors in Swedish patients with COPD: a cross-sectional study analysing video-recorded demonstrations
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High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis

Cismaru, Anca Liliana; Grimm, Livia; Rudin, Deborah; Ibanez, Luisa et al.

Ingår i Frontiers in Genetics, 2020

• DOI för High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis
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Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations

Cismaru, Anca Liliana; Rudin, Deborah; Ibanez, Luisa; Liakoni, Evangelia et al.

Ingår i Genes, 2020

• DOI för Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations
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SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions

Hallberg, Pär; Yue, Qun-Ying; Eliasson, Erik; Melhus, Håkan et al.

Ingår i The Pharmacogenomics Journal, s. 579-585, 2020

• DOI för SWEDEGENE: a Swedish nation-wide DNA sample collection for pharmacogenomic studies of serious adverse drug reactions
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MTHFR, TYMS and SLCO1B1 polymorphisms and adverse liver effects of methotrexate in rheumatoid arthritis

Karlsson Sundbaum, Johanna; Baecklund, Eva; Eriksson, Niclas; Hallberg, Pär et al.

Ingår i Pharmacogenomics (London), s. 337-346, 2020

• DOI för MTHFR, TYMS and SLCO1B1 polymorphisms and adverse liver effects of methotrexate in rheumatoid arthritis

Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.

Kempen, Thomas; Cam, Henrik; Kälvemark, Amanda; Lindner, Karl-Johan et al.

Ingår i Journal of Clinical Pharmacy and Therapeutics, s. 1021-1029, 2020

• DOI för Intervention fidelity and process outcomes of medication reviews including post-discharge follow-up in older hospitalized patients: Process evaluation of the MedBridge trial.
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Comprehensive medication reviews by ward-based pharmacists in Swedish hospitals: What does the patient have to say?

Kempen, Thomas Gerardus Hendrik; Kälvemark, Amanda; Gillespie, Ulrika; Stewart, Derek

Ingår i Journal of Evaluation In Clinical Practice, s. 149-157, 2020

• DOI för Comprehensive medication reviews by ward-based pharmacists in Swedish hospitals: What does the patient have to say?

Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients

Kempen, Thomas; Kälvemark, Amanda; Sawires, Maria; Stewart, Derek et al.

Ingår i European Journal of Clinical Pharmacology, s. 775-784, 2020

• DOI för Facilitators and barriers for performing comprehensive medication reviews and follow-up by multiprofessional teams in older hospitalised patients
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Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema

Maroteau, Cyrielle; Siddiqui, Moneeza Kalhan; Veluchamy, Abirami; Carr, Fiona et al.

Ingår i Clinical Pharmacology and Therapeutics, s. 1195-1202, 2020

• DOI för Exome sequencing reveals common and rare variants in F5 associated with ACE inhibitor and angiotensin receptor blocker-induced angioedema
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Combined associations of body mass index and adherence to a Mediterranean-like diet with all-cause and cardiovascular mortality: A cohort study

Michaëlsson, Karl; Baron, John A.; Byberg, Liisa; Höijer, Jonas et al.

Ingår i PLoS Medicine, 2020

• DOI för Combined associations of body mass index and adherence to a Mediterranean-like diet with all-cause and cardiovascular mortality: A cohort study
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Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics.

Morales-Rosado, Joel A; Goel, Kashish; Zhang, Lingxin; Åkerblom, Axel et al.

Ingår i Cardiovascular Drugs and Therapy, s. 549-559, 2020

• DOI för Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics.