Mårten Fryknäs

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Ingår i Cell Reports, s. 977-990, 2017

• DOI för Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
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Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Ingår i Cancer Research, s. 802-812, 2017

• DOI för Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Segerman, Anna; Niklasson, Mia; Haglund, Caroline; Bergström, Tobias et al.

Ingår i Cell Reports, s. 2994-3009, 2016

• DOI för Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition
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Iron chelators target both proliferating and quiescent cancer cells

Fryknäs, Mårten; Zhang, Xiaonan; Bremberg, Ulf; Senkowski, Wojciech et al.

Ingår i Scientific Reports, 2016

• DOI för Iron chelators target both proliferating and quiescent cancer cells
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Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Senkowski, Wojciech; Jarvius, Malin; Rubin, Jenny; Lengqvist, Johan et al.

Ingår i CELL CHEMICAL BIOLOGY, s. 1428-1438, 2016

• DOI för Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Repositioning Of Quinacrine For Treatment Of Acute Myeloid Leukemia - Synergies And In Vivo Effects

Eriksson, Anna; Gustafsson, Mats; Fryknäs, Mårten; Gullbo, Joachim et al.

Ingår i Haematologica, s. 367-368, 2016

Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

Aftab, Obaid; Fryknäs, Mårten; Hassan, Saadia; Nygren, Peter et al.

Ingår i Chemometrics and Intelligent Laboratory Systems, s. 24-32, 2015

• DOI för Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Senkowski, Wojciech; Zhang, Xiaonan; Nygren, Peter; Olofsson, Maria Hagg et al.

Ingår i Cancer Research, 2015

• DOI för Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Isacson, Ruben et al.

Ingår i Molecular Cancer Therapeutics, s. 1504-1516, 2015

• DOI för Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Mazurkiewicz, Magdalena; Brnjic, Slavica; Fryknas, Marten; Sun, Chao et al.

Ingår i Cancer Research, 2015

• DOI för The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

Eriksson, Anna; Österroos, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood Cancer Journal, 2015

• DOI för Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia
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In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index

Kashif, Muhammad; Andersson, Claes; Hassan, Sadia; Karlsson, Henning et al.

Ingår i Scientific Reports, 2015

• DOI för In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index
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Detection of cell aggregation and altered cell viability by automated label-free video microscopy: A promising alternative to endpoint viability assays in high throughput screening

Aftab, Obaid; Fryknäs, Mårten; Hammerling, Ulf; Larsson, Rolf et al.

Ingår i Journal of Biomolecular Screening, s. 372-381, 2015

• DOI för Detection of cell aggregation and altered cell viability by automated label-free video microscopy: A promising alternative to endpoint viability assays in high throughput screening

Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

Kolosenko, Iryna; Fryknäs, Mårten; Forsberg, Sofi; Johnsson, Per et al.

Ingår i International Journal of Cancer, 2015

• DOI för Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Brnjic, Slavica; Mazurkiewicz, Magdalena; Fryknäs, Mårten; Sun, Chao et al.

Ingår i Antioxidants and Redox Signaling, s. 2271-2285, 2014

• DOI för Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Wang, Xin; Stafford, William; Mazurkiewicz, Magdalena; Fryknäs, Mårten et al.

Ingår i Molecular Pharmacology, s. 932-945, 2014

• DOI för The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Aftab, Obaid; Fryknäs, Mårten; Zhang, Xiaonan; De Milito, Angelo et al.

Ingår i Autophagy, s. 57-69, 2014

• DOI för Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Linder, Stig et al.

Ingår i Cancer Research, 2014

• DOI för A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Ingår i Nature Communications, s. 3295, 2014

• DOI för Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
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Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases

Sun, Chao; Roboti, Peristera; Puumalainen, Marjo-Riitta; Fryknäs, Mårten et al.

Ingår i PLOS ONE, 2014

• DOI för Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases
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AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

Eriksson, Anna; Kalushkova, Antonia; Jarvius, Malin; Hilhorst, Riet et al.

Ingår i Biochemical Pharmacology, s. 284-291, 2014

• DOI för AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia
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Label free high throughput screening for apoptosis inducing chemicals using time-lapse microscopy signal processing

Aftab, Obaid; Nazir, Madiha; Fryknäs, Mårten; Hammerling, Ulf et al.

Ingår i Apoptosis (London), s. 1411-1418, 2014

• DOI för Label free high throughput screening for apoptosis inducing chemicals using time-lapse microscopy signal processing

Identification of an inhibitor of the ubiquitin-proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function

Haglund, Caroline; Mohanty, Chitralekha; Fryknäs, Mårten; D'Arcy, Padraig et al.

Ingår i MedChemComm, s. 376-385, 2014

• DOI för Identification of an inhibitor of the ubiquitin-proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function
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Repositioning of Quinacrine for Treatment of Acute Myeloid Leukemia

Eriksson, Anna; Osterros, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood, 2014

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Fryknäs, Mårten; Gullbo, Joachim; Wang, Xin; Rickardson, Linda et al.

Ingår i BMC Cancer, s. 374, 2013

• DOI för Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance
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Effects of hypoxia on human cancer cell line chemosensitivity

Strese, Sara; Fryknäs, Mårten; Larsson, Rolf; Gullbo, Joachim

Ingår i BMC Cancer, s. 331, 2013

• DOI för Effects of hypoxia on human cancer cell line chemosensitivity
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Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

Felth, Jenny; Lesiak-Mieczkowska, Karolina; Haglund, Caroline; Gullbo, Joachim et al.

Ingår i Investigational new drugs, s. 587-598, 2013

• DOI för Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

Nygren, Peter; Fryknäs, Mårten; Anagel, Bengt; Larsson, Rolf

Ingår i Journal of Cancer Research and Clinical Oncology, s. 2133-2140, 2013

• DOI för Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer
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The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

Strese, Sara; Wickström, Malin; Fuchs, Peder Fredlund; Fryknäs, Mårten et al.

Ingår i Biochemical Pharmacology, s. 888-895, 2013

• DOI för The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

Cell crowding results in accumulation of interferon-stimulated genes independently of STAT1

Kolosenko, Iryna; Edsbacker, Elin; Fryknäs, Mårten; Johnsson, Per et al.

Ingår i Cytokine, s. 278-278, 2013

• DOI för Cell crowding results in accumulation of interferon-stimulated genes independently of STAT1

Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding

Tamm, Katia Pokrovskaja; Kolosenko, Iryna; Fryknäs, Mårten; Johnsson, Per et al.

Ingår i Cytokine, s. 303-303, 2013

• DOI för Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding

Alternative Cytotoxic Effects of the Postulated IGF-IR Inhibitor Picropodophyllin In Vitro

Wu, Xuping; Sooman, Linda; Wickström, Malin; Fryknäs, Mårten et al.

Ingår i Molecular Cancer Therapeutics, s. 1526-1536, 2013

• DOI för Alternative Cytotoxic Effects of the Postulated IGF-IR Inhibitor Picropodophyllin In Vitro

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Jarvius, Malin; Fryknäs, Mårten; D'Arcy, Padraig; Sun, Chao et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 117-123, 2013

• DOI för Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Ingår i BMC Cancer, s. 318, 2012

• DOI för Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
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Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)

Hashemi, Jamileh; Worrall, Claire; Vasilcanu, Daiana; Fryknäs, Mårten et al.

Ingår i PLOS ONE, 2011

• DOI för Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)

Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia

Hallböök, Helene; Felth, Jenny; Eriksson, Anna; Fryknäs, Mårten et al.

Ingår i PLOS ONE, 2011

• DOI för Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Gullbo, Joachim; Fryknäs, Mårten; Rickardson, Linda; Darcy, Padraig et al.

Ingår i Biochemical Pharmacology, s. 139-147, 2011

• DOI för Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Fayad, Walid; Rickardson, Linda; Haglund, Caroline; Hägg Olofsson, Maria et al.

Ingår i Chemical Biology and Drug Design, s. 547-557, 2011

• DOI för Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Novel activity of acriflavine against colorectal cancer tumor cells

Hassan, Saadia; Laryea, Daniel; Mahteme, Haile; Felth, Jenny et al.

Ingår i Cancer Science, s. 2206-2213, 2011

• DOI för Novel activity of acriflavine against colorectal cancer tumor cells

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

D'Arcy, Padraig; Brnjic, Slavica; Olofsson, Maria Hägg; Fryknäs, Mårten et al.

Ingår i Nature Medicine, s. 1636-1640, 2011

• DOI för Inhibition of proteasome deubiquitinating activity as a new cancer therapy

Improving Bayesian credibility intervals for classifier error rates using maximum entropy empirical priors

Gustafsson, Mats G.; Wallman, Mikael; Wickenberg-Bolin, Ulrika; Göransson, Hanna et al.

Ingår i Artificial Intelligence in Medicine, s. 93-104, 2010

• DOI för Improving Bayesian credibility intervals for classifier error rates using maximum entropy empirical priors

High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Leuchowius, Karl-Johan; Jarvius, Malin; Wickström, Malin; Rickardson, Linda et al.

Ingår i Molecular & Cellular Proteomics, s. 178-183, 2010

• DOI för High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Polycomb target genes are silenced in multiple myeloma

Kalushkova, Antonia; Fryknäs, Mårten; Lemaire, Miguel; Fristedt, Charlotte et al.

Ingår i PLOS ONE, 2010

• DOI för Polycomb target genes are silenced in multiple myeloma
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Stathmin as a Marker for Malignancy in Pheochromocytomas

Björklund, Peyman; Cupisti, Kenko; Fryknäs, Mårten; Isaksson, Anders et al.

Ingår i Experimental and clinical endocrinology & diabetes, s. 27-30, 2010

• DOI för Stathmin as a Marker for Malignancy in Pheochromocytomas

Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs

Felth, Jenny; Rickardson, Linda; Rosén, Josefin; Wickström, Malin et al.

Ingår i Journal of natural products (Print), s. 1969-1974, 2009

• DOI för Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

Fayad, Walid; Fryknäs, Mårten; Brnjic, Slavica; Olofsson, Maria Hägg et al.

Ingår i PLOS ONE, 2009

• DOI för Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells

Milani, Lili; Gupta, Manu; Andersen, M.; Dhar, Sumeer et al.

Ingår i Nucleic Acids Research, 2007

• DOI för Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells

STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

Fryknäs, Mårten; Dhar, Sumeer; Öberg, Fredrik; Rickardson, Linda et al.

Ingår i International Journal of Cancer, s. 189-195, 2007

• DOI för STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency

Andersson, Claes R.; Fryknäs, Mårten; Rickardson, Linda; Larsson, Rolf et al.

Ingår i Journal of chemical information and modeling, s. 239-248, 2007

• DOI för In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency

Improved variance estimation of classification performance via reduction of bias caused by small sample size

Wickenberg Bolin, Ulrika; Göransson, Hanna; Fryknäs, Mårten; Gustafsson, Mats G et al.

Ingår i BMC Bioinformatics, s. 127, 2006

Screening of an annotated compound library for drug activity in a resistant myeloma cell line

Rickardson, Linda; Fryknäs, Mårten; Haglund, Caroline; Lövborg, Henrik et al.

Ingår i Cancer Chemotherapy and Pharmacology, s. 749-758, 2006

• DOI för Screening of an annotated compound library for drug activity in a resistant myeloma cell line

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

Fryknäs, Mårten; Rickardson, Linda; Wickström, Malin; Dhar, Sumeer et al.

Ingår i Journal of Biomolecular Screening, s. 457-468, 2006

• DOI för Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

Molecular markers for discrimination of benign and malignant follicular thyroid tumors

Fryknäs, Mårten; Wickenberg Bolin, Ulrika; Göransson, Hanna; Gustafsson, Mats G et al.

Ingår i Tumor Biology, s. 211-220, 2006

• DOI för Molecular markers for discrimination of benign and malignant follicular thyroid tumors

Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles

Rickardson, Linda; Fryknäs, Mårten; Dhar, Sumeer; Lövborg, Henrik et al.

Ingår i British Journal of Cancer, s. 483-492, 2005

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Mansoori, Sharmineh; Blom, Kristin; Andersson, Claes; Fryknäs, Mårten et al.

Ingår i Oncology Reports, 2026

• DOI för Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model
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Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Ingår i Scientific Reports, 2026

• DOI för Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus
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Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Selvin, Tove; Berglund, Malin; Akerstrom, Anders; Zia, Marco et al.

Ingår i SLAS TECHNOLOGY, 2024

• DOI för Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Ingår i Scientific Reports, 2024

• DOI för OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
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Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Ingår i BMC Pharmacology & Toxicology, 2024

• DOI för Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
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Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Mansoori, Sharmineh; Blom, Kristin; Andersson, Claes; Fryknäs, Mårten et al.

Ingår i Oncology Reports, 2026

• DOI för Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model
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Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Ingår i Scientific Reports, 2026

• DOI för Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus
• Ladda ner fulltext (pdf) av Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Selvin, Tove; Berglund, Malin; Akerstrom, Anders; Zia, Marco et al.

Ingår i SLAS TECHNOLOGY, 2024

• DOI för Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models
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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids

Mickols, Evgeniya; Meyer, Alina; Handin, Niklas; Stüwe, Malin et al.

Ingår i Scientific Reports, 2024

• DOI för OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
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Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Ingår i BMC Pharmacology & Toxicology, 2024

• DOI för Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
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Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma

Calitz, Carlemi; Rosenquist, Jenny; Degerstedt, Oliver; Khaled, Jaafar et al.

Ingår i Scientific Reports, 2023

• DOI för Influence of extracellular matrix composition on tumour cell behaviour in a biomimetic in vitro model for hepatocellular carcinoma
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Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Jarvius, Malin et al.

Ingår i BMC Cancer, 2023

• DOI för Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death
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Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients

Andersson, Claes; Ye, Jiawei; Blom, Kristin; Fryknäs, Mårten et al.

Ingår i Anti-Cancer Drugs, s. 92-102, 2023

• DOI för Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients
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Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells

Karlsson, Henning; Fryknäs, Mårten; Senkowski, Wojciech; Larsson, Rolf et al.

Ingår i Oncology Letters, 2022

• DOI för Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells
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Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model

Selvin, Tove; Fasterius, Erik; Jarvius, Malin; Fryknäs, Mårten et al.

Ingår i Scientific Reports, 2022

• DOI för Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model
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Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

Nyberg, Frida; Blom, Kristin; Selvin, Tove; Rudfeldt, Jakob et al.

Ingår i Scientific Reports, 2022

• DOI för Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma
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Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Lu, Xi; Maturi, Naga Prathyusha; Jarvius, Malin; Yildirim, Irem et al.

Ingår i Nature Communications, 2022

• DOI för Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival
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A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer

Mansoori, Sharmineh; Fryknäs, Mårten; Alvfors, Carina; Loskog, Angelica et al.

Ingår i Scientific Reports, 2021

• DOI för A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer
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Conditions for maintenance of hepatocyte differentiation and function in 3D cultures

Handin, Niklas; Mickols, Evgeniya; Ölander, Magnus; Rudfeldt, Jakob et al.

Ingår i iScience, 2021

• DOI för Conditions for maintenance of hepatocyte differentiation and function in 3D cultures
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Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Byrgazov, Konstantin; Lind, Thomas; Rasmusson, Annica J.; Andersson, Claes et al.

Ingår i Bone Reports, 2021

• DOI för Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide

Byrgazov, Konstantin; Andersson, Claes; Salzer, Benjamin; Bozsaky, Eva et al.

Ingår i Therapeutic Advances in Medical Oncology, 2020

• DOI för Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide
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Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway

Andersson, Claes; Selvin, Tove; Blom, Kristin; Rubin, Jenny et al.

Ingår i Scientific Reports, 2020

• DOI för Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway
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Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing.

Hartmann, Rafael; Fahrner, Raphael; Shevshenko, Denys; Fryknäs, Mårten et al.

Ingår i ChemMedChem, s. 2500-2512, 2020

• DOI för Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing.
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Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids

Steinmetz, Julia; Senkowski, Wojciech; Lengqvist, Johan; Rubin, Jenny et al.

Ingår i ACS Omega, s. 17242-17254, 2020

• DOI för Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids
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Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Blom, Kristin; Eriksson, Jenny; Berglund, Malin; Jarvius, Malin et al.

Ingår i BMC Research Notes, 2019

• DOI för Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition
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Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Ingår i Cell Reports, s. 977-990, 2017

• DOI för Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
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Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.

Eriksson, Anna; Chantzi, Efthymia; Fryknäs, Mårten; Gullbo, Joachim et al.

Ingår i Leukemia Research, s. 41-46, 2017

• DOI för Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.
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Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

Karlsson, Henning; Fryknäs, Mårten; Strese, Sara; Gullbo, Joachim et al.

Ingår i Oncotarget, s. 30217-30234, 2017

• DOI för Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity
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Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Ingår i Cancer Research, s. 802-812, 2017

• DOI för Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Targeting tumor cells based on Phosphodiesterase 3A expression

Nazir, Madiha; Senkowski, Wojciech; Nyberg, Frida; Blom, Kristin et al.

Ingår i Experimental Cell Research, s. 308-315, 2017

• DOI för Targeting tumor cells based on Phosphodiesterase 3A expression

The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Blom, Kristin; Senkowski, Wojciech; Jarvius, Malin; Berglund, Malin et al.

Ingår i Immunopharmacology and immunotoxicology, s. 199-210, 2017

• DOI för The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Segerman, Anna; Niklasson, Mia; Haglund, Caroline; Bergström, Tobias et al.

Ingår i Cell Reports, s. 2994-3009, 2016

• DOI för Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition
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Iron chelators target both proliferating and quiescent cancer cells

Fryknäs, Mårten; Zhang, Xiaonan; Bremberg, Ulf; Senkowski, Wojciech et al.

Ingår i Scientific Reports, 2016

• DOI för Iron chelators target both proliferating and quiescent cancer cells
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Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Senkowski, Wojciech; Jarvius, Malin; Rubin, Jenny; Lengqvist, Johan et al.

Ingår i CELL CHEMICAL BIOLOGY, s. 1428-1438, 2016

• DOI för Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Repositioning Of Quinacrine For Treatment Of Acute Myeloid Leukemia - Synergies And In Vivo Effects

Eriksson, Anna; Gustafsson, Mats; Fryknäs, Mårten; Gullbo, Joachim et al.

Ingår i Haematologica, s. 367-368, 2016

Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

Aftab, Obaid; Fryknäs, Mårten; Hassan, Saadia; Nygren, Peter et al.

Ingår i Chemometrics and Intelligent Laboratory Systems, s. 24-32, 2015

• DOI för Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Senkowski, Wojciech; Zhang, Xiaonan; Nygren, Peter; Olofsson, Maria Hagg et al.

Ingår i Cancer Research, 2015

• DOI för Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Isacson, Ruben et al.

Ingår i Molecular Cancer Therapeutics, s. 1504-1516, 2015

• DOI för Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Mazurkiewicz, Magdalena; Brnjic, Slavica; Fryknas, Marten; Sun, Chao et al.

Ingår i Cancer Research, 2015

• DOI för The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

Eriksson, Anna; Österroos, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood Cancer Journal, 2015

• DOI för Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia
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In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index

Kashif, Muhammad; Andersson, Claes; Hassan, Sadia; Karlsson, Henning et al.

Ingår i Scientific Reports, 2015

• DOI för In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index
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Detection of cell aggregation and altered cell viability by automated label-free video microscopy: A promising alternative to endpoint viability assays in high throughput screening

Aftab, Obaid; Fryknäs, Mårten; Hammerling, Ulf; Larsson, Rolf et al.

Ingår i Journal of Biomolecular Screening, s. 372-381, 2015

• DOI för Detection of cell aggregation and altered cell viability by automated label-free video microscopy: A promising alternative to endpoint viability assays in high throughput screening

Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

Kolosenko, Iryna; Fryknäs, Mårten; Forsberg, Sofi; Johnsson, Per et al.

Ingår i International Journal of Cancer, 2015

• DOI för Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Brnjic, Slavica; Mazurkiewicz, Magdalena; Fryknäs, Mårten; Sun, Chao et al.

Ingår i Antioxidants and Redox Signaling, s. 2271-2285, 2014

• DOI för Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Ingår i Nature Communications, s. 3295, 2014

The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Wang, Xin; Stafford, William; Mazurkiewicz, Magdalena; Fryknäs, Mårten et al.

Ingår i Molecular Pharmacology, s. 932-945, 2014

• DOI för The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Aftab, Obaid; Fryknäs, Mårten; Zhang, Xiaonan; De Milito, Angelo et al.

Ingår i Autophagy, s. 57-69, 2014

• DOI för Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Linder, Stig et al.

Ingår i Cancer Research, 2014

• DOI för A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Ingår i Nature Communications, s. 3295, 2014

• DOI för Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
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Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases

Sun, Chao; Roboti, Peristera; Puumalainen, Marjo-Riitta; Fryknäs, Mårten et al.

Ingår i PLOS ONE, 2014

• DOI för Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases
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AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

Eriksson, Anna; Kalushkova, Antonia; Jarvius, Malin; Hilhorst, Riet et al.

Ingår i Biochemical Pharmacology, s. 284-291, 2014

• DOI för AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia
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Label free high throughput screening for apoptosis inducing chemicals using time-lapse microscopy signal processing

Aftab, Obaid; Nazir, Madiha; Fryknäs, Mårten; Hammerling, Ulf et al.

Ingår i Apoptosis (London), s. 1411-1418, 2014

• DOI för Label free high throughput screening for apoptosis inducing chemicals using time-lapse microscopy signal processing

Identification of an inhibitor of the ubiquitin-proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function

Haglund, Caroline; Mohanty, Chitralekha; Fryknäs, Mårten; D'Arcy, Padraig et al.

Ingår i MedChemComm, s. 376-385, 2014

• DOI för Identification of an inhibitor of the ubiquitin-proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function
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Repositioning of Quinacrine for Treatment of Acute Myeloid Leukemia

Eriksson, Anna; Osterros, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood, 2014

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Fryknäs, Mårten; Gullbo, Joachim; Wang, Xin; Rickardson, Linda et al.

Ingår i BMC Cancer, s. 374, 2013

• DOI för Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance
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Effects of hypoxia on human cancer cell line chemosensitivity

Strese, Sara; Fryknäs, Mårten; Larsson, Rolf; Gullbo, Joachim

Ingår i BMC Cancer, s. 331, 2013

• DOI för Effects of hypoxia on human cancer cell line chemosensitivity
• Ladda ner fulltext (pdf) av Effects of hypoxia on human cancer cell line chemosensitivity

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

Felth, Jenny; Lesiak-Mieczkowska, Karolina; Haglund, Caroline; Gullbo, Joachim et al.

Ingår i Investigational new drugs, s. 587-598, 2013

• DOI för Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

Nygren, Peter; Fryknäs, Mårten; Anagel, Bengt; Larsson, Rolf

Ingår i Journal of Cancer Research and Clinical Oncology, s. 2133-2140, 2013

• DOI för Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer
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The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

Strese, Sara; Wickström, Malin; Fuchs, Peder Fredlund; Fryknäs, Mårten et al.

Ingår i Biochemical Pharmacology, s. 888-895, 2013

• DOI för The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

Cell crowding results in accumulation of interferon-stimulated genes independently of STAT1

Kolosenko, Iryna; Edsbacker, Elin; Fryknäs, Mårten; Johnsson, Per et al.

Ingår i Cytokine, s. 278-278, 2013

• DOI för Cell crowding results in accumulation of interferon-stimulated genes independently of STAT1

Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding

Tamm, Katia Pokrovskaja; Kolosenko, Iryna; Fryknäs, Mårten; Johnsson, Per et al.

Ingår i Cytokine, s. 303-303, 2013

• DOI för Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding

Alternative Cytotoxic Effects of the Postulated IGF-IR Inhibitor Picropodophyllin In Vitro

Wu, Xuping; Sooman, Linda; Wickström, Malin; Fryknäs, Mårten et al.

Ingår i Molecular Cancer Therapeutics, s. 1526-1536, 2013

• DOI för Alternative Cytotoxic Effects of the Postulated IGF-IR Inhibitor Picropodophyllin In Vitro

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Jarvius, Malin; Fryknäs, Mårten; D'Arcy, Padraig; Sun, Chao et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 117-123, 2013

• DOI för Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Hernlund, Emma; Olofsson, Maria Hägg; Fayad, Walid; Fryknäs, Mårten et al.

Ingår i European Journal of Cancer, s. 396-406, 2012

• DOI för The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Ingår i BMC Cancer, s. 318, 2012

• DOI för Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
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Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

Karlsson, Henning; Fryknäs, Mårten; Larsson, Rolf; Nygren, Peter

Ingår i Experimental Cell Research, s. 1577-1585, 2012

• DOI för Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)

Hashemi, Jamileh; Worrall, Claire; Vasilcanu, Daiana; Fryknäs, Mårten et al.

Ingår i PLOS ONE, 2011

• DOI för Molecular Characterization of Acquired Tolerance of Tumor Cells to Picropodophyllin (PPP)

Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia

Hallböök, Helene; Felth, Jenny; Eriksson, Anna; Fryknäs, Mårten et al.

Ingår i PLOS ONE, 2011

• DOI för Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Gullbo, Joachim; Fryknäs, Mårten; Rickardson, Linda; Darcy, Padraig et al.

Ingår i Biochemical Pharmacology, s. 139-147, 2011

• DOI för Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Fayad, Walid; Rickardson, Linda; Haglund, Caroline; Hägg Olofsson, Maria et al.

Ingår i Chemical Biology and Drug Design, s. 547-557, 2011

• DOI för Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Novel activity of acriflavine against colorectal cancer tumor cells

Hassan, Saadia; Laryea, Daniel; Mahteme, Haile; Felth, Jenny et al.

Ingår i Cancer Science, s. 2206-2213, 2011

• DOI för Novel activity of acriflavine against colorectal cancer tumor cells

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

D'Arcy, Padraig; Brnjic, Slavica; Olofsson, Maria Hägg; Fryknäs, Mårten et al.

Ingår i Nature Medicine, s. 1636-1640, 2011

• DOI för Inhibition of proteasome deubiquitinating activity as a new cancer therapy

Improving Bayesian credibility intervals for classifier error rates using maximum entropy empirical priors

Gustafsson, Mats G.; Wallman, Mikael; Wickenberg-Bolin, Ulrika; Göransson, Hanna et al.

Ingår i Artificial Intelligence in Medicine, s. 93-104, 2010

• DOI för Improving Bayesian credibility intervals for classifier error rates using maximum entropy empirical priors

The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan

Wickström, Malin; Viktorsson, Kristina; Lundholm, Lovisa; Aesoy, Reidun et al.

Ingår i Biochemical Pharmacology, s. 1281-1290, 2010

• DOI för The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan

High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Leuchowius, Karl-Johan; Jarvius, Malin; Wickström, Malin; Rickardson, Linda et al.

Ingår i Molecular & Cellular Proteomics, s. 178-183, 2010

• DOI för High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Polycomb target genes are silenced in multiple myeloma

Kalushkova, Antonia; Fryknäs, Mårten; Lemaire, Miguel; Fristedt, Charlotte et al.

Ingår i PLOS ONE, 2010

• DOI för Polycomb target genes are silenced in multiple myeloma
• Ladda ner fulltext (pdf) av Polycomb target genes are silenced in multiple myeloma

Stathmin as a Marker for Malignancy in Pheochromocytomas

Björklund, Peyman; Cupisti, Kenko; Fryknäs, Mårten; Isaksson, Anders et al.

Ingår i Experimental and clinical endocrinology & diabetes, s. 27-30, 2010

• DOI för Stathmin as a Marker for Malignancy in Pheochromocytomas

Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs

Felth, Jenny; Rickardson, Linda; Rosén, Josefin; Wickström, Malin et al.

Ingår i Journal of natural products (Print), s. 1969-1974, 2009

• DOI för Cytotoxic effects of cardiac glycosides in colon cancer cells, alone and in combination with standard chemotherapeutic drugs

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

Fayad, Walid; Fryknäs, Mårten; Brnjic, Slavica; Olofsson, Maria Hägg et al.

Ingår i PLOS ONE, 2009

• DOI för Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

Gene expression signature-based chemcial genomics and activity pattern in a panel of tumour cell lines propose linalyl acetate as a protein kinase/NF-κB inhibitor

Hassan, Saadia; Lindhagen, Elin; Göransson, Hanna; Fryknäs, Mårten et al.

Ingår i Gene Therapy and Molecular Biology, s. 359-370, 2008

Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells

Milani, Lili; Gupta, Manu; Andersen, M.; Dhar, Sumeer et al.

Ingår i Nucleic Acids Research, 2007

• DOI för Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells

STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

Fryknäs, Mårten; Dhar, Sumeer; Öberg, Fredrik; Rickardson, Linda et al.

Ingår i International Journal of Cancer, s. 189-195, 2007

• DOI för STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency

Andersson, Claes R.; Fryknäs, Mårten; Rickardson, Linda; Larsson, Rolf et al.

Ingår i Journal of chemical information and modeling, s. 239-248, 2007

• DOI för In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency

Improved variance estimation of classification performance via reduction of bias caused by small sample size

Wickenberg Bolin, Ulrika; Göransson, Hanna; Fryknäs, Mårten; Gustafsson, Mats G et al.

Ingår i BMC Bioinformatics, s. 127, 2006

Screening of an annotated compound library for drug activity in a resistant myeloma cell line

Rickardson, Linda; Fryknäs, Mårten; Haglund, Caroline; Lövborg, Henrik et al.

Ingår i Cancer Chemotherapy and Pharmacology, s. 749-758, 2006

• DOI för Screening of an annotated compound library for drug activity in a resistant myeloma cell line

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

Fryknäs, Mårten; Rickardson, Linda; Wickström, Malin; Dhar, Sumeer et al.

Ingår i Journal of Biomolecular Screening, s. 457-468, 2006

• DOI för Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

Molecular markers for discrimination of benign and malignant follicular thyroid tumors

Fryknäs, Mårten; Wickenberg Bolin, Ulrika; Göransson, Hanna; Gustafsson, Mats G et al.

Ingår i Tumor Biology, s. 211-220, 2006

• DOI för Molecular markers for discrimination of benign and malignant follicular thyroid tumors

Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles

Rickardson, Linda; Fryknäs, Mårten; Dhar, Sumeer; Lövborg, Henrik et al.

Ingår i British Journal of Cancer, s. 483-492, 2005

Drug combination screening in multicellular tumor spheroids identifies synthetic lethalities in quiescent cancer cells

Senkowski, Wojciech; Nazir, Madiha; Gustafsson, Mats G; Nygren, Peter et al.

The hollow fiber assay for modeling quiescent cancer cells in vitro and in vivo 

Ek, Frida; Selvin, Tove; Fryknäs, Mårten

Paired glioblastoma cell cultures of the fluorescent bulk tumor and non-fluorescent tumor margin display differential phenotypes and cell states across patients

Neves, Inês; Lu, Xi; Maturi, Nagaprathyusha; Dang, Yonglong et al.

Proteome-wide thermal profiling supports MAPK14/p38α engagement by mebendazole

Mansoori, Sharmineh; Qi, Xuekang; Jafari, Rozbeh; Orre, Lukas et al.