Ihor Yakymovych

SHP2 negatively regulates TGF-β signaling by destabilizing the TGF-β type I receptor

Zhao, Cen; Yakymovych, Ihor; Yakymovych, Mariya; Xing, Pengwei et al.

Ingår i Cell Communication and Signaling, 2026

• DOI för SHP2 negatively regulates TGF-β signaling by destabilizing the TGF-β type I receptor
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The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling

Yakymovych, Ihor; Yakymovych, Mariya; Hamidi, Anahita; Landström, Maréne et al.

Ingår i Science Signaling, 2022

• DOI för The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling
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The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Song, Jie; Zhou, Yang; Yakymovych, Ihor; Schmidt, Alexej et al.

Ingår i EBioMedicine, 2022

• DOI för The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
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Intracellular trafficking of transforming growth factor beta receptors

Yakymovych, Ihor; Yakymovych, Mariya; Heldin, Carl-Henrik

Ingår i Acta biochimica et biophysica Sinica, s. 3-11, 2018

• DOI för Intracellular trafficking of transforming growth factor beta receptors

CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface

Yakymovych, Ihor; Yakymovych, Mariya; Zang, Guangxiang; Mu, Yabing et al.

Ingår i Journal of Cell Biology, s. 319-332, 2015

• DOI för CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface
• Ladda ner fulltext (pdf) av CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface

SHP2 negatively regulates TGF-β signaling by destabilizing the TGF-β type I receptor

Zhao, Cen; Yakymovych, Ihor; Yakymovych, Mariya; Xing, Pengwei et al.

Ingår i Cell Communication and Signaling, 2026

• DOI för SHP2 negatively regulates TGF-β signaling by destabilizing the TGF-β type I receptor
• Ladda ner fulltext (pdf) av SHP2 negatively regulates TGF-β signaling by destabilizing the TGF-β type I receptor

The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling

Yakymovych, Ihor; Yakymovych, Mariya; Hamidi, Anahita; Landström, Maréne et al.

Ingår i Science Signaling, 2022

• DOI för The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling
• Ladda ner fulltext (pdf) av The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling

The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Song, Jie; Zhou, Yang; Yakymovych, Ihor; Schmidt, Alexej et al.

Ingår i EBioMedicine, 2022

• DOI för The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
• Ladda ner fulltext (pdf) av The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface

Yakymovych, Ihor; Yakymovych, Mariya; Zang, Guangxiang; Mu, Yabing et al.

Ingår i Journal of Cell Biology, s. 319-332, 2015

• DOI för CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface
• Ladda ner fulltext (pdf) av CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface

Phosphorylation of eEF1A1 at Ser300 by T beta R-I Results in Inhibition of mRNA Translation

Lin, Kah Wai; Yakymovych, Ihor; Jia, Min; Yakymovych, Mariya et al.

Ingår i Current Biology, s. 1615-1625, 2010

• DOI för Phosphorylation of eEF1A1 at Ser300 by T beta R-I Results in Inhibition of mRNA Translation

Interactome of transforming growth factor-beta type I receptor (T beta RI): Inhibition of TGF beta signaling by Epac1

Conrotto, Paolo; Yakymovych, Ihor; Yakymovych, Mariya; Souchelnytskyi, Serhiy

Ingår i Journal of Proteome Research, s. 287-297, 2007

• DOI för Interactome of transforming growth factor-beta type I receptor (T beta RI): Inhibition of TGF beta signaling by Epac1

Glycoproteome profiling of transforming growth factor-beta (TGF beta) signaling: Nonglycosylated cell death-inducing DFF-like effector A inhibits TGF beta 1-dependent apoptosis

Iwahana, Hiroyuki; Yakymovych, Ihor; Dubrovska, Anna; Hellman, Ulf et al.

Ingår i Proteomics, s. 6168-6180, 2006

• DOI för Glycoproteome profiling of transforming growth factor-beta (TGF beta) signaling: Nonglycosylated cell death-inducing DFF-like effector A inhibits TGF beta 1-dependent apoptosis

Phosphoproteome profiling of transforming growth factor (TGF)-beta signaling: abrogation of TGFbeta1-dependent phosphorylation of transcription factor-II-I (TFII-I) enhances cooperation of TFII-I and Smad3 in transcription

Stasyk, Taras; Dubrovska, Anna; Lomnytska, Marta; Yakymovych, Ihor et al.

Ingår i Molecular Biology of the Cell, s. 4765-4780, 2005

• DOI för Phosphoproteome profiling of transforming growth factor (TGF)-beta signaling: abrogation of TGFbeta1-dependent phosphorylation of transcription factor-II-I (TFII-I) enhances cooperation of TFII-I and Smad3 in transcription

Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice

Sjöblom, Tobias; Yakymovych, Ihor; Heldin, Carl-Henrik; Östman, Arne et al.

Ingår i European Journal of Cancer, s. 267-274, 2004

• DOI för Smad2 suppresses the growth of Mv1Lu cells subcutaneously inoculated in mice

Smad2 phosphorylation by type I receptor: contribution of arginine 462 and cysteine 463 In the C terminus of Smad2 for specificity

Yakymovych, Ihor; Heldin, Carl-Henrik; Souchelnytskyi, Serhiy

Ingår i Journal of Biological Chemistry, s. 35781-35787, 2004

• DOI för Smad2 phosphorylation by type I receptor: contribution of arginine 462 and cysteine 463 In the C terminus of Smad2 for specificity

Potential role of transforming growth factor beta1 in drug resistance of tumor cells

Stoika, Rostyslav; Yakymovych, Mariya; Souchelnytskyi, Serhiy; Yakymovych, Ihor

Ingår i Acta Biochimica Polonica, s. 497-508, 2003

BRCA2 and Smad3 synergize in regulation of gene transcription

Preobrazhenska, Olena; Yakymovych, Mariya; Kanamoto, Takashi; Yakymovych, Ihor et al.

Ingår i Oncogene, s. 5660-5664, 2002

Inhibition of transforming growth factor-beta signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF beta type I receptor kinase

Yakymovych, Ihor; Engström, Ulla; Grimsby, Susanne; Heldin, Carl-Henrik et al.

Ingår i Biochemistry, s. 11000-11007, 2002

• DOI för Inhibition of transforming growth factor-beta signaling by low molecular weight compounds interfering with ATP- or substrate-binding sites of the TGF beta type I receptor kinase

Regulation of Smad signaling by protein kinase C

Yakymovych, Ihor; ten Dijke, Peter; Heldin, Carl-Henrik; Souchelnytskyi, Serhiy

Ingår i The FASEB Journal, s. 553-555, 2001

• DOI för Regulation of Smad signaling by protein kinase C

Intracellular trafficking of transforming growth factor beta receptors

Yakymovych, Ihor; Yakymovych, Mariya; Heldin, Carl-Henrik

Ingår i Acta biochimica et biophysica Sinica, s. 3-11, 2018

• DOI för Intracellular trafficking of transforming growth factor beta receptors