Karin Fromell

Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes

Eikrem, David; Manivel, Vivek Anand; Whittaker, Jacob; Hamad, Osama A. et al.

Ingår i Frontiers in Immunology, 2025

• DOI för Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes
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Changes in the pulmonary surfactant in patients with mild to moderate COVID-19

Kokelj, Spela; Larsson, Per; Viklund, Emilia; Koca, Hatice et al.

Ingår i PLOS ONE, 2025

• DOI för Changes in the pulmonary surfactant in patients with mild to moderate COVID-19
• Ladda ner fulltext (pdf) av Changes in the pulmonary surfactant in patients with mild to moderate COVID-19

The blood response to subway-derived iron nanoparticles

Ekdahl, Kristina N.; Monie, Lisa; Juárez-Facio, Ana T.; Olofsson, Ulf et al.

Ingår i Environmental Toxicology and Pharmacology, 2025

• DOI för The blood response to subway-derived iron nanoparticles
• Ladda ner fulltext (pdf) av The blood response to subway-derived iron nanoparticles

Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro

Adler, Anna; Fritsch, Marlene; Fromell, Karin; Leneweit, Gero et al.

Ingår i Journal of materials chemistry. B, s. 11121-11134, 2023

• DOI för Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro
• Ladda ner fulltext (pdf) av Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Martin, Myriam; Nilsson, Sara C. C.; Eikrem, David; Fromell, Karin et al.

Ingår i Frontiers in Immunology, 2023

• DOI för Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis
• Ladda ner fulltext (pdf) av Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes

Eikrem, David; Manivel, Vivek Anand; Whittaker, Jacob; Hamad, Osama A. et al.

Ingår i Frontiers in Immunology, 2025

• DOI för Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes
• Ladda ner fulltext (pdf) av Native C3 is activated without proteolytic cleavage by transformation to C3(H2O) on phospholipid-scrambled cell membranes

Changes in the pulmonary surfactant in patients with mild to moderate COVID-19

Kokelj, Spela; Larsson, Per; Viklund, Emilia; Koca, Hatice et al.

Ingår i PLOS ONE, 2025

• DOI för Changes in the pulmonary surfactant in patients with mild to moderate COVID-19
• Ladda ner fulltext (pdf) av Changes in the pulmonary surfactant in patients with mild to moderate COVID-19

The blood response to subway-derived iron nanoparticles

Ekdahl, Kristina N.; Monie, Lisa; Juárez-Facio, Ana T.; Olofsson, Ulf et al.

Ingår i Environmental Toxicology and Pharmacology, 2025

• DOI för The blood response to subway-derived iron nanoparticles
• Ladda ner fulltext (pdf) av The blood response to subway-derived iron nanoparticles

Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro

Adler, Anna; Fritsch, Marlene; Fromell, Karin; Leneweit, Gero et al.

Ingår i Journal of materials chemistry. B, s. 11121-11134, 2023

• DOI för Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro
• Ladda ner fulltext (pdf) av Regulation of the innate immune system by fragmented heparin-conjugated lipids on lipid bilayered membranes in vitro

Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis

Martin, Myriam; Nilsson, Sara C. C.; Eikrem, David; Fromell, Karin et al.

Ingår i Frontiers in Immunology, 2023

• DOI för Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis
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Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies

Beusch, Christian M.; Simonson, Oscar; Wedin, Johan O; Sabatier, Pierre et al.

Ingår i Cellular and Molecular Life Sciences (CMLS), 2023

• DOI för Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies
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How COVID-19 and other pathological conditions and medical treatments activate our intravascular innate immune system

Nilsson, Bo; Eriksson, Oskar; Fromell, Karin; Persson, Barbro et al.

Ingår i Frontiers in Immunology, 2023

• DOI för How COVID-19 and other pathological conditions and medical treatments activate our intravascular innate immune system
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Activation of the Complement and Coagulation Systems in the Small Airways in Asthma

Kokelj, Spela; Östling, Jörgen; Fromell, Karin; Vanfleteren, Lowie E. G. W. et al.

Ingår i Respiration, s. 621-631, 2023

• DOI för Activation of the Complement and Coagulation Systems in the Small Airways in Asthma
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The effect of airborne Palladium nanoparticles on human lung cells, endothelium and blood-A combinatory approach using three in vitro models

Fromell, Karin; Johansson, Ulrika; Abadgar, Sophia; Bourzeix, Pauline et al.

Ingår i Toxicology in Vitro, 2023

• DOI för The effect of airborne Palladium nanoparticles on human lung cells, endothelium and blood-A combinatory approach using three in vitro models
• Ladda ner fulltext (pdf) av The effect of airborne Palladium nanoparticles on human lung cells, endothelium and blood-A combinatory approach using three in vitro models

Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation: A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients

Hultström, Michael; Fromell, Karin; Larsson, Anders; Persson, Barbro et al.

Ingår i Biomedicines, 2022

• DOI för Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation: A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients
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Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients

Hultström, Michael; Fromell, Karin; Larsson, Anders; Quaggin, Susan E et al.

Ingår i Biomedicines, s. 1333-27, 2022

• DOI för Elevated Angiopoietin-2 inhibits thrombomodulin-mediated anticoagulation in critically ill COVID-19 patients
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A Robust Method to Store Complement C3 With Superior Ability to Maintain the Native Structure and Function of the Protein

Adler, Anna; Manivel, Vivek Anand; Fromell, Karin; Teramura, Yuji et al.

Ingår i Frontiers in Immunology, 2022

• DOI för A Robust Method to Store Complement C3 With Superior Ability to Maintain the Native Structure and Function of the Protein
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The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System

Lipcsey, Miklós; Persson, Barbro; Eriksson, Oskar; Blom, Anna M. et al.

Ingår i Frontiers in Immunology, 2021

• DOI för The Outcome of Critically Ill COVID-19 Patients Is Linked to Thromboinflammation Dominated by the Kallikrein/Kinin System
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Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials

Svensson, Fredric G.; Manivel, Vivek Anand; Seisenbaeva, Gulaim A.; Kessler, Vadim G. et al.

Ingår i Nanomaterials, 2021

• DOI för Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials
• Ladda ner fulltext (pdf) av Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials

Smoking induces sex-specific changes in the small airway proteome

Kokelj, Spela; Ostling, Jorgen; Georgi, Benjamin; Fromell, Karin et al.

Ingår i Respiratory Research, 2021

• DOI för Smoking induces sex-specific changes in the small airway proteome
• Ladda ner fulltext (pdf) av Smoking induces sex-specific changes in the small airway proteome

Assessment of the Role of C3(H2O) in the Alternative Pathway

Fromell, Karin; Adler, Anna; Åman, Amanda; Manivel, Vivek Anand et al.

Ingår i Frontiers in Immunology, 2020

• DOI för Assessment of the Role of C3(H2O) in the Alternative Pathway
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Potential of Cell Surface Engineering with Biocompatible Polymers for Biomedical Applications

Teramura, Yuji; Nilsson Ekdahl, Kristina; Fromell, Karin; Nilsson, Bo et al.

Ingår i Langmuir, s. 12088-12106, 2020

• DOI för Potential of Cell Surface Engineering with Biocompatible Polymers for Biomedical Applications

C1q recognizes antigen-bound IgG in a curvature-dependent manner

Zeuthen, Christina M.; Shahrokhtash, Ali; Fromell, Karin; Nilsson Ekdahl, Kristina et al.

Ingår i Nano Reseach, s. 1651-1658, 2020

• DOI för C1q recognizes antigen-bound IgG in a curvature-dependent manner

Is generation of C3(H₂O) necessary for activation of the alternative pathway in real life?

Nilsson Ekdahl, Kristina; Mohlin, Camilla; Adler, Anna; Åman, Amanda et al.

Ingår i Molecular Immunology, s. 353-361, 2019

• DOI för Is generation of C3(H₂O) necessary for activation of the alternative pathway in real life?
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Generation of an alternative pathway convertase by contact-activated C3 is dependent on the conformation of C3

Fromell, Karin; Johansson, Ulrika; Dührkop, Claudia; Adler, Anna et al.

Ingår i Molecular Immunology, s. 193-193, 2018

• DOI för Generation of an alternative pathway convertase by contact-activated C3 is dependent on the conformation of C3

The lectin pathway of complement and the contact/kallikrein system are integrated

Fromell, Karin; Dührkop, Claudia; Kozarcanin, Huda; Johansson, Ulrika et al.

Ingår i Molecular Immunology, s. 151-152, 2018

• DOI för The lectin pathway of complement and the contact/kallikrein system are integrated

Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe2O3 nanoparticles.

Nilsson Ekdahl, Kristina; Davoodpour, Padideh; Ekstrand-Hammarström, Barbro; Fromell, Karin et al.

Ingår i Nanomedicine, s. 735-744, 2018

• DOI för Contact (kallikrein/kinin) system activation in whole human blood induced by low concentrations of α-Fe2O3 nanoparticles.

Shiga toxin 2a binds antithrombin and heparin, but does not directly activate platelets

Knabl, Ludwig; Berktold, Michael; Hamad, Osama A.; Fromell, Karin et al.

Ingår i International Journal of Medical Microbiology, s. 969-976, 2018

• DOI för Shiga toxin 2a binds antithrombin and heparin, but does not directly activate platelets

Absence of conformational change in complement factor 3 and factor XII adsorbed to acrylate polymers is related to a high degree of polymer backbone flexibility

Fromell, Karin; Yang, Yi; Nilsson Ekdahl, Kristina; Nilsson, Bo et al.

Ingår i Biointerphases, 2017

• DOI för Absence of conformational change in complement factor 3 and factor XII adsorbed to acrylate polymers is related to a high degree of polymer backbone flexibility
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Dispersion of TiO₂ nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins

Seisenbaeva, Gulaim A.; Fromell, Karin; Vinogradov, Vasiliy V.; Terekhov, Aleksey N. et al.

Ingår i Scientific Reports, 2017

• DOI för Dispersion of TiO₂ nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins
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Forms of contact-activated C3 associated with AP convertase formation

Fromell, Karin; Dührkop, Claudia; Johansson, Ulrika; Nilsson Ekdahl, Kristina et al.

Ingår i Molecular Immunology, s. 141-141, 2017

• DOI för Forms of contact-activated C3 associated with AP convertase formation

Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human blood

Huang, Shan; Engberg, Anna E.; Jonsson, Nina; Sandholm, Kerstin et al.

Ingår i Biomaterials, s. 111-119, 2016

• DOI för Reciprocal relationship between contact and complement system activation on artificial polymers exposed to whole human blood

Dangerous liaisons: complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation

Nilsson Ekdahl, Kristina; Teramura, Yuji; Hamad, Osama A.; Asif, Sana et al.

Ingår i Immunological Reviews, s. 245-269, 2016

• DOI för Dangerous liaisons: complement, coagulation, and kallikrein/kinin cross-talk act as a linchpin in the events leading to thromboinflammation

Heparinization of cell surfaces with short pepetide-conjugated PEG-lipid regulates thromboinflammation in thransplantation of human MSCs and hepatocytes

Asif, Sana; Ekdahl, Kristina N; Fromell, Karin; Gustafson, Elisabet et al.

Ingår i Acta Biomaterialia, s. 194-205, 2016

• DOI för Heparinization of cell surfaces with short pepetide-conjugated PEG-lipid regulates thromboinflammation in thransplantation of human MSCs and hepatocytes

Development and characterization of an innovtive heparin coating to stabilize and protect liposomes against adverse immune reactions

Duehrkop, Claudia; Leneweit, Gero; Heyder, Christoph; Fromell, Karin et al.

Ingår i Colloids and Surfaces B, s. 576-583, 2016

• DOI för Development and characterization of an innovtive heparin coating to stabilize and protect liposomes against adverse immune reactions

Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18

Hamad, Osama A.; Mitroulis, Ioannis; Fromell, Karin; Kozarcanin, Huda et al.

Ingår i Thrombosis and Haemostasis, s. 1207-1217, 2015

• DOI för Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18

Vascular repair utilising immobilised heparin conjugate for protection against early activation of inflammation and coagulation

Nordling, Sofia; Hong, Jaan; Fromell, Karin; Edin, Fredrik et al.

Ingår i Thrombosis and Haemostasis, s. 1312-1322, 2015

• DOI för Vascular repair utilising immobilised heparin conjugate for protection against early activation of inflammation and coagulation

Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18

Hamad, Osama A.; Mitroulis, Ioannis; Fromell, Karin; Kozarcanin, Huda et al.

Ingår i Molecular Immunology, s. 141-142, 2015

Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma

Engberg, Anna E.; Nilsson, Per H.; Huang, Shan; Fromell, Karin et al.

Ingår i Biomaterials, s. 55-65, 2015

• DOI för Prediction of inflammatory responses induced by biomaterials in contact with human blood using protein fingerprint from plasma

Contact activation of C3 enables tethering between activated platelets and polymorphonuclear leukocytes via CD11b/CD18

Ekdahl, Kristina N.; Hamad, Osama A.; Mitroulis, Ioannis; Fromell, Karin et al.

Ingår i Molecular Immunology, s. 242-243, 2014

Designed protein binders in combination with nanocrystalline diamond for use in high-sensitivity biosensors

Fromell, Karin; Forsberg, Pontus; Karlsson, Mikael; Larsson, Karin et al.

Ingår i Analytical and Bioanalytical Chemistry, s. 1643-1651, 2012

• DOI för Designed protein binders in combination with nanocrystalline diamond for use in high-sensitivity biosensors

Comparison between Chicken and Rabbit Antibody Based Particle Enhanced Cystatin C Reagents for Immunoturbidimetry

Hansson, Lars-Olof; Flodin, Mats; Nilsen, Tom; Caldwell, Karin et al.

Ingår i Journal of immunoassay & immunochemistry, s. 1-9, 2008

• DOI för Comparison between Chicken and Rabbit Antibody Based Particle Enhanced Cystatin C Reagents for Immunoturbidimetry

Nanoparticle decorated surfaces with potential use in glycosylation analysis

Fromell, Karin; Andersson, Margaretha; Elihn, Karine; Caldwell, Karin

Ingår i Colloids and Surfaces B: Biointerfaces, 2005

Shifts in polystyrene particle surface charge upon adsorption of the Pluronic F108 surfactant

ter Veen, Rik; Fromell, Karin; Caldwell, Karin

Ingår i Journal of Colloid and Interface Science, s. 124-128, 2005

Characterization of Surface-Modified Nanoparticles for in Vivo Biointeraction. A Sedimentation Field Flow Fractionation Study

Andersson, Margaretha; Fromell, Karin; Gullberg, Elisabet; Artursson, Per et al.

Ingår i Analytical Chemistry, s. 5488-5493, 2005

Surface attachment of nanoparticles using oligonucleotides

Andersson, Margaretha; Elihn, K.; Fromell, Karin; Caldwell, Karin

Ingår i Colloids and Surfaces B: Biointerfaces, s. 165-171, 2004

Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop

Ekdahl, Kristina N.; Fromell, Karin; Mannes, Marco; Grinnemo, Karl-Henrik et al.

Ingår i Immunological Reviews, s. 91-103, 2023

• DOI för Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop
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How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment

Nilsson, Bo; Persson, Barbro; Eriksson, Oskar; Fromell, Karin et al.

Ingår i Frontiers in Immunology, 2022

• DOI för How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment
• Ladda ner fulltext (pdf) av How the Innate Immune System of the Blood Contributes to Systemic Pathology in COVID-19-Induced ARDS and Provides Potential Targets for Treatment

A human whole-blood model to study the activation of innate immunity system triggered by nanoparticles as a demonstrator for toxicity

N.Ekdahl, Kristina; Fromell, Karin; Mohlin, Camilla; Teramura, Yuji et al.

Ingår i Science and Technology of Advanced Materials, s. 688-698, 2019

• DOI för A human whole-blood model to study the activation of innate immunity system triggered by nanoparticles as a demonstrator for toxicity
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Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions

Huber-Lang, Markus; Nilsson Ekdahl, Kristina; Wiegner, Rebecca; Fromell, Karin et al.

Ingår i Seminars in Immunopathology, s. 87-102, 2018

• DOI för Auxiliary activation of the complement system and its importance for the pathophysiology of clinical conditions
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The innate immunity response: A key factor in biocompatibility

Ekdahl, Kristina N; Fromell, Karin; Hilborn, Jöns; Nilsson, Bo

Ingår i Bioresorbable Polymers for Biomedical Applications, s. 85-94, Elsevier, 2017