Laia Caja Puigsubira
Universitetsadjunkt Docent vid Institutionen för medicinsk biokemi och mikrobiologi; Biokemi och Cancer; Laia Caja Puigsubira
- Telefon:
- 018-471 46 41, 073-469 72 02
- E-post:
- laia.caja@imbim.uu.se
- Besöksadress:
- BMC
Husargatan 3
752 37 UPPSALA - Postadress:
- Box 582
751 23 UPPSALA
Universitetsadjunkt Docent vid Institutionen för medicinsk biokemi och mikrobiologi; Administration
- Telefon:
- 073-469 72 02
- Besöksadress:
- BMC
Husargatan 3
752 37 UPPSALA - Postadress:
- Box 582
751 23 UPPSALA
- ORCID:
- 0000-0002-8786-8763
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Nyckelord
- emt
- glioblastoma
- nadph oxidases
- oxidative stress
- tgf-beta
Publikationer
Senaste publikationer
- The TGF-β Family in Glioblastoma (2024)
- The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion (2023)
- Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation (2023)
- The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition (2023)
- The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma (2022)
Alla publikationer
Artiklar
- The TGF-β Family in Glioblastoma (2024)
- The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion (2023)
- Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation (2023)
- The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition (2023)
- The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma (2022)
- Editorial (2022)
- NOX4 regulates TGF beta-induced proliferation and self-renewal in glioblastoma stem cells (2022)
- Metabolic determinants of stemness in medulloblastoma (2022)
- Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity (2022)
- Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types (2021)
- The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma (2021)
- The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling (2021)
- Downregulation of Epidermal Growth Factor Receptor in hepatocellular carcinoma facilitates Transforming Growth Factor-beta-induced epithelial to amoeboid transition (2019)
- The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity (2019)
- TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells (2019)
- Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma (2018)
- TGF-β and the Tissue Microenvironment (2018)
- Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells (2018)
- Transforming growth factor beta as regulator of cancer stemness and metastasis (2016)
- Transforming growth factor beta and bone morphogenetic protein actions in brain tumors (2015)
- Vascular smooth muscle cell phenotypic changes in patients with Marfan syndrome (2015)
- Caveolin-1 is required for TGF-β-induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17 (2014)
- A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins (2014)
- Overactivation of the TGF-β pathway confers a mesenchymal-like phenotype and CXCR4-dependent migratory properties to liver tumor cells (2013)
- The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins (2013)
- Context-dependent action of transforming growth factor β family members on normal and cancer stem cells (2012)
- Lack of amino acids in mouse hepatocytes in culture induces the selection of preneoplastic cells. (2012)
- Sorafenib sensitizes hepatocellular carcinoma cells to physiological apoptotic stimuli. (2012)
- Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes. (2012)
- Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition (2012)
- The transforming growth factor-beta (TGF-β) mediates acquisition of a mesenchymal stem cell-like phenotype in human liver cells. (2011)
- Dissecting the effect of targeting the epidermal growth factor receptor on TGF-β-induced-apoptosis in human hepatocellular carcinoma cells. (2011)
- The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms. (2011)
- Role of CXCR4/SDF-1 alpha in the migratory phenotype of hepatoma cells that have undergone epithelial-mesenchymal transition in response to the transforming growth factor-beta. (2009)
- Overactivation of the MEK/ERK pathway in liver tumor cells confers resistance to TGF-{beta}-induced cell death through impairing up-regulation of the NADPH oxidase NOX4. (2009)
- The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms. (2009)
- Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity (2008)
- Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells (2008)
- Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells (2007)
- Snail regulates BMP and TGF-β pathways to control the differentiation status of glioma initiating cells
- Glutamine deprivation alters TGF-β signaling in hepatocellular carcinoma
- TGFβ signaling down-regulates LINC00707 to inhibit inflammatory responses
- Epigenetic coupling of transcription factor CXXC5 regulates stemness genes in glioblastoma
- The liver kinase B1 inhibits transforming growth factor β signaling during mammary epithelial morphogenesis
