Sergiy Korol

GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus

Netsyk, Olga; Korol, Sergiy; Birnir, Bryndis; Jin, Zhe

Ingår i Frontiers in Cellular Neuroscience, 2025

• DOI för GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus
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GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

Netsyk, Olga; Korol, Sergiy V; Li, Jin-ping; Birnir, Bryndis et al.

Ingår i Journal of Alzheimer's Disease, s. 420-428, 2025

• DOI för GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA_A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells

Netsyk, Olga; Korol, Sergiy; Westermark, Gunilla; Birnir, Bryndis et al.

Ingår i Frontiers in Cellular Neuroscience, 2025

• DOI för Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA_A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
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GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol; Korol, Sergiy Vasylyovych et al.

Ingår i EBioMedicine, 2024

• DOI för GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels
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GABA signalling in human pancreatic islets

Jin, Zhe; Korol, Sergiy V.

Ingår i Frontiers in Endocrinology, 2023

• DOI för GABA signalling in human pancreatic islets
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GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus

Netsyk, Olga; Korol, Sergiy; Birnir, Bryndis; Jin, Zhe

Ingår i Frontiers in Cellular Neuroscience, 2025

• DOI för GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus
• Ladda ner fulltext (pdf) av GLP-1 selectively enhances tonic GABA_A receptor-mediated currents in mouse dentate gyrus granule cells of the ventral hippocampus

GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

Netsyk, Olga; Korol, Sergiy V; Li, Jin-ping; Birnir, Bryndis et al.

Ingår i Journal of Alzheimer's Disease, s. 420-428, 2025

• DOI för GABA-activated slow spontaneous inhibitory postsynaptic currents are decreased in dorsal hippocampal dentate gyrus granule cells in an aged mouse model of Alzheimer's disease

Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA_A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells

Netsyk, Olga; Korol, Sergiy; Westermark, Gunilla; Birnir, Bryndis et al.

Ingår i Frontiers in Cellular Neuroscience, 2025

• DOI för Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA_A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells
• Ladda ner fulltext (pdf) av Rodent islet amyloid polypeptide (IAPP) selectively enhances GABA_A receptor-mediated neuronal inhibition in mouse ventral but not dorsal hippocampal dentate gyrus granule cells

GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol; Korol, Sergiy Vasylyovych et al.

Ingår i EBioMedicine, 2024

• DOI för GABA-mediated inhibition of human CD4⁺ T cell functions is enhanced by insulin but impaired by high glucose levels
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Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Ingår i Journal of Medicinal Chemistry, s. 1380-1425, 2023

• DOI för Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
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New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Durcik, Martina; Cotman, Andrej Emanuel; Toplak, Zan; Mozina, Stefan et al.

Ingår i Journal of Medicinal Chemistry, s. 3968-3994, 2023

• DOI för New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
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Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease

Hammoud, Hayma; Netsyk, Olga; Tafreshiha, Atieh S.; Korol, Sergiy V. et al.

Ingår i Acta Physiologica, 2021

• DOI för Insulin differentially modulates GABA signalling in hippocampal neurons and, in an age-dependent manner, normalizes GABA-activated currents in the tg-APPSwe mouse model of Alzheimer's disease
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Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis

Netsyk, Olga; Hammoud, Hayma; Korol, Sergiy; Jin, Zhe et al.

Ingår i Hippocampus, s. 1146-1157, 2020

• DOI för Tonic GABA-activated synaptic and extrasynaptic currents in dentate gyrus granule cells and CA3 pyramidal neurons along the mouse hippocampal dorsoventral axis
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GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets

Korol, Sergiy; Jin, Zhe; Birnir, Bryndis

Ingår i International Journal of Molecular Sciences, 2020

• DOI för GABA(A) Receptor-Mediated Currents and Hormone mRNAs in Cells Expressing More Than One Hormone Transcript in Intact Human Pancreatic Islets
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Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers

Bhandage, Amol K.; Cunningham, Janet L.; Jin, Zhe; Shen, Qiujin et al.

Ingår i International Journal of Molecular Sciences, 2019

• DOI för Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers
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Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons

Flood, Louise; Korol, Sergiy; Ekselius, Lisa; Birnir, Bryndis et al.

Ingår i Journal of Neuroimmunology, 2019

• DOI för Interferon-gamma potentiates GABA(A) receptor-mediated inhibitory currents in rat hippocampal CA1 pyramidal neurons
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Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment

Schuster, Jens; Laan, Loora; Klar, Joakim; Jin, Zhe et al.

Ingår i Neurobiology of Disease, 2019

• DOI för Transcriptomes of Dravet syndrome iPSC derived GABAergic cells reveal dysregulated pathways for chromatin remodeling and neurodevelopment
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Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion reveals skewed fate choice in neural progenitors and impaired neuronal functionality

Lam, Matti; Moslem, Mohsen; Bryois, Julien; Pronk, Robin J. et al.

Ingår i Experimental Cell Research, 2019

• DOI för Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion reveals skewed fate choice in neural progenitors and impaired neuronal functionality
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Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes

Bhandage, Amol; Jin, Zhe; Korol, Sergiy V; Tafreshiha, Atieh et al.

Ingår i PLOS ONE, 2018

• DOI för Expression of calcium release-activated and voltage-gated calcium channels genes in peripheral blood mononuclear cells is altered in pregnancy and in type 1 diabetes
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Insulin enhances GABA_A receptor-mediated inhibitory currents in rat central amygdala neurons

Korol, Sergiy V.; Tafreshiha, Atieh; Bhandage, Amol K.; Birnir, Bryndis et al.

Ingår i Neuroscience Letters, s. 76-81, 2018

• DOI för Insulin enhances GABA_A receptor-mediated inhibitory currents in rat central amygdala neurons
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GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4⁺ T Cells and Is Immunosuppressive in Type 1 Diabetes

Bhandage, Amol K.; Jin, Zhe; Korol, Sergiy V.; Shen, Qiujin et al.

Ingår i EBioMedicine, s. 283-294, 2018

• DOI för GABA Regulates Release of Inflammatory Cytokines From Peripheral Blood Mononuclear Cells and CD4⁺ T Cells and Is Immunosuppressive in Type 1 Diabetes
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Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Ingår i EBioMedicine, 2018

• DOI för Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
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Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism

Babateen, Omar; Korol, Sergiy V.; Jin, Zhe; Bhandage, Amol K. et al.

Ingår i BMC Pharmacology & Toxicology, 2017

• DOI för Liraglutide modulates GABAergic signaling in rat hippocampal CA3 pyramidal neurons predominantly by presynaptic mechanism
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AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women

Bhandage, Amol K.; Jin, Zhe; Hellgren, Charlotte; Korol, Sergiy V. et al.

Ingår i Journal of Neuroimmunology, s. 51-58, 2017

• DOI för AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women

Normal human CD4⁺ helper T cells express Kv1.1 voltage-gated K⁺ channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway

Fellerhoff-Losch, Barbara; Korol, Sergiy V.; Ganor, Yonatan; Gu, Songhai et al.

Ingår i Journal of neural transmission, s. 137-157, 2016

• DOI för Normal human CD4⁺ helper T cells express Kv1.1 voltage-gated K⁺ channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway

GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar; Birnir, Bryndis

Ingår i Diabetes, s. 79-89, 2015

• DOI för GLP-1 and Exendin-4 Transiently Enhance GABA(A) Receptor-Mediated Synaptic and Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
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Insulin modulates GABAA receptor-mediated neuronal inhibition in rat hippocampus and amygdala

Jin, Zhe; Korol, Sergiy V.; Jin, Yang; Birnir, Bryndis

Ingår i Acta Physiologica, s. 90-90, 2015

Modulation of GABAA receptor-mediated synaptic and tonic currents in the rat hippocampus by GLP-1, exendin-4 and diazepam

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar; Birnir, Bryndis

Ingår i Acta Physiologica, s. 89-90, 2015

The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABA_A Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons

Korol, Sergiy V.; Jin, Zhe; Birnir, Bryndis

Ingår i PLOS ONE, 2015

• DOI för The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABA_A Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons
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Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

Babateen, Omar; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V et al.

Ingår i European Journal of Pharmacology, s. 101-107, 2015

• DOI för Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from Human glioblastoma

GABA(A) receptor-mediated currents in the hippocampus are transiently enhanced by glucagon-like peptide-1 receptor (GLP-1R) agonists

Korol, Sergiy V.; Jin, Zhe; Babateen, Omar M.; Birnir, Bryndis

Ingår i Acta Physiologica, s. 83-83, 2014

Insulin modulates GABA(A) receptor-mediated inhibition in rat amygdala neurons

Jin, Zhe; Korol, Sergiy V.; Birnir, Bryndis

Ingår i Acta Physiologica, s. 83-83, 2014

GABA-A receptor currents in a cell line (U3047MG) derived from a human glioblastoma tumor are enhanced by etomidate, propofol and diazepam

Babateen, Omar M.; Jin, Zhe; Bhandage, Amol K.; Korol, Sergiy V. et al.

Ingår i Acta Physiologica, s. 100-100, 2014

In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

Jin, Yang; Korol, Sergiy V; Jin, Zhe; Barg, Sebastian et al.

Ingår i PLOS ONE, 2013

• DOI för In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
• Ladda ner fulltext (pdf) av In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

GABA signalling in human pancreatic islets

Jin, Zhe; Korol, Sergiy V.

Ingår i Frontiers in Endocrinology, 2023

• DOI för GABA signalling in human pancreatic islets
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In a cell-type specific manner, high-affinity GABA-A receptors participate in autocrine and paracrine GABA signaling in human pancreatic islets

Jin, Yang; Korol, Sergiy; Jin, Zhe; Laver, Derek et al.

GABA, insulin and glucose orchestrate effector functions of human CD4+ T cells

Jin, Zhe; Hammoud, Hayma; Bhandage, Amol; Korol, Sergiy et al.