Douglas Huseby

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI för Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
• Ladda ner fulltext (pdf) av Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

The Evolutionary Maintenance of Amino Acid Prototrophy in Escherichia coli

Lindahl, Otto; Berruga-Fernández, Talía; Soekhoe, Jivanti; Huseby, Douglas L. et al.

Ingår i Genome Biology and Evolution, 2026

• DOI för The Evolutionary Maintenance of Amino Acid Prototrophy in Escherichia coli
• Ladda ner fulltext (pdf) av The Evolutionary Maintenance of Amino Acid Prototrophy in Escherichia coli

The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development

Hansen, Jon U.; Arrazuria, Rakel; Hoover, Jennifer L.; Kerscher, Bernhard et al.

Ingår i Microbiology Spectrum, 2026

• DOI för The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development
• Ladda ner fulltext (pdf) av The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development

Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes

Berruga Fernández, Talia; Huseby, Douglas L.; Koshla, Oksana; Shaukat, Anum et al.

Ingår i Molecular biology and evolution, 2026

• DOI för Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes
• Ladda ner fulltext (pdf) av Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI för Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
• Ladda ner fulltext (pdf) av Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models

Frimodt-Møller, Niels; Hansen, Jon U.; Plattner, Michel; Huseby, Douglas L. et al.

Ingår i International Journal of Antimicrobial Agents, 2024

• DOI för Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models
• Ladda ner fulltext (pdf) av Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models

The Evolutionary Maintenance of Amino Acid Prototrophy in Escherichia coli

Lindahl, Otto; Berruga-Fernández, Talía; Soekhoe, Jivanti; Huseby, Douglas L. et al.

Ingår i Genome Biology and Evolution, 2026

• DOI för The Evolutionary Maintenance of Amino Acid Prototrophy in Escherichia coli
• Ladda ner fulltext (pdf) av The Evolutionary Maintenance of Amino Acid Prototrophy in Escherichia coli

The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development

Hansen, Jon U.; Arrazuria, Rakel; Hoover, Jennifer L.; Kerscher, Bernhard et al.

Ingår i Microbiology Spectrum, 2026

• DOI för The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development
• Ladda ner fulltext (pdf) av The COMBINE pneumonia model: a multicenter study to standardize a mouse pneumonia model with Pseudomonas aeruginosa and Klebsiella pneumoniae for antibiotic development

Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes

Berruga Fernández, Talia; Huseby, Douglas L.; Koshla, Oksana; Shaukat, Anum et al.

Ingår i Molecular biology and evolution, 2026

• DOI för Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes
• Ladda ner fulltext (pdf) av Integrated conjugative elements drive the formation of pandemic clones of Escherichia coli with hybrid chromosomes

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Huseby, Douglas L.; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2024

• DOI för Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria
• Ladda ner fulltext (pdf) av Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria

Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models

Frimodt-Møller, Niels; Hansen, Jon U.; Plattner, Michel; Huseby, Douglas L. et al.

Ingår i International Journal of Antimicrobial Agents, 2024

• DOI för Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models
• Ladda ner fulltext (pdf) av Apramycin efficacy against carbapenem- and aminoglycoside-resistant Escherichia coli and Klebsiella pneumoniae in murine bloodstream infection models

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

Cotman, Andrej Emanuel; Durcik, Martina; Tiz, Davide Benedetto; Fulgheri, Federica et al.

Ingår i Journal of Medicinal Chemistry, s. 1380-1425, 2023

• DOI för Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa
• Ladda ner fulltext (pdf) av Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold- Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Durcik, Martina; Cotman, Andrej Emanuel; Toplak, Zan; Mozina, Stefan et al.

Ingår i Journal of Medicinal Chemistry, s. 3968-3994, 2023

• DOI för New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus
• Ladda ner fulltext (pdf) av New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

Cao, Sha; Brandis, Gerrit; Huseby, Douglas L; Hughes, Diarmaid

Ingår i Molecular biology and evolution, 2022

• DOI för Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria
• Ladda ner fulltext (pdf) av Positive Selection during Niche Adaptation Results in Large-Scale and Irreversible Rearrangement of Chromosomal Gene Order in Bacteria

Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes

Bartke, Katrin; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Ingår i Genome Biology and Evolution, 2022

• DOI för Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes
• Ladda ner fulltext (pdf) av Evolution of Bacterial Interspecies Hybrids with Enlarged Chromosomes

Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

Praski Alzrigat, Lisa; Huseby, Douglas L.; Brandis, Gerrit; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 77-83, 2021

• DOI för Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli
• Ladda ner fulltext (pdf) av Resistance/fitness trade-off is a barrier to the evolution of MarR inactivation mutants in Escherichia coli

Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins

Yadav, Kavita; Garoff, Linnea; Huseby, Douglas L; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 1441-1447, 2021

• DOI för Phenotypic and genetic barriers to establishment of horizontally transferred genes encoding ribosomal protection proteins

Genetic Architecture and Fitness of Bacterial Interspecies Hybrids

Bartke, Katrin; Garoff, Linnéa; Huseby, Douglas L; Brandis, Gerrit et al.

Ingår i Molecular biology and evolution, s. 1472-1481, 2021

• DOI för Genetic Architecture and Fitness of Bacterial Interspecies Hybrids
• Ladda ner fulltext (pdf) av Genetic Architecture and Fitness of Bacterial Interspecies Hybrids

Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis

Becker, Katja; Cao, Sha; Nilsson, Anna; Erlandsson, Maria et al.

Ingår i EBioMedicine, 2021

• DOI för Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis
• Ladda ner fulltext (pdf) av Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis

Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections

Berryhill, Brandon A.; Huseby, Douglas L; McCall, Ingrid C.; Hughes, Diarmaid et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2021

• DOI för Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections
• Ladda ner fulltext (pdf) av Evaluating the potential efficacy and limitations of a phage for joint antibiotic and phage therapy of Staphylococcus aureus infections

Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

Brandis, Gerrit; Granström, Susanna; Leber, Anna T.; Bartke, Katrin et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 606-615, 2021

• DOI för Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response
• Ladda ner fulltext (pdf) av Mutant RNA polymerase can reduce susceptibility to antibiotics via ppGpp-independent induction of a stringent-like response

Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli

Garoff, Linnéa; Pietsch, Franziska; Huseby, Douglas L; Lilja, Tua et al.

Ingår i Molecular biology and evolution, s. 1637-1646, 2020

• DOI för Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli
• Ladda ner fulltext (pdf) av Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli

Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues

Loza, Einars; Sarciaux, Matthieu; Ikaunieks, Martins; Katkevics, Martins et al.

Ingår i Bioorganic & Medicinal Chemistry, 2020

• DOI för Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues

Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

Huseby, Douglas L; Brandis, Gerrit; Praski Alzrigat, Lisa; Hughes, Diarmaid

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 3185-3191, 2020

• DOI för Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene
• Ladda ner fulltext (pdf) av Antibiotic resistance by high-level intrinsic suppression of a frameshift mutation in an essential gene

In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii

Juhas, Mario; Widlake, Emma; Teo, Jeanette; Huseby, Douglas L et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 944-952, 2019

• DOI för In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii
• Ladda ner fulltext (pdf) av In vitro activity of apramycin against multidrug-, carbapenem- and aminoglycoside-resistant Enterobacteriaceae and Acinetobacter baumannii

Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site

Pantel, Lucile; Florin, Tanja; Dobosz-Bartoszek, Malgorzata; Racine, Emilie et al.

Ingår i Molecular Cell, s. 83-94, 2018

• DOI för Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site

Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium

Vestö, Kim; Huseby, Douglas L; Snygg, Lina; Wang, Helen et al.

Ingår i Frontiers in Microbiology, 2018

• DOI för Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium
• Ladda ner fulltext (pdf) av Muramyl Endopeptidase Spr Contributes to Intrinsic Vancomycin Resistance in Salmonella enterica Serovar Typhimurium

Methods to determine mutational trajectories after experimental evolution of antibiotic resistance.

Huseby, Douglas L; Hughes, Diarmaid

Ingår i Methods in Molecular Biology, s. 95-103, 2018

• DOI för Methods to determine mutational trajectories after experimental evolution of antibiotic resistance.

Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli

Garoff, Linnéa; Huseby, Douglas L; Praski Alzrigat, Lisa; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 3285-3292, 2018

• DOI för Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli
• Ladda ner fulltext (pdf) av Effect of aminoacyl-tRNA synthetase mutations on susceptibility to ciprofloxacin in Escherichia coli

Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones

Jeannot, Frédéric; Taillier, Thomas; Despeyroux, Pierre; Renard, Stéphane et al.

Ingår i Journal of Medicinal Chemistry, s. 3565-3581, 2018

• DOI för Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones

Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli

Huseby, Douglas L.; Pietsch, Franziska; Brandis, Gerrit; Garoff, Linnéa et al.

Ingår i Molecular biology and evolution, s. 1029-1039, 2017

• DOI för Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli
• Ladda ner fulltext (pdf) av Mutation supply and relative fitness shape the genotypes of ciprofloxacin-resistant Escherichia coli

Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice

Petursdottir, Dagbjort H.; Nordlander, Sofia; Qazi, Khaleda Rahman; Carvalho-Queiroz, Claudia et al.

Ingår i Frontiers in Immunology, 2017

• DOI för Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice
• Ladda ner fulltext (pdf) av Early-Life Human Microbiota Associated With Childhood Allergy Promotes the T Helper 17 Axis in Mice

Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects

Pietsch, Franziska; Bergman, Jessica M.; Brandis, Gerrit; Marcusson, Linda L. et al.

Ingår i Journal of Antimicrobial Chemotherapy, s. 75-84, 2017

• DOI för Ciprofloxacin selects for RNA polymerase mutations with pleiotropic antibiotic resistance effects

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

De Rosa, Maria; Lu, Lu; Zamaratski, Edouard; Szałaj, Natalia et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 897-911, 2017

• DOI för Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
• Ladda ner fulltext (pdf) av Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs

Praski Alzrigat, Lisa; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Ingår i Journal of Antimicrobial Chemotherapy, s. 3016-3024, 2017

• DOI för Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs
• Ladda ner fulltext (pdf) av Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli: Multiple Antibiotic-Resistance, Gram-Negative Bacteria, Multidrug Efflux Pump, Urinary-Tract-Infections, Fluoroquinolone Resistance, Quinolone Resistance, Mechanisms, Expression, Sequence, Soxs

Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance

Brandis, Gerrit; Cao, Sha; Huseby, Douglas L.; Hughes, Diarmaid

Ingår i MICROBIAL CELL, s. 275-277, 2017

• DOI för Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance
• Ladda ner fulltext (pdf) av Having your cake and eating it - Staphylococcus aureus small colony variants can evolve faster growth rate without losing their antibiotic resistance

Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

Cao, Sha; Huseby, Douglas L; Brandis, Gerrit; Hughes, Diarmaid

Ingår i mBio, 2017

• DOI för Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus
• Ladda ner fulltext (pdf) av Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus

Biological barriers to chromosomal hybrid formation in Escherichia coli

Berruga Fernández, Talia; Henriksson, Sofia; Borowiec, Karolina; Huseby, Douglas L. et al.

Clinical isolates of Klebsiella pneumoniae can transfer chromosomal DNA into Escherichia coli to create novel bacteria with stable hybrid chromosomes

Berruga Fernández, Talia; Kawaguchi, Jun; Huseby, Douglas L.; Hughes, Diarmaid