Marcel den Hoed

The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration

Punga, Tanel; Larsson, Mårten; Mujica, Endrina; Melo, Fabio R. et al.

Ingår i Scientific Reports, 2026

• DOI för The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
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Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease

Jamialahmadi, Oveis; Mujica, Endrina; Morris, Lowri; Mancina, Rosellina Margherita et al.

Ingår i Clinical and Molecular Hepatology, s. 1252-1268, 2025

• DOI för Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease
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Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD

Bentanachs, Roger; Ramirez-Carrasco, Patricia; Braster, Bianca; Emmanouilidou, Anastasia et al.

Ingår i Pharmacological Research, 2025

• DOI för Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD
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A functional genomic framework to elucidate novel causal metabolic dysfunction-associated fatty liver disease genes

Saliba-Gustafsson, Peter; Justesen, Johanne M.; Ranta, Amanda; Sharma, Disha et al.

Ingår i Hepatology, s. 165-183, 2025

• DOI för A functional genomic framework to elucidate novel causal metabolic dysfunction-associated fatty liver disease genes
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Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning.

Mazzaferro, Eugenia; Mujica, Endrina; Zhang, Hanqing; Emmanouilidou, Anastasia et al.

Ingår i Scientific Reports, s. 5408, 2025

• DOI för Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning.
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The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration

Punga, Tanel; Larsson, Mårten; Mujica, Endrina; Melo, Fabio R. et al.

Ingår i Scientific Reports, 2026

• DOI för The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
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Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease

Jamialahmadi, Oveis; Mujica, Endrina; Morris, Lowri; Mancina, Rosellina Margherita et al.

Ingår i Clinical and Molecular Hepatology, s. 1252-1268, 2025

• DOI för Genome-wide interaction study with body mass index identifies CYP7A1 and GIPR as genetic modulators of metabolic dysfunction-associated steatotic liver disease
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Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD

Bentanachs, Roger; Ramirez-Carrasco, Patricia; Braster, Bianca; Emmanouilidou, Anastasia et al.

Ingår i Pharmacological Research, 2025

• DOI för Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD
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A functional genomic framework to elucidate novel causal metabolic dysfunction-associated fatty liver disease genes

Saliba-Gustafsson, Peter; Justesen, Johanne M.; Ranta, Amanda; Sharma, Disha et al.

Ingår i Hepatology, s. 165-183, 2025

• DOI för A functional genomic framework to elucidate novel causal metabolic dysfunction-associated fatty liver disease genes
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Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning.

Mazzaferro, Eugenia; Mujica, Endrina; Zhang, Hanqing; Emmanouilidou, Anastasia et al.

Ingår i Scientific Reports, s. 5408, 2025

• DOI för Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning.
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Investigating the role of lipid genes in liver disease using models of steatotic liver disease in zebrafish (Danio rerio)

Mujica, Endrina; den Hoed, Marcel

Ingår i Liver international, s. 2348-2350, 2023

• DOI för Investigating the role of lipid genes in liver disease using models of steatotic liver disease in zebrafish (Danio rerio)

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Mathieson, Iain; Day, Felix R.; Barban, Nicola; Tropf, Felix C. et al.

Ingår i Nature Human Behaviour, s. 790-801, 2023

• DOI för Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

Genetic insights into resting heart rate and its role in cardiovascular disease

van de Vegte, Yordi; Eppinga, Ruben P.; van der Ende, M. Yldau; Hagemeijer, Yanick et al.

Ingår i Nature Communications, 2023

• DOI för Genetic insights into resting heart rate and its role in cardiovascular disease
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GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Lagou, Vasiliki; Jiang, Longda; Ulrich, Anna; Zudina, Liudmila et al.

Ingår i Nature Genetics, s. 1448-+, 2023

• DOI för GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
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Distilling causality between physical activity traits and obesity via Mendelian randomization

Wang, Zhe; Davey Smith, George; Loos, Ruth J. F.; den Hoed, Marcel

Ingår i Communications Medicine, 2023

• DOI för Distilling causality between physical activity traits and obesity via Mendelian randomization
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Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

Mattis, Katia K; Krentz, Nicole A J; Metzendorf, Christoph; Abaitua, Fernando et al.

Ingår i Diabetologia, s. 674-694, 2023

• DOI för Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
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Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Wang, Zhe; Emmerich, Andrew; Pillon, Nicolas J; Moore, Tim et al.

Ingår i Nature Genetics, s. 1332-1344, 2022

• DOI för Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
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CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations

Höijer, Ida; Emmanouilidou, Anastasia; Östlund, Rebecka; van Schendel, Robin et al.

Ingår i Nature Communications, 2022

• DOI för CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations
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Stroke genetics informs drug discovery and risk prediction across ancestries

Mishra, Aniket; den Hoed, Marcel; Gustafsson, Stefan; Ingelsson, Erik et al.

Ingår i Nature, s. 115-+, 2022

• DOI för Stroke genetics informs drug discovery and risk prediction across ancestries
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Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

Pellegrinelli, V; Rodriguez-Cuenca, S.; Rouault, C.; Figueroa-Juarez, E. et al.

Ingår i Nature Metabolism, s. 476-+, 2022

• DOI för Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Mills, Melinda C.; Tropf, Felix C.; Brazel, David M.; van Zuydam, Natalie et al.

Ingår i Nature Human Behaviour, s. 1717-1730, 2021

• DOI för Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities

Huang, Lam O.; Rauch, Alexander; Mazzaferro, Eugenia; Preuss, Michael et al.

Ingår i Nature Metabolism, s. 228-243, 2021

• DOI för Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities

Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity

Höijer, Ida; Johansson, Josefin; Gudmundsson, Sanna; Chin, Chen-Shan et al.

Ingår i Genome Biology, 2020

• DOI för Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity
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Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach

von der Heyde, Benedikt; Emmanouilidou, Anastasia; Mazzaferro, Eugenia; Vicenzi, Silvia et al.

Ingår i Scientific Reports, 2020

• DOI för Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach
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Test-retest variability of VO_2max using total-capture indirect calorimetry reveals linear relationship of VO₂ and Power

Schoffelen, Paul F. M.; den Hoed, Marcel; van Breda, Eric; Plasqui, Guy

Ingår i Scandinavian Journal of Medicine and Science in Sports, s. 213-222, 2019

• DOI för Test-retest variability of VO_2max using total-capture indirect calorimetry reveals linear relationship of VO₂ and Power
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Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Malik, Rainer; Chauhan, Ganesh; Traylor, Matthew; Sargurupremraj, Muralidharan et al.

Ingår i Nature Genetics, s. 524-537, 2018

• DOI för Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

van Setten, Jessica; Brody, Jennifer A.; Jamshidi, Yalda; Swenson, Brenton R. et al.

Ingår i Nature Communications, 2018

• DOI för PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity
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Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Strawbridge, Rona J.; Silveira, Angela; den Hoed, Marcel; Gustafsson, Stefan et al.

Ingår i Atherosclerosis, s. 196-204, 2017

• DOI för Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
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Genome-wide physical activity interactions in adiposity: A meta-analysis of 200,452 adults.

Graff, Mariaelisa; Scott, Robert A; Justice, Anne E; Young, Kristin L et al.

Ingår i PLOS Genetics, 2017

• DOI för Genome-wide physical activity interactions in adiposity: A meta-analysis of 200,452 adults.
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Maternal diabetes and incidence of childhood cancer: a nationwide cohort study and exploratory genetic analysis

Deleskog, Anna; den Hoed, Marcel; Tettamanti, Giorgio; Carlsson, Sofia et al.

Ingår i Clinical Epidemiology, s. 633-642, 2017

• DOI för Maternal diabetes and incidence of childhood cancer: a nationwide cohort study and exploratory genetic analysis
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Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Nolte, Ilja M.; Munoz, M. Loretto; Tragante, Vinicius; Amare, Azmeraw T. et al.

Ingår i Nature Communications, 2017

• DOI för Genetic loci associated with heart rate variability and their effects on cardiac disease risk
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Extensive Type II Muscle Fiber Atrophy in Elderly Female Hip Fracture Patients

Kramer, Irene Fleur; Snijders, Tim; Smeets, Joey S. J.; Leenders, Marika et al.

Ingår i The journals of gerontology. Series A, Biological sciences and medical sciences, s. 1369-1375, 2017

• DOI för Extensive Type II Muscle Fiber Atrophy in Elderly Female Hip Fracture Patients

Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.

den Hoed, Marcel

Ingår i Lancet Neurology, s. 695-707, 2016

• DOI för Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.

Genome-wide analysis identifies 12 loci influencing human reproductive behavior

Barban, Nicola; Jansen, Rick; de Vlaming, Ronald; Vaez, Ahmad et al.

Ingår i Nature Genetics, s. 1462-1472, 2016

• DOI för Genome-wide analysis identifies 12 loci influencing human reproductive behavior

A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Scott, Robert A.; Freitag, Daniel F.; Li, Li; Chu, Audrey Y. et al.

Ingår i Science Translational Medicine, 2016

• DOI för A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb

den Hoed, Marcel; Strawbridge, Rona J; Almgren, Peter; Gustafsson, Stefan et al.

Ingår i Atherosclerosis, s. 304-310, 2015

• DOI för GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb

Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis

Richmond, Rebecca C.; Smith, George Davey; Ness, Andy R.; den Hoed, Marcel et al.

Ingår i PLoS Medicine, 2014

• DOI för Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis
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Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

den Hoed, Marcel; Eijgelsheim, Mark; Esko, Tonu; Brundel, Bianca J. J. M. et al.

Ingår i Nature Genetics, s. 621-+, 2013

• DOI för Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

Heritability of objectively assessed daily physical activity and sedentary behavior

den Hoed, Marcel; Brage, Soren; Zhao, Jing Hua; Westgate, Kate et al.

Ingår i American Journal of Clinical Nutrition, s. 1317-1325, 2013

• DOI för Heritability of objectively assessed daily physical activity and sedentary behavior

Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals

van Vliet-Ostaptchouk, J. V.; den Hoed, Marcel; Luan, J.; Zhao, J. et al.

Ingår i Diabetologia, 2013

Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals

van Vliet-Ostaptchouk, J. V.; den Hoed, Marcel; Luan, J.; Zhao, J. H. et al.

Ingår i Diabetologia, s. 2134-2146, 2013

• DOI för Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals

Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.

den Hoed, Marcel

Ingår i Diabetes, s. 2980-8, 2010

• DOI för Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.

Biological/Genetic Regulation of Physical Activity Level: Consensus From Genbiopac

Lightfoot, J. Timothy; De Geus, Eco J. C.; Booth, Frank W.; Bray, Molly S. et al.

Ingår i Medicine & Science in Sports & Exercise, s. 863-873, 2018

• DOI för Biological/Genetic Regulation of Physical Activity Level: Consensus From Genbiopac

Image-based, in vivo characterization of cardiometabolic consequences of mutations in pcsk9

Bandaru, Manoj Kumar; Mazzaferro, Eugenia; Emmanouilidou, Anastasia; Larsson, Anders et al.

Apoc2 mutant zebrafish: a model for hypertriglyceridemia and early-stage atherosclerosis

Bandaru, Manoj Kumar; Emmanouilidou, Anastasia; Larsson, Anders; Erik, Ingelsson et al.

Kita crispants for systematic image-based genetic screens of complex traits in zebrafish larvae

Mazzaferro, Eugenia; Metzendorf, Christoph; Zhang, Hanqing; Mujica, Endrina et al.

Characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning

Mazzaferro, Eugenia; Mujica, Endrina; Zhang, Hanqing; Emmanouilidou, Anastasia et al.

Characterizing candidate genes in GWAS-identified loci that may uncouple excess adiposity from its comorbidities

Mazzaferro, Eugenia; Zhang, Hanqing; Mujica, Endrina; Azizah, Isyatul et al.