Konstantin Gängel

Cdc42 is crucial for mural cell migration, proliferation and patterning of the retinal vasculature

Alvarez-Aznar, Alberto; Desai, Malavika; Orlich, Michael M.; Vázquez-Liébanas, Elisa et al.

Ingår i Vascular pharmacology, 2025

• DOI för Cdc42 is crucial for mural cell migration, proliferation and patterning of the retinal vasculature
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Intravital Imaging of Disease Mechanisms in a Mouse Model of CCM Skin Lesions-Brief Report

Orlich, Michael M.; Norrén, Amanda; Desai, Malavika; Holm, Annegret et al.

Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, s. 113-118, 2025

• DOI för Intravital Imaging of Disease Mechanisms in a Mouse Model of CCM Skin Lesions-Brief Report
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Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage

Vázquez-Liébanas, Elisa; Mocci, Giuseppe; Li, Weihan; Laviña, Bàrbara et al.

Ingår i Cell Reports, 2024

• DOI för Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage
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Incongruence between transcriptional and vascular pathophysiological cell states

Fernandez-Chacon, Macarena; Muhleder, Severin; Regano, Alvaro; Garcia-Ortega, Lourdes et al.

Ingår i NATURE CARDIOVASCULAR RESEARCH, s. 530-549, 2023

• DOI för Incongruence between transcriptional and vascular pathophysiological cell states
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Cellular Origin of Sporadic CCMs

Betsholtz, Christer; Gängel, Konstantin; Mäkinen, Taija

Ingår i New England Journal of Medicine, s. 1291-1291, 2022

• DOI för Cellular Origin of Sporadic CCMs

Cdc42 is crucial for mural cell migration, proliferation and patterning of the retinal vasculature

Alvarez-Aznar, Alberto; Desai, Malavika; Orlich, Michael M.; Vázquez-Liébanas, Elisa et al.

Ingår i Vascular pharmacology, 2025

• DOI för Cdc42 is crucial for mural cell migration, proliferation and patterning of the retinal vasculature
• Ladda ner fulltext (pdf) av Cdc42 is crucial for mural cell migration, proliferation and patterning of the retinal vasculature

Intravital Imaging of Disease Mechanisms in a Mouse Model of CCM Skin Lesions-Brief Report

Orlich, Michael M.; Norrén, Amanda; Desai, Malavika; Holm, Annegret et al.

Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, s. 113-118, 2025

• DOI för Intravital Imaging of Disease Mechanisms in a Mouse Model of CCM Skin Lesions-Brief Report
• Ladda ner fulltext (pdf) av Intravital Imaging of Disease Mechanisms in a Mouse Model of CCM Skin Lesions-Brief Report

Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage

Vázquez-Liébanas, Elisa; Mocci, Giuseppe; Li, Weihan; Laviña, Bàrbara et al.

Ingår i Cell Reports, 2024

• DOI för Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage
• Ladda ner fulltext (pdf) av Mosaic deletion of claudin-5 reveals rapid non-cell-autonomous consequences of blood-brain barrier leakage

Incongruence between transcriptional and vascular pathophysiological cell states

Fernandez-Chacon, Macarena; Muhleder, Severin; Regano, Alvaro; Garcia-Ortega, Lourdes et al.

Ingår i NATURE CARDIOVASCULAR RESEARCH, s. 530-549, 2023

• DOI för Incongruence between transcriptional and vascular pathophysiological cell states
• Ladda ner fulltext (pdf) av Incongruence between transcriptional and vascular pathophysiological cell states

Cellular Origin of Sporadic CCMs

Betsholtz, Christer; Gängel, Konstantin; Mäkinen, Taija

Ingår i New England Journal of Medicine, s. 1291-1291, 2022

• DOI för Cellular Origin of Sporadic CCMs

Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow

Orlich, Michael M.; Dieguez-Hurtado, Rodrigo; Muehlfriedel, Regine; Sothilingam, Vithiyanjali et al.

Ingår i Circulation Research, s. 308-327, 2022

• DOI för Mural Cell SRF Controls Pericyte Migration, Vessel Patterning and Blood Flow
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Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines

Alvarez, Alberto; Martinez-Corral, Ines; Daubel, Nina; Betsholtz, Christer et al.

Ingår i Transgenic research, s. 53-68, 2020

• DOI för Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines
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Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization

Yanagida, Keisuke; Engelbrecht, Eric; Niaudet, Colin; Jung, Bongnam et al.

Ingår i Developmental Cell, s. 779-+, 2020

• DOI för Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization

Integrins are required for synchronous ommatidial rotation in the Drosophila eye linking planar cell polarity signalling to the extracellular matrix

Thuveson, Maria; Gängel, Konstantin; Collu, Giovanna M.; Chin, Mei-ling et al.

Ingår i Open Biology, 2019

• DOI för Integrins are required for synchronous ommatidial rotation in the Drosophila eye linking planar cell polarity signalling to the extracellular matrix
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CDC42 deletion elicits cerebral vascular malformations via increased MEKK3-dependent KLF4 expression

Castro, Marco; Laviña, Bàrbara; Ando, Koji; Alvarez-Aznar, Alberto et al.

Ingår i Circulation Research, s. 1240-1252, 2019

• DOI för CDC42 deletion elicits cerebral vascular malformations via increased MEKK3-dependent KLF4 expression

Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment

Collu, Giovanna M.; Jenny, Andreas; Gängel, Konstantin; Mirkovic, Ivana et al.

Ingår i PLOS Genetics, 2018

• DOI för Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment
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Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations

Laviña, Bàrbara; Castro, Marco; Niaudet, Colin; Cruys, Bert et al.

Ingår i Development, 2018

• DOI för Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations

Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium

Niaudet, Colin; Hofmann, Jennifer J.; Mae, Maarja A.; Jung, Bongnam et al.

Ingår i PLOS ONE, 2015

• DOI för Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium

Endocytosis regulates VEGF signalling during angiogenesis

Gängel, Konstantin; Betsholtz, Christer

Ingår i Nature Cell Biology, s. 233-235, 2013

• DOI för Endocytosis regulates VEGF signalling during angiogenesis

New imaging methods and tools to study vascular biology

Lavina, Barbara; Gängel, Konstantin

Ingår i Current opinion in hematology, s. 258-266, 2015

• DOI för New imaging methods and tools to study vascular biology

Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations: Cdc42 and vascular malformations

Laviña, Bàrbara; Castro, Marco; Niaudet, Colin; Bert, Cruys et al.

Resilience of lymphatic endothelium through isotropic stretch-induced cytoskeletal regulation of puzzle cell shape

Schoofs, Hans; Daubel, Nina; Schnabellehner, Sarah; Grönloh, Max et al.