Taija Mäkinen
Professor vid Institutionen för immunologi, genetik och patologi; Forskningsprogram: Vaskulärbiologi; Forskargrupp Taija Mäkinen
- Telefon:
- 018-471 41 51
- Mobiltelefon:
- 070-425 03 60
- E-post:
- taija.makinen@igp.uu.se
- Besöksadress:
- Rudbecklaboratoriet
751 85 Uppsala - Postadress:
- Rudbecklaboratoriet
751 85 UPPSALA
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Nyckelord
- endothelial cell heterogeneity
- lymphangiogenesis
- lymphedema
- vascular morphogenesis
Forskning
Denna text finns inte på svenska, därför visas den engelska versionen.
The long-term aim of my research is to understand how endothelial cells lining blood and lymphatic vessels communicate with the tissue environment to co-ordinate morphogenesis and functional specialisation of the vasculature. Most of our research has focused on the lymphatic vasculature that was traditionally considered a passive drainage system for removal of excess of tissue fluid but has recently been shown to play an active role in many important processes and common diseases such as autoimmune disease and cancer. We also investigate how the regulators of developmental (lymph) angiogenesis impact on genetic human diseases such as lymphoedema and vascular malformations.
More information about our research is found here.
Publikationer
Urval av publikationer
- Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program (2018)
- Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms (2018)
- Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels (2018)
- Vascular heterogeneity and specialization in development and disease (2017)
- EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis (2016)
- Nonvenous Origin of Dermal Lymphatic Vasculature (2015)
- cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels (2015)
- Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis. (2013)
- Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. (2012)
- Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice. (2011)
- Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. (2009)
Senaste publikationer
- Lymphatic malformations (2024)
- Hemogenic activity of lymphatic endothelium unleashed (2023)
- Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation (2023)
- Molecular anatomy of adult mouse leptomeninges (2023)
- Mapping the lymphatic system across body scales and expertise domains (2023)
Alla publikationer
Artiklar
- Lymphatic malformations (2024)
- Hemogenic activity of lymphatic endothelium unleashed (2023)
- Immune-interacting lymphatic endothelial subtype at capillary terminals drives lymphatic malformation (2023)
- Molecular anatomy of adult mouse leptomeninges (2023)
- Mapping the lymphatic system across body scales and expertise domains (2023)
- APOLD1 loss causes endothelial dysfunction involving cell junctions, cytoskeletal architecture, and Weibel-Palade bodies, while disrupting hemostasis (2023)
- Cellular Origin of Sporadic CCMs (2022)
- Angiogenesis depends upon EPHB4-mediated export of collagen IV from vascular endothelial cells (2022)
- Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression (2022)
- The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells (2022)
- Cdh5-lineage–independent origin of dermal lymphatics shown by temporally restricted lineage tracing (2022)
- Upregulation of VCAM-1 in lymphatic collectors supports dendritic cell entry and rapid migration to lymph nodes in inflammation (2021)
- Transcription factor FOXP2 is a flow-induced regulator of collecting lymphatic vessels (2021)
- Mutations in EPHB4 cause human venous valve aplasia (2021)
- Lymphatic Malformations (2021)
- An inducible Cldn11-CreERT2 mouse line for selective targeting of lymphatic valves (2021)
- Homeostatic maintenance of the lymphatic vasculature (2021)
- Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER(T2) lines (2020)
- EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity (2020)
- Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation (2020)
- YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis (2019)
- Neurobiology (2019)
- Gut microbiota regulates lacteal integrity by inducing VEGF-C in intestinal villus macrophages (2019)
- Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth (2019)
- Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program (2018)
- PROX1 is a transcriptional regulator of MMP14 (2018)
- Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds (2018)
- Genetic Lineage Tracing of Lymphatic Endothelial Cells in Mice. (2018)
- Heterogeneity in VEGFR3 levels drives lymphatic vessel hyperplasia through cell-autonomous and non-cell-autonomous mechanisms (2018)
- Transient loss of venous integrity during developmental vascular remodeling leads to red blood cell extravasation and clearance by lymphatic vessels (2018)
- Mechanisms underlying human venous valve disease caused by mutations in Foxc2 and connexin47 (2017)
- Human venous valve disease caused by mutations in FOXC2 and GJC2 (2017)
- Human Venous Valve Disease Caused by Mutations in FOXC2 and GJC2 (2017)
- Vascular heterogeneity and specialization in development and disease (2017)
- Dachsousl-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report (2017)
- Lymphangiogenesis guidance by paracrine and pericellular factors (2017)
- Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity (2017)
- Lymphatic System in Cardiovascular Medicine (2016)
- EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis (2016)
- Vegfr3-CreER (T2) mouse, a new genetic tool for targeting the lymphatic system (2016)
- Pdgfrb-Cre targets lymphatic endothelial cells of both venous and non-venous origins (2016)
- Heterogeneity in the lymphatic vascular system and its origin (2016)
- Therapeutic Insights to Lymphangiogenic Growth Factors (2015)
- A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research (2015)
- Nonvenous Origin of Dermal Lymphatic Vasculature (2015)
- Organ-Specific Origins of Lymphatic Vasculature (2015)
- Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction (2015)
- FOXC2 and fluid shear stress stabilize postnatal lymphatic vasculature (2015)
- cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels (2015)
- VEGFR3 does not sustain retinal angiogenesis without VEGFR2 (2015)
- The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like vessel (2014)
- Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. (2014)
- Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity (2014)
- Flow control in our vessels (2013)
- Regulation of lymphatic vascular morphogenesis (2013)
- Adrenomedullin haploinsufficiency predisposes to secondary lymphedema. (2013)
- Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis. (2013)
- Blood flow reprograms lymphatic vessels to blood vessels. (2012)
- Smooth muscle-endothelial cell communication activates Reelin signaling and regulates lymphatic vessel formation. (2012)
- Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. (2012)
- Mechanotransduction, PROX1, and FOXC2 cooperate to control connexin37 and calcineurin during lymphatic-valve formation. (2012)
- Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development (2012)
- Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice. (2011)
- Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis. (2011)
- Mutations in FOXC2 in humans (lymphoedema distichiasis syndrome) cause lymphatic dysfunction on dependency. (2011)
- Mutations in GATA2 cause primary lymphedema associated with a predisposition to acute myeloid leukemia (Emberger syndrome). (2011)
- VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. (2011)
- EphB-ephrin-B2 interactions are required for thymus migration during organogenesis. (2010)
- Lymphatic dysfunction, not aplasia, underlies Milroy disease. (2010)
- Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. (2010)
- Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. (2009)
- Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. (2008)
- Lymphatic vasculature (2007)
- Lymphangiogenesis in development and disease. (2007)
- Molecular mechanisms of lymphatic vascular development. (2007)
- EphB receptors and ephrin-B3 regulate axon guidance at the ventral midline of the embryonic mouse spinal cord. (2006)
- Regulation of lymphangiogenesis--from cell fate determination to vessel remodeling. (2006)
- Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation. (2006)
- Neural guidance molecules regulate vascular remodeling and vessel navigation. (2005)
- PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculature. (2005)
- Preexisting lymphatic endothelium but not endothelial progenitor cells are essential for tumor lymphangiogenesis and lymphatic metastasis. (2004)
- Vegfc is required for vascular development and endoderm morphogenesis in zebrafish. (2004)
- Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. (2004)
- Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites (2003)
- Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites (2003)
- Intrinsic versus microenvironmental regulation of lymphatic endothelial cell phenotype and function. (2003)
- Lymphatic endothelium (2002)
- Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea. (2002)
- [Lymphatic growth factors play a part in metastasis formation]. (2002)
- Molecular mechanisms of lymphangiogenesis. (2002)
- Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor. (2002)
- Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. (2001)
- Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. (2001)
- Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice. (2001)
- Monoclonal antibodies to vascular endothelial growth factor-D block its interactions with both VEGF receptor-2 and VEGF receptor-3. (2000)
- Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1. (1999)
- Effect of inflammatory cytokines on the expression of the vascular endothelial growth factor-C. (1999)
- Endothelial growth factor receptors in human fetal heart. (1999)
- Signaling via vascular endothelial growth factor receptors. (1999)
- Vascular endothelial growth factor receptor-3. (1999)
- Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. (1999)
- Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). (1998)
- Venous-specific autocrine signalling promotes PIK3CA-driven vascular malformations
- Organ-specific mechanisms of Pik3ca-driven lymphatic malformation
- Alternative lymphatic endothelial progenitor cells compensate for the loss of non-venous-derived progenitors to form mesenteric lymphatic vessels
Kapitel
