Karl-Henrik Grinnemo

Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis

Grinnemo, Karl-Henrik; Braesch-Andersen, Ken; Wedin, Johan; Velica, Anna et al.

Ingår i Cell Stem Cell, s. 1324-1338, 2026

• DOI för Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis
• Ladda ner fulltext (pdf) av Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis

Ga-68-Labeled Affibody Molecule-Based Radiopharmaceutical Targeting Platelet Derived Growth Factor Receptor Beta for Detection of Active Fibrosis in Patients with Myocardial Infarction

Velikyan, Irina; Grinnemo, Karl-Henrik; Flodin, Viktor; James, Stefan et al.

Ingår i Pharmaceuticals, 2025

• DOI för Ga-68-Labeled Affibody Molecule-Based Radiopharmaceutical Targeting Platelet Derived Growth Factor Receptor Beta for Detection of Active Fibrosis in Patients with Myocardial Infarction
• Ladda ner fulltext (pdf) av Ga-68-Labeled Affibody Molecule-Based Radiopharmaceutical Targeting Platelet Derived Growth Factor Receptor Beta for Detection of Active Fibrosis in Patients with Myocardial Infarction

Global analysis of protein turnover dynamics in single cells

Sabatier, Pierre; Lechner, Maico; Guzman, Ulises H.; Beusch, Christian et al.

Ingår i Cell, 2025

• DOI för Global analysis of protein turnover dynamics in single cells
• Ladda ner fulltext (pdf) av Global analysis of protein turnover dynamics in single cells

Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics

Ye, Zilu; Sabatier, Pierre; van der Hoeven, Leander; Lechner, Maico Y. et al.

Ingår i Nature Methods, 2025

• DOI för Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics
• Ladda ner fulltext (pdf) av Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics

Conduction Disturbances and Outcome After Surgical Aortic Valve Replacement in Patients With Bicuspid and Tricuspid Aortic Stenosis

Wedin, Johan O.; Näslund, Viktor; Rodin, Sergey; Simonson, Oscar E. et al.

Ingår i Circulation, s. 288-298, 2025

• DOI för Conduction Disturbances and Outcome After Surgical Aortic Valve Replacement in Patients With Bicuspid and Tricuspid Aortic Stenosis
• Ladda ner fulltext (pdf) av Conduction Disturbances and Outcome After Surgical Aortic Valve Replacement in Patients With Bicuspid and Tricuspid Aortic Stenosis

Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis

Grinnemo, Karl-Henrik; Braesch-Andersen, Ken; Wedin, Johan; Velica, Anna et al.

Ingår i Cell Stem Cell, s. 1324-1338, 2026

• DOI för Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis
• Ladda ner fulltext (pdf) av Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis

Ga-68-Labeled Affibody Molecule-Based Radiopharmaceutical Targeting Platelet Derived Growth Factor Receptor Beta for Detection of Active Fibrosis in Patients with Myocardial Infarction

Velikyan, Irina; Grinnemo, Karl-Henrik; Flodin, Viktor; James, Stefan et al.

Ingår i Pharmaceuticals, 2025

• DOI för Ga-68-Labeled Affibody Molecule-Based Radiopharmaceutical Targeting Platelet Derived Growth Factor Receptor Beta for Detection of Active Fibrosis in Patients with Myocardial Infarction
• Ladda ner fulltext (pdf) av Ga-68-Labeled Affibody Molecule-Based Radiopharmaceutical Targeting Platelet Derived Growth Factor Receptor Beta for Detection of Active Fibrosis in Patients with Myocardial Infarction

Global analysis of protein turnover dynamics in single cells

Sabatier, Pierre; Lechner, Maico; Guzman, Ulises H.; Beusch, Christian et al.

Ingår i Cell, 2025

• DOI för Global analysis of protein turnover dynamics in single cells
• Ladda ner fulltext (pdf) av Global analysis of protein turnover dynamics in single cells

Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics

Ye, Zilu; Sabatier, Pierre; van der Hoeven, Leander; Lechner, Maico Y. et al.

Ingår i Nature Methods, 2025

• DOI för Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics
• Ladda ner fulltext (pdf) av Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics

Conduction Disturbances and Outcome After Surgical Aortic Valve Replacement in Patients With Bicuspid and Tricuspid Aortic Stenosis

Wedin, Johan O.; Näslund, Viktor; Rodin, Sergey; Simonson, Oscar E. et al.

Ingår i Circulation, s. 288-298, 2025

• DOI för Conduction Disturbances and Outcome After Surgical Aortic Valve Replacement in Patients With Bicuspid and Tricuspid Aortic Stenosis
• Ladda ner fulltext (pdf) av Conduction Disturbances and Outcome After Surgical Aortic Valve Replacement in Patients With Bicuspid and Tricuspid Aortic Stenosis

A multi-tissue longitudinal proteomics study to evaluate the suitability of post-mortem samples for pathophysiological research

Beusch, Christian; Braesch-Andersen, Ken; Felldin, Ulrika; Sabatier, Pierre et al.

Ingår i Communications Biology, 2025

• DOI för A multi-tissue longitudinal proteomics study to evaluate the suitability of post-mortem samples for pathophysiological research
• Ladda ner fulltext (pdf) av A multi-tissue longitudinal proteomics study to evaluate the suitability of post-mortem samples for pathophysiological research

Left Atrial Dissection Resulting in Asystole: A Rare Complication After Mitral Valve Surgery

Sahar, Ramin; Wedin, Johan O.; Grinnemo, Karl-Henrik

Ingår i Case, s. 369-372, 2024

• DOI för Left Atrial Dissection Resulting in Asystole: A Rare Complication After Mitral Valve Surgery
• Ladda ner fulltext (pdf) av Left Atrial Dissection Resulting in Asystole: A Rare Complication After Mitral Valve Surgery

Left atrial dysfunction in bicuspid aortic valve patients with severe aortic stenosis is associated with post-operative atrial fibrillation following aortic valve replacement

Wedin, Johan O; Rodin, Sergey; Flachskampf, Frank A; Simonson, Oscar E et al.

Ingår i European Heart Journal Open, 2024

• DOI för Left atrial dysfunction in bicuspid aortic valve patients with severe aortic stenosis is associated with post-operative atrial fibrillation following aortic valve replacement
• Ladda ner fulltext (pdf) av Left atrial dysfunction in bicuspid aortic valve patients with severe aortic stenosis is associated with post-operative atrial fibrillation following aortic valve replacement

Why Are Bicuspid Aortic Valve Patients Flying Under the Radar?

Wedin, Johan O; Rodin, Sergey; Grinnemo, Karl-Henrik

Ingår i Journal of the American Society of Echocardiography, s. 127-128, 2023

• DOI för Why Are Bicuspid Aortic Valve Patients Flying Under the Radar?

Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies

Beusch, Christian M.; Simonson, Oscar; Wedin, Johan O; Sabatier, Pierre et al.

Ingår i Cellular and Molecular Life Sciences (CMLS), 2023

• DOI för Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies
• Ladda ner fulltext (pdf) av Analysis of local extracellular matrix identifies different aetiologies behind bicuspid and tricuspid aortic valve degeneration and suggests therapies

Patients With Bicuspid Aortic Stenosis Demonstrate Adverse Left Ventricular Remodeling and Impaired Cardiac Function Before Surgery With Increased Risk of Postoperative Heart Failure

Wedin, Johan O; Vedin, Ola; Rodin, Sergey; Simonson, Oscar E. et al.

Ingår i Circulation, s. 1310-1322, 2022

• DOI för Patients With Bicuspid Aortic Stenosis Demonstrate Adverse Left Ventricular Remodeling and Impaired Cardiac Function Before Surgery With Increased Risk of Postoperative Heart Failure
• Ladda ner fulltext (pdf) av Patients With Bicuspid Aortic Stenosis Demonstrate Adverse Left Ventricular Remodeling and Impaired Cardiac Function Before Surgery With Increased Risk of Postoperative Heart Failure

Surgical Removal of a Detached Mitral Valve Repair Clip to Resolve Cardiogenic Shock

Wedin, Johan O; Karlsson, Per; Holm, Lovisa; Buccheri, Sergio et al.

Ingår i JACC, s. 658-662, 2022

• DOI för Surgical Removal of a Detached Mitral Valve Repair Clip to Resolve Cardiogenic Shock
• Ladda ner fulltext (pdf) av Surgical Removal of a Detached Mitral Valve Repair Clip to Resolve Cardiogenic Shock

Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells

Olesen, Kim; Moruzzi, Noah; Bulatovic, Ivana; Folmes, Clifford et al.

Ingår i Metabolism Open, 2022

• DOI för Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells
• Ladda ner fulltext (pdf) av Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells

An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation

Sabatier, Pierre; Beusch, Christian M.; Saei, Amir A.; Aoun, Mike et al.

Ingår i Nature Communications, 2021

• DOI för An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation
• Ladda ner fulltext (pdf) av An integrative proteomics method identifies a regulator of translation during stem cell maintenance and differentiation

Spatiotemporal extracellular matrix modeling for in situ cell niche studies

Olesen, Kim; Rodin, Sergey; Mak, Wing Cheung; Felldin, Ulrika et al.

Ingår i Stem Cells, s. 1751-1765, 2021

• DOI för Spatiotemporal extracellular matrix modeling for in situ cell niche studies
• Ladda ner fulltext (pdf) av Spatiotemporal extracellular matrix modeling for in situ cell niche studies

Characterization of Laminins in Healthy Human Aortic Valves and a Modified Decellularized Rat Scaffold

Granath, Carl; Noren, Hunter; Björck, Hanna; Simon, Nancy et al.

Ingår i BioResearch Open Access, s. 269-278, 2020

• DOI för Characterization of Laminins in Healthy Human Aortic Valves and a Modified Decellularized Rat Scaffold
• Ladda ner fulltext (pdf) av Characterization of Laminins in Healthy Human Aortic Valves and a Modified Decellularized Rat Scaffold

Compared with matched controls, patients with postoperative atrial fibrillation (POAF) have increased long-term AF after CABG, and POAF is further associated with increased ischemic stroke, heart failure and mortality even after adjustment for AF.

Thorén, Emma; Wernroth, Lisa; Christersson, Christina; Grinnemo, Karl-Henrik et al.

Ingår i Clinical Research in Cardiology, s. 1232-1242, 2020

• DOI för Compared with matched controls, patients with postoperative atrial fibrillation (POAF) have increased long-term AF after CABG, and POAF is further associated with increased ischemic stroke, heart failure and mortality even after adjustment for AF.
• Ladda ner fulltext (pdf) av Compared with matched controls, patients with postoperative atrial fibrillation (POAF) have increased long-term AF after CABG, and POAF is further associated with increased ischemic stroke, heart failure and mortality even after adjustment for AF.

5-year Follow up After MSC-based Treatment of Severe Acute Respiratory Distress Syndrome

Simonson, Oscar; Ståhle, Elisabeth; Hansen, Tomas; Wedin, Johan O et al.

Ingår i American Journal of Respiratory and Critical Care Medicine, s. 1051-1055, 2020

• DOI för 5-year Follow up After MSC-based Treatment of Severe Acute Respiratory Distress Syndrome
• Ladda ner fulltext (pdf) av 5-year Follow up After MSC-based Treatment of Severe Acute Respiratory Distress Syndrome

Synthetic tracheal grafts seeded with bone marrow cells fail to generate functional tracheae: First long-term follow-up study

Fux, Thomas; Österholm, Cecilia; Themudo, Raquel; Simonson, Oscar et al.

Ingår i Journal of Thoracic and Cardiovascular Surgery, s. 2525-2.537e+26, 2020

• DOI för Synthetic tracheal grafts seeded with bone marrow cells fail to generate functional tracheae: First long-term follow-up study
• Ladda ner fulltext (pdf) av Synthetic tracheal grafts seeded with bone marrow cells fail to generate functional tracheae: First long-term follow-up study

Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells

Grinnemo, Karl-Henrik; Löfling, Marie; Nathanson, Lubov; Baumgartner, Roland et al.

Ingår i Stem Cell Research & Therapy, 2019

• DOI för Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells
• Ladda ner fulltext (pdf) av Immunomodulatory effects of interferon-gamma on human fetal cardiac mesenchymal stromal cells

Human Fetal Cardiac Mesenchymal Stromal Cells Differentiate In Vivo into Endothelial Cells and Contribute to Vasculogenesis in Immunocompetent Mice

Ljung, Karin; Grönlund, Anna; Felldin, Ulrika; Rodin, Sergey et al.

Ingår i Stem Cells and Development, s. 310-318, 2019

• DOI för Human Fetal Cardiac Mesenchymal Stromal Cells Differentiate In Vivo into Endothelial Cells and Contribute to Vasculogenesis in Immunocompetent Mice

New insights into the human heart development using a combined spatial and single-cell transcriptomics approach

Giacomello, Stefania; Asp, Michaela; Wärdell, Eva; Reimegård, Johan et al.

Ingår i Human Genomics, s. 50-51, 2018

• DOI för New insights into the human heart development using a combined spatial and single-cell transcriptomics approach
• Ladda ner fulltext (pdf) av New insights into the human heart development using a combined spatial and single-cell transcriptomics approach

Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop

Ekdahl, Kristina N.; Fromell, Karin; Mannes, Marco; Grinnemo, Karl-Henrik et al.

Ingår i Immunological Reviews, s. 91-103, 2023

• DOI för Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop
• Ladda ner fulltext (pdf) av Therapeutic regulation of complement activation in extracorporeal circuits and intravascular treatments with special reference to the alternative pathway amplification loop

Differences and similarities between cancer and somatic stem cells: therapeutic implications

Rossi, Fiorella; Noren, Hunter; Jove, Richard; Beljanski, Vladimir et al.

Ingår i Stem Cell Research & Therapy, 2020

• DOI för Differences and similarities between cancer and somatic stem cells: therapeutic implications
• Ladda ner fulltext (pdf) av Differences and similarities between cancer and somatic stem cells: therapeutic implications

Pleiotropic roles of autophagy in stem cell-based therapies

Beljanski, Vladimir; Grinnemo, Karl-Henrik; Österholm, Cecilia

Ingår i Cytotherapy, s. 380-392, 2019

• DOI för Pleiotropic roles of autophagy in stem cell-based therapies