Thomas Juan
Biträdande universitetslektor vid Institutionen för immunologi, genetik och patologi; Forskningsprogram: Vaskulärbiologi; Forskargrupp Thomas Juan
- E-post:
- thomas.juan@igp.uu.se
- Besöksadress:
- Dag Hammarskjölds väg 20
751 85 Uppsala - Postadress:
- Rudbecklaboratoriet
751 85 UPPSALA
- ORCID:
- 0000-0002-9654-3717
Nyckelord
- zebrafish
- developmental genetics
- genome editing
- mechanobiology
- cardiovascular diseases
Forskning
Mitt laboratorium syftar till att förstå hur blodflödeskrafter formar utvecklingen och funktionen av det kardiovaskulära systemet. Vi genererar genetiska verktyg för att kontrollera hjärtats sammandragningar och modulera funktionen hos mekanosensorproteiner i kardiovaskulära subpopulationer.

Publikationer
Senaste publikationer
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Time-resolved single-cell transcriptomics maps zebrafish heart development
Ingår i Cell Reports, 2026
- DOI för Time-resolved single-cell transcriptomics maps zebrafish heart development
- Ladda ner fulltext (pdf) av Time-resolved single-cell transcriptomics maps zebrafish heart development
-
Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
Ingår i Science Advances, 2026
- DOI för Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
- Ladda ner fulltext (pdf) av Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
-
Induction of a transcriptional adaptation response by RNA destabilization events
Ingår i EMBO Reports, s. 2262-2279, 2025
- DOI för Induction of a transcriptional adaptation response by RNA destabilization events
- Ladda ner fulltext (pdf) av Induction of a transcriptional adaptation response by RNA destabilization events
-
Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy
Ingår i Nature, s. 493-502, 2025
-
A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish
Ingår i PLOS Genetics, 2025
Alla publikationer
Artiklar i tidskrift
-
Time-resolved single-cell transcriptomics maps zebrafish heart development
Ingår i Cell Reports, 2026
- DOI för Time-resolved single-cell transcriptomics maps zebrafish heart development
- Ladda ner fulltext (pdf) av Time-resolved single-cell transcriptomics maps zebrafish heart development
-
Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
Ingår i Science Advances, 2026
- DOI för Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
- Ladda ner fulltext (pdf) av Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
-
Induction of a transcriptional adaptation response by RNA destabilization events
Ingår i EMBO Reports, s. 2262-2279, 2025
- DOI för Induction of a transcriptional adaptation response by RNA destabilization events
- Ladda ner fulltext (pdf) av Induction of a transcriptional adaptation response by RNA destabilization events
-
Transcriptional adaptation upregulates utrophin in Duchenne muscular dystrophy
Ingår i Nature, s. 493-502, 2025
-
A recombinase-activated ribozyme to knock down endogenous gene expression in zebrafish
Ingår i PLOS Genetics, 2025
-
egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis
Ingår i Science Advances, 2024
-
Ingår i Development, 2024
- DOI för flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response
- Ladda ner fulltext (pdf) av flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response
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Control of cardiac contractions using Cre-lox and degron strategies in zebrafish.
Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2024
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In preprints: Shh signaling activity predicts cardiac laterality in Astyanax mexicanus populations.
Ingår i Development, 2024
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Pathway to Independence: the future of developmental biology.
Ingår i Development, 2023
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Multiple pkd and piezo gene family members are required for atrioventricular valve formation.
Ingår i Nature Communications, s. 214, 2023
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Pathway to independence - an interview with Thomas Juan
Ingår i Development, 2023
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Parental mutations influence wild-type offspring via transcriptional adaptation.
Ingår i Science Advances, 2022
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Biogenesis and function of ESCRT-dependent extracellular vesicles.
Ingår i Seminars in Cell and Developmental Biology, s. 66-77, 2018
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Myosin1D is an evolutionarily conserved regulator of animal left-right asymmetry.
Ingår i Nature Communications, s. 1942, 2018
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Companion Blood Cells Control Ovarian Stem Cell Niche Microenvironment and Homeostasis.
Ingår i Cell Reports, s. 546-560, 2015
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The ESCRT complex: from endosomal transport to the development of multicellular organisms.
Ingår i Biologie aujourd'hui, s. 111-24, 2015