Nicole Metzendorf

Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Metzendorf, Nicole G.; Sehlin, Dag; Hultqvist, Greta

Ingår i Frontiers in Neuroscience, 2025

• DOI för Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates
• Ladda ner fulltext (pdf) av Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment

Metzendorf, Nicole G.; Petersen, Inga; Hultqvist, Greta

Ingår i Frontiers in Pharmacology, 2025

• DOI för Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment
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Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies

Morrison, Jamie; Metzendorf, Nicole G.; Liu, Jielu; Hultqvist, Greta

Ingår i Drug Delivery and Translational Research, s. 3321-3337, 2025

• DOI för Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies
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Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration

de la Rosa, Andrés; Metzendorf, Nicole G.; Efverström, Jonathan; Godec, Ana et al.

Ingår i Neurotherapeutics, 2025

• DOI för Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
• Ladda ner fulltext (pdf) av Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration

Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton

Macarron-Palacios, Victor; Hubrich, Jasmine; Lima, Maria Augusta do Rego Barros Fernandes; Metzendorf, Nicole G. et al.

Ingår i Science Advances, 2025

• DOI för Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton
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Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Metzendorf, Nicole G.; Sehlin, Dag; Hultqvist, Greta

Ingår i Frontiers in Neuroscience, 2025

• DOI för Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates
• Ladda ner fulltext (pdf) av Key considerations for ELISA-based quantification of diverse amyloid beta forms in murine brain homogenates

Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment

Metzendorf, Nicole G.; Petersen, Inga; Hultqvist, Greta

Ingår i Frontiers in Pharmacology, 2025

• DOI för Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment
• Ladda ner fulltext (pdf) av Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment

Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies

Morrison, Jamie; Metzendorf, Nicole G.; Liu, Jielu; Hultqvist, Greta

Ingår i Drug Delivery and Translational Research, s. 3321-3337, 2025

• DOI för Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies
• Ladda ner fulltext (pdf) av Serotransferrin enhances transferrin receptor-mediated brain uptake of antibodies

Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration

de la Rosa, Andrés; Metzendorf, Nicole G.; Efverström, Jonathan; Godec, Ana et al.

Ingår i Neurotherapeutics, 2025

• DOI för Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration
• Ladda ner fulltext (pdf) av Lowering the affinity of single-chain monovalent BBB shuttle scFc-scFv8D3 prolongs its half-life and increases brain concentration

Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton

Macarron-Palacios, Victor; Hubrich, Jasmine; Lima, Maria Augusta do Rego Barros Fernandes; Metzendorf, Nicole G. et al.

Ingår i Science Advances, 2025

• DOI för Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton
• Ladda ner fulltext (pdf) av Paralemmin-1 controls the nanoarchitecture of the neuronal submembrane cytoskeleton

A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

Petersen, Inga; Morrison, Jamie I.; Petrovic, Alex; Babic, Neira et al.

Ingår i Scientific Reports, 2024

• DOI för A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
• Ladda ner fulltext (pdf) av A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro

Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the App^NL-F Mouse Model of Alzheimer's Disease

Portal, Benjamin; Södergren, Moa; Parés i Borrell, Teo; Giraud, Romain et al.

Ingår i Journal of Alzheimer's Disease, s. 1017-1037, 2024

• DOI för Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the App^NL-F Mouse Model of Alzheimer's Disease
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Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease

Gustavsson, Tobias; Metzendorf, Nicole G.; Wik, Elin; Roshanbin, Sahar et al.

Ingår i Alzheimer's Research & Therapy, 2023

• DOI för Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer's disease
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A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses

Morrison, Jamie I.; Metzendorf, Nicole G.; Rofo, Fadi; Petrovic, Alex et al.

Ingår i Journal of Neurochemistry, s. 413-425, 2023

• DOI för A single-chain fragment constant design enables easy production of a monovalent blood-brain barrier transporter and provides an improved brain uptake at elevated doses
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Standardized Preclinical In Vitro Blood-Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways

Morrison, Jamie; Petrovic, Alex; Metzendorf, Nicole G.; Rofo, Fadi et al.

Ingår i Molecular Pharmaceutics, s. 1564-1576, 2023

• DOI för Standardized Preclinical In Vitro Blood-Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways
• Ladda ner fulltext (pdf) av Standardized Preclinical In Vitro Blood-Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Rofo, Fadi; Meier, Silvio R.; Metzendorf, Nicole G.; Morrison, Jamie et al.

Ingår i Neurotherapeutics, s. 1588-1602, 2022

• DOI för A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice
• Ladda ner fulltext (pdf) av A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer's Disease Mice

Destination and Specific Impact of Different Bile Acids in the Intestinal Pathogen Clostridioides difficile

Metzendorf, Nicole G.; Lange, Lena Melanie; Lainer, Nina; Schlüter, Rabea et al.

Ingår i Frontiers in Microbiology, 2022

• DOI för Destination and Specific Impact of Different Bile Acids in the Intestinal Pathogen Clostridioides difficile
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Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3

de la Rosa, Andres; Metzendorf, Nicole G.; Morrison, Jamie; Faresjö, Rebecca et al.

Ingår i Scientific Reports, 2022

• DOI för Introducing or removing heparan sulfate binding sites does not alter brain uptake of the blood-brain barrier shuttle scFv8D3
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Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease

Rofo, Fadi; Metzendorf, Nicole; Saubi, Cristina; Suominen, Laura et al.

Ingår i Alzheimer's Research & Therapy, 2022

• DOI för Blood-brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
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Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Rofo, Fadi; Buijs, Jos; Falk, Ronny; Honek, Ken et al.

Ingår i Translational Neurodegeneration, 2021

• DOI för Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta
• Ladda ner fulltext (pdf) av Novel multivalent design of a monoclonal antibody improves binding strength to soluble aggregates of amyloid beta

Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Rofo, Fadi; Yilmaz, Canan Ugur; Metzendorf, Nicole G.; Gustavsson, Tobias et al.

Ingår i Theranostics, s. 789-804, 2021

• DOI för Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain
• Ladda ner fulltext (pdf) av Enhanced neprilysin-mediated degradation of hippocampal A beta 42 with a somatostatin peptide that enters the brain

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

Rofo, Fadi; Sandbaumhüter, Friederike A.; Chourlia, Aikaterini; Metzendorf, Nicole G. et al.

Ingår i ACS Chemical Neuroscience, s. 2529-2541, 2021

• DOI för Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
• Ladda ner fulltext (pdf) av Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer's Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

The paralemmin protein family: Phosphoproteins involved in filopodia and dendritic spine formation

Neumann, Nicole G.

2011