Emma Eriksson

Tumor Microenvironment Gene Engineering with LOAd703 in Patients with Solid Malignancies: LOKON002 Phase I/IIb Clinical Trial

Hahn, Amanda; Irenaeus, Sandra; Sandin, Linda C.; Nordström, Clara et al.

Ingår i Clinical Cancer Research, s. 3157-3168, 2026

• DOI för Tumor Microenvironment Gene Engineering with LOAd703 in Patients with Solid Malignancies: LOKON002 Phase I/IIb Clinical Trial

LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial

Hamid, O.; Ekström-Rydén, Viktoria; Mehmi, I.; Wang, D. et al.

Ingår i Nature Communications, 2026

• DOI för LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial
• Ladda ner fulltext (pdf) av LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial

Reprogramming myeloid cells and restoring T cell fitness in checkpoint inhibitor resistant melanoma patients

Grauers Wiktorin, Hanna; Rydén, Viktoria; Ek, Ida; Eriksson, Emma et al.

Ingår i Biomarker Research, 2026

• DOI för Reprogramming myeloid cells and restoring T cell fitness in checkpoint inhibitor resistant melanoma patients
• Ladda ner fulltext (pdf) av Reprogramming myeloid cells and restoring T cell fitness in checkpoint inhibitor resistant melanoma patients

CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling

Naseri, Sedigheh; Mejia Cordova, Mariela; Wenthe, Jessica; Lövgren, Tanja et al.

Ingår i Journal of Cellular and Molecular Medicine, 2024

• DOI för CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling
• Ladda ner fulltext (pdf) av CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling

Transferability of Human and Environmental Microbiome on Clothes as a Tool for Forensic Investigations

Procopio, Noemi; Sguazzi, Giulia; Eriksson, Emma; Ogbanga, Nengi et al.

Ingår i Genes, 2024

• DOI för Transferability of Human and Environmental Microbiome on Clothes as a Tool for Forensic Investigations
• Ladda ner fulltext (pdf) av Transferability of Human and Environmental Microbiome on Clothes as a Tool for Forensic Investigations

Tumor Microenvironment Gene Engineering with LOAd703 in Patients with Solid Malignancies: LOKON002 Phase I/IIb Clinical Trial

Hahn, Amanda; Irenaeus, Sandra; Sandin, Linda C.; Nordström, Clara et al.

Ingår i Clinical Cancer Research, s. 3157-3168, 2026

• DOI för Tumor Microenvironment Gene Engineering with LOAd703 in Patients with Solid Malignancies: LOKON002 Phase I/IIb Clinical Trial

LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial

Hamid, O.; Ekström-Rydén, Viktoria; Mehmi, I.; Wang, D. et al.

Ingår i Nature Communications, 2026

• DOI för LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial
• Ladda ner fulltext (pdf) av LOAd703-induced tumor microenvironment gene engineering in combination with atezolizumab in metastatic malignant melanoma: a phase I/II trial

Reprogramming myeloid cells and restoring T cell fitness in checkpoint inhibitor resistant melanoma patients

Grauers Wiktorin, Hanna; Rydén, Viktoria; Ek, Ida; Eriksson, Emma et al.

Ingår i Biomarker Research, 2026

• DOI för Reprogramming myeloid cells and restoring T cell fitness in checkpoint inhibitor resistant melanoma patients
• Ladda ner fulltext (pdf) av Reprogramming myeloid cells and restoring T cell fitness in checkpoint inhibitor resistant melanoma patients

CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling

Naseri, Sedigheh; Mejia Cordova, Mariela; Wenthe, Jessica; Lövgren, Tanja et al.

Ingår i Journal of Cellular and Molecular Medicine, 2024

• DOI för CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling
• Ladda ner fulltext (pdf) av CD40 stimulation via CD40 ligand enhances adenovirus-mediated tumour immunogenicity including 'find-me', 'eat-me', and 'kill-me' signalling

Transferability of Human and Environmental Microbiome on Clothes as a Tool for Forensic Investigations

Procopio, Noemi; Sguazzi, Giulia; Eriksson, Emma; Ogbanga, Nengi et al.

Ingår i Genes, 2024

• DOI för Transferability of Human and Environmental Microbiome on Clothes as a Tool for Forensic Investigations
• Ladda ner fulltext (pdf) av Transferability of Human and Environmental Microbiome on Clothes as a Tool for Forensic Investigations

LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001) results from arm 1 of a non-randomised, single-centre, phase 1/2 study

Musher, Benjamin L.; Rowinsky, Eric K.; Smaglo, Brandon G.; Abidi, Wasif et al.

Ingår i The Lancet Oncology, s. 488-500, 2024

• DOI för LOAd703, an oncolytic virus-based immunostimulatory gene therapy, combined with chemotherapy for unresectable or metastatic pancreatic cancer (LOKON001) results from arm 1 of a non-randomised, single-centre, phase 1/2 study

Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models

Wenthe, Jessica; Eriksson, Emma; Hellström, Ann-Charlotte; Moreno, Rafael et al.

Ingår i Journal of Translational Medicine, 2023

• DOI för Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models
• Ladda ner fulltext (pdf) av Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models

Immune priming using DC- and T cell-targeting gene therapy sensitizes both treated and distant B16 tumors to checkpoint inhibition

Wenthe, Jessica; Naseri, Sedigheh; Hellström, Ann-Charlotte; Moreno, Rafael et al.

Ingår i MOLECULAR THERAPY-ONCOLYTICS, s. 429-442, 2022

• DOI för Immune priming using DC- and T cell-targeting gene therapy sensitizes both treated and distant B16 tumors to checkpoint inhibition
• Ladda ner fulltext (pdf) av Immune priming using DC- and T cell-targeting gene therapy sensitizes both treated and distant B16 tumors to checkpoint inhibition

Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes

Labani-Motlagh, Alireza; Naseri, Sedigheh; Wenthe, Jessica; Eriksson, Emma et al.

Ingår i MOLECULAR THERAPY-ONCOLYTICS, s. 508-518, 2021

• DOI för Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes
• Ladda ner fulltext (pdf) av Systemic immunity upon local oncolytic virotherapy armed with immunostimulatory genes may be supported by tumor-derived exosomes

Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas-Long-Term Follow Up

Saellstrom, Sara; Sadeghi, Arian; Eriksson, Emma; Segall, Thomas et al.

Ingår i Frontiers in Veterinary Science, 2021

• DOI för Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas-Long-Term Follow Up
• Ladda ner fulltext (pdf) av Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas-Long-Term Follow Up

Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy

Wenthe, Jessica; Naseri, Sedigheh; Labani-Motlagh, Alireza; Enblad, Gunilla et al.

Ingår i Cancer Immunology and Immunotherapy, s. 2851-2865, 2021

• DOI för Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy
• Ladda ner fulltext (pdf) av Boosting CAR T-cell responses in lymphoma by simultaneous targeting of CD40/4-1BB using oncolytic viral gene therapy

Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40

Wenthe, Jessica; Naseri, Sedigheh; Hellström, Ann-Charlotte; Jernberg Wiklund, Helena et al.

Ingår i Cancer Gene Therapy, s. 948-959, 2020

• DOI för Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40
• Ladda ner fulltext (pdf) av Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40

Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients

Amini, Rose-Marie; Enblad, Gunilla; Hollander, Peter; Laszlo, S. et al.

Ingår i BMC Cancer, 2019

• DOI för Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients
• Ladda ner fulltext (pdf) av Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients

IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-beta, Collagen Type I, and PD-L1/PD-1

Eriksson, Emma; Milenova, Ioanna; Wenthe, Jessica; Moreno, Rafael et al.

Ingår i Journal of Immunology, s. 787-798, 2019

• DOI för IL-6 Signaling Blockade during CD40-Mediated Immune Activation Favors Antitumor Factors by Reducing TGF-beta, Collagen Type I, and PD-L1/PD-1

Immunostimulatory gene therapy enhances PD-1 blockade antibody therapy in experimental lung cancer

Wenthe, Jessica; Eriksson, Emma; Hellström, Ann-Charlotte; Loskog, Angelica S.

Ingår i CANCER IMMUNOLOGY RESEARCH, 2018

• DOI för Immunostimulatory gene therapy enhances PD-1 blockade antibody therapy in experimental lung cancer

Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Schiza, Aglaia; Wenthe, Jessica; Mangsbo, Sara; Svensson, Emma et al.

Ingår i Journal of Translational Medicine, 2017

• DOI för Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients
• Ladda ner fulltext (pdf) av Adenovirus-mediated CD40L gene transfer increases Teffector/Tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients

Irenaeus, Sandra; Schiza, Aglaia; Mangsbo, Sara M.; Wenthe, Jessica et al.

Ingår i Oncotarget, s. 78573-78587, 2017

• DOI för Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients
• Ladda ner fulltext (pdf) av Local irradiation does not enhance the effect of immunostimulatory AdCD40L gene therapy combined with low dose cyclophosphamide in melanoma patients

Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus.

Svensson, Emma; Milenova, Ioanna; Wenthe, Jessica; Ståhle, Magnus et al.

Ingår i Clinical Cancer Research, s. 5846-5857, 2017

• DOI för Shaping the Tumor Stroma and Sparking Immune Activation by CD40 and 4-1BB Signaling Induced by an Armed Oncolytic Virus.

An oncolytic virus targeting desmoplasia and immune activation in pancreatic cancer

Eriksson, Emma; Milenova, Ioanna; Wenthe, Jessica; Moreno, Rafael et al.

Ingår i Scandinavian Journal of Immunology, s. 335-335, 2017

Adenovirus-mediated CD40L gene transfer increases teffector/tregulatory cell ratio and upregulates death receptors in metastatic melanoma patients

Schiza, Aglaia; Wenthe, Jessica; Mangsbo, Sara; Eriksson, Emma et al.

Ingår i Scandinavian Journal of Immunology, s. 337-337, 2017

Activating CD40 While Inhibiting IL6R Induces Cytokine Production without PDL1 Upregulation in DCs

Eriksson, Emma; Milenova, Ioanna; Wenthe, Jessica; Moreno, Rafael et al.

Ingår i Molecular Therapy, s. 54-54, 2017

Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment

Eriksson, Emma; Moreno, R; Milenova, I. Yoanna; Liljenfeldt, L et al.

Ingår i Gene Therapy, s. 92-103, 2017

• DOI för Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment
• Ladda ner fulltext (pdf) av Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment

Gemcitabine reduces MDSCs, tregs and TGF beta-1 while restoring the teff/treg ratio in patients with pancreatic cancer

Eriksson, Emma; Wenthe, Jessica; Irenaeus, Sandra; Loskog, Angelica et al.

Ingår i Journal of Translational Medicine, 2016

• DOI för Gemcitabine reduces MDSCs, tregs and TGF beta-1 while restoring the teff/treg ratio in patients with pancreatic cancer
• Ladda ner fulltext (pdf) av Gemcitabine reduces MDSCs, tregs and TGF beta-1 while restoring the teff/treg ratio in patients with pancreatic cancer

A Novel Oncolytic Adenovirus Expressing Tumor Microenvironment Stimulators to Evoke and Facilitate Anti-Tumor Immune Responses

Wenthe, Jessica; Eriksson, Emma; Milenova, Ioanna; Moreno, Rafael et al.

Ingår i Molecular Therapy, 2016

An Oncolytic Adenovirus Gene Therapy Targeting Both Tumor Cell Survival and Desmoplasia in Pancreatic Cancer

Milenova, Ioanna; Eriksson, Emma; Moreno, Rafael; Alemany, Ramon et al.

Ingår i Molecular Therapy, 2016

Immunotherapy with a CD40L/4-1BBL double-armed oncolytic adenovirus drives Th1 immunity and control tumor progression in a pancreas cancer model

Svensson, Emma; Milenova, Ioanna; Moreno, Rafael; Alemany, Ramon et al.

Ingår i Cancer Research, 2015

• DOI för Immunotherapy with a CD40L/4-1BBL double-armed oncolytic adenovirus drives Th1 immunity and control tumor progression in a pancreas cancer model

Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors

Karlsson, Hannah; Svensson, Emma; Gigg, Camilla; Jarvius, Malin et al.

Ingår i PLOS ONE, 2015

• DOI för Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors
• Ladda ner fulltext (pdf) av Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors

Insertion of exogenous epitopes in the E3-19K of oncolytic adenoviruses to enhance TAP-independent presentation and immunogenicity

Rodriguez-Garcia, A.; Svensson, Emma; Gil-Hoyos, R.; Fajardo, C. A. et al.

Ingår i Gene Therapy, s. 596-601, 2015

• DOI för Insertion of exogenous epitopes in the E3-19K of oncolytic adenoviruses to enhance TAP-independent presentation and immunogenicity

Development of Gene Transfer Technology

Svensson, Emma; Moreno, R.; Milenova, Ioanna; Christiansson, Lisa et al.

Ingår i Human Gene Therapy, 2014

AdCD40L Immunostimulatory Gene Therapy in Combination with Cyclophosphamide Prolongs 6-Months Survival in a Phase I/II Trial for Malignant Melanoma

Loskog, Angelica; Maleka, Aglaia; Mangsbo, Sara; Svensson, Emma et al.

Ingår i Molecular Therapy, 2014

• DOI för AdCD40L Immunostimulatory Gene Therapy in Combination with Cyclophosphamide Prolongs 6-Months Survival in a Phase I/II Trial for Malignant Melanoma

Antigen Signaling Enhances Proliferation and Cytotoxic Capacity of CD19-Targeting CD28/4-1BB CAR T Cells During Expansion Without Inducing Exhaustion

Karlsson, Hannah; Gigg, Camilla; Svensson, Emma; Larsson, Rolf et al.

Ingår i Molecular Therapy, 2014

Immunostimulating Gene Therapy Using an Oncolytic Adenovirus Armed with CD40 Ligand Potently Kill Tumor Cells, Activates Dendritic Cells and Induces T Cell Responses

Svensson, Emma; Moreno, Rafael; Milenova, Ioanna; Christiansson, Lisa et al.

Ingår i Molecular Therapy, 2014

Enhanced therapeutic anti-tumor immunity induced by co-administration of 5-fluorouracil and adenovirus expressing CD40 ligand

Liljenfeldt, Lina; Gkirtzimanaki, Katerina; Vyrla, Dimitra; Svensson, Emma et al.

Ingår i Cancer Immunology and Immunotherapy, s. 273-282, 2014

• DOI för Enhanced therapeutic anti-tumor immunity induced by co-administration of 5-fluorouracil and adenovirus expressing CD40 ligand

Tim-3 and PD-1: Regulators of adaptive immunity in multiple sclerosis

Burman, Joachim; Svensson, Emma; Fransson, Moa; Loskog, Angelica et al.

Ingår i Journal of Neuroimmunology, s. 141-141, 2014

• DOI för Tim-3 and PD-1: Regulators of adaptive immunity in multiple sclerosis

The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to the Th1/Th2/Th17 convention

Burman, Joachim; Svensson, Emma; Fransson, Moa; Loskog, Angelica S I et al.

Ingår i Journal of Neuroimmunology, s. 153-159, 2014

• DOI för The cerebrospinal fluid cytokine signature of multiple sclerosis: A homogenous response that does not conform to the Th1/Th2/Th17 convention

Increased Level of Myeloid-Derived Suppressor Cells, Programmed Death Receptor Ligand 1/Programmed Death Receptor 1, and Soluble CD25 in Sokal High Risk Chronic Myeloid Leukemia

Christiansson, Lisa; Söderlund, Stina; Svensson, Emma; Mustjoki, Satu et al.

Ingår i PLOS ONE, 2013

• DOI för Increased Level of Myeloid-Derived Suppressor Cells, Programmed Death Receptor Ligand 1/Programmed Death Receptor 1, and Soluble CD25 in Sokal High Risk Chronic Myeloid Leukemia
• Ladda ner fulltext (pdf) av Increased Level of Myeloid-Derived Suppressor Cells, Programmed Death Receptor Ligand 1/Programmed Death Receptor 1, and Soluble CD25 in Sokal High Risk Chronic Myeloid Leukemia

Treatment Efficacy and Immune Stimulation by AdCD40L Gene Therapy of Spontaneous Canine Malignant Melanoma

Westberg, Sara; Sadeghi, Arian; Svensson, Emma; Segall, Thomas et al.

Ingår i Journal of immunotherapy (1997), s. 350-358, 2013

• DOI för Treatment Efficacy and Immune Stimulation by AdCD40L Gene Therapy of Spontaneous Canine Malignant Melanoma

Preclinical evaluation of immunostimulatory gene therapy for pancreatic cancer

Eriksson, Emma

2017

• Ladda ner fulltext (pdf) av Preclinical evaluation of immunostimulatory gene therapy for pancreatic cancer

Safety of intratumoral immunostimulatory LOAd703 gene therapy in patients with advanced cancer

Irenaeus, Sandra; Wenthe, Jessica; Eriksson, Emma; Schiza, Aglaia et al.

Immunological evaluation of immunostimulatory gene therapy targeting CD40/4-1BB in advanced cancer patients (LOKON002)

Wenthe, Jessica; Eriksson, Emma; Naseri, Sedigheh; Sandin, Linda et al.

Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models

Wenthe, Jessica; Eriksson, Emma; Hellström, Ann-Charlotte; Moreno, Rafael et al.

LOAd703 Gene Engineering Induces Tumor Cell Immunogenicity and Enhances the Effect of Chemotherapy in Ovarian Cancer Models

Naseri, Sedigheh; Härdin, Jonas; Mejia Cordova, Mariela; Eriksson, Emma et al.