Sebastian Barg

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Ingår i Nature Communications, 2020

• DOI för Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
• Ladda ner fulltext (pdf) av Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Gucek, Alenka; Gandasi, Nikhil R; Omar-Hmeadi, Muhmmad; Bakke, Marit et al.

Ingår i eLIFE, 2019

• DOI för Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
• Ladda ner fulltext (pdf) av Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

Gandasi, Nikhil R; Yin, Peng; Omar-Hmeadi, Muhmmad; Ottosson Laakso, Emilia et al.

Ingår i Cell Metabolism, s. 470-478, 2018

• DOI för Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

Syntaxin clusters at secretory granules in a munc18-bound conformation

Yin, Peng; Gandasi, Nikhil R.; Arora, Swati; Omar-Hmeadi, Muhmmad et al.

Ingår i Molecular Biology of the Cell, s. 2700-2708, 2018

• DOI för Syntaxin clusters at secretory granules in a munc18-bound conformation
• Ladda ner fulltext (pdf) av Syntaxin clusters at secretory granules in a munc18-bound conformation

Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Gandasi, Nikhil R.; Yin, Peng; Riz, Michela; Chibalina, Margarita V et al.

Ingår i Journal of Clinical Investigation, s. 2353-2364, 2017

• DOI för Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
• Ladda ner fulltext (pdf) av Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

Gandasi, Nikhil R; Barg, Sebastian

Ingår i Nature Communications, 2014

• DOI för Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

Syntaxin clusters assemble reversibly at sites of secretory granules in live cells

Barg, Sebastian; Knowles, M. K.; Chen, X.; Midorikawa, M. et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 20804-20809, 2010

• DOI för Syntaxin clusters assemble reversibly at sites of secretory granules in live cells

Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells

Barg, Sebastian; Olofsson, Charlotta S; Schriever-Abeln, Jenny; Wendt, Anna et al.

Ingår i Neuron, s. 287-299, 2002

• DOI för Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

Oqua, Affiong I; Chao, Kin; El Eid, Liliane; Casteller, Lisa et al.

Ingår i eLIFE, 2024

• DOI för Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Ingår i Diabetologia, s. 1642-1662, 2024

• DOI för RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
• Ladda ner fulltext (pdf) av RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Sanchez, Gonzalo; Incedal, Tugce Ceren; Prada, Juan; O'Callaghan, Paul et al.

Ingår i Journal of Cell Biology, 2023

• DOI för The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling
• Ladda ner fulltext (pdf) av The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis

Liu, Chen; Mentzelopoulou, Andriani; Papagavriil, Fotini; Ramachandran, Prashanth et al.

Ingår i PLoS biology, 2023

• DOI för SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis
• Ladda ner fulltext (pdf) av SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Yeh, Yu-Te; Sona, Chandan; Yan, Xin; Li, Yunxiao et al.

Ingår i Nature Communications, 2023

• DOI för Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
• Ladda ner fulltext (pdf) av Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

Oqua, Affiong I; Chao, Kin; El Eid, Liliane; Casteller, Lisa et al.

Ingår i eLIFE, 2024

• DOI för Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

Ibrahim, Hazem; Balboa, Diego; Saarimäki-Vire, Jonna; Montaser, Hossam et al.

Ingår i Diabetologia, s. 1642-1662, 2024

• DOI för RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function
• Ladda ner fulltext (pdf) av RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function

The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

Sanchez, Gonzalo; Incedal, Tugce Ceren; Prada, Juan; O'Callaghan, Paul et al.

Ingår i Journal of Cell Biology, 2023

• DOI för The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling
• Ladda ner fulltext (pdf) av The β-cell primary cilium is an autonomous Ca²⁺ compartment for paracrine GABA signaling

SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis

Liu, Chen; Mentzelopoulou, Andriani; Papagavriil, Fotini; Ramachandran, Prashanth et al.

Ingår i PLoS biology, 2023

• DOI för SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis
• Ladda ner fulltext (pdf) av SEC14-like condensate phase transitions at plasma membranes regulate root growth in Arabidopsis

Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Yeh, Yu-Te; Sona, Chandan; Yan, Xin; Li, Yunxiao et al.

Ingår i Nature Communications, 2023

• DOI för Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction
• Ladda ner fulltext (pdf) av Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis

Omar-Hmeadi, Muhmmad; Gucek, Alenka; Barg, Sebastian

Ingår i Cell Reports, 2023

• DOI för Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis
• Ladda ner fulltext (pdf) av Local PI(4,5)P₂ signaling inhibits fusion pore expansion during exocytosis

Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Golec, Ewelina; Ekstrom, Alexander; Noga, Maciej; Omar-Hmeadi, Muhmmad et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, 2022

• DOI för Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets
• Ladda ner fulltext (pdf) av Alternative splicing encodes functional intracellular CD59 isoforms that mediate insulin secretion and are down-regulated in diabetic islets

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Balboa, Diego; Barsby, Tom; Lithovius, Väinö; Saarimäki-Vire, Jonna et al.

Ingår i Nature Biotechnology, s. 1042-1055, 2022

• DOI för Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
• Ladda ner fulltext (pdf) av Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Ingår i Nature Communications, 2020

• DOI för Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.
• Ladda ner fulltext (pdf) av Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes.

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Petrenko, Volodymyr; Gandasi, Nikhil; Sage, Daniel; Tengholm, Anders et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 2484-2495, 2020

• DOI för In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis
• Ladda ner fulltext (pdf) av In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

Gucek, Alenka; Gandasi, Nikhil R; Omar-Hmeadi, Muhmmad; Bakke, Marit et al.

Ingår i eLIFE, 2019

• DOI för Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis
• Ladda ner fulltext (pdf) av Fusion pore regulation by cAMP/Epac2 controls cargo release during insulin exocytosis

The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Mojtaba Ghiasi, Seyed; Dahlby, Tina; Hede Andersen, Caroline; Haataja, Leena et al.

Ingår i Diabetes, s. 747-760, 2019

• DOI för The Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 is Essential for Proinsulin Handling

Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

Korol, Sergiy V; Jin, Zhe; Jin, Yang; Bhandage, Amol K. et al.

Ingår i EBioMedicine, 2018

• DOI för Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells
• Ladda ner fulltext (pdf) av Functional Characterization of Native, High-Affinity GABA_A Receptors in Human Pancreatic β Cells

PtdIns(4,5)P₂ is not required for secretory granule docking

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R; Barg, Sebastian

Ingår i Traffic, s. 436-445, 2018

• DOI för PtdIns(4,5)P₂ is not required for secretory granule docking

Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

Gandasi, Nikhil R; Yin, Peng; Omar-Hmeadi, Muhmmad; Ottosson Laakso, Emilia et al.

Ingår i Cell Metabolism, s. 470-478, 2018

• DOI för Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes

Syntaxin clusters at secretory granules in a munc18-bound conformation

Yin, Peng; Gandasi, Nikhil R.; Arora, Swati; Omar-Hmeadi, Muhmmad et al.

Ingår i Molecular Biology of the Cell, s. 2700-2708, 2018

• DOI för Syntaxin clusters at secretory granules in a munc18-bound conformation
• Ladda ner fulltext (pdf) av Syntaxin clusters at secretory granules in a munc18-bound conformation

MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles

Salunkhe, Vishal A.; Ofori, Jones K.; Gandasi, Nikhil R; Salo, Sofia A. et al.

Ingår i Physiological Reports, 2017

• DOI för MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles
• Ladda ner fulltext (pdf) av MiR-335 overexpression impairs insulin secretion through defective priming of insulin vesicles

Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Alenkvist, Ida; Gandasi, Nikhil R; Barg, Sebastian; Tengholm, Anders

Ingår i Diabetes, s. 2610-2622, 2017

• DOI för Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Omar-Hmeadi, Muhmmad; Gandasi, Nikhil R.; Barg, Sebastian

Ingår i Molecular Biology of the Cell, s. 3727-3727, 2017

• DOI för Plasma membrane PI(4,5)P-2 is critical for secretory granule exocytosis

Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Gandasi, Nikhil R.; Yin, Peng; Riz, Michela; Chibalina, Margarita V et al.

Ingår i Journal of Clinical Investigation, s. 2353-2364, 2017

• DOI för Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes
• Ladda ner fulltext (pdf) av Ca²⁺ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells

Cortese, Giuliana; Gandasi, Nikhil R.; Barg, Sebastian; Pedersen, Morten Gram

Ingår i PLOS ONE, 2016

• DOI för Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells
• Ladda ner fulltext (pdf) av Statistical Frailty Modeling for Quantitative Analysis of Exocytotic Events Recorded by Live Cell Imaging: Rapid Release of Insulin-Containing Granules Is Impaired in Human Diabetic beta-cells

Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca2+-Influx and Insulin Secretion from Pancreatic beta Cells

Xie, Beichen; Nguyen, Phuoc My; Gucek, Alenka; Thonig, Antje et al.

Ingår i CELL CHEMICAL BIOLOGY, s. 816-826, 2016

• DOI för Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca2+-Influx and Insulin Secretion from Pancreatic beta Cells

How Kiss-and-Run Can Make Us Sick: SOX4 Puts a Break on the Pore

Barg, Sebastian; Gucek, Alenka

Ingår i Diabetes, s. 1791-1793, 2016

• DOI för How Kiss-and-Run Can Make Us Sick: SOX4 Puts a Break on the Pore

Quantitative Imaging of the Exocytosis Machinery Assembly

Gandasi, Nikhil R.; Barg, Sebastian

Ingår i Biophysical Journal, 2015

Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis

Gandasi, Nikhil R.; Vesto, Kim; Helou, Maria; Yin, Peng et al.

Ingår i PLOS ONE, 2015

• DOI för Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis
• Ladda ner fulltext (pdf) av Survey of Red Fluorescence Proteins as Markers for Secretory Granule Exocytosis

MiR-335 regulates exocytotic proteins and affects glucose-stimulated insulin secretion through decreased Ca2+-dependent exocytosis in beta cells

Salunkhe, V. A.; Ofori, J.; Gandasi, Nikhil R.; Salo, S. A. et al.

Ingår i Diabetologia, 2015

G-protein coupled receptor dynamics in insulin secreting cells

Kay, Emma I.; Barg, Sebastian

Ingår i Diabetologia, 2015

CD59 is required for pancreatic beta cell insulin exocytosis

Krus, Ulrika; King, Benjamin C.; Nagaraj, Vini; Gandasi, Nikhil et al.

Ingår i Molecular Immunology, s. 279-279, 2014

Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

Gandasi, Nikhil R; Barg, Sebastian

Ingår i Nature Communications, 2014

• DOI för Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events

Krus, Ulrika; King, Ben C; Nagaraj, Vini; Gandasi, Nikhil R et al.

Ingår i Cell Metabolism, s. 883-890, 2014

• DOI för The Complement Inhibitor CD59 Regulates Insulin Secretion by Modulating Exocytotic Events

In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

Jin, Yang; Korol, Sergiy V; Jin, Zhe; Barg, Sebastian et al.

Ingår i PLOS ONE, 2013

• DOI för In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells
• Ladda ner fulltext (pdf) av In Intact Islets Interstitial GABA Activates GABA(A) Receptors That Generate Tonic Currents in alpha-Cells

Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

Zang, Guangxiang; Christoffersson, Gustaf; Tian, Geng; Harun-Or-Rashid, Mohammad et al.

Ingår i Cellular Signalling, s. 85-92, 2013

• DOI för Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells
• Ladda ner fulltext (pdf) av Aberrant association between vascular endothelial growth factor receptor-2 and VE-cadherin in response to vascular endothelial growth factor-a in Shb-deficient lung endothelial cells

Multivesicular exocytosis in rat pancreatic beta cells

Hoppa, M B; Jones, E; Karanauskaite, J; Ramracheya, R et al.

Ingår i Diabetologia, s. 1001-1012, 2012

• DOI för Multivesicular exocytosis in rat pancreatic beta cells

PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

Iglesias, José; Barg, Sebastian; Vallois, David; Lahiri, Shawon et al.

Ingår i Journal of Clinical Investigation, s. 4105-4117, 2012

• DOI för PPARβ/δ affects pancreatic β cell mass and insulin secretion in mice

cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Idevall Hagren, Olof; Barg, Sebastian; Gylfe, Erik; Tengholm, Anders

Ingår i Journal of Biological Chemistry, s. 23005-23016, 2010

• DOI för cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

Quantitative analysis of t-SNARE and Ca2+-channel clusters near secretory granules

Barg, Sebastian; Gandasi, Nikhil

Ingår i Diabetologia, 2010

• DOI för Quantitative analysis of t-SNARE and Ca2+-channel clusters near secretory granules

Defective secretion of islet hormones in chromogranin-B deficient mice

Obermüller, Stefanie; Calegari, Federico; King, Angus; Lindqvist, Anders et al.

Ingår i PLOS ONE, 2010

• DOI för Defective secretion of islet hormones in chromogranin-B deficient mice

Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers

Knowles, M. K.; Barg, Sebastian; Wan, L.; Midorikawa, M. et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 20810-20815, 2010

• DOI för Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers

Syntaxin clusters assemble reversibly at sites of secretory granules in live cells

Barg, Sebastian; Knowles, M. K.; Chen, X.; Midorikawa, M. et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 20804-20809, 2010

• DOI för Syntaxin clusters assemble reversibly at sites of secretory granules in live cells

Impaired glucose homeostasis in Shb-/- mice

Åkerblom, Björn; Barg, Sebastian; Calounova, Gabriela; Mokhtari, Dariush et al.

Ingår i Journal of Endocrinology, s. 271-279, 2009

• DOI för Impaired glucose homeostasis in Shb-/- mice

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

da Silva Xavier, Gabriela; Loder, Merewyn K; McDonald, Angela; Tarasov, Andrei I et al.

Ingår i Diabetes, s. 894-905, 2009

• DOI för TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

High extracellular glucose inhibits exocytosis through disruption of syntaxin 1A-containing lipid rafts

Somanath, Sangeeta; Barg, Sebastian; Marshall, Catriona; Silwood, Christopher J et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 241-246, 2009

• DOI för High extracellular glucose inhibits exocytosis through disruption of syntaxin 1A-containing lipid rafts

Release of the styryl dyes from single synaptic vesicles in hippocampal neurons.

Chen, Xi; Barg, Sebastian; Almers, Wolfhard

Ingår i The Journal of neuroscience : the official journal of the Society for Neuroscience, s. 1894-1903, 2008

• DOI för Release of the styryl dyes from single synaptic vesicles in hippocampal neurons.
• Ladda ner fulltext (pdf) av Release of the styryl dyes from single synaptic vesicles in hippocampal neurons.

Granule docking and cargo release in pancreatic β-cells

Barg, Sebastian; Lindqvist, Anders; Obermüller, Stefanie

Ingår i Biochemical Society Transactions, s. 294-299, 2008

• DOI för Granule docking and cargo release in pancreatic β-cells

Selective nucleotide-release from dense-core granules in insulin-secreting cells

Obermüller, Stefanie; Lindqvist, Anders; Karanauskaite, Jovita; Galvanovskis, Juris et al.

Ingår i Journal of Cell Science, s. 4271-82, 2005

• DOI för Selective nucleotide-release from dense-core granules in insulin-secreting cells
• Ladda ner fulltext (pdf) av Selective nucleotide-release from dense-core granules in insulin-secreting cells

Membrane phosphoinositides control insulin secretion through their effects on ATP-sensitive K+ channel activity.

Lin, Chia-Wei; Yan, Feifei; Shimamura, Satoko; Barg, Sebastian et al.

Ingår i Diabetes, s. 2852-8, 2005

Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.

Kanno, Takahiro; Ma, Xiasong; Barg, Sebastian; Eliasson, Lena et al.

Ingår i Methods, s. 302-11, 2004

• DOI för Large dense-core vesicle exocytosis in pancreatic beta-cells monitored by capacitance measurements.

Insulin secretion: a high-affinity Ca2+ sensor after all?

Barg, Sebastian; Rorsman, Patrik

Ingår i The Journal of General Physiology, s. 623-5, 2004

• DOI för Insulin secretion: a high-affinity Ca2+ sensor after all?

SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.

Eliasson, Lena; Ma, Xiaosong; Renström, Erik; Barg, Sebastian et al.

Ingår i The Journal of General Physiology, s. 181-97, 2003

Mechanisms of exocytosis in insulin-secreting B-cells and glucagon-secreting A-cells.

Barg, Sebastian

Ingår i Pharmacology and Toxicology, s. 3-13, 2003

Characterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene.

Cervin, C; Orho-Melander, M; Ridderstråle, M; Lehto, M et al.

Ingår i Diabetologia, s. 1703-8, 2002

• DOI för Characterization of a naturally occurring mutation (L107I) in the HNF1 alpha (MODY3) gene.

Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells

Barg, Sebastian; Olofsson, Charlotta S; Schriever-Abeln, Jenny; Wendt, Anna et al.

Ingår i Neuron, s. 287-299, 2002

• DOI för Delay between fusion pore opening and peptide release from large dense-core vesicles in neuroendocrine cells

Sulfonylurea-mediated stimulation of insulin exocytosis via an ATP-sensitive K+ channel-independent action.

Renström, Erik; Barg, Sebastian; Thévenod, Frank; Rorsman, Patrik

Ingår i Diabetes, 2002

Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.

Olofsson, Charlotta S; Göpel, Sven O; Barg, Sebastian; Galvanovskis, Juris et al.

Ingår i Pflügers Archiv, s. 43-51, 2002

• DOI för Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells.

Differential activation by Ca2+, ATP and caffeine of cardiac and skeletal muscle ryanodine receptors after block by Mg2+.

Copello, J A; Barg, S; Sonnleitner, A; Porta, M et al.

Ingår i Journal of Membrane Biology, s. 51-64, 2002

• DOI för Differential activation by Ca2+, ATP and caffeine of cardiac and skeletal muscle ryanodine receptors after block by Mg2+.

Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line.

Lotharius, Julie; Barg, Sebastian; Wiekop, Pia; Lundberg, Cecilia et al.

Ingår i Journal of Biological Chemistry, s. 38884-94, 2002

• DOI för Effect of mutant alpha-synuclein on dopamine homeostasis in a new human mesencephalic cell line.

A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.

Barg, Sebastian; Eliasson, Lena; Renström, Erik; Rorsman, Patrik

Ingår i Diabetes, 2002

Priming of insulin granules for exocytosis by granular Cl(-) uptake and acidification

Barg, Sebastian; Huang, Ping; Eliasson, Lena; Nelson, Deborah J et al.

Ingår i Journal of Cell Science, s. 2145-54, 2001

Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells

Barg, Sebastian; Ma, Xiaosong; Eliasson, Lena; Galvanovskis, Juris et al.

Ingår i Biophysical Journal, s. 3308-23, 2001

• DOI för Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells

The Cell Physiology of Biphasic Insulin Secretion.

Rorsman, Patrik; Eliasson, Lena; Renström, Erik; Gromada, Jesper et al.

Ingår i News in Physiological Sciences - NIPS, s. 72-77, 2000

Patch-clamp characterisation of somatostatin-secreting -cells in intact mouse pancreatic islets.

Göpel, S O; Kanno, T; Barg, S; Rorsman, P

Ingår i Journal of Physiology, s. 497-507, 2000

Regulation of glucagon release in mouse -cells by KATP channels and inactivation of TTX-sensitive Na+ channels.

Göpel, S O; Kanno, T; Barg, S; Weng, X G et al.

Ingår i Journal of Physiology, s. 509-20, 2000

Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.

Barg, S; Galvanovskis, J; Göpel, S O; Rorsman, P et al.

Ingår i Diabetes, s. 1500-10, 2000

Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial-like ATP-sensitive K+ (KATP) conductance in rat pancreatic A-cells.

Høy, M; Olsen, H L; Bokvist, K; Buschard, K et al.

Ingår i Journal of Physiology, s. 109-20, 2000

Voltage-gated and resting membrane currents recorded from B-cells in intact mouse pancreatic islets.

Göpel, S; Kanno, T; Barg, S; Galvanovskis, J et al.

Ingår i Journal of Physiology, s. 717-28, 1999

Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells.

Göpel, S O; Kanno, T; Barg, S; Eliasson, L et al.

Ingår i The Journal of General Physiology, s. 759-70, 1999

The voltage sensitive Lc-type Ca2+ channel is functionally coupled to the exocytotic machinery.

Wiser, O; Trus, M; Hernández, A; Renström, E et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 248-53, 1999

The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein

Barg, Sebastian; Renström, Erik; Berggren, Per-Olof; Bertorello, Alejandro et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 5539-44, 1999

• Ladda ner fulltext (pdf) av The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein

Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels.

Gromada, J; Bokvist, K; Ding, W G; Barg, S et al.

Ingår i The Journal of General Physiology, s. 217-28, 1997

Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors.

Gromada, J; Ding, W G; Barg, S; Renström, E et al.

Ingår i Pflügers Archiv, s. 515-24, 1997

Heterogeneity of Ca2+ gating of skeletal muscle and cardiac ryanodine receptors.

Copello, J A; Barg, S; Onoue, H; Fleischer, S

Ingår i Biophysical Journal, s. 141-56, 1997

• DOI för Heterogeneity of Ca2+ gating of skeletal muscle and cardiac ryanodine receptors.

Different interactions of cardiac and skeletal muscle ryanodine receptors with FK-506 binding protein isoforms

Barg, Sebastian; Copello, J A; Fleischer, S

Ingår i American Journal of Physiology, 1997

Selective binding of FKBP12.6 by the cardiac ryanodine receptor.

Timerman, A P; Onoue, H; Xin, H B; Barg, S et al.

Ingår i Journal of Biological Chemistry, s. 20385-91, 1996

Compensatory endocytosis in chromaffin cells

Barg, Sebastian; Machado, Jose David

Ingår i Acta Physiologica, s. 195-201, 2008

• DOI för Compensatory endocytosis in chromaffin cells

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

Omar-Hmeadi, Muhmmad; Lund, Per-Eric; Gandasi, Nikhil; Tengholm, Anders et al.

Fusion pore regulation by transient local generation of PI(4,5)P₂ in pancreatic in β-cells

Omar-Hmeadi, Muhmmad; Gucek, Alenka; Barg, Sebastian