Tove Fall
Professor vid Institutionen för medicinska vetenskaper; Molekylär epidemiologi
- Mobiltelefon:
- 070-221 58 59
- E-post:
- tove.fall@medsci.uu.se
- Besöksadress:
- EpiHubben,Dag Hammarskjölds väg 14B
751 85 Uppsala - Postadress:
- EpiHubben, MTC-huset
751 85 Uppsala
- CV:
- Ladda ned CV
- ORCID:
- 0000-0003-2071-5866
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Kort presentation
Professor i Molekylär Epidemiologi och ledamot i Sveriges Unga Akademi, läs gärna mer på min forskargrupps hemsida.
Nyckelord
- epidemiology
- type 2 diabetes
Biografi
Denna text finns inte på svenska, därför visas den engelska versionen.
My graduate education is in Veterinary Medicine from SLU, Uppsala (2005). After a PhD on the epidemiology of diabetes in dogs (2009) and a transition to human medical and genetic epidemiology in my post-doc at Karoinska Insitutet, I qualified as Associate Professor in Epidemiology at Uppsala University in 2013, Sweden and started my own research group in 2016. The focus of my research is to identify risk factors and causes for diabetes and cardiovascular disease onset and progression. . So far, my group has taken part in the development and application of bioinformatics analysis pipelines for metabolomics and proteomics data in large population-based studies, which I anticipate will have large impacts on the field of epidemiology. I have also led work on the use of Mendelian Randomization methods in the context of circulating lipids, an article which was accompanied by an Editorial in the journal Diabetes. I have organized the linkage of several large national registers and have now access to two databases, one on 4.5 million adults, and the other one comprising one million children, with detailed information on health and exposure to animals. The latter has been used for assessing the long-standing question regarding an association of early exposure to animals and childhood asthma, a study which not only gained huge media interest including interviews for BBC World and title story in The Times in 2015, but is also used as part of the scientific basis for new policies on pediatrician advice to parents about pet ownership in Sweden. My scientific accomplishments were awarded in 2015 with the Oscar prize at Uppsala University (all disciplines), the Göran Gustafssons grand prize for young researchers in 2016, the Thureus prize in 2021 and the Leif Groop award in 2023. As detailed in my list of research grants, I have been awarded project grants as Principal Investigator from Vetenskapsrådet, FORMAS, Diabetesfonden and Hjärt-Lungfonden, among others. I have both initiated and participated in many collaborative efforts. Some of these were large international scientific collaborations including up to 150 study groups that I participated in first as a contributor and later as part of the steering committees. I am often invited to give lectures to lay audiences and the general public and I have written a book for children together with colleagues in the Swedish Young Academy ("Forskardrömmar") In 2017, I was selected for a position as Assistant Senior Lecturer (Tenure Track). In 2018, I was promoted to Senior Lecturer in 2018 and to Professor in 2019. In 2018, I was also awarded a prestigious Starting Grant from the European Reserach Council to study links between the gut microbiota and vascular health. During the pandemic 2020-2023, I wanted to contribute to society by using my knowledge and time to contribute to the Covid Symptom Study Sweden (covid19app.lu.se) in collaboration with Lund University and in the CRUSH-Covid project in collaboration with Region Uppsala. My overall long-term goal is to establish a world-class scientific environment at my University within the molecular epidemiology field to attract international and diverse talents in the field to achieve important scientific findings that can translate to improvements for the patients and the wider community.
Forskning
Denna text finns inte på svenska, därför visas den engelska versionen.
For current research projects, please see tovefall.se
Publikationer
Urval av publikationer
- Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS (2024)
- Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women (2023)
- Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort (2023)
- An online atlas of human plasma metabolite signatures of gut microbiome composition (2022)
- App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden (2022)
- The shared risk of diabetes between dog and cat owners and their pets (2020)
- Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes (2020)
Senaste publikationer
- Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS (2024)
- Pulmonary function and atherosclerosis in the general population (2024)
- The interaction of genetics and physical activity in the pathogenesis of metabolic dysfunction associated liver disease (2024)
- Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts. (2024)
- The genetic architecture of dog ownership (2024)
Alla publikationer
Artiklar
- Accelerometer-based physical activity is associated with the gut microbiota in 8416 individuals in SCAPIS (2024)
- Pulmonary function and atherosclerosis in the general population (2024)
- The interaction of genetics and physical activity in the pathogenesis of metabolic dysfunction associated liver disease (2024)
- Analysis of plasma metabolomes from 11 309 subjects in five population-based cohorts. (2024)
- The genetic architecture of dog ownership (2024)
- Markers of imminent myocardial infarction (2024)
- Sociodemographic characteristics and COVID-19 testing rates (2024)
- Major cardiovascular events and death in parents of children with type 1 diabetes (2024)
- New connections of medication use and polypharmacy with the gut microbiota composition and functional potential in a large population (2024)
- Cardiac biomarkers for detection of coronary artery disease in the community (2024)
- Response by Sayols-Baixeras et al to Letter Regarding Article, "Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort". (2024)
- Predicting COVID-19 hospitalizations (2024)
- Associations between epigenetic aging and diabetes mellitus in a Swedish longitudinal study. (2024)
- OSA Is Associated With the Human Gut Microbiota Composition and Functional Potential in the Population-Based Swedish CardioPulmonary bioImage Study (2023)
- Loci for insulin processing and secretion provide insight into type 2 diabetes risk. (2023)
- Identification of three bacterial species associated with increased appendicular lean mass (2023)
- Sociodemographic characteristics and COVID-19 testingrates: spatiotemporal patterns and impact of testaccessibility in Sweden (2023)
- The metabolic profile of waist to hip ratio-A multi-cohort study (2023)
- Large-Scale Metabolomics and the Incidence of Cardiovascular Disease (2023)
- Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women (2023)
- Targeted proteomics identifies potential biomarkers of dysglycaemia, beta cell function and insulin sensitivity in Black African men and women (2023)
- Prevalence of atherosclerosis in individuals with prediabetes and diabetes compared to normoglycaemic individuals-a Swedish population-based study (2023)
- Cardiovascular disease-linked plasma proteins are mainly associated with lung volume (2023)
- Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort (2023)
- Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes (2023)
- Prevalence of Charcot Foot in Subjects With Diabetes (2023)
- Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake (2023)
- The metabolomic profiling of total fat and fat distribution in a multi-cohort study of women and men (2023)
- Genetics of liver fat and volume associate with altered metabolism and whole body magnetic resonance imaging (2022)
- Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome (2022)
- Evening chronotype is associated with elevated biomarkers of cardiometabolic risk in the EpiHealth cohort: a cross-sectional study (2022)
- A regression discontinuity analysis of the social distancing recommendations for older adults in Sweden during COVID-19. (2022)
- Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity (2022)
- An online atlas of human plasma metabolite signatures of gut microbiome composition (2022)
- App-based COVID-19 syndromic surveillance and prediction of hospital admissions in COVID Symptom Study Sweden (2022)
- Metabolic Profiling of Obesity With and Without the Metabolic Syndrome (2022)
- The metabolomic profile associated with clustering of cardiovascular risk factors (2022)
- The COVID-19 pandemic may be receding but the diabetes pandemic rages on (2022)
- Hematopoietic loss of Y chromosome leads to cardiac fibrosis and heart failure mortality (2022)
- Spatio-temporal predictions of COVID-19 test positivity in Uppsala County, Sweden (2022)
- Development of gut microbiota during the first 2 years of life (2022)
- The ABCC4 gene is associated with pyometra in golden retriever dogs (2021)
- Technological readiness and implementation of genomic-driven precision medicine for complex diseases (2021)
- Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (2021)
- Cancer and Risk of COVID-19 Through a General Community Survey (2021)
- Multicohort Metabolomics Analysis Discloses 9-Decenoylcarnitine to Be Associated With Incident Atrial Fibrillation (2021)
- Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years (2021)
- Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index? (2021)
- Fasting glucose, bone area and bone mineral density (2021)
- Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts (2021)
- Impaired HMG-CoA reductase activity caused by genetic variants or statin exposure (2021)
- Symptom clusters in COVID-19 (2021)
- Attributes and predictors of long COVID (2021)
- Sleep duration is associated with protein biomarkers for cardiometabolic health (2021)
- Association of cardiometabolic risk factors with hospitalisation or death due to COVID-19 (2021)
- Association between pet ownership and sleep in the Swedish CArdioPulmonary bioImage Study (SCAPIS) (2021)
- Detecting COVID-19 infection hotspots in England using large-scale self-reported data from a mobile application (2021)
- Blood pressure phenotypes based on ambulatory monitoring in a general middle-aged population (2021)
- Association of the Mediterranean Diet With Onset of Diabetes in the Women’s Health Study (2020)
- Season of birth, childhood asthma and allergy in a nationwide cohort (2020)
- GDF-15 is associated with sudden cardiac death due to incident myocardial infarction (2020)
- Growth differentiation factor 15 (GDF-15) is a potential biomarker of both diabetic kidney disease and future cardiovascular events in cohorts of individuals with type 2 diabetes (2020)
- The shared risk of diabetes between dog and cat owners and their pets (2020)
- Longitudinal plasma inflammatory proteome profiling during pregnancy in the Born into Life study (2020)
- Changes in Proteomic Profiles are Related to Changes in BMI and Fat Distribution During 10 Years of Aging (2020)
- A Multi-Cohort Metabolomics Analysis Discloses Sphingomyelin (32:1) Levels to be Inversely Related to Incident Ischemic Stroke (2020)
- SARS-CoV-2 (COVID-19) infection in pregnant women (2020)
- Non-targeted urine metabolomics and associations with prevalent and incident type 2 diabetes (2020)
- Early Childhood Antibiotic Treatment for Otitis Media and Other Respiratory Tract Infections Is Associated With Risk of Type 1 Diabetes (2020)
- Global Plasma Metabolomics to Identify Potential Biomarkers of Blood Pressure Progression (2020)
- In search of causal pathways in diabetes (2019)
- Reference Intervals for Fecal Calprotectin in Pregnant Women Using a Particle Enhanced Turbidimetric Assay (2019)
- Evidence of large genetic influences on dog ownership in the Swedish Twin Registry has implications for understanding domestication and health associations (2019)
- Circulating proteins as predictors of cardiovascular mortality in end-stage renal disease (2019)
- Oral Microbiota Development in Early Childhood (2019)
- Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies' (2019)
- Dog Ownership and Survival After a Major Cardiovascular Event (2019)
- Dog ownership and Cardiovascular Risk Factors (2019)
- Identification of metabolic profiles associated with human exposure to perfluoroalkyl substances. (2019)
- The metabolites urobilin and sphingomyelin (30:1) are associated with incident heart failure in the general population (2019)
- Cathepsin D improves the prediction of undetected diabetes in patients with myocardial infarction (2019)
- Proteomic Analysis of Longitudinal Changes in Blood Pressure (2019)
- A targeted proteomic profile of prevalent diabetes in a population-based sample (2018)
- Dog characteristics and future risk of asthma in children growing up with dogs (2018)
- Genome-wide association study of coronary artery disease among individuals with diabetes (2018)
- Associations of Circulating Protein Levels With Lipid Fractions in the General Population (2018)
- Role of peroxisome proliferator-activated receptor gamma Pro12Ala polymorphism in human adipose tissue (2018)
- Proteomic Biomarkers for Incident Aortic Stenosis Requiring Valvular Replacement (2018)
- Type 2 Diabetes in Relation to Hip Bone Density, Area, and Bone Turnover in Swedish Men and Women (2018)
- Multiplex proteomics for prediction of major cardiovascular events in type 2 diabetes (2018)
- Multiplex proteomics for prediction of major cardiovascular events in type 2 diabetes (2018)
- Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance (2018)
- Normal values for calprotectin in stool samples of infants from the population-based longitudinal born into life study (2018)
- Changes in markers of liver function in relation to changes in perfluoroalkyl substances - A longitudinal study (2018)
- Circulating proteins as predictors of incident heart failure in the elderly (2018)
- Effect of insulin treatment on circulating insulin-like growth factor I and IGF-binding proteins in cats with diabetes mellitus. (2018)
- Use of Proteomics to Investigate Blood Pressure Progress in the Elderly (2018)
- Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants (2017)
- Childhood adiposity and risk of type 1 diabetes (2017)
- Reference Intervals for Fecal Calprotectin in Adults Using Two Different Extraction Methods in the Uppsala-SCAPIS Cohort (2017)
- Recent Advances in Human Genetics and Epigenetics of Adiposity (2017)
- Genotype-based recall to study metabolic effects of genetic variation (2017)
- PPARG Pro12Ala variant in relation to adipose tissue metabolism and differentiation (2017)
- Dog ownership and the risk of cardiovascular disease and death (2017)
- Environmental Risk Factors for Diabetes Mellitus in Cats (2017)
- Dog Exposure During the First Year of Life and Type 1 Diabetes in Childhood (2017)
- Parental antibiotics and childhood asthma (2017)
- Sibship and risk of asthma in a total population (2016)
- The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals (2016)
- Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes (2016)
- Large-scale non-targeted metabolomic profiling in three human population-based studies (2016)
- Measurement of serum C-reactive protein concentration for discriminating between suppurative arthritis and osteoarthritis in dogs (2016)
- Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels (2016)
- Protein Biomarkers for Insulin Resistance and Type 2 Diabetes Risk in Two Large Community Cohorts (2016)
- The metabolic fingerprint of p,p'-DDE and HCB exposure in humans (2016)
- Cystatin C and Cardiovascular Disease (2016)
- Age- and sex-specific causal effects of adiposity on cardiovascular risk factors (2015)
- Early Exposure to Dogs and Farm Animals and the Risk of Childhood Asthma (2015)
- Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes (2015)
- Adiposity as a cause of cardiovascular disease (2015)
- No Evidence of a Causal Relationship between Plasma Homocysteine and Type 2 Diabetes (2015)
- Genetic studies of body mass index yield new insights for obesity biology (2015)
- Use of type 2 diabetes risk scores in clinical practice (2015)
- Incidence of Diabetes Mellitus in Insured Swedish Cats in Relation to Age, Breed and Sex (2015)
- New genetic loci link adipose and insulin biology to body fat distribution (2015)
- Proteomic profiling and the risk of heart failure (2015)
- The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape (2015)
- Lack of evidence for a role of islet autoimmunity in the aetiology of canine diabetes mellitus (2014)
- Amylase activity is associated with AMY2B copy numbers in dog (2014)
- Multifactorial analysis of changes in body mass index across the adult life course (2014)
- Genome-wide association studies of obesity and metabolic syndrome (2014)
- Large-scale Metabolomic Profiling Identifies Novel Biomarkers for Incident Coronary Heart Disease (2014)
- Genome-wide association analysis identifies six new loci associated with forced vital capacity (2014)
- The dog as a genetic model for immunoglobulin A (IgA) deficiency (2014)
- Antibiotics in fetal and early life and subsequent childhood asthma (2014)
- Genetic variation in the CYP2B6 Gene is related to circulating 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) concentrations (2014)
- FKBP5 expression in human adipose tissue increases following dexamethasone exposure and is associated with insulin resistance (2014)
- FKBP5 gene polymorphisms and expression in human adipose tissue are associated with insulin resistance and type 2 diabetes (2014)
- A Central Role for GRB10 in Regulation of Islet Function in Man (2014)
- Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity (2014)
- Relationship among Insulin Resistance, Growth Hormone, and Insulin-Like Growth Factor I Concentrations in Diestrous Swedish Elkhounds (2014)
- Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function (2014)
- FTO Genetic Variants and Risk of Obesity and Type 2 Diabetes (2014)
- Quality control and conduct of genome-wide association meta-analyses (2014)
- Defining the role of common variation in the genomic and biological architecture of adult human height (2014)
- Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture (2013)
- A multifactorial life course perspective on change in body mass index (2013)
- The Role of Adiposity in Cardiometabolic Traits (2013)
- 1-acyl-sn-glycero-3-phosphocholine Levels are Related to Obesity and Several Markers of Subclinical CV Disease and its Biosynthesis is Associated With Genetic Variants in the 9p21 Region (2013)
- Evidence of a Causal Relationship Between Adiponectin Levels and Insulin Sensitivity (2013)
- Global DNA hypermethylation is associated with high serum levels of persistent organic pollutants in an elderly population (2013)
- A genetic risk score comprising common variants associated with fasting insulin is associated with OGTT- and clamp-based indices of whole body insulin sensitivity (2013)
- A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents (2013)
- Relations of circulating vitamin D concentrations with left ventricular geometry and function (2012)
- The role of obesity-related genetic loci in insulin sensitivity (2012)
- Evaluation of circulating concentrations of glucose homeostasis biomarkers, progesterone, and growth hormone in healthy Elkhounds during anestrus and diestrus (2012)
- Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways (2012)
- Associations of variants in FTO and near MC4R with obesity traits in South Asian Indians (2012)
- Regional occurrence, high frequency but low diversity of mitochondrial DNA haplogroup d1 suggests a recent dog-wolf hybridization in Scandinavia (2011)
- Identification of genomic regions associated with phenotypic variation between dog breeds using selection mapping (2011)
- Lifestyle risk factors for progesterone-related diabetes mellitus in elkhounds (2011)
- Validation of a species-optimized enzyme-linked immunosorbent assay for determination of serum concentrations of insulin in dogs (2011)
- Diabetes Mellitus in Elkhounds Is Associated with Diestrus and Pregnancy (2010)
- Mammary tumor development in dogs is associated with BRCA1 and BRCA2 (2009)
- Glucagon stimulation test for estimating endogenous insulin secretion in dogs (2008)
- Gestational Diabetes Mellitus in 13 Dogs (2008)
- Diabetes mellitus in a population of 180,000 insured dogs (2007)
- Integration of whole-body PET/MRI with non-targeted metabolomics provides new insights into insulin sensitivity of various tissues
- Genome-wide meta-analysis identifies inherited variation contributing to overall risk and age of onset in canine angiosarcoma
- Type 2 diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Elderly Swedish Men and Women
- Type 2 diabetes, glycaemic traits and cardiovascular disease
- Metabolite profiles during an oral glucose tolerance test reveal new associations with clamp-measured insulin sensitivity
- Genetic Variation and Sex-Stratified Advanced Body Composition Analysis
- Recent death of a family member during the teenage years is associated with type 1 diabetes
- Blood pressure phenotypes based on ambulatory monitoring in a general middle-aged population
- Association of the gut microbiome composition with 24-hour blood pressure measurements in 4,459 participants from the SCAPIS cohort
Dataset
- Supplementary Table 1. An overview of metabolite differences between certain groups (2021)
- Metabolic Profiling of Obesity With and Without the Metabolic Syndrome - A Multi-Sample Evaluation (2021)
- Type 2 diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Elderly Swedish Men and Women: Supplementary material (2021)