Aristidis Moustakas

TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

Mendes Rodrigues Junior, Dorival; Tsirigoti, Chrysoula; Psatha, Konstantina; Kletsas, Dimitris et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2025

• DOI för TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles
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Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

Voytyuk, Oleksandr; Ohata, Yae; Moustakas, Aristidis; ten Dijke, Peter et al.

Ingår i Journal of Biological Chemistry, 2024

• DOI för Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling
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ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness

Vasilaki, Eleftheria; Bai, Yu; Ali, Mohamad Moustafa; Sundqvist, Anders et al.

Ingår i Cell Communication and Signaling, 2024

• DOI för ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
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Unboxing the network among long non-coding RNAs and TGF-β signaling in cancer

Mendes Rodrigues Junior, Dorival; Moustakas, Aristidis

Ingår i Upsala Journal of Medical Sciences, 2024

• DOI för Unboxing the network among long non-coding RNAs and TGF-β signaling in cancer
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Special issue: TGF-β and epithelial-mesenchymal transition in cancer

ten Dijke, Peter; Miyazono, Kohei; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Seminars in Cancer Biology, s. 1-3, 2024

• DOI för Special issue: TGF-β and epithelial-mesenchymal transition in cancer

TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

Mendes Rodrigues Junior, Dorival; Tsirigoti, Chrysoula; Psatha, Konstantina; Kletsas, Dimitris et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2025

• DOI för TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles
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Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

Voytyuk, Oleksandr; Ohata, Yae; Moustakas, Aristidis; ten Dijke, Peter et al.

Ingår i Journal of Biological Chemistry, 2024

• DOI för Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling
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ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness

Vasilaki, Eleftheria; Bai, Yu; Ali, Mohamad Moustafa; Sundqvist, Anders et al.

Ingår i Cell Communication and Signaling, 2024

• DOI för ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
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Special issue: TGF-β and epithelial-mesenchymal transition in cancer

ten Dijke, Peter; Miyazono, Kohei; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Seminars in Cancer Biology, s. 1-3, 2024

• DOI för Special issue: TGF-β and epithelial-mesenchymal transition in cancer

Crosstalk between TGF-β and EGF receptors via direct phosphorylation

Moustakas, Aristidis

Ingår i Journal of Cell Biology, 2024

• DOI för Crosstalk between TGF-β and EGF receptors via direct phosphorylation
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The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion

Gélabert, Caroline; Papoutsoglou, Panagiotis; Cancela Golan, Irene; Ahlström, Eric et al.

Ingår i Cell Communication and Signaling, 2023

• DOI för The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
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Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation

Peleli, Maria; Antoniadou, Ivi; Mendes Rodrigues Junior, Dorival; Savvoulidou, Odysseia et al.

Ingår i Redox Biology, 2023

• DOI för Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation
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The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Tzavlaki, Kalliopi; Ohata, Yae; Morén, Anita; Watanabe, Yukihide et al.

Ingår i Journal of Cellular Physiology, s. 790-812, 2023

• DOI för The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
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Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action

Moustakas, Aristidis; Lohr, J. Matthias; Heuchel, Rainer L.

Ingår i SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022

• DOI för Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action
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Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Maturi, Varun; Heldin, Carl-Henrik et al.

Ingår i Cell Death and Disease, 2022

• DOI för Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
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The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Mendes Rodrigues-Junior, Dorival et al.

Ingår i Journal of Cellular Physiology, s. 743-762, 2022

• DOI för The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma
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TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Tsubakihara, Yutaro; Ohata, Yae; Okita, Yukari; Younis, Shady et al.

Ingår i Molecular Oncology, s. 2330-2354, 2022

• DOI för TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition
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Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity

Mendes Rodrigues Junior, Dorival; Raminelli, Cristiano; Hassanie, Haifa; Trossini, Gustavo Henrique Goulart et al.

Ingår i Scientific Reports, s. 21113, 2022

• DOI för Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity
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Mast cell chymase has a negative impact on human osteoblasts

Lind, Thomas; Melo, Fabio R.; Gustafson, Ann-Marie; Sundqvist, Anders et al.

Ingår i Matrix Biology, s. 1-19, 2022

• DOI för Mast cell chymase has a negative impact on human osteoblasts
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The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Dadras, Mahsa Shahidi; Caja, Laia; Mezheyeuski, Artur; Liu, Sijia et al.

Ingår i Cell Death and Disease, 2021

• DOI för The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma
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The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling

Papoutsoglou, Panagiotis; Rodrigues Junior, Dorival Mendes; Morén, Anita; Bergman, Andrew et al.

Ingår i Oncogene, s. 3748-3765, 2021

• DOI för The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling
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BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

Fukuda, Tomohiko; Fukuda, Risa; Koinuma, Daizo; Moustakas, Aristidis et al.

Ingår i Cellular Signalling, 2021

• DOI för BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

BMP signaling is a therapeutic target in ovarian cancer

Fukuda, Tomohiko; Fukuda, Risa; Tanabe, Ryo; Koinuma, Daizo et al.

Ingår i Cell Death Discovery, 2020

• DOI för BMP signaling is a therapeutic target in ovarian cancer
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TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness

Sundqvist, Anders; Vasilaki, Eleftheria; Voytyuk, Oleksandr; Bai, Yu et al.

Ingår i Oncogene, s. 4436-4449, 2020

• DOI för TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness
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The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity

Papoutsoglou, Panagiotis; Tsubakihara, Yutaro; Caja, Laia; Pallis, Paris et al.

Ingår i Cell Reports, s. 3182-319800000000000, 2019

• DOI för The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity
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Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

Kolliopoulos, Constantinos; Lin, Chun-Yu; Heldin, Carl-Henrik; Moustakas, Aristidis et al.

Ingår i Matrix Biology, s. 29-45, 2019

• DOI för Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Kolliopoulos, Constantinos; Raja, Erna; Razmara, Masoud; Heldin, Paraskevi et al.

Ingår i Journal of Biological Chemistry, s. 4119-4136, 2019

• DOI för Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
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JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Sundqvist, Anders; Voytyuk, Olexandr; Hamdi, Mohamed; Popeijus, Herman E. et al.

Ingår i CELLS, 2019

• DOI för JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses
• Ladda ner fulltext (pdf) av JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells

Zhang, Yanyu; Valsala Madhavan Unnithan, Ragaseema; Hamidi, Anahita; Caja, Laia et al.

Ingår i The FASEB Journal, s. 7822-7832, 2019

• DOI för TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells

LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation

Morén, Anita; Bellomo, Claudia; Tsubakihara, Yutaro; Kardassis, Dimitris et al.

Ingår i Oncogenesis, 2019

• DOI för LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation
• Ladda ner fulltext (pdf) av LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation

Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells

Batool, Tahira; Fang, Jianping; Jansson, Viktor; Zhao, Hongxing et al.

Ingår i Cellular Signalling, s. 122-129, 2019

• DOI för Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells

The protein kinase SIK downregulates the polarity protein Par3

Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta; Mahzabin, Tanzila et al.

Ingår i Oncotarget, s. 5716-5735, 2018

• DOI för The protein kinase SIK downregulates the polarity protein Par3

TGF-beta Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition

Kahata, Kaoru; Dadras, Mahsa Shahidi; Moustakas, Aristidis

Ingår i Cold Spring Harbor Perspectives in Biology, 2018

• DOI för TGF-beta Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition

TGF-beta Family Signaling in Ductal Differentiation and Branching Morphogenesis

Kahata, Kaoru; Maturi, Varun; Moustakas, Aristidis

Ingår i Cold Spring Harbor Perspectives in Biology, 2018

• DOI för TGF-beta Family Signaling in Ductal Differentiation and Branching Morphogenesis

Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases

Enroth, Stefan; Maturi, Varun; Berggrund, Malin; Bosdotter Enroth, Sofia et al.

Ingår i Scientific Reports, 2018

• DOI för Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases
• Ladda ner fulltext (pdf) av Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases

Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Caja, Laia; Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Tan, E-Jean et al.

Ingår i Oncogene, s. 2515-2531, 2018

• DOI för Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells
• Ladda ner fulltext (pdf) av Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling

Bouris, Panagiotis; Manou, Dimitra; Sopaki-Valalaki, Anastasia; Kolokotroni, Anthi et al.

Ingår i Matrix Biology, s. 35-51, 2018

• DOI för Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Bellomo, Claudia; Caja, Laia; Fabregat, Isabel; Mikulits, Wolfgang et al.

Ingår i Cell Death and Differentiation, s. 885-903, 2018

• DOI för Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
• Ladda ner fulltext (pdf) av Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

Maturi, Varun; Enroth, Stefan; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 7113-7127, 2018

• DOI för Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells
• Ladda ner fulltext (pdf) av Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

Maturi, Varun; Morén, Anita; Enroth, Stefan; Heldin, Carl-Henrik et al.

Ingår i Molecular Oncology, s. 1153-1174, 2018

• DOI för Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells
• Ladda ner fulltext (pdf) av Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells

Batool, Tahira; Fang, Jianping; Barash, Uri; Moustakas, Aristidis et al.

Ingår i FEBS Open Bio, s. 405-413, 2017

• DOI för Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells
• Ladda ner fulltext (pdf) av Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Lehmann, Laura C.; Hewitt, Graeme; Aibara, Shintaro; Leitner, Alexander et al.

Ingår i Molecular Cell, s. 847-8590000000, 2017

• DOI för Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
• Ladda ner fulltext (pdf) av Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer

Mathot, Lucy; Kundu, Snehangshu; Ljungström, Viktor; Svedlund, Jessica et al.

Ingår i Cancer Research, s. 1730-1740, 2017

• DOI för Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer

Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells

Batool, Tahira; Fang, Jianping; Barash, Uri; Moustakas, Aristidis et al.

Ingår i International journal of experimental pathology (Print), 2017

Epithelial-mesenchymal transition in cancer

Moustakas, Aristidis; Garcia de Herreros, Antonio

Ingår i Molecular Oncology, s. 715-717, 2017

• DOI för Epithelial-mesenchymal transition in cancer
• Ladda ner fulltext (pdf) av Epithelial-mesenchymal transition in cancer

Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF- Signaling

Carthy, Jon M.; Engstrom, Ulla; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Biochemistry, s. 938-945, 2016

• DOI för Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF- Signaling

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling

Raja, Erna; Tzavlaki, Kalliopi; Vuilleumier, Robin; Edlund, Karolina et al.

Ingår i Oncotarget, s. 1120-1143, 2016

• DOI för The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling
• Ladda ner fulltext (pdf) av The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling

Signaling Receptors for TGF-beta Family Members

Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Cold Spring Harbor Perspectives in Biology, 2016

• DOI för Signaling Receptors for TGF-beta Family Members

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation

Carthy, Jon M.; Stoeter, Martin; Bellomo, Claudia; Vanlandewijck, Michael et al.

Ingår i Scientific Reports, 2016

• DOI för Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation
• Ladda ner fulltext (pdf) av Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation

Ras and TGF-beta signaling enhance cancer progression by promoting the Delta Np63 transcriptional program

Vasilaki, Eleftheria; Morikawa, Masato; Koinuma, Daizo; Mizutani, Anna et al.

Ingår i Science Signaling, 2016

• DOI för Ras and TGF-beta signaling enhance cancer progression by promoting the Delta Np63 transcriptional program

Single Chain Antibodies as Tools to Study transforming growth factor--Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens

Blokzijl, Andries; Zieba, Agata; Hust, Michael; Schirrmann, Thomas et al.

Ingår i Molecular & Cellular Proteomics, s. 1848-1856, 2016

• DOI för Single Chain Antibodies as Tools to Study transforming growth factor--Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens

Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation

Watanabe, Yukihide; Papoutsoglou, Panagiotis; Maturi, Varun; Tsubakihara, Yutaro et al.

Ingår i Journal of Biological Chemistry, s. 12706-12723, 2016

• DOI för Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation

TGF beta and the nuclear receptor LXR alpha crosstalk on lipid metabolism and epithelial to mesenchymal transition in hepatocellular carcinoma

Bellomo, Claudia; Gahman, T. C.; Shiau, A. K.; Heldin, Carl-Henrik et al.

Ingår i European Journal of Clinical Investigation, s. 36-36, 2016

In vitro and ex vivo vanadium antitumor activity in (TGF-beta)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients

Petanidis, Savvas; Kioseoglou, Efrosini; Domvri, Kalliopi; Zarogoulidis, Paul et al.

Ingår i International Journal of Biochemistry and Cell Biology, s. 121-134, 2016

• DOI för In vitro and ex vivo vanadium antitumor activity in (TGF-beta)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients

The mitotic checkpoint protein kinase BUB1 is an engine in the TGF-beta signaling apparatus

Moustakas, Aristidis

Ingår i Science Signaling, 2015

• DOI för The mitotic checkpoint protein kinase BUB1 is an engine in the TGF-beta signaling apparatus

Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells

Bouris, Panagiotis; Skandalis, Spyros S.; Piperigkou, Zoi; Afratis, Nikos et al.

Ingår i Matrix Biology, s. 42-60, 2015

• DOI för Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells

Targeting Tgf-Beta I With The Transforming Growth Factor Receptor Type I Kinase Inhibitor, Ly2157299, Modulates Stemness-Related Biomarkers In Hepatocellular Carcinoma

Rani, B.; Dituri, F.; Cao, Y.; Engstrom, U. et al.

Ingår i Journal of Hepatology, 2015

MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures

Mondal, Tanmoy; Subhash, Santhilal; Vaid, Roshan; Enroth, Stefan et al.

Ingår i Nature Communications, 2015

• DOI för MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures
• Ladda ner fulltext (pdf) av MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures

The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition

Tan, E-Jean; Kahata, Kaoru; Idås, Oskar; Thuault, Sylvie et al.

Ingår i Nucleic Acids Research, s. 162-178, 2015

• DOI för The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition
• Ladda ner fulltext (pdf) av The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition

Tamoxifen Inhibits TGF-beta-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2

Carthy, Jon M.; Sundqvist, Anders; Heldin, Angelos; Van Dam, Hans et al.

Ingår i Journal of Cellular Physiology, s. 3084-3092, 2015

• DOI för Tamoxifen Inhibits TGF-beta-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2

Transforming growth factor beta and bone morphogenetic protein actions in cancer progression

Moustakas, Aristidis

Ingår i The FEBS Journal, s. 35-35, 2015

Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells

Enroth, Stefan; Andersson, Robin; Bysani, Madhusudhan Reddy; Wallerman, Ola et al.

Ingår i Nucleic Acids Research, s. 6921-6934, 2014

• DOI för Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells

Nucleosome regulatory dynamics in response to TGF beta

Enroth, Stefan; Andersson, Robin; Bysani, Madhusudhan; Wallerman, Ola et al.

Ingår i Nucleic Acids Research, s. 6921-6934, 2014

• DOI för Nucleosome regulatory dynamics in response to TGF beta

Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

Dahl, Markus; Maturi, Varun; Lönn, Peter; Papoutsoglou, Panagiotis et al.

Ingår i PLOS ONE, 2014

• DOI för Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
• Ladda ner fulltext (pdf) av Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

Knock-Down of CD44 Regulates Endothelial Cell Differentiation via NF kappa B-Mediated Chemokine Production

Olofsson, Berit; Porsch, Helena; Heldin, Paraskevi

Ingår i PLOS ONE, 2014

• DOI för Knock-Down of CD44 Regulates Endothelial Cell Differentiation via NF kappa B-Mediated Chemokine Production
• Ladda ner fulltext (pdf) av Knock-Down of CD44 Regulates Endothelial Cell Differentiation via NF kappa B-Mediated Chemokine Production

Invasive cells follow Snail's slow and persistent pace

García de Herreros, Antonio; Moustakas, Aristidis

Ingår i Cell Cycle, s. 2320-2321, 2014

• DOI för Invasive cells follow Snail's slow and persistent pace

Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells

Korpetinou, Angeliki; Skandalis, Spyros S.; Moustakas, Aristidis; Happonen, Kaisa E. et al.

Ingår i PLOS ONE, 2013

• DOI för Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells
• Ladda ner fulltext (pdf) av Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells

The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins

Coppotelli, Giuseppe; Mughal, Nouman; Callegari, Simone; Sompallae, Ramakrishna et al.

Ingår i Nucleic Acids Research, s. 2950-2962, 2013

• DOI för The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins
• Ladda ner fulltext (pdf) av The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins

HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment

Cedervall, Jessica; Zhang, Yanyu; Ringvall, Maria; Thulin, Åsa et al.

Ingår i Angiogenesis, s. 889-902, 2013

• DOI för HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment

p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β

Termén, Stefan; Tan, E-Jean; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 801-813, 2013

• DOI för p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β

Coordination of TGF-beta Signaling by Ubiquitylation

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Molecular Cell, s. 555-556, 2013

• DOI för Coordination of TGF-beta Signaling by Ubiquitylation

Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase

Lönn, Peter; Vanlandewijck, Michael; Raja, Erna; Kowanetz, Marcin et al.

Ingår i Journal of Biological Chemistry, s. 12867-12878, 2012

• DOI för Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase

Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition

Tan, E-Jean; Thuault, Sylvie; Caja, Laia; Carletti, Tea et al.

Ingår i Journal of Biological Chemistry, s. 7134-7145, 2012

• DOI för Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition

Context-dependent action of transforming growth factor β family members on normal and cancer stem cells

Caja, Laia; Kahata, Kaoru; Moustakas, Aristidis

Ingår i Current pharmaceutical design, s. 4072-4086, 2012

• DOI för Context-dependent action of transforming growth factor β family members on normal and cancer stem cells

Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition

Papadimitriou, E; Vasilaki, Eleftheria; Vorvis, C; Iliopoulos, D et al.

Ingår i Oncogene, s. 2862-2875, 2012

• DOI för Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition

Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase

Zieba, Agata; Pardali, Katerina; Söderberg, Ola; Lindbom, Lena et al.

Ingår i Molecular & Cellular Proteomics, 2012

• DOI för Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase

Induction of epithelial-mesenchymal transition by transforming growth factor β

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Seminars in Cancer Biology, s. 446-454, 2012

• DOI för Induction of epithelial-mesenchymal transition by transforming growth factor β

Role of TGF-β signaling in EMT, cancer progression and metastasis

Savary, Katia; Moustakas, Aristidis

Ingår i Drug Discovery Today, s. 121-126, 2011

• DOI för Role of TGF-β signaling in EMT, cancer progression and metastasis

The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma.

Sjölund, Jonas; Boström, Anna-Karin; Lindgren, David; Manna, Sugata et al.

Ingår i PLOS ONE, 2011

• DOI för The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma.

Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

Sideridou, Maria; Zakopoulou, Roubini; Evangelou, Konstantinos; Liontos, Michalis et al.

Ingår i Journal of Cell Biology, s. 1123-1140, 2011

• DOI för Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

Quantitative analysis of transient and sustained transforming growth factor-beta signaling dynamics

Zi, Zhike; Feng, Zipei; Chapnick, Douglas A.; Dahl, Markus et al.

Ingår i Molecular Systems Biology, 2011

• DOI för Quantitative analysis of transient and sustained transforming growth factor-beta signaling dynamics

Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1)

Bernert, Berit; Porsch, Helena; Heldin, Paraskevi

Ingår i Journal of Biological Chemistry, s. 42349-42359, 2011

• DOI för Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1)

Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1

Morén, Anita; Raja, Erna; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Biological Chemistry, s. 341-353, 2011

• DOI för Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1

Hyaluronan Synthesis Is Inhibited by Adenosine Monophosphate-activated Protein Kinase through the Regulation of HAS2 Activity in Human Aortic Smooth Muscle Cells

Vigetti, Davide; Clerici, Moira; Deleonibus, Sara; Karousou, Evgenia et al.

Ingår i Journal of Biological Chemistry, s. 7917-7924, 2011

• DOI för Hyaluronan Synthesis Is Inhibited by Adenosine Monophosphate-activated Protein Kinase through the Regulation of HAS2 Activity in Human Aortic Smooth Muscle Cells

TGF beta Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death

van der Heide, Lars P.; van Dinther, Maarten; Moustakas, Aristidis; ten Dijke, Peter

Ingår i Journal of Biological Chemistry, s. 5003-5011, 2011

• DOI för TGF beta Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death

Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: A useful in vitro model for testing new treatments

Chamcheu, Jean Christopher; Pihl-Lundin, Inger; Eteti Mouyobo, Cedrique; Gester, Therese et al.

Ingår i British Journal of Dermatology, s. 263-272, 2011

• DOI för Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: A useful in vitro model for testing new treatments

Regulation of Myosin Light Chain Function by BMP Signaling Controls Actin Cytoskeleton Remodeling

Konstantinidis, Georgios; Moustakas, Aristidis; Stournaras, Christos

Ingår i Cellular Physiology and Biochemistry, s. 1031-1044, 2011

• DOI för Regulation of Myosin Light Chain Function by BMP Signaling Controls Actin Cytoskeleton Remodeling

TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2

Papadimitriou, Elsa; Kardassis, Dimitris; Moustakas, Aristidis; Stournaras, Christos

Ingår i Cellular Physiology and Biochemistry, s. 229-238, 2011

• DOI för TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2

Immortalized keratinocytes from Epidermolytic Ichthyosis-patients reproduce the disease phenotype in vitro

Chamcheu, Jean Christopher; Virtanen, Marie; Moustakas, Aristidis; Navsaria, Harshad et al.

Ingår i Journal of Investigative Dermatology, 2010

Transforming growth factor β promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin

Bergström, Rosita; Savary, Katia; Morén, Anita; Guibert, Sylvain et al.

Ingår i Journal of Biological Chemistry, s. 19727-19737, 2010

• DOI för Transforming growth factor β promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin

The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination

Karousou, Eugenia; Kamiryo, Masaru; Skandalis, Spyros S; Ruusala, Aino et al.

Ingår i Journal of Biological Chemistry, s. 23647-23654, 2010

• DOI för The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination

Proteomic identification of CD44 interacting proteins

Skandalis, Spyros S.; Kozlova, Inna; Engström, Ulla; Hellman, Ulf et al.

Ingår i IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, s. 833-840, 2010

• DOI för Proteomic identification of CD44 interacting proteins

PARP-1 attenuates Smad-mediated transcription

Lönn, Peter; van der Heide, Lars; Dahl, Markus; Hellman, Ulf et al.

Ingår i Molecular Cell, s. 521-532, 2010

• DOI för PARP-1 attenuates Smad-mediated transcription

Integrins open the way to epithelial-mesenchymal transitions: Comment on: Bianchi A, et al. Cell Cycle 2010; 9:1647–59

Moustakas, Aristidis

Ingår i Cell Cycle, s. 1682-1682, 2010

• DOI för Integrins open the way to epithelial-mesenchymal transitions: Comment on: Bianchi A, et al. Cell Cycle 2010; 9:1647–59

Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom

Huminiecki, Lukasz; Goldovsky, Leon; Freilich, Shiri; Moustakas, Aristidis et al.

Ingår i BMC Evolutionary Biology, s. 28, 2009

• DOI för Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom

Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition

Chamcheu, Jean Christopher; Lorié, Elizabeth Pavez; Akgul, Baki; Bannbers, Elin et al.

Ingår i Journal of dermatological science (Amsterdam), s. 198-206, 2009

• DOI för Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF‑β mediated epithelial–mesenchymal transition

Vincent, Theresa; Neve, Etienne P. A.; Johnson, Jill R.; Kukalev, Alexander et al.

Ingår i Nature Cell Biology, s. 943-950, 2009

• DOI för A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF‑β mediated epithelial–mesenchymal transition

HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition

Thuault, Sylvie; Tan, E-Jean; Peinado, Hector; Cano, Amparo et al.

Ingår i Journal of Biological Chemistry, s. 33437-33446, 2008

• DOI för HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition

Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis

Heldin, Paraskevi; Karousou, Eugenia; Bernert, Berit; Porsch, Helena et al.

Ingår i Connective Tissue Research, s. 215-218, 2008

• DOI för Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis

TGFβ induces SIK to negatively regulate type I receptor kinase signaling

Kowanetz, Marcin; Lönn, Peter; Vanlandewijck, Michael; Kowanetz, Katarzyna et al.

Ingår i Journal of Cell Biology, s. 655-662, 2008

• DOI för TGFβ induces SIK to negatively regulate type I receptor kinase signaling

TGF-beta Targets PAX3 to Control Melanocyte Differentiation

Moustakas, Aristidis

Ingår i Developmental Cell, s. 797-799, 2008

• DOI för TGF-beta Targets PAX3 to Control Melanocyte Differentiation

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

Gal, Annamaria; Sjöblom, Tobias; Fedorova, L.; Imreh, S. et al.

Ingår i Oncogene, s. 1218-1230, 2008

• DOI för Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells

Li, Yuejuan; Li, Lingli; Brown, Tracey J.; Heldin, Paraskevi

Ingår i International Journal of Cancer, s. 2557-2567, 2007

• DOI för Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

Li, Lingli; Asteriou, Trias; Bernert, Berit; Heldin, Carl-Henrik et al.

Ingår i Biochemical Journal, s. 327-336, 2007

• DOI för Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

Functional role of Meox2 during the epithelial cytostatic response to TGF-beta

Valcourt, Ulrich; Thuault, Sylvie; Pardali, Katerina; Heldin, Carl-Henrik et al.

Ingår i Molecular Oncology, s. 55-71, 2007

• DOI för Functional role of Meox2 during the epithelial cytostatic response to TGF-beta

Notch signaling is necessary for epithelial growth arrest by TGF-beta

Niimi, Hideki; Pardali, Katerina; Vanlandewijck, Michael; Heldin, Carl-Henrik et al.

Ingår i Journal of Cell Biology, s. 695-707, 2007

• DOI för Notch signaling is necessary for epithelial growth arrest by TGF-beta

Operational criteria for selecting a cDNA microarray data normalization algorithm

Argyropoulos, C.; Chatziioannou, A. A.; Nikiforidis, G.; Moustakas, Aristidis et al.

Ingår i Oncology Reports, s. 983-996, 2006

A new twist in Smad signaling

Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Developmental Cell, s. 685-686, 2006

• DOI för A new twist in Smad signaling

Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition

Thuault, Sylvie; Valcourt, Ulrich; Petersen, Maj; Manfioletti, Guidalberto et al.

Ingår i Journal of Cell Biology, s. 175-183, 2006

• DOI för Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition

The mechanism of nuclear export of smad3 involves exportin 4 and Ran

Kurisaki, Akira; Kurisaki, Keiko; Kowanetz, Marcin; Sugino, Hiromu et al.

Ingår i Molecular and Cellular Biology, s. 1318-1332, 2006

• DOI för The mechanism of nuclear export of smad3 involves exportin 4 and Ran

TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

Valcourt, Ulrich; Kowanetz, Marcin; Niimi, Hideki; Heldin, Carl-Henrik et al.

Ingår i Molecular Biology of the Cell, s. 1987-2002, 2005

• DOI för TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21Waf1/Cip1

Pardali, Katerina; Kowanetz, Marcin; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 260-272, 2005

• DOI för Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21Waf1/Cip1

Hyaluronan fragments induce endothelial cell differentiation in a CD44- and CXCL1/GRO1-dependent manner.

Takahashi, Yoshinori; Li, Lingli; Kamiryo, Masaru; Asteriou, Trias et al.

Ingår i J Biol Chem, 2005

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

Morén, Anita; Imamura, Takeshi; Miyazono, Kohei; Heldin, Carl-Henrik et al.

Ingår i Journal of Biological Chemistry, s. 22115-22123, 2005

• DOI för Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

Non-Smad TGF-{beta} signals

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Journal of Cell Science, s. 3573-3584, 2005

• DOI för Non-Smad TGF-{beta} signals

Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

Kurisaki, Keiko; Kurisaki, Akira; Valcourt, Ulrich; Terentiev, Alexei A et al.

Ingår i Molecular and Cellular Biology, s. 4494-4510, 2003

• DOI för Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

Differential ubiquitination defines the functional status of the tumor suppressor Smad4

Morén, Anita; Hellman, Ulf; Inada, Yuri; Imamura, Takeshi et al.

Ingår i Journal of Biological Chemistry, s. 33571-33582, 2003

• DOI för Differential ubiquitination defines the functional status of the tumor suppressor Smad4

Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells

Kaivo-Oja, Noora; Bondestam, Jonas; Kämäräinen, Meerit; Koskimies, Janne et al.

Ingår i Journal of Clinical Endocrinology and Metabolism, s. 755-762, 2003

• DOI för Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells

Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4

Chou, Wan-Chih; Prokova, Vassiliki; Shiraishi, Keiko; Valcourt, Ulrich et al.

Ingår i Molecular Biology of the Cell, s. 1279-1294, 2003

• DOI för Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4

Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

Itoh, Susumu; Thorikay, Midory; Kowanetz, Marcin; Moustakas, Aristidis et al.

Ingår i Journal of Biological Chemistry, s. 3751-3761, 2003

• DOI för Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter

Koutsodontis, George; Moustakas, Aristidis; Kardassis, Dimitris

Ingår i Biochemistry, s. 12771-12784, 2002

• DOI för The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter

Engagement of activin and bone morphogenetic protein signaling pathway Smad proteins in the induction of inhibin B production in ovarian granulosa cells

Bondestam, Jonas; Kaivo-oja, Noora; Kallio, Janne; Groome, Nigel et al.

Ingår i Molecular and Cellular Endocrinology, s. 79-88, 2002

• DOI för Engagement of activin and bone morphogenetic protein signaling pathway Smad proteins in the induction of inhibin B production in ovarian granulosa cells

Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes

Valcourt, Ulrich; Gouttenoire, Jérôme; Moustakas, Aristidis; Herbage, Daniel et al.

Ingår i Journal of Biological Chemistry, s. 33545-33558, 2002

• DOI för Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes

PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4

Kintscher, Ulrich; Lyon, Christopher; Wakino, Shu; Bruemmer, Dennis et al.

Ingår i Circulation Research, 2002

• DOI för PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4

cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)

Bondestam, Jonas; Huotari, Mar-Anne; Morén, Anita; Ustinov, Jarkko et al.

Ingår i Cytogenetics and Cell Genetics, s. 157-162, 2001

• DOI för cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)

Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

Kurisaki, Akira; Kose, Shingo; Yoneda, Yoshihiro; Heldin, Carl-Henrik et al.

Ingår i Molecular Biology of the Cell, s. 1079-1091, 2001

• DOI för Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

Unboxing the network among long non-coding RNAs and TGF-β signaling in cancer

Mendes Rodrigues Junior, Dorival; Moustakas, Aristidis

Ingår i Upsala Journal of Medical Sciences, 2024

• DOI för Unboxing the network among long non-coding RNAs and TGF-β signaling in cancer
• Ladda ner fulltext (pdf) av Unboxing the network among long non-coding RNAs and TGF-β signaling in cancer

Dual inhibition of TGF-beta and PD-L1: a novel approach to cancer treatment

Gulley, James L.; Schlom, Jeffrey; Barcellos-Hoff, Mary Helen; Wang, Xiao-Jing et al.

Ingår i Molecular Oncology, s. 2117-2134, 2022

• DOI för Dual inhibition of TGF-beta and PD-L1: a novel approach to cancer treatment
• Ladda ner fulltext (pdf) av Dual inhibition of TGF-beta and PD-L1: a novel approach to cancer treatment

NUAK1 and NUAK2 Fine-Tune TGF-β Signaling

van de Vis, Reinofke A. J.; Moustakas, Aristidis; van der Heide, Lars P.

Ingår i Cancers, 2021

• DOI för NUAK1 and NUAK2 Fine-Tune TGF-β Signaling
• Ladda ner fulltext (pdf) av NUAK1 and NUAK2 Fine-Tune TGF-β Signaling

Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types

Chisari, Andrea; Golan, Irene; Campisano, Sabrina; Gélabert, Caroline et al.

Ingår i Frontiers in Pharmacology, 2021

• DOI för Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types
• Ladda ner fulltext (pdf) av Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types

TGF-β Signaling

Tzavlaki, Kalliopi; Moustakas, Aristidis

Ingår i Biomolecules, 2020

• DOI för TGF-β Signaling
• Ladda ner fulltext (pdf) av TGF-β Signaling

Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies

Peleli, Maria; Moustakas, Aristidis; Papapetropoulos, Andreas

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies
• Ladda ner fulltext (pdf) av Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies

Long non-coding RNAs and TGF-beta signaling in cancer

Papoutsoglou, Panagiotis; Moustakas, Aristidis

Ingår i Cancer Science, s. 2672-2681, 2020

• DOI för Long non-coding RNAs and TGF-beta signaling in cancer
• Ladda ner fulltext (pdf) av Long non-coding RNAs and TGF-beta signaling in cancer

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

Caja, Laia; Dituri, Francesco; Mancarella, Serena; Caballero-Diaz, Daniel et al.

Ingår i International Journal of Molecular Sciences, 2018

• DOI för TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
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Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor

Tsubakihara, Yutaro; Moustakas, Aristidis

Ingår i International Journal of Molecular Sciences, 2018

• DOI för Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor
• Ladda ner fulltext (pdf) av Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor

Mechanisms of TGF beta-Induced Epithelial-Mesenchymal Transition

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Journal of Clinical Medicine, 2016

• DOI för Mechanisms of TGF beta-Induced Epithelial-Mesenchymal Transition
• Ladda ner fulltext (pdf) av Mechanisms of TGF beta-Induced Epithelial-Mesenchymal Transition

Transforming growth factor beta as regulator of cancer stemness and metastasis

Bellomo, Claudia; Caja, Laia; Moustakas, Aristidis

Ingår i British Journal of Cancer, s. 761-769, 2016

• DOI för Transforming growth factor beta as regulator of cancer stemness and metastasis
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Mechanisms of action of bone morphogenetic proteins in cancer

Davis, Hayley; Raja, Erna; Miyazono, Kohei; Tsubakihara, Yutaro et al.

Ingår i Cytokine & growth factor reviews, s. 81-92, 2016

• DOI för Mechanisms of action of bone morphogenetic proteins in cancer

The rationale for targeting TGF-beta in chronic liver diseases

Giannelli, Gianluigi; Mikulits, Wolfgang; Dooley, Steven; Fabregat, Isabel et al.

Ingår i European Journal of Clinical Investigation, s. 349-361, 2016

• DOI för The rationale for targeting TGF-beta in chronic liver diseases

Transforming growth factor beta and bone morphogenetic protein actions in brain tumors

Caja, Laia Puigsubira; Bellomo, Claudia; Moustakas, Aristidis

Ingår i FEBS Letters, s. 1588-1597, 2015

• DOI för Transforming growth factor beta and bone morphogenetic protein actions in brain tumors
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Reprogramming during epithelial to mesenchymal transition under the control of TGF beta

Tan, E-Jean; Olsson, Anna-Karin; Moustakas, Aristidis

Ingår i CELL ADHESION & MIGRATION, s. 233-246, 2015

• DOI för Reprogramming during epithelial to mesenchymal transition under the control of TGF beta

TGF beta and matrix-regulated epithelial to mesenchymal transition

Moustakas, Aristidis; Heldin, Paraskevi

Ingår i Biochimica et Biophysica Acta - General Subjects, s. 2621-2634, 2014

• DOI för TGF beta and matrix-regulated epithelial to mesenchymal transition

Role of Smads in TGFβ signaling

Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Cell and Tissue Research, s. 21-36, 2012

• DOI för Role of Smads in TGFβ signaling

Regulation of EMT by TGFβ in cancer

Heldin, Carl-Henrik; Vanlandewijck, Michael; Moustakas, Aristidis

Ingår i FEBS Letters, s. 1959-1970, 2012

• DOI för Regulation of EMT by TGFβ in cancer

Hyaluronan-CD44 interactions as potential targets for cancer therapy

Misra, Suniti; Heldin, Paraskevi; Hascall, Vincent C.; Karamanos, Nikos K. et al.

Ingår i The FEBS Journal, s. 1429-1443, 2011

• DOI för Hyaluronan-CD44 interactions as potential targets for cancer therapy

Growth factor regulation of hyaluronan metabolism in tumor progression

Heldin, Paraskevi

Ingår i The Science of Hyaluronan Today - Glycoforum, 2009

Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

Heldin, Carl-Henrik; Landström, Maréne; Moustakas, Aristidis

Ingår i Current Opinion in Cell Biology, s. 166-176, 2009

• DOI för Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

Control of transforming growth factor beta signal transduction by small GTPases

Kardassis, Dimitris; Murphy, Carol; Fotsis, Theodore; Moustakas, Aristidis et al.

Ingår i The FEBS Journal, s. 2947-2965, 2009

• DOI för Control of transforming growth factor beta signal transduction by small GTPases

Regulating the stability of TGFβ receptors and Smads

Lönn, Peter; Morén, Anita; Raja, Erna; Dahl, Markus et al.

Ingår i Cell Research, s. 21-35, 2009

• DOI för Regulating the stability of TGFβ receptors and Smads

The regulation of TGFβ signal transduction

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Development, s. 3699-3714, 2009

• DOI för The regulation of TGFβ signal transduction

Dynamic control of TGF-beta signaling and its links to the cytoskeleton

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i FEBS Letters, s. 2051-2065, 2008

• DOI för Dynamic control of TGF-beta signaling and its links to the cytoskeleton

Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer

Pardali, Katerina; Moustakas, Aristidis

Ingår i Biochimica et Biophysica Acta, s. 21-62, 2007

• DOI för Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer

Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Cancer Science, s. 1512-1520, 2007

• DOI för Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

The nuts and bolts of IRF structure

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Nature Structural Biology, s. 874-876, 2003

• DOI för The nuts and bolts of IRF structure

Ecsit-ement on the crossroads of Toll and BMP signal transduction

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Genes & Development, s. 2855-2859, 2003

• DOI för Ecsit-ement on the crossroads of Toll and BMP signal transduction

TGF-beta signaling from a three-dimensional perspective: insight into selection of partners

Souchelnytskyi, Serhiy; Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Trends in Cell Biolology, s. 304-307, 2002

• DOI för TGF-beta signaling from a three-dimensional perspective: insight into selection of partners

Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation

Moustakas, Aristidis; Pardali, Katerina; Gaal, Annamaria; Heldin, Carl-Henrik

Ingår i Immunology Letters, s. 85-91, 2002

• DOI för Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation

Smad signalling network

Moustakas, Aristidis

Ingår i Journal of Cell Science, s. 3355-3356, 2002

From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Genes & Development, s. 1867-1871, 2002

• DOI för From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction

Smad regulation in TGF-beta signal transduction

Moustakas, Aristidis; Souchelnytskyi, Serhiy; Heldin, Carl-Henrik

Ingår i Journal of Cell Science, s. 4359-4369, 2001

Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β

Valcourt, Ulrich; Carthy, Jonathon; Okita, Yukari; Alcaraz, Lindsay et al.

Ingår i TGF-Beta Signaling, s. 147-181, Springer, 2016

• DOI för Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β

Epithelial-mesenchymal transition as a mechanism of metastasis

Savary, Katia; Termén, Stefan; Thuault, Sylvie; Keshamouni, Venkateshwar et al.

Ingår i Lung Cancer Metastasis, s. 65-92, Springer, 2009

• DOI för Epithelial-mesenchymal transition as a mechanism of metastasis

Growth factor regulation of hyaluronan deposition in malignancies.

Heldin, Paraskevi; Karousou, Eugenia; Skandalis, Spyros S.

Ingår i Hyaluronan in Cancer Biology., s. 37-50, Elsevier Inc., 2009

• DOI för Growth factor regulation of hyaluronan deposition in malignancies.

TGF-beta and Smad signaling in transcriptome reprogramming during EMT

Thuault, Sylvie; Valcourt, Ulrich; Kowanetz, Marcin; Moustakas, Aristidis

Ingår i Transforming Growth Factor-Beta in Cancer Therapy, The Human Press Inc., 2008

Cancer-associated fibroblasts and the role of TGFbeta

Micke, Patrick; Moustakas, Aristidis; Ohshima, Mitsuhiro; Kappert, Kai

Ingår i Transforming Growth Factor-beta in Cancer Therapy, Vol II, s. 417-441, The Humana Press, Inc., 2008

• DOI för Cancer-associated fibroblasts and the role of TGFbeta

TGFß/Smad signaling in epithelial to mesenchymal transition

Moustakas, Aristidis; Kowanetz, Marcin; Thuault, Sylvie

Ingår i Smad Signal Transduction, s. 131-150, Springer, 2006

SIK phosphorylates and degrades Par3 to mediate tight junction disassembly during epithelial-mesenchymal transition

Vanlandewijck, Michael; Lomnytska, Marta; Busch, Christer; Heldin, Carl-Henrik et al.

2011

SIK and Smurf2 cooperate to downregulate the TGF-β type I receptor

Lönn, Peter; Vanlandewijck, Michael; Kowanetz, Marcin; Kowanetz, Katarzyna et al.

The non-coding MIR100HG RNA mediates cytostatic responses of epithelial cells to transforming growth factor β

Papoutsoglou, Panagiotis; Bergman, Andrew; Heldin, Carl-Henrik; Moustakas, Aristidis

TGFβ signaling down-regulates LINC00707 to inhibit inflammatory responses

Papoutsoglou, Panagiotis; Caja, Laia; Ameur, Adam; Heldin, Carl-Henrik et al.

Epigenetic coupling of transcription factor CXXC5 regulates stemness genes in glioblastoma

Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Morén, Anita et al.

The liver kinase B1 inhibits transforming growth factor β signaling during mammary epithelial morphogenesis

Tzavlaki, Kalliopi; Morén, Anita; Watanabe, Yukihide; Eriksson, Jens et al.

SNAI2 knockout induces metabolic and cell cycle changes in breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Heldin, Carl-Henrik; Moustakas, Aristidis

TGF-β induces cholesterol accumulation to regulate the fate of tumor-derived extracellular vesicles

Mendes Rodrigues-Junior, Dorival; Tsirigoti, Chrysoula; Psatha, Konstantina; Kletsas, Dimitris et al.

SNAI1 and SMAD/TGF-β signals antagonize FOXA1 to control PSD4/EFA6B expression and couple integrin-mediated adhesion to endocytic fate in triple-negative breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Mendes Rodrigues-Junior, Dorival; Johansson, Staffan et al.

Glutamine deprivation alters TGF-β signaling in hepatocellular carcinoma

Gélabert, Caroline; Campisano, Sabrina; Golán, Irene C.; Beyene, T. Nathanael et al.

TGF-beta in Human Disease

Moustakas, Aristidis; Miyazawa, Keiji

Springer, 2013

• DOI för TGF-beta in Human Disease