Aristidis Moustakas

Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles

Mendes Rodrigues Junior, Dorival; Saez-Ibañez, Ana Rosa; Terabayashi, Takeshi; Daubel, Nina et al.

Ingår i Journal of Cell Biology, 2025

• DOI för Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles
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The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

Ohata, Yae; Ali, Mohamad M.; Tsubakihara, Yutaro; Itoh, Yuka et al.

Ingår i Cell Death and Differentiation, s. 1915-1929, 2025

• DOI för The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
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Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial

Tullberg, Axel Stenmark; Thurfjell, Viktoria; Kovacs, Aniko; Micke, Patrick et al.

Ingår i Breast Cancer Research and Treatment, s. 499-509, 2025

• DOI för Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial
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TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

Mendes Rodrigues Junior, Dorival; Tsirigoti, Chrysoula; Psatha, Konstantina; Kletsas, Dimitris et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2025

• DOI för TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles
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Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

Voytyuk, Oleksandr; Ohata, Yae; Moustakas, Aristidis; ten Dijke, Peter et al.

Ingår i Journal of Biological Chemistry, 2024

• DOI för Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling
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Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles

Mendes Rodrigues Junior, Dorival; Saez-Ibañez, Ana Rosa; Terabayashi, Takeshi; Daubel, Nina et al.

Ingår i Journal of Cell Biology, 2025

• DOI för Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles
• Ladda ner fulltext (pdf) av Loss of ErbB3 redirects Integrin β1 from early endosomal recycling to secretion in extracellular vesicles

The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

Ohata, Yae; Ali, Mohamad M.; Tsubakihara, Yutaro; Itoh, Yuka et al.

Ingår i Cell Death and Differentiation, s. 1915-1929, 2025

• DOI för The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma
• Ladda ner fulltext (pdf) av The transcription factor LHX2 mediates and enhances oncogenic BMP signaling in medulloblastoma

Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial

Tullberg, Axel Stenmark; Thurfjell, Viktoria; Kovacs, Aniko; Micke, Patrick et al.

Ingår i Breast Cancer Research and Treatment, s. 499-509, 2025

• DOI för Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial
• Ladda ner fulltext (pdf) av Tumoral pSMAD2 as a prognostic biomarker in early-stage breast cancer: insights from the randomized SweBCG91RT trial

TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

Mendes Rodrigues Junior, Dorival; Tsirigoti, Chrysoula; Psatha, Konstantina; Kletsas, Dimitris et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2025

• DOI för TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles
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Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

Voytyuk, Oleksandr; Ohata, Yae; Moustakas, Aristidis; ten Dijke, Peter et al.

Ingår i Journal of Biological Chemistry, 2024

• DOI för Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling
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ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness

Vasilaki, Eleftheria; Bai, Yu; Ali, Mohamad Moustafa; Sundqvist, Anders et al.

Ingår i Cell Communication and Signaling, 2024

• DOI för ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
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Special issue: TGF-β and epithelial-mesenchymal transition in cancer

ten Dijke, Peter; Miyazono, Kohei; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Seminars in Cancer Biology, s. 1-3, 2024

• DOI för Special issue: TGF-β and epithelial-mesenchymal transition in cancer

Crosstalk between TGF-β and EGF receptors via direct phosphorylation

Moustakas, Aristidis

Ingår i Journal of Cell Biology, 2024

• DOI för Crosstalk between TGF-β and EGF receptors via direct phosphorylation
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The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion

Gélabert, Caroline; Papoutsoglou, Panagiotis; Cancela Golan, Irene; Ahlström, Eric et al.

Ingår i Cell Communication and Signaling, 2023

• DOI för The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
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Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation

Peleli, Maria; Antoniadou, Ivi; Mendes Rodrigues Junior, Dorival; Savvoulidou, Odysseia et al.

Ingår i Redox Biology, 2023

• DOI för Cystathionine gamma-lyase (CTH) inhibition attenuates glioblastoma formation
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The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Tzavlaki, Kalliopi; Ohata, Yae; Morén, Anita; Watanabe, Yukihide et al.

Ingår i Journal of Cellular Physiology, s. 790-812, 2023

• DOI för The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
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Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action

Moustakas, Aristidis; Lohr, J. Matthias; Heuchel, Rainer L.

Ingår i SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2022

• DOI för Cellular heterogeneity in pancreatic cancer: the different faces of gremlin action
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Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Maturi, Varun; Heldin, Carl-Henrik et al.

Ingår i Cell Death and Disease, 2022

• DOI för Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
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The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Mendes Rodrigues-Junior, Dorival et al.

Ingår i Journal of Cellular Physiology, s. 743-762, 2022

• DOI för The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma
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TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Tsubakihara, Yutaro; Ohata, Yae; Okita, Yukari; Younis, Shady et al.

Ingår i Molecular Oncology, s. 2330-2354, 2022

• DOI för TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition
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Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity

Mendes Rodrigues Junior, Dorival; Raminelli, Cristiano; Hassanie, Haifa; Trossini, Gustavo Henrique Goulart et al.

Ingår i Scientific Reports, s. 21113, 2022

• DOI för Aporphine and isoquinoline derivatives block glioblastoma cell stemness and enhance temozolomide cytotoxicity
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Mast cell chymase has a negative impact on human osteoblasts

Lind, Thomas; Melo, Fabio R.; Gustafson, Ann-Marie; Sundqvist, Anders et al.

Ingår i Matrix Biology, s. 1-19, 2022

• DOI för Mast cell chymase has a negative impact on human osteoblasts
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The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Dadras, Mahsa Shahidi; Caja, Laia; Mezheyeuski, Artur; Liu, Sijia et al.

Ingår i Cell Death and Disease, 2021

• DOI för The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma
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The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling

Papoutsoglou, Panagiotis; Rodrigues Junior, Dorival Mendes; Morén, Anita; Bergman, Andrew et al.

Ingår i Oncogene, s. 3748-3765, 2021

• DOI för The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling
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BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

Fukuda, Tomohiko; Fukuda, Risa; Koinuma, Daizo; Moustakas, Aristidis et al.

Ingår i Cellular Signalling, 2021

• DOI för BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

BMP signaling is a therapeutic target in ovarian cancer

Fukuda, Tomohiko; Fukuda, Risa; Tanabe, Ryo; Koinuma, Daizo et al.

Ingår i Cell Death Discovery, 2020

• DOI för BMP signaling is a therapeutic target in ovarian cancer
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TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness

Sundqvist, Anders; Vasilaki, Eleftheria; Voytyuk, Oleksandr; Bai, Yu et al.

Ingår i Oncogene, s. 4436-4449, 2020

• DOI för TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness
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The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity

Papoutsoglou, Panagiotis; Tsubakihara, Yutaro; Caja, Laia; Pallis, Paris et al.

Ingår i Cell Reports, s. 3182-319800000000000, 2019

• DOI för The TGFB2-AS1 lncRNA regulates TGFβ signaling by modulating corepressor activity
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Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

Kolliopoulos, Constantinos; Lin, Chun-Yu; Heldin, Carl-Henrik; Moustakas, Aristidis et al.

Ingår i Matrix Biology, s. 29-45, 2019

• DOI för Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Kolliopoulos, Constantinos; Raja, Erna; Razmara, Masoud; Heldin, Paraskevi et al.

Ingår i Journal of Biological Chemistry, s. 4119-4136, 2019

• DOI för Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
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JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Sundqvist, Anders; Voytyuk, Olexandr; Hamdi, Mohamed; Popeijus, Herman E. et al.

Ingår i CELLS, 2019

• DOI för JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses
• Ladda ner fulltext (pdf) av JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells

Zhang, Yanyu; Valsala Madhavan Unnithan, Ragaseema; Hamidi, Anahita; Caja, Laia et al.

Ingår i The FASEB Journal, s. 7822-7832, 2019

• DOI för TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells

LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation

Morén, Anita; Bellomo, Claudia; Tsubakihara, Yutaro; Kardassis, Dimitris et al.

Ingår i Oncogenesis, 2019

• DOI för LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation
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Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells

Batool, Tahira; Fang, Jianping; Jansson, Viktor; Zhao, Hongxing et al.

Ingår i Cellular Signalling, s. 122-129, 2019

• DOI för Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells

The protein kinase SIK downregulates the polarity protein Par3

Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta; Mahzabin, Tanzila et al.

Ingår i Oncotarget, s. 5716-5735, 2018

• DOI för The protein kinase SIK downregulates the polarity protein Par3

TGF-beta Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition

Kahata, Kaoru; Dadras, Mahsa Shahidi; Moustakas, Aristidis

Ingår i Cold Spring Harbor Perspectives in Biology, 2018

• DOI för TGF-beta Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition

TGF-beta Family Signaling in Ductal Differentiation and Branching Morphogenesis

Kahata, Kaoru; Maturi, Varun; Moustakas, Aristidis

Ingår i Cold Spring Harbor Perspectives in Biology, 2018

• DOI för TGF-beta Family Signaling in Ductal Differentiation and Branching Morphogenesis

Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases

Enroth, Stefan; Maturi, Varun; Berggrund, Malin; Bosdotter Enroth, Sofia et al.

Ingår i Scientific Reports, 2018

• DOI för Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases
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Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Caja, Laia; Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Tan, E-Jean et al.

Ingår i Oncogene, s. 2515-2531, 2018

• DOI för Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells
• Ladda ner fulltext (pdf) av Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling

Bouris, Panagiotis; Manou, Dimitra; Sopaki-Valalaki, Anastasia; Kolokotroni, Anthi et al.

Ingår i Matrix Biology, s. 35-51, 2018

• DOI för Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Bellomo, Claudia; Caja, Laia; Fabregat, Isabel; Mikulits, Wolfgang et al.

Ingår i Cell Death and Differentiation, s. 885-903, 2018

• DOI för Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
• Ladda ner fulltext (pdf) av Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

Maturi, Varun; Enroth, Stefan; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 7113-7127, 2018

• DOI för Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells
• Ladda ner fulltext (pdf) av Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

Maturi, Varun; Morén, Anita; Enroth, Stefan; Heldin, Carl-Henrik et al.

Ingår i Molecular Oncology, s. 1153-1174, 2018

• DOI för Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells
• Ladda ner fulltext (pdf) av Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells

Batool, Tahira; Fang, Jianping; Barash, Uri; Moustakas, Aristidis et al.

Ingår i FEBS Open Bio, s. 405-413, 2017

• DOI för Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells
• Ladda ner fulltext (pdf) av Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells

Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Lehmann, Laura C.; Hewitt, Graeme; Aibara, Shintaro; Leitner, Alexander et al.

Ingår i Molecular Cell, s. 847-8590000000, 2017

• DOI för Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1
• Ladda ner fulltext (pdf) av Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1

Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer

Mathot, Lucy; Kundu, Snehangshu; Ljungström, Viktor; Svedlund, Jessica et al.

Ingår i Cancer Research, s. 1730-1740, 2017

• DOI för Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer

Overexpression of heparanase attenuated TGF-beta-stimulated signaling in tumor cells

Batool, Tahira; Fang, Jianping; Barash, Uri; Moustakas, Aristidis et al.

Ingår i International journal of experimental pathology (Print), 2017

Epithelial-mesenchymal transition in cancer

Moustakas, Aristidis; Garcia de Herreros, Antonio

Ingår i Molecular Oncology, s. 715-717, 2017

• DOI för Epithelial-mesenchymal transition in cancer
• Ladda ner fulltext (pdf) av Epithelial-mesenchymal transition in cancer

Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF- Signaling

Carthy, Jon M.; Engstrom, Ulla; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Biochemistry, s. 938-945, 2016

• DOI för Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF- Signaling

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling

Raja, Erna; Tzavlaki, Kalliopi; Vuilleumier, Robin; Edlund, Karolina et al.

Ingår i Oncotarget, s. 1120-1143, 2016

• DOI för The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling
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Signaling Receptors for TGF-beta Family Members

Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Cold Spring Harbor Perspectives in Biology, 2016

• DOI för Signaling Receptors for TGF-beta Family Members

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation

Carthy, Jon M.; Stoeter, Martin; Bellomo, Claudia; Vanlandewijck, Michael et al.

Ingår i Scientific Reports, 2016

• DOI för Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation
• Ladda ner fulltext (pdf) av Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation

Ras and TGF-beta signaling enhance cancer progression by promoting the Delta Np63 transcriptional program

Vasilaki, Eleftheria; Morikawa, Masato; Koinuma, Daizo; Mizutani, Anna et al.

Ingår i Science Signaling, 2016

• DOI för Ras and TGF-beta signaling enhance cancer progression by promoting the Delta Np63 transcriptional program

Single Chain Antibodies as Tools to Study transforming growth factor--Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens

Blokzijl, Andries; Zieba, Agata; Hust, Michael; Schirrmann, Thomas et al.

Ingår i Molecular & Cellular Proteomics, s. 1848-1856, 2016

• DOI för Single Chain Antibodies as Tools to Study transforming growth factor--Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens

Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation

Watanabe, Yukihide; Papoutsoglou, Panagiotis; Maturi, Varun; Tsubakihara, Yutaro et al.

Ingår i Journal of Biological Chemistry, s. 12706-12723, 2016

• DOI för Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation

TGF beta and the nuclear receptor LXR alpha crosstalk on lipid metabolism and epithelial to mesenchymal transition in hepatocellular carcinoma

Bellomo, Claudia; Gahman, T. C.; Shiau, A. K.; Heldin, Carl-Henrik et al.

Ingår i European Journal of Clinical Investigation, s. 36-36, 2016

In vitro and ex vivo vanadium antitumor activity in (TGF-beta)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients

Petanidis, Savvas; Kioseoglou, Efrosini; Domvri, Kalliopi; Zarogoulidis, Paul et al.

Ingår i International Journal of Biochemistry and Cell Biology, s. 121-134, 2016

• DOI för In vitro and ex vivo vanadium antitumor activity in (TGF-beta)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients

The mitotic checkpoint protein kinase BUB1 is an engine in the TGF-beta signaling apparatus

Moustakas, Aristidis

Ingår i Science Signaling, 2015

• DOI för The mitotic checkpoint protein kinase BUB1 is an engine in the TGF-beta signaling apparatus

Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells

Bouris, Panagiotis; Skandalis, Spyros S.; Piperigkou, Zoi; Afratis, Nikos et al.

Ingår i Matrix Biology, s. 42-60, 2015

• DOI för Estrogen receptor alpha mediates epithelial to mesenchymal transition, expression of specific matrix effectors and functional properties of breast cancer cells

Targeting Tgf-Beta I With The Transforming Growth Factor Receptor Type I Kinase Inhibitor, Ly2157299, Modulates Stemness-Related Biomarkers In Hepatocellular Carcinoma

Rani, B.; Dituri, F.; Cao, Y.; Engstrom, U. et al.

Ingår i Journal of Hepatology, 2015

MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures

Mondal, Tanmoy; Subhash, Santhilal; Vaid, Roshan; Enroth, Stefan et al.

Ingår i Nature Communications, 2015

• DOI för MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures
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The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition

Tan, E-Jean; Kahata, Kaoru; Idås, Oskar; Thuault, Sylvie et al.

Ingår i Nucleic Acids Research, s. 162-178, 2015

• DOI för The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition
• Ladda ner fulltext (pdf) av The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition

Tamoxifen Inhibits TGF-beta-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2

Carthy, Jon M.; Sundqvist, Anders; Heldin, Angelos; Van Dam, Hans et al.

Ingår i Journal of Cellular Physiology, s. 3084-3092, 2015

• DOI för Tamoxifen Inhibits TGF-beta-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2

Transforming growth factor beta and bone morphogenetic protein actions in cancer progression

Moustakas, Aristidis

Ingår i The FEBS Journal, s. 35-35, 2015

Nucleosome regulatory dynamics in response to TGF beta

Enroth, Stefan; Andersson, Robin; Bysani, Madhusudhan; Wallerman, Ola et al.

Ingår i Nucleic Acids Research, s. 6921-6934, 2014

• DOI för Nucleosome regulatory dynamics in response to TGF beta

Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells

Enroth, Stefan; Andersson, Robin; Bysani, Madhusudhan Reddy; Wallerman, Ola et al.

Ingår i Nucleic Acids Research, s. 6921-6934, 2014

• DOI för Nucleosome regulatory dynamics in response to TGF-beta treatment in HepG2 cells

Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

Dahl, Markus; Maturi, Varun; Lönn, Peter; Papoutsoglou, Panagiotis et al.

Ingår i PLOS ONE, 2014

• DOI för Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
• Ladda ner fulltext (pdf) av Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

Knock-Down of CD44 Regulates Endothelial Cell Differentiation via NF kappa B-Mediated Chemokine Production

Olofsson, Berit; Porsch, Helena; Heldin, Paraskevi

Ingår i PLOS ONE, 2014

• DOI för Knock-Down of CD44 Regulates Endothelial Cell Differentiation via NF kappa B-Mediated Chemokine Production
• Ladda ner fulltext (pdf) av Knock-Down of CD44 Regulates Endothelial Cell Differentiation via NF kappa B-Mediated Chemokine Production

Invasive cells follow Snail's slow and persistent pace

García de Herreros, Antonio; Moustakas, Aristidis

Ingår i Cell Cycle, s. 2320-2321, 2014

• DOI för Invasive cells follow Snail's slow and persistent pace

Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells

Korpetinou, Angeliki; Skandalis, Spyros S.; Moustakas, Aristidis; Happonen, Kaisa E. et al.

Ingår i PLOS ONE, 2013

• DOI för Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells
• Ladda ner fulltext (pdf) av Serglycin Is Implicated in the Promotion of Aggressive Phenotype of Breast Cancer Cells

The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins

Coppotelli, Giuseppe; Mughal, Nouman; Callegari, Simone; Sompallae, Ramakrishna et al.

Ingår i Nucleic Acids Research, s. 2950-2962, 2013

• DOI för The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins
• Ladda ner fulltext (pdf) av The Epstein-Barr virus nuclear antigen-1 reprograms transcription by mimicry of high mobility group A proteins

HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment

Cedervall, Jessica; Zhang, Yanyu; Ringvall, Maria; Thulin, Åsa et al.

Ingår i Angiogenesis, s. 889-902, 2013

• DOI för HRG regulates tumor progression, epithelial to mesenchymal transition and metastasis via platelet-induced signaling in the pre-tumorigenic microenvironment

p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β

Termén, Stefan; Tan, E-Jean; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 801-813, 2013

• DOI för p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β

Coordination of TGF-beta Signaling by Ubiquitylation

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Molecular Cell, s. 555-556, 2013

• DOI för Coordination of TGF-beta Signaling by Ubiquitylation

Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition

Tan, E-Jean; Thuault, Sylvie; Caja, Laia; Carletti, Tea et al.

Ingår i Journal of Biological Chemistry, s. 7134-7145, 2012

• DOI för Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition

Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase

Lönn, Peter; Vanlandewijck, Michael; Raja, Erna; Kowanetz, Marcin et al.

Ingår i Journal of Biological Chemistry, s. 12867-12878, 2012

• DOI för Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase

Context-dependent action of transforming growth factor β family members on normal and cancer stem cells

Caja, Laia; Kahata, Kaoru; Moustakas, Aristidis

Ingår i Current pharmaceutical design, s. 4072-4086, 2012

• DOI för Context-dependent action of transforming growth factor β family members on normal and cancer stem cells

Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition

Papadimitriou, E; Vasilaki, Eleftheria; Vorvis, C; Iliopoulos, D et al.

Ingår i Oncogene, s. 2862-2875, 2012

• DOI för Differential regulation of the two RhoA-specific GEF isoforms Net1/Net1A by TGF-β and miR-24: role in epithelial-to-mesenchymal transition

Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase

Zieba, Agata; Pardali, Katerina; Söderberg, Ola; Lindbom, Lena et al.

Ingår i Molecular & Cellular Proteomics, 2012

• DOI för Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase

Induction of epithelial-mesenchymal transition by transforming growth factor β

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Seminars in Cancer Biology, s. 446-454, 2012

• DOI för Induction of epithelial-mesenchymal transition by transforming growth factor β

Role of TGF-β signaling in EMT, cancer progression and metastasis

Savary, Katia; Moustakas, Aristidis

Ingår i Drug Discovery Today, s. 121-126, 2011

• DOI för Role of TGF-β signaling in EMT, cancer progression and metastasis

Hyaluronan Synthesis Is Inhibited by Adenosine Monophosphate-activated Protein Kinase through the Regulation of HAS2 Activity in Human Aortic Smooth Muscle Cells

Vigetti, Davide; Clerici, Moira; Deleonibus, Sara; Karousou, Evgenia et al.

Ingår i Journal of Biological Chemistry, s. 7917-7924, 2011

• DOI för Hyaluronan Synthesis Is Inhibited by Adenosine Monophosphate-activated Protein Kinase through the Regulation of HAS2 Activity in Human Aortic Smooth Muscle Cells

TGF beta Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death

van der Heide, Lars P.; van Dinther, Maarten; Moustakas, Aristidis; ten Dijke, Peter

Ingår i Journal of Biological Chemistry, s. 5003-5011, 2011

• DOI för TGF beta Activates Mitogen- and Stress-activated Protein Kinase-1 (MSK1) to Attenuate Cell Death

Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1

Morén, Anita; Raja, Erna; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Biological Chemistry, s. 341-353, 2011

• DOI för Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1

Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1)

Bernert, Berit; Porsch, Helena; Heldin, Paraskevi

Ingår i Journal of Biological Chemistry, s. 42349-42359, 2011

• DOI för Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1)

Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

Sideridou, Maria; Zakopoulou, Roubini; Evangelou, Konstantinos; Liontos, Michalis et al.

Ingår i Journal of Cell Biology, s. 1123-1140, 2011

• DOI för Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins

The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma.

Sjölund, Jonas; Boström, Anna-Karin; Lindgren, David; Manna, Sugata et al.

Ingår i PLOS ONE, 2011

• DOI för The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma.

Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: A useful in vitro model for testing new treatments

Chamcheu, Jean Christopher; Pihl-Lundin, Inger; Eteti Mouyobo, Cedrique; Gester, Therese et al.

Ingår i British Journal of Dermatology, s. 263-272, 2011

• DOI för Immortalized keratinocytes derived from patients with epidermolytic ichthyosis reproduce the disease phenotype: A useful in vitro model for testing new treatments

Quantitative analysis of transient and sustained transforming growth factor-beta signaling dynamics

Zi, Zhike; Feng, Zipei; Chapnick, Douglas A.; Dahl, Markus et al.

Ingår i Molecular Systems Biology, 2011

• DOI för Quantitative analysis of transient and sustained transforming growth factor-beta signaling dynamics

Regulation of Myosin Light Chain Function by BMP Signaling Controls Actin Cytoskeleton Remodeling

Konstantinidis, Georgios; Moustakas, Aristidis; Stournaras, Christos

Ingår i Cellular Physiology and Biochemistry, s. 1031-1044, 2011

• DOI för Regulation of Myosin Light Chain Function by BMP Signaling Controls Actin Cytoskeleton Remodeling

TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2

Papadimitriou, Elsa; Kardassis, Dimitris; Moustakas, Aristidis; Stournaras, Christos

Ingår i Cellular Physiology and Biochemistry, s. 229-238, 2011

• DOI för TGFβ-induced early activation of the small GTPase RhoA is Smad2/3-independent and involves Src and the guanine nucleotide exchange factor Vav2

The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination

Karousou, Eugenia; Kamiryo, Masaru; Skandalis, Spyros S; Ruusala, Aino et al.

Ingår i Journal of Biological Chemistry, s. 23647-23654, 2010

• DOI för The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination

Proteomic identification of CD44 interacting proteins

Skandalis, Spyros S.; Kozlova, Inna; Engström, Ulla; Hellman, Ulf et al.

Ingår i IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, s. 833-840, 2010

• DOI för Proteomic identification of CD44 interacting proteins

PARP-1 attenuates Smad-mediated transcription

Lönn, Peter; van der Heide, Lars; Dahl, Markus; Hellman, Ulf et al.

Ingår i Molecular Cell, s. 521-532, 2010

• DOI för PARP-1 attenuates Smad-mediated transcription

Immortalized keratinocytes from Epidermolytic Ichthyosis-patients reproduce the disease phenotype in vitro

Chamcheu, Jean Christopher; Virtanen, Marie; Moustakas, Aristidis; Navsaria, Harshad et al.

Ingår i Journal of Investigative Dermatology, 2010

Transforming growth factor β promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin

Bergström, Rosita; Savary, Katia; Morén, Anita; Guibert, Sylvain et al.

Ingår i Journal of Biological Chemistry, s. 19727-19737, 2010

• DOI för Transforming growth factor β promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin

Integrins open the way to epithelial-mesenchymal transitions: Comment on: Bianchi A, et al. Cell Cycle 2010; 9:1647–59

Moustakas, Aristidis

Ingår i Cell Cycle, s. 1682-1682, 2010

• DOI för Integrins open the way to epithelial-mesenchymal transitions: Comment on: Bianchi A, et al. Cell Cycle 2010; 9:1647–59

Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom

Huminiecki, Lukasz; Goldovsky, Leon; Freilich, Shiri; Moustakas, Aristidis et al.

Ingår i BMC Evolutionary Biology, s. 28, 2009

• DOI för Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom

A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF‑β mediated epithelial–mesenchymal transition

Vincent, Theresa; Neve, Etienne P. A.; Johnson, Jill R.; Kukalev, Alexander et al.

Ingår i Nature Cell Biology, s. 943-950, 2009

• DOI för A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF‑β mediated epithelial–mesenchymal transition

Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition

Chamcheu, Jean Christopher; Lorié, Elizabeth Pavez; Akgul, Baki; Bannbers, Elin et al.

Ingår i Journal of dermatological science (Amsterdam), s. 198-206, 2009

• DOI för Characterization of immortalized human epidermolysis bullosa simplex (KRT5) cell lines: trimethylamine N-oxide protects the keratin cytoskeleton against disruptive stress condition

TGF-beta Targets PAX3 to Control Melanocyte Differentiation

Moustakas, Aristidis

Ingår i Developmental Cell, s. 797-799, 2008

• DOI för TGF-beta Targets PAX3 to Control Melanocyte Differentiation

TGFβ induces SIK to negatively regulate type I receptor kinase signaling

Kowanetz, Marcin; Lönn, Peter; Vanlandewijck, Michael; Kowanetz, Katarzyna et al.

Ingår i Journal of Cell Biology, s. 655-662, 2008

• DOI för TGFβ induces SIK to negatively regulate type I receptor kinase signaling

HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition

Thuault, Sylvie; Tan, E-Jean; Peinado, Hector; Cano, Amparo et al.

Ingår i Journal of Biological Chemistry, s. 33437-33446, 2008

• DOI för HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition

Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis

Heldin, Paraskevi; Karousou, Eugenia; Bernert, Berit; Porsch, Helena et al.

Ingår i Connective Tissue Research, s. 215-218, 2008

• DOI för Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis

Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

Gal, Annamaria; Sjöblom, Tobias; Fedorova, L.; Imreh, S. et al.

Ingår i Oncogene, s. 1218-1230, 2008

• DOI för Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

Li, Lingli; Asteriou, Trias; Bernert, Berit; Heldin, Carl-Henrik et al.

Ingår i Biochemical Journal, s. 327-336, 2007

• DOI för Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells

Li, Yuejuan; Li, Lingli; Brown, Tracey J.; Heldin, Paraskevi

Ingår i International Journal of Cancer, s. 2557-2567, 2007

• DOI för Silencing of hyaluronan synthase 2 suppresses the malignant phenotype of invasive breast cancer cells

Functional role of Meox2 during the epithelial cytostatic response to TGF-beta

Valcourt, Ulrich; Thuault, Sylvie; Pardali, Katerina; Heldin, Carl-Henrik et al.

Ingår i Molecular Oncology, s. 55-71, 2007

• DOI för Functional role of Meox2 during the epithelial cytostatic response to TGF-beta

Notch signaling is necessary for epithelial growth arrest by TGF-beta

Niimi, Hideki; Pardali, Katerina; Vanlandewijck, Michael; Heldin, Carl-Henrik et al.

Ingår i Journal of Cell Biology, s. 695-707, 2007

• DOI för Notch signaling is necessary for epithelial growth arrest by TGF-beta

Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition

Thuault, Sylvie; Valcourt, Ulrich; Petersen, Maj; Manfioletti, Guidalberto et al.

Ingår i Journal of Cell Biology, s. 175-183, 2006

• DOI för Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition

A new twist in Smad signaling

Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Developmental Cell, s. 685-686, 2006

• DOI för A new twist in Smad signaling

Operational criteria for selecting a cDNA microarray data normalization algorithm

Argyropoulos, C.; Chatziioannou, A. A.; Nikiforidis, G.; Moustakas, Aristidis et al.

Ingår i Oncology Reports, s. 983-996, 2006

The mechanism of nuclear export of smad3 involves exportin 4 and Ran

Kurisaki, Akira; Kurisaki, Keiko; Kowanetz, Marcin; Sugino, Hiromu et al.

Ingår i Molecular and Cellular Biology, s. 1318-1332, 2006

• DOI för The mechanism of nuclear export of smad3 involves exportin 4 and Ran

Non-Smad TGF-β signals

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Journal of Cell Science, s. 3573-3584, 2005

• DOI för Non-Smad TGF-β signals

TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

Valcourt, Ulrich; Kowanetz, Marcin; Niimi, Hideki; Heldin, Carl-Henrik et al.

Ingår i Molecular Biology of the Cell, s. 1987-2002, 2005

• DOI för TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21Waf1/Cip1

Pardali, Katerina; Kowanetz, Marcin; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 260-272, 2005

• DOI för Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21Waf1/Cip1

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

Morén, Anita; Imamura, Takeshi; Miyazono, Kohei; Heldin, Carl-Henrik et al.

Ingår i Journal of Biological Chemistry, s. 22115-22123, 2005

• DOI för Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4

Chou, Wan-Chih; Prokova, Vassiliki; Shiraishi, Keiko; Valcourt, Ulrich et al.

Ingår i Molecular Biology of the Cell, s. 1279-1294, 2003

• DOI för Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4

Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells

Kaivo-Oja, Noora; Bondestam, Jonas; Kämäräinen, Meerit; Koskimies, Janne et al.

Ingår i Journal of Clinical Endocrinology and Metabolism, s. 755-762, 2003

• DOI för Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells

Differential ubiquitination defines the functional status of the tumor suppressor Smad4

Morén, Anita; Hellman, Ulf; Inada, Yuri; Imamura, Takeshi et al.

Ingår i Journal of Biological Chemistry, s. 33571-33582, 2003

• DOI för Differential ubiquitination defines the functional status of the tumor suppressor Smad4

Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

Kurisaki, Keiko; Kurisaki, Akira; Valcourt, Ulrich; Terentiev, Alexei A et al.

Ingår i Molecular and Cellular Biology, s. 4494-4510, 2003

• DOI för Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

Itoh, Susumu; Thorikay, Midory; Kowanetz, Marcin; Moustakas, Aristidis et al.

Ingår i Journal of Biological Chemistry, s. 3751-3761, 2003

• DOI för Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4

Kintscher, Ulrich; Lyon, Christopher; Wakino, Shu; Bruemmer, Dennis et al.

Ingår i Circulation Research, 2002

• DOI för PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4

Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes

Valcourt, Ulrich; Gouttenoire, Jérôme; Moustakas, Aristidis; Herbage, Daniel et al.

Ingår i Journal of Biological Chemistry, s. 33545-33558, 2002

• DOI för Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes

Engagement of activin and bone morphogenetic protein signaling pathway Smad proteins in the induction of inhibin B production in ovarian granulosa cells

Bondestam, Jonas; Kaivo-oja, Noora; Kallio, Janne; Groome, Nigel et al.

Ingår i Molecular and Cellular Endocrinology, s. 79-88, 2002

• DOI för Engagement of activin and bone morphogenetic protein signaling pathway Smad proteins in the induction of inhibin B production in ovarian granulosa cells

The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter

Koutsodontis, George; Moustakas, Aristidis; Kardassis, Dimitris

Ingår i Biochemistry, s. 12771-12784, 2002

• DOI för The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter

cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)

Bondestam, Jonas; Huotari, Mar-Anne; Morén, Anita; Ustinov, Jarkko et al.

Ingår i Cytogenetics and Cell Genetics, s. 157-162, 2001

• DOI för cDNA cloning, expression studies and chromosome mapping of human type I serine/threonine kinase receptor ALK7 (ACVR1C)

Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

Kurisaki, Akira; Kose, Shingo; Yoneda, Yoshihiro; Heldin, Carl-Henrik et al.

Ingår i Molecular Biology of the Cell, s. 1079-1091, 2001

• DOI för Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

Unboxing the network among long non-coding RNAs and TGF-β signaling in cancer

Mendes Rodrigues Junior, Dorival; Moustakas, Aristidis

Ingår i Upsala Journal of Medical Sciences, 2024

• DOI för Unboxing the network among long non-coding RNAs and TGF-β signaling in cancer
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Dual inhibition of TGF-beta and PD-L1: a novel approach to cancer treatment

Gulley, James L.; Schlom, Jeffrey; Barcellos-Hoff, Mary Helen; Wang, Xiao-Jing et al.

Ingår i Molecular Oncology, s. 2117-2134, 2022

• DOI för Dual inhibition of TGF-beta and PD-L1: a novel approach to cancer treatment
• Ladda ner fulltext (pdf) av Dual inhibition of TGF-beta and PD-L1: a novel approach to cancer treatment

NUAK1 and NUAK2 Fine-Tune TGF-β Signaling

van de Vis, Reinofke A. J.; Moustakas, Aristidis; van der Heide, Lars P.

Ingår i Cancers, 2021

• DOI för NUAK1 and NUAK2 Fine-Tune TGF-β Signaling
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Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types

Chisari, Andrea; Golan, Irene; Campisano, Sabrina; Gélabert, Caroline et al.

Ingår i Frontiers in Pharmacology, 2021

• DOI för Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types
• Ladda ner fulltext (pdf) av Glucose and Amino Acid Metabolic Dependencies Linked to Stemness and Metastasis in Different Aggressive Cancer Types

TGF-β Signaling

Tzavlaki, Kalliopi; Moustakas, Aristidis

Ingår i Biomolecules, 2020

• DOI för TGF-β Signaling
• Ladda ner fulltext (pdf) av TGF-β Signaling

Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies

Peleli, Maria; Moustakas, Aristidis; Papapetropoulos, Andreas

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies
• Ladda ner fulltext (pdf) av Endothelial-Tumor Cell Interaction in Brain and CNS Malignancies

Long non-coding RNAs and TGF-beta signaling in cancer

Papoutsoglou, Panagiotis; Moustakas, Aristidis

Ingår i Cancer Science, s. 2672-2681, 2020

• DOI för Long non-coding RNAs and TGF-beta signaling in cancer
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TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

Caja, Laia; Dituri, Francesco; Mancarella, Serena; Caballero-Diaz, Daniel et al.

Ingår i International Journal of Molecular Sciences, 2018

• DOI för TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
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Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor

Tsubakihara, Yutaro; Moustakas, Aristidis

Ingår i International Journal of Molecular Sciences, 2018

• DOI för Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor
• Ladda ner fulltext (pdf) av Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor

Mechanisms of TGF beta-Induced Epithelial-Mesenchymal Transition

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Journal of Clinical Medicine, 2016

• DOI för Mechanisms of TGF beta-Induced Epithelial-Mesenchymal Transition
• Ladda ner fulltext (pdf) av Mechanisms of TGF beta-Induced Epithelial-Mesenchymal Transition

Transforming growth factor beta as regulator of cancer stemness and metastasis

Bellomo, Claudia; Caja, Laia; Moustakas, Aristidis

Ingår i British Journal of Cancer, s. 761-769, 2016

• DOI för Transforming growth factor beta as regulator of cancer stemness and metastasis
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Mechanisms of action of bone morphogenetic proteins in cancer

Davis, Hayley; Raja, Erna; Miyazono, Kohei; Tsubakihara, Yutaro et al.

Ingår i Cytokine & growth factor reviews, s. 81-92, 2016

• DOI för Mechanisms of action of bone morphogenetic proteins in cancer

The rationale for targeting TGF-beta in chronic liver diseases

Giannelli, Gianluigi; Mikulits, Wolfgang; Dooley, Steven; Fabregat, Isabel et al.

Ingår i European Journal of Clinical Investigation, s. 349-361, 2016

• DOI för The rationale for targeting TGF-beta in chronic liver diseases

Transforming growth factor beta and bone morphogenetic protein actions in brain tumors

Caja, Laia Puigsubira; Bellomo, Claudia; Moustakas, Aristidis

Ingår i FEBS Letters, s. 1588-1597, 2015

• DOI för Transforming growth factor beta and bone morphogenetic protein actions in brain tumors
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Reprogramming during epithelial to mesenchymal transition under the control of TGF beta

Tan, E-Jean; Olsson, Anna-Karin; Moustakas, Aristidis

Ingår i CELL ADHESION & MIGRATION, s. 233-246, 2015

• DOI för Reprogramming during epithelial to mesenchymal transition under the control of TGF beta

TGF beta and matrix-regulated epithelial to mesenchymal transition

Moustakas, Aristidis; Heldin, Paraskevi

Ingår i Biochimica et Biophysica Acta - General Subjects, s. 2621-2634, 2014

• DOI för TGF beta and matrix-regulated epithelial to mesenchymal transition

Role of Smads in TGFβ signaling

Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Cell and Tissue Research, s. 21-36, 2012

• DOI för Role of Smads in TGFβ signaling

Regulation of EMT by TGFβ in cancer

Heldin, Carl-Henrik; Vanlandewijck, Michael; Moustakas, Aristidis

Ingår i FEBS Letters, s. 1959-1970, 2012

• DOI för Regulation of EMT by TGFβ in cancer

Hyaluronan-CD44 interactions as potential targets for cancer therapy

Misra, Suniti; Heldin, Paraskevi; Hascall, Vincent C.; Karamanos, Nikos K. et al.

Ingår i The FEBS Journal, s. 1429-1443, 2011

• DOI för Hyaluronan-CD44 interactions as potential targets for cancer therapy

Control of transforming growth factor beta signal transduction by small GTPases

Kardassis, Dimitris; Murphy, Carol; Fotsis, Theodore; Moustakas, Aristidis et al.

Ingår i The FEBS Journal, s. 2947-2965, 2009

• DOI för Control of transforming growth factor beta signal transduction by small GTPases

Regulating the stability of TGFβ receptors and Smads

Lönn, Peter; Morén, Anita; Raja, Erna; Dahl, Markus et al.

Ingår i Cell Research, s. 21-35, 2009

• DOI för Regulating the stability of TGFβ receptors and Smads

The regulation of TGFβ signal transduction

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Development, s. 3699-3714, 2009

• DOI för The regulation of TGFβ signal transduction

Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

Heldin, Carl-Henrik; Landström, Maréne; Moustakas, Aristidis

Ingår i Current Opinion in Cell Biology, s. 166-176, 2009

• DOI för Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

Growth factor regulation of hyaluronan metabolism in tumor progression

Heldin, Paraskevi

Ingår i The Science of Hyaluronan Today - Glycoforum, 2009

Dynamic control of TGF-beta signaling and its links to the cytoskeleton

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i FEBS Letters, s. 2051-2065, 2008

• DOI för Dynamic control of TGF-beta signaling and its links to the cytoskeleton

Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer

Pardali, Katerina; Moustakas, Aristidis

Ingår i Biochimica et Biophysica Acta, s. 21-62, 2007

• DOI för Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer

Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Cancer Science, s. 1512-1520, 2007

• DOI för Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression

Ecsit-ement on the crossroads of Toll and BMP signal transduction

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Genes & Development, s. 2855-2859, 2003

• DOI för Ecsit-ement on the crossroads of Toll and BMP signal transduction

The nuts and bolts of IRF structure

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Nature Structural Biology, s. 874-876, 2003

• DOI för The nuts and bolts of IRF structure

From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Genes & Development, s. 1867-1871, 2002

• DOI för From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction

Smad signalling network

Moustakas, Aristidis

Ingår i Journal of Cell Science, s. 3355-3356, 2002

Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation

Moustakas, Aristidis; Pardali, Katerina; Gaal, Annamaria; Heldin, Carl-Henrik

Ingår i Immunology Letters, s. 85-91, 2002

• DOI för Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation

TGF-beta signaling from a three-dimensional perspective: insight into selection of partners

Souchelnytskyi, Serhiy; Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Trends in Cell Biolology, s. 304-307, 2002

• DOI för TGF-beta signaling from a three-dimensional perspective: insight into selection of partners

Smad regulation in TGF-beta signal transduction

Moustakas, Aristidis; Souchelnytskyi, Serhiy; Heldin, Carl-Henrik

Ingår i Journal of Cell Science, s. 4359-4369, 2001

Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β

Valcourt, Ulrich; Carthy, Jonathon; Okita, Yukari; Alcaraz, Lindsay et al.

Ingår i TGF-Beta Signaling, s. 147-181, Springer, 2016

• DOI för Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β

Epithelial-mesenchymal transition as a mechanism of metastasis

Savary, Katia; Termén, Stefan; Thuault, Sylvie; Keshamouni, Venkateshwar et al.

Ingår i Lung Cancer Metastasis, s. 65-92, Springer, 2009

• DOI för Epithelial-mesenchymal transition as a mechanism of metastasis

Growth factor regulation of hyaluronan deposition in malignancies.

Heldin, Paraskevi; Karousou, Eugenia; Skandalis, Spyros S.

Ingår i Hyaluronan in Cancer Biology., s. 37-50, Elsevier Inc., 2009

• DOI för Growth factor regulation of hyaluronan deposition in malignancies.

Cancer-associated fibroblasts and the role of TGFbeta

Micke, Patrick; Moustakas, Aristidis; Ohshima, Mitsuhiro; Kappert, Kai

Ingår i Transforming Growth Factor-beta in Cancer Therapy, Vol II, s. 417-441, The Humana Press, Inc., 2008

• DOI för Cancer-associated fibroblasts and the role of TGFbeta

TGF-beta and Smad signaling in transcriptome reprogramming during EMT

Thuault, Sylvie; Valcourt, Ulrich; Kowanetz, Marcin; Moustakas, Aristidis

Ingår i Transforming Growth Factor-Beta in Cancer Therapy, The Human Press Inc., 2008

TGFß/Smad signaling in epithelial to mesenchymal transition

Moustakas, Aristidis; Kowanetz, Marcin; Thuault, Sylvie

Ingår i Smad Signal Transduction, s. 131-150, Springer, 2006

SIK phosphorylates and degrades Par3 to mediate tight junction disassembly during epithelial-mesenchymal transition

Vanlandewijck, Michael; Lomnytska, Marta; Busch, Christer; Heldin, Carl-Henrik et al.

2011

SIK and Smurf2 cooperate to downregulate the TGF-β type I receptor

Lönn, Peter; Vanlandewijck, Michael; Kowanetz, Marcin; Kowanetz, Katarzyna et al.

The non-coding MIR100HG RNA mediates cytostatic responses of epithelial cells to transforming growth factor β

Papoutsoglou, Panagiotis; Bergman, Andrew; Heldin, Carl-Henrik; Moustakas, Aristidis

TGFβ signaling down-regulates LINC00707 to inhibit inflammatory responses

Papoutsoglou, Panagiotis; Caja, Laia; Ameur, Adam; Heldin, Carl-Henrik et al.

Epigenetic coupling of transcription factor CXXC5 regulates stemness genes in glioblastoma

Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Morén, Anita et al.

The liver kinase B1 inhibits transforming growth factor β signaling during mammary epithelial morphogenesis

Tzavlaki, Kalliopi; Morén, Anita; Watanabe, Yukihide; Eriksson, Jens et al.

SNAI2 knockout induces metabolic and cell cycle changes in breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Heldin, Carl-Henrik; Moustakas, Aristidis

TGF-β induces cholesterol accumulation to regulate the fate of tumor-derived extracellular vesicles

Mendes Rodrigues-Junior, Dorival; Tsirigoti, Chrysoula; Psatha, Konstantina; Kletsas, Dimitris et al.

SNAI1 and SMAD/TGF-β signals antagonize FOXA1 to control PSD4/EFA6B expression and couple integrin-mediated adhesion to endocytic fate in triple-negative breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Mendes Rodrigues-Junior, Dorival; Johansson, Staffan et al.

Glutamine deprivation alters TGF-β signaling in hepatocellular carcinoma

Gélabert, Caroline; Campisano, Sabrina; Golán, Irene C.; Beyene, T. Nathanael et al.

TGF-beta in Human Disease

Moustakas, Aristidis; Miyazawa, Keiji

Springer, 2013

• DOI för TGF-beta in Human Disease