Chuan Jin

Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model

Gao, Menghan; Kechagia, Soultana; Ramachandran, Mohanraj; Anand Manivel, Vivek et al.

Ingår i Molecular Cancer Therapeutics, s. 469-479, 2026

• DOI för Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model
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Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse

Yngve, Erik; Eriksson, Malin; Hedin, Anders; Ali, Arwa et al.

Ingår i Cancer Gene Therapy, s. 297-305, 2025

• DOI för Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse
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Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas

Ma, Jing; Sarén, Tina; Jin, Chuan; Kim, Hyeong Su et al.

Ingår i Cancer Immunology and Immunotherapy, 2025

• DOI för Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas
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Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response

Ali, Arwa; Contreras, Paola; Darweesh, Mahmoud; Andersson, Leif et al.

Ingår i Molecular Therapy Nucleic Acids, 2024

• DOI för Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response
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Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment

Ali, Arwa; Gao, Menghan; Iskantar, Alexandros; Wang, Hai et al.

Ingår i Frontiers in Immunology, 2023

• DOI för Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment
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Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model

Gao, Menghan; Kechagia, Soultana; Ramachandran, Mohanraj; Anand Manivel, Vivek et al.

Ingår i Molecular Cancer Therapeutics, s. 469-479, 2026

• DOI för Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model
• Ladda ner fulltext (pdf) av Shaping Tumor Microenvironment by Amplifying the Complement Cascade for Improved Immune Response in Pancreatic Cancer Model

Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse

Yngve, Erik; Eriksson, Malin; Hedin, Anders; Ali, Arwa et al.

Ingår i Cancer Gene Therapy, s. 297-305, 2025

• DOI för Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse
• Ladda ner fulltext (pdf) av Biodistribution and toxicity evaluation of oncolytic adenovirus Adf35(OGN) in Syrian hamster and mouse

Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas

Ma, Jing; Sarén, Tina; Jin, Chuan; Kim, Hyeong Su et al.

Ingår i Cancer Immunology and Immunotherapy, 2025

• DOI för Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas
• Ladda ner fulltext (pdf) av Pre-clinical safety and efficacy evaluation of Helicobacter Pylori neutrophil-activating protein (NAP)-armed CAR-T cells targeting B cell lymphomas

Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response

Ali, Arwa; Contreras, Paola; Darweesh, Mahmoud; Andersson, Leif et al.

Ingår i Molecular Therapy Nucleic Acids, 2024

• DOI för Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response
• Ladda ner fulltext (pdf) av Targeting ZC3H11A elicits immunogenic cancer cell death through augmentation of antigen presentation and interferon response

Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment

Ali, Arwa; Gao, Menghan; Iskantar, Alexandros; Wang, Hai et al.

Ingår i Frontiers in Immunology, 2023

• DOI för Proinflammatory allogeneic dendritic cells enhance the therapeutic efficacy of systemic anti-4-1BB treatment
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A qPCR-Based Method for Quantification of RCA Contaminants in Oncolytic Adenovirus Products

Gao, Menghan; Yngve, Erik; Yu, Di; Jin, Chuan

Ingår i Frontiers in Molecular Biosciences, 2022

• DOI för A qPCR-Based Method for Quantification of RCA Contaminants in Oncolytic Adenovirus Products
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Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-turnor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response

Jin, Chuan; Ali, Arwa; Iskantar, Alexandros; Fotaki, Grammatiki et al.

Ingår i Oncoimmunology, 2022

• DOI för Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-turnor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response
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ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression

Darweesh, Mahmoud; Younis, Shady; Hajikhezri, Zamaneh; Ali, Arwa et al.

Ingår i Frontiers in Immunology, 2022

• DOI för ZC3H11A loss of function enhances NF-κB signaling through defective IκBα protein expression
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CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Jin, Chuan; Ma, Jing; Ramachandran, Mohanraj; Yu, Di et al.

Ingår i Nature Biomedical Engineering, s. 830-841, 2022

• DOI för CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers
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Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus

Ma, Jing; Jin, Chuan; Čančer, Matko; Wang, Hai et al.

Ingår i MOLECULAR THERAPY-ONCOLYTICS, s. 356-366, 2021

• DOI för Concurrent expression of HP-NAP enhances antitumor efficacy of oncolytic vaccinia virus but not for Semliki Forest virus
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Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer

Ma, Jing; Ramachandran, Mohanraj; Jin, Chuan; Quijano-Rubio, Clara et al.

Ingår i Cell Death and Disease, 2020

• DOI för Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer
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LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Xie, Yuan; Sundström, Anders; Maturi, Naga P; Tan, E-Jean et al.

Ingår i Journal of Pathology, s. 228-240, 2019

• DOI för LGR5 promotes tumorigenicity and invasion of glioblastoma stem-like cells and is a potential therapeutic target for a subset of glioblastoma patients

Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models

Fotaki, Grammatiki; Jin, Chuan; Kerzeli, Iliana Kyriaki; Ramachandran, Mohanraj et al.

Ingår i Oncoimmunology, 2018

• DOI för Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models
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Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses

Fotaki, Grammatiki; Jin, Chuan; Ramachandran, Mohanraj; Kerzeli, Iliana Kyriaki et al.

Ingår i Oncoimmunology, 2018

• DOI för Pro-inflammatory allogeneic DCs promote activation of bystander immune cells and thereby license antigen-specific T-cell responses

Adenovirus, Semliki Forest virus and vaccinia virus-induced immunogenic cell death augments oncolytic virus immunotherapy

Ma, Jing; Ramachandran, Mohanraj; Jin, Chuan; Essand, Magnus et al.

Ingår i Scandinavian Journal of Immunology, s. 341-341, 2017

CAR T-Cells with Induced Secretion of Helicobacter Pylori Neutrophil-Activating Protein (HP-NAP) Yields Improved Anti-Tumor Activity and Reduced Immunosuppression

Essand, Magnus; Ma, Jing; Jin, Chuan; Ramachandran, Mohanraj et al.

Ingår i Molecular Therapy, s. 288-288, 2017

Prospects to improve chimeric antigen receptor T-cell therapy for solid tumors

Jin, Chuan; Yu, Di; Essand, Magnus

Ingår i Immunotherapy, s. 1355-1361, 2016

• DOI för Prospects to improve chimeric antigen receptor T-cell therapy for solid tumors

Allogeneic dendritic cells (AlloDCs) transduced with an infection enhanced adenovirus as adjuvant for cancer immunotherapy

Fotaki, Grammatiki; Jin, Chuan; Karlsson-Parra, Alex; Yu, Di et al.

Ingår i CANCER IMMUNOLOGY RESEARCH, 2016

• DOI för Allogeneic dendritic cells (AlloDCs) transduced with an infection enhanced adenovirus as adjuvant for cancer immunotherapy

Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer

Jin, Chuan; Ramachandran, Mohanraj; Fotaki, Grammatiki; Nilsson, Berith et al.

Ingår i CANCER IMMUNOLOGY RESEARCH, 2016

• DOI för Long-term episomal gene transfer for safe engineering of T cells for adoptive cell therapy of cancer

Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer

Jin, Chuan; Fotaki, Grammatiki; Ramachandran, Mohanraj; Nilsson, Berith et al.

Ingår i EMBO Molecular Medicine, s. 702-711, 2016

• DOI för Safe engineering of CAR T cells for adoptive cell therapy of cancer using long-term episomal gene transfer
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Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Zhang, Lei; Kundu, Soumi; Feenstra, Tjerk; Li, Xiujuan et al.

Ingår i Science Signaling, 2015

• DOI för Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas.

Long-term episomal gene transfer for safe engineering of T-cells for adoptive cell therapy of cancer

Jin, Chuan; Ramachandran, Mohanraj; Fotaki, Grammatiki; Nilsson, Bo et al.

Ingår i Human Gene Therapy, 2014

Allogeneic lymphocyte-licensed DCs expand T cells withimproved antitumor activity and resistance to oxidative stress andimmunosuppressive factors

Jin, Chuan; Yu, Di; Hillerdal, Victoria; Wallgren, AnnaCarin et al.

Ingår i Molecular Therapy Methods & Clinical Development, 2014

• DOI för Allogeneic lymphocyte-licensed DCs expand T cells withimproved antitumor activity and resistance to oxidative stress andimmunosuppressive factors

Vector-Encoded Helicobacter pylori Neutrophil-Activating Protein Promotes Maturation of Dendritic Cells with Th1 Polarization and Improved Migration

Ramachandran, Mohanraj; Jin, Chuan; Yu, Di; Eriksson, Fredrik et al.

Ingår i Journal of Immunology, s. 2287-2296, 2014

• DOI för Vector-Encoded Helicobacter pylori Neutrophil-Activating Protein Promotes Maturation of Dendritic Cells with Th1 Polarization and Improved Migration

Adenovirus Encoded Helicobacter pylori Neutrophil Activating Protein Promotes Maturation of DCs with Th-1 Polarization, Improved Antigen Presentation and Migration

Ramachandran, Mohanraj; Jin, Chuan; Yu, Di; Eriksson, Fredrik et al.

Ingår i Molecular Therapy, 2014

Allogeneic Lymphocyte-Licensed DCs Expand TCR/CAR-Engineered T Cells, Which Are Insensitive To Oxidative Stress and Immunosuppressive Factors

Jin, Chuan; Yu, Di; Karlsson-Parra, Alex; Essand, Magnus

Ingår i Molecular Therapy, 2014

Engineering Regulatory Cells With a T Cell Receptor for Controlled Activation

Hillerdal, Victoria; Berglund, David; Boura, Vanessa; Jin, Chuan et al.

Ingår i Molecular Therapy, 2014

Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures

Yu, Di; Jin, Chuan; Ramachandran, Mohanraj; Xu, Jing et al.

Ingår i PLOS ONE, 2013

• DOI för Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
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Tat‐PTD‐modified Oncolytic Adenovirus Driven by the SCG3 Promoter and ASH1 Enhancer for Neuroblastoma Therapy

Jin, Chuan; Yu, Di; Čančer, Matko; Nilsson, Berith et al.

Ingår i Human Gene Therapy, s. 766-775, 2013

• DOI för Tat‐PTD‐modified Oncolytic Adenovirus Driven by the SCG3 Promoter and ASH1 Enhancer for Neuroblastoma Therapy
• Ladda ner fulltext (pdf) av Tat‐PTD‐modified Oncolytic Adenovirus Driven by the SCG3 Promoter and ASH1 Enhancer for Neuroblastoma Therapy

Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors

Yu, Di; Jin, Chuan; Leja, Justyna; Majdalani, Nadim et al.

Ingår i Journal of Virology, s. 13114-13123, 2011

• DOI för Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors
• Ladda ner fulltext (pdf) av Adenovirus with Hexon Tat-Protein Transduction Domain Modification Exhibits Increased Therapeutic Effect in Experimental Neuroblastoma and Neuroendocrine Tumors

Improvement of adoptive T-cell therapy for Cancer

Jin, Chuan

2016

• Ladda ner fulltext (pdf) av Improvement of adoptive T-cell therapy for Cancer

Tumor antigen-loaded allogeneic dendritic cells augment therapeutic effect of adoptively transferred T-cells by altering tumor immune-microenvironment

Fotaki, Grammatiki; Jin, Chuan; Kerzeli, Iliana Kyriaki; Ramachandran, Mohanraj et al.

CD19 CAR T-cells with induced secretion of Helicobacter Pylori Neutrophil-Activating Protein (HP-NAP) yields improved anti-tumor activity and reduced immunosuppression

Jin, Chuan; Ma, Jing; Ramachandran, Mohanraj; Yu, Di et al.

Therapeutic vaccination of HPV-associated tumors using pro-inflammatory allogeneic dendritic cells and an HPV-E6/E7-encoding vector

Fotaki, Grammatiki; Ma, Jing; Jin, Chuan; Karlsson-Parra, Alex et al.

Preclinical evaluation of CAR20(NAP)-T cells for B cell lymphoma

Sarén, Tina; Ma, Jing; Jin, Chuan; Kim, Hyeongsu et al.