Carl-Henrik Heldin

Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Tsioumpekou, Maria; Cunha, Sara I.; Ma, Haisha; Åhgren, Aive et al.

Ingår i Theranostics, s. 1122-1135, 2020

• DOI för Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression
• Ladda ner fulltext (pdf) av Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

Kolliopoulos, Constantinos; Lin, Chun-Yu; Heldin, Carl-Henrik; Moustakas, Aristidis et al.

Ingår i Matrix Biology, s. 29-45, 2019

• DOI för Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity

Lin, Chun-Yu; Kolliopoulos, Constantinos; Huang, Chung-Hao; Tenhunen, Jyrki et al.

Ingår i EBioMedicine, s. 425-441, 2019

• DOI för High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity
• Ladda ner fulltext (pdf) av High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity

Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Kolliopoulos, Constantinos; Raja, Erna; Razmara, Masoud; Heldin, Paraskevi et al.

Ingår i Journal of Biological Chemistry, s. 4119-4136, 2019

• DOI för Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
• Ladda ner fulltext (pdf) av Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Sundqvist, Anders; Voytyuk, Olexandr; Hamdi, Mohamed; Popeijus, Herman E. et al.

Ingår i CELLS, 2019

• DOI för JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses
• Ladda ner fulltext (pdf) av JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Morikawa, Masato; Mitani, Yoshihide; Holmborn, Katarina; Kato, Taichi et al.

Ingår i Science Signaling, 2019

• DOI för The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation

Morén, Anita; Bellomo, Claudia; Tsubakihara, Yutaro; Kardassis, Dimitris et al.

Ingår i Oncogenesis, 2019

• DOI för LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation
• Ladda ner fulltext (pdf) av LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation

Intracellular trafficking of transforming growth factor beta receptors

Yakymovych, Ihor; Yakymovych, Mariya; Heldin, Carl-Henrik

Ingår i Acta biochimica et biophysica Sinica, s. 3-11, 2018

• DOI för Intracellular trafficking of transforming growth factor beta receptors

The protein kinase SIK downregulates the polarity protein Par3

Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta; Mahzabin, Tanzila et al.

Ingår i Oncotarget, s. 5716-5735, 2018

• DOI för The protein kinase SIK downregulates the polarity protein Par3

JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion

Sundqvist, Anders; Morikawa, Masato; Ren, Jiang; Vasilaki, Eleftheria et al.

Ingår i Nucleic Acids Research, s. 1180-1195, 2018

• DOI för JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion
• Ladda ner fulltext (pdf) av JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion

TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling

Kawasaki, Natsumi; Isogaya, Kazunobu; Dan, Shingo; Yamori, Takao et al.

Ingår i CELL DISCOVERY, 2018

• DOI för TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling
• Ladda ner fulltext (pdf) av TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling

Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Caja, Laia; Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Tan, E-Jean et al.

Ingår i Oncogene, s. 2515-2531, 2018

• DOI för Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells
• Ladda ner fulltext (pdf) av Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Bellomo, Claudia; Caja, Laia; Fabregat, Isabel; Mikulits, Wolfgang et al.

Ingår i Cell Death and Differentiation, s. 885-903, 2018

• DOI för Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
• Ladda ner fulltext (pdf) av Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Ingår i Journal of Cell Biology, s. 1701-1717, 2018

• DOI för PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis

Heldin, Carl-Henrik; Lennartsson, Johan; Westermark, Bengt

Ingår i Journal of Internal Medicine, s. 16-44, 2018

• DOI för Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

Hamidi, Anahita; Song, Jie; Thakur, Noopur; Itoh, Susumu et al.

Ingår i Science Signaling, 2017

• DOI för TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF beta stimulation in cancer

Gudey, Shyam Kumar; Sundar, Reshma; Heldin, Carl-Henrik; Bergh, Anders et al.

Ingår i Oncotarget, s. 97703-97726, 2017

• Ladda ner fulltext (pdf) av Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF beta stimulation in cancer

The TGFβ superfamily in Lisbon: navigating through development and disease

Christian, Jan L.; Heldin, Carl-Henrik

Ingår i Development, s. 4476-4480, 2017

• DOI för The TGFβ superfamily in Lisbon: navigating through development and disease

The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB

Okita, Yukari; Kimura, Minori; Xie, Rudy; Chen, Chen et al.

Ingår i Science Signaling, 2017

• DOI för The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB

APPL proteins promote TGF beta-induced nuclear transport of the TGF beta type I receptor intracellular domain

Song, Jie; Mu, Yabing; Li, Chunyan; Bergh, Anders et al.

Ingår i Oncotarget, s. 279-292, 2016

• DOI för APPL proteins promote TGF beta-induced nuclear transport of the TGF beta type I receptor intracellular domain
• Ladda ner fulltext (pdf) av APPL proteins promote TGF beta-induced nuclear transport of the TGF beta type I receptor intracellular domain

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling

Raja, Erna; Tzavlaki, Kalliopi; Vuilleumier, Robin; Edlund, Karolina et al.

Ingår i Oncotarget, s. 1120-1143, 2016

• DOI för The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling
• Ladda ner fulltext (pdf) av The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling

Signals and Receptors

Heldin, Carl-Henrik; Lu, Benson; Evans, Ron; Gutkind, J. Silvio

Ingår i Cold Spring Harbor Perspectives in Biology, 2016

• DOI för Signals and Receptors

Signaling Receptors for TGF-beta Family Members

Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Cold Spring Harbor Perspectives in Biology, 2016

• DOI för Signaling Receptors for TGF-beta Family Members

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation

Carthy, Jon M.; Stoeter, Martin; Bellomo, Claudia; Vanlandewijck, Michael et al.

Ingår i Scientific Reports, 2016

• DOI för Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation
• Ladda ner fulltext (pdf) av Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation

BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Kruppel-like Factors

Morikawa, Masato; Koinuma, Daizo; Mizutani, Anna; Kawasaki, Natsumi et al.

Ingår i Stem Cell Reports, s. 64-73, 2016

• DOI för BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Kruppel-like Factors
• Ladda ner fulltext (pdf) av BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Kruppel-like Factors

Ras and TGF-beta signaling enhance cancer progression by promoting the Delta Np63 transcriptional program

Vasilaki, Eleftheria; Morikawa, Masato; Koinuma, Daizo; Mizutani, Anna et al.

Ingår i Science Signaling, 2016

• DOI för Ras and TGF-beta signaling enhance cancer progression by promoting the Delta Np63 transcriptional program

The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor beta (PDGFR beta) Internalization and Signaling

Rorsman, Charlotte; Tsioumpekou, Maria; Heldin, Carl-Henrik; Lennartsson, Johan

Ingår i Journal of Biological Chemistry, s. 11608-11618, 2016

• DOI för The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor beta (PDGFR beta) Internalization and Signaling

Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation

Ma, Haisha; Wardega, Piotr; Mazaud, David; Klosowska-Wardega, Agnieszka et al.

Ingår i Cellular Signalling, s. 2209-2219, 2015

• DOI för Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation

The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition

Tan, E-Jean; Kahata, Kaoru; Idås, Oskar; Thuault, Sylvie et al.

Ingår i Nucleic Acids Research, s. 162-178, 2015

• DOI för The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition
• Ladda ner fulltext (pdf) av The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition

CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface

Yakymovych, Ihor; Yakymovych, Mariya; Zang, Guangxiang; Mu, Yabing et al.

Ingår i Journal of Cell Biology, s. 319-332, 2015

• DOI för CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface
• Ladda ner fulltext (pdf) av CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface

TRAF6 promotes TGF beta-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGF beta type I receptor

Sundar, Reshma; Gudey, Shyam Kumar; Heldin, Carl-Henrik; Landstrom, Marene

Ingår i Cell Cycle, s. 554-565, 2015

• DOI för TRAF6 promotes TGF beta-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGF beta type I receptor

Platelet-derived Growth Factor beta-Receptor, Transforming Growth Factor beta Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability

Porsch, Helena; Mehic, Merima; Olofsson, Berit; Heldin, Paraskevi et al.

Ingår i Journal of Biological Chemistry, s. 19747-19757, 2014

• DOI för Platelet-derived Growth Factor beta-Receptor, Transforming Growth Factor beta Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability

Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

Dahl, Markus; Maturi, Varun; Lönn, Peter; Papoutsoglou, Panagiotis et al.

Ingår i PLOS ONE, 2014

• DOI för Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
• Ladda ner fulltext (pdf) av Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1

Thakur, Noopur; Gudey, Shyam Kumar; Marcusson, Anders; Fu, Jing Yi et al.

Ingår i Cell Cycle, s. 2400-2414, 2014

• DOI för TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1

Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases.

Heldin, Carl-Henrik

Ingår i Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, s. 69-79, 2014

• DOI för Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases.

TRAF6 Stimulates the Tumor-Promoting Effects of TGFβ Type I Receptor Through Polyubiquitination and Activation of Presenilin 1

Gudey, Shyam Kumar; Sundar, Reshma; Mu, Yabing; Wallenius, Anders et al.

Ingår i Science signaling, 2014

• DOI för TRAF6 Stimulates the Tumor-Promoting Effects of TGFβ Type I Receptor Through Polyubiquitination and Activation of Presenilin 1

Genome-wide mechanisms of Smad binding

Morikawa, Masato; Koinuma, D; Miyazono, Kohei; Heldin, Carl-Henrik

Ingår i Oncogene, s. 1609-1615, 2013

• DOI för Genome-wide mechanisms of Smad binding

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion

Sundqvist, Anders; Zieba, Agata; Vasilaki, Eleftheria; Herrera Hidalgo, Carmen et al.

Ingår i Oncogene, s. 3606-3615, 2013

• DOI för Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion

Efficient TGF beta-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2

Porsch, Helena; Bernert, Berit; Mehić, Merima; Theocharis, A D et al.

Ingår i Oncogene, s. 4355-4365, 2013

• DOI för Efficient TGF beta-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2

p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β

Termén, Stefan; Tan, E-Jean; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 801-813, 2013

• DOI för p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β

The Fer Tyrosine Kinase Is Important for Platelet-derived Growth Factor-BB-induced Signal Transducer and Activator of Transcription 3 (STAT3) Protein Phosphorylation, Colony Formation in Soft Agar, and Tumor Growth in Vivo.

Lennartsson, Johan; Ma, Haisha; Wardega, Piotr; Pelka, Karin et al.

Ingår i Journal of Biological Chemistry, s. 15736-15744, 2013

• DOI för The Fer Tyrosine Kinase Is Important for Platelet-derived Growth Factor-BB-induced Signal Transducer and Activator of Transcription 3 (STAT3) Protein Phosphorylation, Colony Formation in Soft Agar, and Tumor Growth in Vivo.

APC and Smad7 link the TGFβ type I receptors to the microtubule system to promote cell migration

Ekman, Maria; Mu, Yabing; Lee, So Young; Edlund, Sofia et al.

Ingår i Molecular Biology of the Cell, s. 2109-2121, 2012

• DOI för APC and Smad7 link the TGFβ type I receptors to the microtubule system to promote cell migration

Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase

Lönn, Peter; Vanlandewijck, Michael; Raja, Erna; Kowanetz, Marcin et al.

Ingår i Journal of Biological Chemistry, s. 12867-12878, 2012

• DOI för Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase

Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V

Schmees, Christian; Villaseñor, R; Zheng, Wei; Ma, Haisha et al.

Ingår i Molecular Biology of the Cell, s. 2571-2582, 2012

• DOI för Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V

Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli

Hamidi, Anahita; von Bulow, Verena; Hamidi, Rosita; Winssinger, Nicolas et al.

Ingår i Journal of Biological Chemistry, s. 123-133, 2012

• DOI för Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli

Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase

Zieba, Agata; Pardali, Katerina; Söderberg, Ola; Lindbom, Lena et al.

Ingår i Molecular & Cellular Proteomics, 2012

• DOI för Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase

Autocrine PDGF stimulation in malignancies

Heldin, Carl-Henrik

Ingår i Upsala Journal of Medical Sciences, s. 83-91, 2012

• DOI för Autocrine PDGF stimulation in malignancies

Regulation of EMT by TGFβ in cancer

Heldin, Carl-Henrik; Vanlandewijck, Michael; Moustakas, Aristidis

Ingår i FEBS Letters, s. 1959-1970, 2012

• DOI för Regulation of EMT by TGFβ in cancer

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

Mu, Yabing; Sundar, Reshma; Thakur, Noopur; Ekman, Maria et al.

Ingår i Nature Communications, 2011

• DOI för TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

SIK phosphorylates and degrades Par3 to mediate tight junction disassembly during epithelial-mesenchymal transition

Vanlandewijck, Michael; Lomnytska, Marta; Busch, Christer; Heldin, Carl-Henrik et al.

2011

Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1

Morén, Anita; Raja, Erna; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Biological Chemistry, s. 341-353, 2011

• DOI för Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

Morikawa, Masato; Koinuma, Daizo; Tsutsumi, Shuichi; Vasilaki, Eleftheria et al.

Ingår i Nucleic Acids Research, s. 8712-8727, 2011

• DOI för ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

PARP-1 attenuates Smad-mediated transcription

Lönn, Peter; van der Heide, Lars; Dahl, Markus; Hellman, Ulf et al.

Ingår i Molecular Cell, s. 521-532, 2010

• DOI för PARP-1 attenuates Smad-mediated transcription

Activation of Protein Kinase C α Is Necessary for Sorting the PDGF β-Receptor to Rab4a-dependent Recycling

Hellberg, Carina; Schmees, Christian; Karlsson, Susann; Åhgren, Aive et al.

Ingår i Molecular Biology of the Cell, s. 2856-2863, 2009

• DOI för Activation of Protein Kinase C α Is Necessary for Sorting the PDGF β-Receptor to Rab4a-dependent Recycling

A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse

Pielberg, Gerli Rosengren; Golovko, Anna; Sundström, Elisabeth; Curik, Ino et al.

Ingår i Nature Genetics, s. 1004-1009, 2008

• DOI för A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse

TGFβ induces SIK to negatively regulate type I receptor kinase signaling

Kowanetz, Marcin; Lönn, Peter; Vanlandewijck, Michael; Kowanetz, Katarzyna et al.

Ingår i Journal of Cell Biology, s. 655-662, 2008

• DOI för TGFβ induces SIK to negatively regulate type I receptor kinase signaling

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

Sorrentino, Alessandro; Thakur, Noopur; Grimsby, Susanne; Marcusson, Anders et al.

Ingår i Nature Cell Biology, s. 1199-1207, 2008

• DOI för The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

The European Research Council--a new opportunity for European science

Heldin, Carl-Henrik

Ingår i Nature reviews. Molecular cell biology, s. 417-420, 2008

• DOI för The European Research Council--a new opportunity for European science

Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling

Hasumi, Yoko; Kłosowska-Wardega, Agnieszka; Furuhashi, Masao; Östman, Arne et al.

Ingår i International Journal of Cancer, s. 2606-2614, 2007

• DOI för Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling

SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma

Kallin, Anders; Johannessen, Lene E.; Cani, Patrice D.; Marbehant, Catherine Y. et al.

Ingår i Journal of Lipid Research, s. 1628-1636, 2007

• DOI för SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma

Notch signaling is necessary for epithelial growth arrest by TGF-beta

Niimi, Hideki; Pardali, Katerina; Vanlandewijck, Michael; Heldin, Carl-Henrik et al.

Ingår i Journal of Cell Biology, s. 695-707, 2007

• DOI för Notch signaling is necessary for epithelial growth arrest by TGF-beta

Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition

Thuault, Sylvie; Valcourt, Ulrich; Petersen, Maj; Manfioletti, Guidalberto et al.

Ingår i Journal of Cell Biology, s. 175-183, 2006

• DOI för Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition

Deletion of exon I of SMAD7 in mice results in altered B cell responses

Li, Ronggui; Rosendahl, Alexander; Brodin, Greger; Cheng, Alec M. et al.

Ingår i Journal of Immunology, s. 6777-6784, 2006

The mechanism of nuclear export of smad3 involves exportin 4 and Ran

Kurisaki, Akira; Kurisaki, Keiko; Kowanetz, Marcin; Sugino, Hiromu et al.

Ingår i Molecular and Cellular Biology, s. 1318-1332, 2006

• DOI för The mechanism of nuclear export of smad3 involves exportin 4 and Ran

Loss of T-Cell Protein Tyrosine Phosphatase Induces Recycling of the Platelet-derived Growth Factor (PDGF) beta-Receptor but Not the PDGF {alpha}-Receptor

Karlsson, Susann; Kowanetz, Katarzyna; Sandin, Åsa; Persson, Camilla et al.

Ingår i Molecular Biology of the Cell, s. 4846-4855, 2006

• DOI för Loss of T-Cell Protein Tyrosine Phosphatase Induces Recycling of the Platelet-derived Growth Factor (PDGF) beta-Receptor but Not the PDGF {alpha}-Receptor

Alix Facilitates the Interaction between c-Cbl and Platelet-derived Growth Factor beta-Receptor and Thereby Modulates Receptor Down-regulation

Lennartsson, Johan; Wardega, Piotr; Engström, Ulla; Hellman, Ulf et al.

Ingår i Journal of Biological Chemistry, s. 39152-39158, 2006

• DOI för Alix Facilitates the Interaction between c-Cbl and Platelet-derived Growth Factor beta-Receptor and Thereby Modulates Receptor Down-regulation

Regulation of chemotaxis by the cytoplasmic domain of tissue factor

Siegbahn, Agneta; Johnell, Matilda; Sorensen, Brit B.; Petersen, Lars C. et al.

Ingår i Thrombosis and Haemostasis, s. 27-34, 2005

• DOI för Regulation of chemotaxis by the cytoplasmic domain of tissue factor

Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21Waf1/Cip1

Pardali, Katerina; Kowanetz, Marcin; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 260-272, 2005

• DOI för Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21Waf1/Cip1

TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

Valcourt, Ulrich; Kowanetz, Marcin; Niimi, Hideki; Heldin, Carl-Henrik et al.

Ingår i Molecular Biology of the Cell, s. 1987-2002, 2005

• DOI för TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

The balance between acetylation and deacetylation controls Smad7 stability

Simonsson, Maria; Heldin, Carl-Henrik; Ericsson, Johan; Grönroos, Eva

Ingår i Journal of Biological Chemistry, s. 21797-21803, 2005

• DOI för The balance between acetylation and deacetylation controls Smad7 stability

Non-Smad TGF-{beta} signals

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Journal of Cell Science, s. 3573-3584, 2005

• DOI för Non-Smad TGF-{beta} signals

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

Morén, Anita; Imamura, Takeshi; Miyazono, Kohei; Heldin, Carl-Henrik et al.

Ingår i Journal of Biological Chemistry, s. 22115-22123, 2005

• DOI för Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis

Edlund, Sofia; Lee, So Young; Grimsby, Susanne; Zhang, Shouthing et al.

Ingår i Molecular and Cellular Biology, s. 1475-1488, 2005

• DOI för Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis

Smad7 is required for TGF-ß-induced activation of the small GTPase Cdc42

Edlund, Sofia; Landström, Maréne; Heldin, Carl-Henrik; Aspenström, Pontus

Ingår i Journal of Cell Science, s. 1835-1847, 2004

• DOI för Smad7 is required for TGF-ß-induced activation of the small GTPase Cdc42

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

Furuhashi, Masao; Sjöblom, Tobias; Abramsson, Alexandra; Ellingsen, Jens et al.

Ingår i Cancer Research, s. 2725-2733, 2004

• DOI för Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases

Persson, Camilla; Sjöblom, Tobias; Groen, Arnoud; Kappert, Kai et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 1886-1891, 2004

• DOI för Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases

Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor β and bone morphogenetic protein

Kowanetz, Marcin; Valcourt, Ulrich; Bergström, Rosita; Heldin, Carl-Henrik et al.

Ingår i Molecular and Cellular Biology, s. 4241-4254, 2004

• DOI för Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor β and bone morphogenetic protein

A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity

Chiara, Federica; Goumans, Marie-José; Forsberg, Henrik; Åhgrén, Aive et al.

Ingår i Journal of Biological Chemistry, s. 42516-42527, 2004

• DOI för A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity

Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail

Chiara, Federica; Bishayee, Subal; Heldin, Carl-Henrik; Demoulin, Jean-Baptiste

Ingår i Journal of Biological Chemistry, s. 19732-19738, 2004

• DOI för Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail

Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

Kowanetz, Katarzyna; Crosetto, Nicola; Haglund, Kaisa; Schmidt, Mirko H H et al.

Ingår i Journal of Biological Chemistry, s. 32786-32795, 2004

• DOI för Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins

Demoulin, Jean-Baptiste; Ericsson, Johan; Kallin, Anders; Rorsman, Charlotte et al.

Ingår i Journal of Biological Chemistry, s. 35392-35402, 2004

• DOI för Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins

Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor

Kallin, Anders; Demoulin, Jean-Baptiste; Nishida, Keigo; Hirano, Toshio et al.

Ingår i Journal of Biological Chemistry, s. 17897-17904, 2004

• DOI för Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor

High interstitial fluid pressure - an obstacle in cancer therapy.

Heldin, Carl-Henrik; Rubin, Kristofer; Pietras, Kristian; Östman, Arne

Ingår i Nat Rev Cancer, s. 806-13, 2004

Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.

Leppänen, Olli; Rutanen, Juha; Hiltunen, Mikko O; Rissanen, Tuomas T et al.

Ingår i Circulation, s. 1140-6, 2004

Thematic issue on platelet-derived growth factor

Heldin, Carl-Henrik

Elsevier Ltd., 2004

Transforming Growth Factor-β1 (TGF-β)–induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-β-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3

Edlund, Sofia; Bu, Shizhong; Schuster, Norbert; Aspenström, Pontus et al.

Ingår i Molecular Biology of the Cell, s. 529-544, 2003

• DOI för Transforming Growth Factor-β1 (TGF-β)–induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-β-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3

Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

Kurisaki, Keiko; Kurisaki, Akira; Valcourt, Ulrich; Terentiev, Alexei A et al.

Ingår i Molecular and Cellular Biology, s. 4494-4510, 2003

• DOI för Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

Differential ubiquitination defines the functional status of the tumor suppressor Smad4

Morén, Anita; Hellman, Ulf; Inada, Yuri; Imamura, Takeshi et al.

Ingår i Journal of Biological Chemistry, s. 33571-33582, 2003

• DOI för Differential ubiquitination defines the functional status of the tumor suppressor Smad4

Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

Itoh, Susumu; Thorikay, Midory; Kowanetz, Marcin; Moustakas, Aristidis et al.

Ingår i Journal of Biological Chemistry, s. 3751-3761, 2003

• DOI för Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

STI571 enhances the therapeutic index of epothilone B by a tumor-selectiveincrease of drug uptake.

Pietras, Kristian; Stumm, Michael; Hubert, Martine; Buchdunger, Elisabeth et al.

Ingår i Clin Cancer Res, s. 3779, 2003

PDGF receptors as cancer drug targets.

Pietras, Kristian; Sjöblom, Tobias; Rubin, Kristofer; Heldin, Carl-Henrik et al.

Ingår i Cancer Cell, s. 439, 2003

Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy

Pietras, Kristian; Rubin, Kristofer; Sjöblom, Tobias; Buchdunger, Elisabeth et al.

Ingår i Cancer Research, s. 5476-5484, 2002

SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF β-receptor

Ekman, Simon; Kallin, Anders; Engström, Ulla; Heldin, Carl-Henrik et al.

Ingår i Oncogene, s. 1870-1875, 2002

• DOI för SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF β-receptor

Control of Smad7 stability by competition between acetylation and ubiquitination

Grönroos, Eva; Hellman, Ulf; Heldin, Carl-Henrik; Ericsson, Johan

Ingår i Molecular Cell, s. 483-493, 2002

• DOI för Control of Smad7 stability by competition between acetylation and ubiquitination

Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration

Palumbo, Roberta; Gaetano, Carlo; Antonini, Annalisa; Pompilio, Giulio et al.

Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, s. 405-411, 2002

• DOI för Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration

Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

Kurisaki, Akira; Kose, Shingo; Yoneda, Yoshihiro; Heldin, Carl-Henrik et al.

Ingår i Molecular Biology of the Cell, s. 1079-1091, 2001

• DOI för Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

Regulation of Smad signaling by protein kinase C

Yakymovych, Ihor; ten Dijke, Peter; Heldin, Carl-Henrik; Souchelnytskyi, Serhiy

Ingår i The FASEB Journal, s. 553-555, 2001

• DOI för Regulation of Smad signaling by protein kinase C

Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.

Pietras, Kristian; Östman, Arne; Sjöquist, Mats; Buchdunger, Elisabeth et al.

Ingår i Cancer Res, s. 2929, 2001

Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases

Souchelnytskyi, Serhiy; Rönnstrand, Lars; Heldin, Carl-Henrik; ten Dijke, Peter

Ingår i Protein Kinase Protocols, s. 107-120, Humana Press, 2001

• DOI för Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases

Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis.

Sjöblom, Tobias; Shimizu, Akira; O'Brien, Kevin P.; Pietras, Kristian et al.

Ingår i Cancer Res, s. 5778-83, 2001

Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis.

Siegbahn, A; Johnell, M; Rorsman, C; Ezban, M et al.

Ingår i Blood, s. 3452-8, 2000

Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis

Rönnstrand, Lars; Siegbahn, Agneta; Rorsman, Charlotte; Johnell, Matilda et al.

Ingår i Journal of Biological Chemistry, s. 22089-22094, 1999

• DOI för Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis

Mechanism of action and in vivo role of platelet-derived growth factor

Heldin, Carl-Henrik; Westermark, Bengt

Ingår i Physiological Reviews, s. 1283-1316, 1999

Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling

Heuchel, Rainer; Berg, Ansgar; Tallquist, Michelle; Åhlén, Karina et al.

Ingår i Proc Natl Acad Sci U S A, s. 11410-5, 1999

Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis

Hansen, Klaus; Johnell, Matilda; Siegbahn, Agneta; Rorsman, Charlotte et al.

Ingår i EMBO Journal, s. 5299-5313, 1996

Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.

Blume-Jensen, P; Siegbahn, A; Stabel, S; Heldin, C H et al.

Ingår i EMBO J, s. 4199-209, 1993

Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes

Heldin, Carl-Henrik; Östman, Arne; Eriksson, Anders; Siegbahn, Agneta et al.

Ingår i Kidney International, s. 571-574, 1992

• DOI för Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes

Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis

Blume-Jensen, Peter; Claesson-Welsh, Lena; Siegbahn, Agneta; Zsebo, Krisztina M. et al.

Ingår i EMBO Journal, s. 4121-4128, 1991

A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets.

Nistér, M; Hammacher, A; Mellström, K; Siegbahn, A et al.

Ingår i Cell, s. 791-9, 1988

TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

Mendes Rodrigues Junior, Dorival; Tsirigoti, Chrysoula; Psatha, Konstantina; Kletsas, Dimitris et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2025

• DOI för TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles
• Ladda ner fulltext (pdf) av TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

Special issue: frontiers in recent advances on cancer diagnosis and treatment

Westermark, Bengt; Heldin, Carl-Henrik

Ingår i Upsala Journal of Medical Sciences, 2024

• DOI för Special issue: frontiers in recent advances on cancer diagnosis and treatment
• Ladda ner fulltext (pdf) av Special issue: frontiers in recent advances on cancer diagnosis and treatment

PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells

Rubin Sander, Marie; Tsiatsiou, Agni Karolina; Wang, Kehuan; Papadopoulos, Natalia et al.

Ingår i Growth Factors, s. 147-160, 2024

• DOI för PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells
• Ladda ner fulltext (pdf) av PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells

Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

Voytyuk, Oleksandr; Ohata, Yae; Moustakas, Aristidis; ten Dijke, Peter et al.

Ingår i Journal of Biological Chemistry, 2024

• DOI för Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling
• Ladda ner fulltext (pdf) av Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness

Vasilaki, Eleftheria; Bai, Yu; Ali, Mohamad Moustafa; Sundqvist, Anders et al.

Ingår i Cell Communication and Signaling, 2024

• DOI för ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
• Ladda ner fulltext (pdf) av ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness

TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

Mendes Rodrigues Junior, Dorival; Tsirigoti, Chrysoula; Psatha, Konstantina; Kletsas, Dimitris et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2025

• DOI för TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles
• Ladda ner fulltext (pdf) av TGF-β induces cholesterol accumulation to regulate the secretion of tumor-derived extracellular vesicles

Special issue: frontiers in recent advances on cancer diagnosis and treatment

Westermark, Bengt; Heldin, Carl-Henrik

Ingår i Upsala Journal of Medical Sciences, 2024

• DOI för Special issue: frontiers in recent advances on cancer diagnosis and treatment
• Ladda ner fulltext (pdf) av Special issue: frontiers in recent advances on cancer diagnosis and treatment

PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells

Rubin Sander, Marie; Tsiatsiou, Agni Karolina; Wang, Kehuan; Papadopoulos, Natalia et al.

Ingår i Growth Factors, s. 147-160, 2024

• DOI för PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells
• Ladda ner fulltext (pdf) av PDGF-induced internalisation promotes proteolytic cleavage of PDGFRβ in mesenchymal cells

Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

Voytyuk, Oleksandr; Ohata, Yae; Moustakas, Aristidis; ten Dijke, Peter et al.

Ingår i Journal of Biological Chemistry, 2024

• DOI för Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling
• Ladda ner fulltext (pdf) av Smad7 palmitoylation by the S-acyltransferase zDHHC17 enhances its inhibitory effect on TGF-β/Smad signaling

ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness

Vasilaki, Eleftheria; Bai, Yu; Ali, Mohamad Moustafa; Sundqvist, Anders et al.

Ingår i Cell Communication and Signaling, 2024

• DOI för ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness
• Ladda ner fulltext (pdf) av ΔNp63 bookmarks and creates an accessible epigenetic environment for TGFβ-induced cancer cell stemness and invasiveness

Special issue: TGF-β and epithelial-mesenchymal transition in cancer

ten Dijke, Peter; Miyazono, Kohei; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Seminars in Cancer Biology, s. 1-3, 2024

• DOI för Special issue: TGF-β and epithelial-mesenchymal transition in cancer

The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion

Gélabert, Caroline; Papoutsoglou, Panagiotis; Cancela Golan, Irene; Ahlström, Eric et al.

Ingår i Cell Communication and Signaling, 2023

• DOI för The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion
• Ladda ner fulltext (pdf) av The long non-coding RNA LINC00707 interacts with Smad proteins to regulate TGFβ signaling and cancer cell invasion

Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival

Lin, Chun-Yu; Basu, Kaustuv; Ruusala, Aino; Kozlova, Inna et al.

Ingår i Cancers, 2023

• DOI för Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival
• Ladda ner fulltext (pdf) av Hyaluronan-Induced CD44-iASPP Interaction Affects Fibroblast Migration and Survival

SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation

Wang, Kehuan; Papadopoulos, Natalia; Hamidi, Anahita; Lennartsson, Johan et al.

Ingår i BMC Molecular and Cell Biology, 2023

• DOI för SUMOylation of PDGF receptor α affects signaling via PLCγ and STAT3, and cell proliferation
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The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

Sarri, Niki; Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Ingår i International Journal of Molecular Sciences, 2023

• DOI för The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ
• Ladda ner fulltext (pdf) av The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ

The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

Tzavlaki, Kalliopi; Ohata, Yae; Morén, Anita; Watanabe, Yukihide et al.

Ingår i Journal of Cellular Physiology, s. 790-812, 2023

• DOI för The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition
• Ladda ner fulltext (pdf) av The liver kinase B1 supports mammary epithelial morphogenesis by inhibiting critical factors that mediate epithelial-mesenchymal transition

CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence

Kolliopoulos, Constantinos; Ali, Mohamad Moustafa; Castillejo-Lopez, Casimiro; Heldin, Carl-Henrik et al.

Ingår i Cancers, 2022

• DOI för CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence
• Ladda ner fulltext (pdf) av CD44 Depletion in Glioblastoma Cells Suppresses Growth and Stemness and Induces Senescence

Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells

Karalis, Theodoros; Shiau, Andrew K. K.; Gahman, Timothy C. C.; Skandalis, Spyros S. S. et al.

Ingår i Cancers, 2022

• DOI för Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells
• Ladda ner fulltext (pdf) av Identification of a Small Molecule Inhibitor of Hyaluronan Synthesis, DDIT, Targeting Breast Cancer Cells

Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Maturi, Varun; Heldin, Carl-Henrik et al.

Ingår i Cell Death and Disease, 2022

• DOI för Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
• Ladda ner fulltext (pdf) av Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells

Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

Sarri, Niki; Wang, Kehuan; Tsioumpekou, Maria; Castillejo-Lopez, Casimiro et al.

Ingår i Cellular and Molecular Life Sciences (CMLS), 2022

• DOI för Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling
• Ladda ner fulltext (pdf) av Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFR beta and affect PDGF-BB-induced STAT3 signalling

The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling

Yakymovych, Ihor; Yakymovych, Mariya; Hamidi, Anahita; Landström, Maréne et al.

Ingår i Science Signaling, 2022

• DOI för The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling
• Ladda ner fulltext (pdf) av The type II TGF-β receptor phosphorylates Tyr ¹⁸² in the type I receptor to activate downstream Src signaling

The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

Caja, Laia; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Mendes Rodrigues-Junior, Dorival et al.

Ingår i Journal of Cellular Physiology, s. 743-762, 2022

• DOI för The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma
• Ladda ner fulltext (pdf) av The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma

TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

Tsubakihara, Yutaro; Ohata, Yae; Okita, Yukari; Younis, Shady et al.

Ingår i Molecular Oncology, s. 2330-2354, 2022

• DOI för TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition
• Ladda ner fulltext (pdf) av TGF beta selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition

PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A

Tanabe, Ryo; Miyazono, Kohei; Todo, Tomoki; Saito, Nobuhito et al.

Ingår i Molecular Oncology, s. 269-288, 2022

• DOI för PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A
• Ladda ner fulltext (pdf) av PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A

The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

Song, Jie; Zhou, Yang; Yakymovych, Ihor; Schmidt, Alexej et al.

Ingår i EBioMedicine, 2022

• DOI för The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells
• Ladda ner fulltext (pdf) av The ubiquitin-ligase TRAF6 and TGFβ type I receptor form a complex with Aurora kinase B contributing to mitotic progression and cytokinesis in cancer cells

The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma

Dadras, Mahsa Shahidi; Caja, Laia; Mezheyeuski, Artur; Liu, Sijia et al.

Ingår i Cell Death and Disease, 2021

• DOI för The polarity protein Par3 coordinates positively self-renewal and negatively invasiveness in glioblastoma
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The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling

Papoutsoglou, Panagiotis; Rodrigues Junior, Dorival Mendes; Morén, Anita; Bergman, Andrew et al.

Ingår i Oncogene, s. 3748-3765, 2021

• DOI för The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor beta signaling
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TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation

Kolliopoulos, Constantinos; Chatzopoulos, Athanasios; Skandalis, Spyros S.; Heldin, Carl-Henrik et al.

Ingår i Cancers, 2021

• DOI för TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation
• Ladda ner fulltext (pdf) av TRAF4/6 Is Needed for CD44 Cleavage and Migration via RAC1 Activation

BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

Fukuda, Tomohiko; Fukuda, Risa; Koinuma, Daizo; Moustakas, Aristidis et al.

Ingår i Cellular Signalling, 2021

• DOI för BMP2-induction of FN14 promotes protumorigenic signaling in gynecologic cancer cells

Tumor Promoting Effect of BMP Signaling in Endometrial Cancer

Fukuda, Tomohiko; Fukuda, Risa; Miyazono, Kohei; Heldin, Carl-Henrik

Ingår i International Journal of Molecular Sciences, 2021

• DOI för Tumor Promoting Effect of BMP Signaling in Endometrial Cancer
• Ladda ner fulltext (pdf) av Tumor Promoting Effect of BMP Signaling in Endometrial Cancer

Smad7 Enhances TGF-beta-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Thakur, Noopur; Hamidi, Anahita; Song, Jie; Itoh, Susumu et al.

Ingår i iScience, 2020

• DOI för Smad7 Enhances TGF-beta-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells
• Ladda ner fulltext (pdf) av Smad7 Enhances TGF-beta-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Smad7 Enhances TGF-b-Induced Transcription of c-Jun and HDAC6 Promoting Invasion of Prostate Cancer Cells

Thakur, Noopur; Hamidi, Anahita; Song, Jie; Itoh, Susumu et al.

Ingår i iScience, 2020

Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

Tsioumpekou, Maria; Cunha, Sara I.; Ma, Haisha; Åhgren, Aive et al.

Ingår i Theranostics, s. 1122-1135, 2020

• DOI för Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression
• Ladda ner fulltext (pdf) av Specific targeting of PDGFR beta in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression

BMP signaling is a therapeutic target in ovarian cancer

Fukuda, Tomohiko; Fukuda, Risa; Tanabe, Ryo; Koinuma, Daizo et al.

Ingår i Cell Death Discovery, 2020

• DOI för BMP signaling is a therapeutic target in ovarian cancer
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TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness

Sundqvist, Anders; Vasilaki, Eleftheria; Voytyuk, Oleksandr; Bai, Yu et al.

Ingår i Oncogene, s. 4436-4449, 2020

• DOI för TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness
• Ladda ner fulltext (pdf) av TGF beta and EGF signaling orchestrates the AP-1-and p63 transcriptional regulation of breast cancer invasiveness

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Zhang, Yanyu; Cedervall, Jessica; Hamidi, Anahita; Herre, Melanie et al.

Ingår i Cancer Research, s. 3345-3358, 2020

• DOI för Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

Kolliopoulos, Constantinos; Lin, Chun-Yu; Heldin, Carl-Henrik; Moustakas, Aristidis et al.

Ingår i Matrix Biology, s. 29-45, 2019

• DOI för Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer

High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity

Lin, Chun-Yu; Kolliopoulos, Constantinos; Huang, Chung-Hao; Tenhunen, Jyrki et al.

Ingår i EBioMedicine, s. 425-441, 2019

• DOI för High levels of serum hyaluronan is an early predictor of dengue warning signs and perturbs vascular integrity
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Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

Kolliopoulos, Constantinos; Raja, Erna; Razmara, Masoud; Heldin, Paraskevi et al.

Ingår i Journal of Biological Chemistry, s. 4119-4136, 2019

• DOI för Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output
• Ladda ner fulltext (pdf) av Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output

JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Sundqvist, Anders; Voytyuk, Olexandr; Hamdi, Mohamed; Popeijus, Herman E. et al.

Ingår i CELLS, 2019

• DOI för JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses
• Ladda ner fulltext (pdf) av JNK-Dependent cJun Phosphorylation Mitigates TGF beta- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

Morikawa, Masato; Mitani, Yoshihide; Holmborn, Katarina; Kato, Taichi et al.

Ingår i Science Signaling, 2019

• DOI för The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension

LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation

Morén, Anita; Bellomo, Claudia; Tsubakihara, Yutaro; Kardassis, Dimitris et al.

Ingår i Oncogenesis, 2019

• DOI för LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation
• Ladda ner fulltext (pdf) av LXR alpha limits TGF beta-dependent hepatocellular carcinoma associated fibroblast differentiation

The protein kinase SIK downregulates the polarity protein Par3

Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta; Mahzabin, Tanzila et al.

Ingår i Oncotarget, s. 5716-5735, 2018

• DOI för The protein kinase SIK downregulates the polarity protein Par3

JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion

Sundqvist, Anders; Morikawa, Masato; Ren, Jiang; Vasilaki, Eleftheria et al.

Ingår i Nucleic Acids Research, s. 1180-1195, 2018

• DOI för JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion
• Ladda ner fulltext (pdf) av JUNB governs a feed-forward network of TGF beta signaling that aggravates breast cancer invasion

TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling

Kawasaki, Natsumi; Isogaya, Kazunobu; Dan, Shingo; Yamori, Takao et al.

Ingår i CELL DISCOVERY, 2018

• DOI för TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling
• Ladda ner fulltext (pdf) av TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling

Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Caja, Laia; Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Tan, E-Jean et al.

Ingår i Oncogene, s. 2515-2531, 2018

• DOI för Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells
• Ladda ner fulltext (pdf) av Snail regulates BMP and TGF beta pathways to control the differentiation status of glioma-initiating cells

Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Bellomo, Claudia; Caja, Laia; Fabregat, Isabel; Mikulits, Wolfgang et al.

Ingår i Cell Death and Differentiation, s. 885-903, 2018

• DOI för Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma
• Ladda ner fulltext (pdf) av Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma

Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

Maturi, Varun; Enroth, Stefan; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 7113-7127, 2018

• DOI för Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells
• Ladda ner fulltext (pdf) av Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells

Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

Maturi, Varun; Morén, Anita; Enroth, Stefan; Heldin, Carl-Henrik et al.

Ingår i Molecular Oncology, s. 1153-1174, 2018

• DOI för Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells
• Ladda ner fulltext (pdf) av Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells

PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

Papadopoulos, Natalia; Lennartsson, Johan; Heldin, Carl-Henrik

Ingår i Journal of Cell Biology, s. 1701-1717, 2018

• DOI för PDGFR beta translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1

TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

Hamidi, Anahita; Song, Jie; Thakur, Noopur; Itoh, Susumu et al.

Ingår i Science Signaling, 2017

• DOI för TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α

Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF beta stimulation in cancer

Gudey, Shyam Kumar; Sundar, Reshma; Heldin, Carl-Henrik; Bergh, Anders et al.

Ingår i Oncotarget, s. 97703-97726, 2017

• Ladda ner fulltext (pdf) av Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF beta stimulation in cancer

The TGFβ superfamily in Lisbon: navigating through development and disease

Christian, Jan L.; Heldin, Carl-Henrik

Ingår i Development, s. 4476-4480, 2017

• DOI för The TGFβ superfamily in Lisbon: navigating through development and disease

The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB

Okita, Yukari; Kimura, Minori; Xie, Rudy; Chen, Chen et al.

Ingår i Science Signaling, 2017

• DOI för The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB

APPL proteins promote TGF beta-induced nuclear transport of the TGF beta type I receptor intracellular domain

Song, Jie; Mu, Yabing; Li, Chunyan; Bergh, Anders et al.

Ingår i Oncotarget, s. 279-292, 2016

• DOI för APPL proteins promote TGF beta-induced nuclear transport of the TGF beta type I receptor intracellular domain
• Ladda ner fulltext (pdf) av APPL proteins promote TGF beta-induced nuclear transport of the TGF beta type I receptor intracellular domain

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling

Raja, Erna; Tzavlaki, Kalliopi; Vuilleumier, Robin; Edlund, Karolina et al.

Ingår i Oncotarget, s. 1120-1143, 2016

• DOI för The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling
• Ladda ner fulltext (pdf) av The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling

Signals and Receptors

Heldin, Carl-Henrik; Lu, Benson; Evans, Ron; Gutkind, J. Silvio

Ingår i Cold Spring Harbor Perspectives in Biology, 2016

• DOI för Signals and Receptors

Signaling Receptors for TGF-beta Family Members

Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Cold Spring Harbor Perspectives in Biology, 2016

• DOI för Signaling Receptors for TGF-beta Family Members

Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation

Carthy, Jon M.; Stoeter, Martin; Bellomo, Claudia; Vanlandewijck, Michael et al.

Ingår i Scientific Reports, 2016

• DOI för Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation
• Ladda ner fulltext (pdf) av Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation

BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Kruppel-like Factors

Morikawa, Masato; Koinuma, Daizo; Mizutani, Anna; Kawasaki, Natsumi et al.

Ingår i Stem Cell Reports, s. 64-73, 2016

• DOI för BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Kruppel-like Factors
• Ladda ner fulltext (pdf) av BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Kruppel-like Factors

Ras and TGF-beta signaling enhance cancer progression by promoting the Delta Np63 transcriptional program

Vasilaki, Eleftheria; Morikawa, Masato; Koinuma, Daizo; Mizutani, Anna et al.

Ingår i Science Signaling, 2016

• DOI för Ras and TGF-beta signaling enhance cancer progression by promoting the Delta Np63 transcriptional program

The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor beta (PDGFR beta) Internalization and Signaling

Rorsman, Charlotte; Tsioumpekou, Maria; Heldin, Carl-Henrik; Lennartsson, Johan

Ingår i Journal of Biological Chemistry, s. 11608-11618, 2016

• DOI för The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor beta (PDGFR beta) Internalization and Signaling

Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation

Ma, Haisha; Wardega, Piotr; Mazaud, David; Klosowska-Wardega, Agnieszka et al.

Ingår i Cellular Signalling, s. 2209-2219, 2015

• DOI för Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation

The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition

Tan, E-Jean; Kahata, Kaoru; Idås, Oskar; Thuault, Sylvie et al.

Ingår i Nucleic Acids Research, s. 162-178, 2015

• DOI för The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition
• Ladda ner fulltext (pdf) av The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition

CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface

Yakymovych, Ihor; Yakymovych, Mariya; Zang, Guangxiang; Mu, Yabing et al.

Ingår i Journal of Cell Biology, s. 319-332, 2015

• DOI för CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface
• Ladda ner fulltext (pdf) av CIN85 modulates TGF beta signaling by promoting the presentation of TGF beta receptors on the cell surface

TRAF6 promotes TGF beta-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGF beta type I receptor

Sundar, Reshma; Gudey, Shyam Kumar; Heldin, Carl-Henrik; Landstrom, Marene

Ingår i Cell Cycle, s. 554-565, 2015

• DOI för TRAF6 promotes TGF beta-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGF beta type I receptor

Platelet-derived Growth Factor beta-Receptor, Transforming Growth Factor beta Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability

Porsch, Helena; Mehic, Merima; Olofsson, Berit; Heldin, Paraskevi et al.

Ingår i Journal of Biological Chemistry, s. 19747-19757, 2014

• DOI för Platelet-derived Growth Factor beta-Receptor, Transforming Growth Factor beta Type I Receptor, and CD44 Protein Modulate Each Other's Signaling and Stability

Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

Dahl, Markus; Maturi, Varun; Lönn, Peter; Papoutsoglou, Panagiotis et al.

Ingår i PLOS ONE, 2014

• DOI för Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling
• Ladda ner fulltext (pdf) av Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling

TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1

Thakur, Noopur; Gudey, Shyam Kumar; Marcusson, Anders; Fu, Jing Yi et al.

Ingår i Cell Cycle, s. 2400-2414, 2014

• DOI för TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1

Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases.

Heldin, Carl-Henrik

Ingår i Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, s. 69-79, 2014

• DOI för Targeting the PDGF Signaling Pathway in the Treatment of Non-Malignant Diseases.

TRAF6 Stimulates the Tumor-Promoting Effects of TGFβ Type I Receptor Through Polyubiquitination and Activation of Presenilin 1

Gudey, Shyam Kumar; Sundar, Reshma; Mu, Yabing; Wallenius, Anders et al.

Ingår i Science signaling, 2014

• DOI för TRAF6 Stimulates the Tumor-Promoting Effects of TGFβ Type I Receptor Through Polyubiquitination and Activation of Presenilin 1

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion

Sundqvist, Anders; Zieba, Agata; Vasilaki, Eleftheria; Herrera Hidalgo, Carmen et al.

Ingår i Oncogene, s. 3606-3615, 2013

• DOI för Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion

Efficient TGF beta-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2

Porsch, Helena; Bernert, Berit; Mehić, Merima; Theocharis, A D et al.

Ingår i Oncogene, s. 4355-4365, 2013

• DOI för Efficient TGF beta-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2

p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β

Termén, Stefan; Tan, E-Jean; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 801-813, 2013

• DOI för p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β

The Fer Tyrosine Kinase Is Important for Platelet-derived Growth Factor-BB-induced Signal Transducer and Activator of Transcription 3 (STAT3) Protein Phosphorylation, Colony Formation in Soft Agar, and Tumor Growth in Vivo.

Lennartsson, Johan; Ma, Haisha; Wardega, Piotr; Pelka, Karin et al.

Ingår i Journal of Biological Chemistry, s. 15736-15744, 2013

• DOI för The Fer Tyrosine Kinase Is Important for Platelet-derived Growth Factor-BB-induced Signal Transducer and Activator of Transcription 3 (STAT3) Protein Phosphorylation, Colony Formation in Soft Agar, and Tumor Growth in Vivo.

APC and Smad7 link the TGFβ type I receptors to the microtubule system to promote cell migration

Ekman, Maria; Mu, Yabing; Lee, So Young; Edlund, Sofia et al.

Ingår i Molecular Biology of the Cell, s. 2109-2121, 2012

• DOI för APC and Smad7 link the TGFβ type I receptors to the microtubule system to promote cell migration

Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase

Lönn, Peter; Vanlandewijck, Michael; Raja, Erna; Kowanetz, Marcin et al.

Ingår i Journal of Biological Chemistry, s. 12867-12878, 2012

• DOI för Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase

Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition

Tan, E-Jean; Thuault, Sylvie; Caja, Laia; Carletti, Tea et al.

Ingår i Journal of Biological Chemistry, s. 7134-7145, 2012

• DOI för Regulation of transcription factor Twist expression by the DNA architectural protein high mobility group A2 during epithelial-to-mesenchymal transition

Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V

Schmees, Christian; Villaseñor, R; Zheng, Wei; Ma, Haisha et al.

Ingår i Molecular Biology of the Cell, s. 2571-2582, 2012

• DOI för Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V

Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli

Hamidi, Anahita; von Bulow, Verena; Hamidi, Rosita; Winssinger, Nicolas et al.

Ingår i Journal of Biological Chemistry, s. 123-133, 2012

• DOI för Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli

Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase

Zieba, Agata; Pardali, Katerina; Söderberg, Ola; Lindbom, Lena et al.

Ingår i Molecular & Cellular Proteomics, 2012

• DOI för Intercellular variation in signaling through the TGF-β pathway and its relation to cell densityand cell cycle phase

TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

Mu, Yabing; Sundar, Reshma; Thakur, Noopur; Ekman, Maria et al.

Ingår i Nature Communications, 2011

• DOI för TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer

Filamin A mediates HGF/c-MET signaling in tumor cell migration

Zhou, Alex-Xianghua; Toylu, Asli; Nallapalli, Rajesh K.; Nilsson, Gisela et al.

Ingår i International Journal of Cancer, s. 839-846, 2011

• DOI för Filamin A mediates HGF/c-MET signaling in tumor cell migration

A decisive function of transforming growth factor-β/Smad signaling in tissue morphogenesis and differentiation of human HaCaT keratinocytes

Buschke, Susanne; Stark, Hans-Jürgen; Cerezo, Ana; Prätzel-Wunder, Silke et al.

Ingår i Molecular Biology of the Cell, s. 782-794, 2011

• DOI för A decisive function of transforming growth factor-β/Smad signaling in tissue morphogenesis and differentiation of human HaCaT keratinocytes

The LAR protein tyrosine phosphatase enables PDGF β-receptor activation through attenuation of the c-Abl kinase activity

Zheng, Wei; Lennartsson, Johan; Hendriks, Wiljan; Heldin, Carl-Henrik et al.

Ingår i Cellular Signalling, s. 1050-1056, 2011

• DOI för The LAR protein tyrosine phosphatase enables PDGF β-receptor activation through attenuation of the c-Abl kinase activity

Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1

Morén, Anita; Raja, Erna; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Biological Chemistry, s. 341-353, 2011

• DOI för Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1

Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation

Jurek, Aleksandra; Heldin, Carl-Henrik; Lennartsson, Johan

Ingår i Cellular Signalling, s. 280-287, 2011

• DOI för Platelet-derived growth factor-induced signaling pathways interconnect to regulate the temporal pattern of Erk1/2 phosphorylation

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

Morikawa, Masato; Koinuma, Daizo; Tsutsumi, Shuichi; Vasilaki, Eleftheria et al.

Ingår i Nucleic Acids Research, s. 8712-8727, 2011

• DOI för ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif

Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor β- and Bone Morphogenetic Protein-Independent Manner

Krampert, Monika; Chirasani, Sridhar Reddy; Wachs, Frank-Peter; Aigner, Robert et al.

Ingår i Molecular and Cellular Biology, s. 3685-3694, 2010

• DOI för Smad7 Regulates the Adult Neural Stem/Progenitor Cell Pool in a Transforming Growth Factor β- and Bone Morphogenetic Protein-Independent Manner

Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis

Lennartsson, Johan; Burovic, Fatima; Witek, Barbara; Jurek, Aleksandra et al.

Ingår i Cellular Signalling, s. 955-960, 2010

• DOI för Erk 5 is necessary for sustained PDGF-induced Akt phosphorylation and inhibition of apoptosis

Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro

Tian, Fei; Zhou, Alex-Xianghua; Smits, Anke M; Larsson, Erik et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 283-288, 2010

• DOI för Endothelial cells are activated during hypoxia via endoglin/ALK-1/SMAD1/5 signaling in vivo and in vitro

Mutation of tyrosine residue 857 in the PDGF β-receptor affects cell proliferation but not migration

Wardega, Piotr; Heldin, Carl-Henrik; Lennartsson, Johan

Ingår i Cellular Signalling, s. 1363-1368, 2010

• DOI för Mutation of tyrosine residue 857 in the PDGF β-receptor affects cell proliferation but not migration

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis

Cunha, Sara I; Pardali, Evangelia; Thorikay, Midory; Anderberg, Charlotte et al.

Ingår i Journal of Experimental Medicine, s. 85-100, 2010

• DOI för Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis

PARP-1 attenuates Smad-mediated transcription

Lönn, Peter; van der Heide, Lars; Dahl, Markus; Hellman, Ulf et al.

Ingår i Molecular Cell, s. 521-532, 2010

• DOI för PARP-1 attenuates Smad-mediated transcription

Transforming growth factor β promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin

Bergström, Rosita; Savary, Katia; Morén, Anita; Guibert, Sylvain et al.

Ingår i Journal of Biological Chemistry, s. 19727-19737, 2010

• DOI för Transforming growth factor β promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin

The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination

Karousou, Eugenia; Kamiryo, Masaru; Skandalis, Spyros S; Ruusala, Aino et al.

Ingår i Journal of Biological Chemistry, s. 23647-23654, 2010

• DOI för The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination

Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom

Huminiecki, Lukasz; Goldovsky, Leon; Freilich, Shiri; Moustakas, Aristidis et al.

Ingår i BMC Evolutionary Biology, s. 28, 2009

• DOI för Emergence, development and diversification of the TGF-beta signalling pathway within the animal kingdom

TGF-beta uses the E3-ligase TRAF6 to turn on the kinase TAK1 to kill prostate cancer cells

Thakur, Noopur; Sorrentino, Alessandro; Heldin, Carl-Henrik; Landström, Maréne

Ingår i Future oncology (London, England), s. 1-3, 2009

• DOI för TGF-beta uses the E3-ligase TRAF6 to turn on the kinase TAK1 to kill prostate cancer cells

Activation of Protein Kinase C α Is Necessary for Sorting the PDGF β-Receptor to Rab4a-dependent Recycling

Hellberg, Carina; Schmees, Christian; Karlsson, Susann; Åhgren, Aive et al.

Ingår i Molecular Biology of the Cell, s. 2856-2863, 2009

• DOI för Activation of Protein Kinase C α Is Necessary for Sorting the PDGF β-Receptor to Rab4a-dependent Recycling

Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation

Jurek, Aleksandra; Amagasaki, Kenichi; Gembarska, Agnieszka; Heldin, Carl-Henrik et al.

Ingår i Journal of Biological Chemistry, s. 4626-4634, 2009

• DOI för Negative and positive regulation of MAPK phosphatase 3 controls platelet-derived growth factor-induced Erk activation

Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer

Paulsson, Janna; Sjöblom, Tobias; Micke, Patrick; Pontén, Fredrik et al.

Ingår i American Journal of Pathology, s. 334-341, 2009

• DOI för Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer

A gain-of-function mutation in the PDGFR-beta alters thekinetics of injury response in liver and skin

Krampert, Monika; Heldin, Carl-Henrik; Heuchel, Rainer L.

Ingår i Laboratory Investigation, s. 1204-1214, 2008

• DOI för A gain-of-function mutation in the PDGFR-beta alters thekinetics of injury response in liver and skin

A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse

Pielberg, Gerli Rosengren; Golovko, Anna; Sundström, Elisabeth; Curik, Ino et al.

Ingår i Nature Genetics, s. 1004-1009, 2008

• DOI för A cis-acting regulatory mutation causes premature hair graying and susceptibility to melanoma in the horse

TGFβ induces SIK to negatively regulate type I receptor kinase signaling

Kowanetz, Marcin; Lönn, Peter; Vanlandewijck, Michael; Kowanetz, Katarzyna et al.

Ingår i Journal of Cell Biology, s. 655-662, 2008

• DOI för TGFβ induces SIK to negatively regulate type I receptor kinase signaling

The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

Sorrentino, Alessandro; Thakur, Noopur; Grimsby, Susanne; Marcusson, Anders et al.

Ingår i Nature Cell Biology, s. 1199-1207, 2008

• DOI för The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition

Thuault, Sylvie; Tan, E-Jean; Peinado, Hector; Cano, Amparo et al.

Ingår i Journal of Biological Chemistry, s. 33437-33446, 2008

• DOI för HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition

Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor

Ruusala, Aino; Pawson, Tony; Heldin, Carl-Henrik; Aspenström, Pontus

Ingår i Journal of Biological Chemistry, s. 30034-30044, 2008

• DOI för Nck adapters are involved in the formation of dorsal ruffles, cell migration, and Rho signaling downstream of the platelet-derived growth factor beta receptor

Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

Li, Lingli; Asteriou, Trias; Bernert, Berit; Heldin, Carl-Henrik et al.

Ingår i Biochemical Journal, s. 327-336, 2007

• DOI för Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB

Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling

Hasumi, Yoko; Kłosowska-Wardega, Agnieszka; Furuhashi, Masao; Östman, Arne et al.

Ingår i International Journal of Cancer, s. 2606-2614, 2007

• DOI för Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling

SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma

Kallin, Anders; Johannessen, Lene E.; Cani, Patrice D.; Marbehant, Catherine Y. et al.

Ingår i Journal of Lipid Research, s. 1628-1636, 2007

• DOI för SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma

Notch signaling is necessary for epithelial growth arrest by TGF-beta

Niimi, Hideki; Pardali, Katerina; Vanlandewijck, Michael; Heldin, Carl-Henrik et al.

Ingår i Journal of Cell Biology, s. 695-707, 2007

• DOI för Notch signaling is necessary for epithelial growth arrest by TGF-beta

Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition

Thuault, Sylvie; Valcourt, Ulrich; Petersen, Maj; Manfioletti, Guidalberto et al.

Ingår i Journal of Cell Biology, s. 175-183, 2006

• DOI för Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition

Deletion of exon I of SMAD7 in mice results in altered B cell responses

Li, Ronggui; Rosendahl, Alexander; Brodin, Greger; Cheng, Alec M. et al.

Ingår i Journal of Immunology, s. 6777-6784, 2006

The mechanism of nuclear export of smad3 involves exportin 4 and Ran

Kurisaki, Akira; Kurisaki, Keiko; Kowanetz, Marcin; Sugino, Hiromu et al.

Ingår i Molecular and Cellular Biology, s. 1318-1332, 2006

• DOI för The mechanism of nuclear export of smad3 involves exportin 4 and Ran

Loss of T-Cell Protein Tyrosine Phosphatase Induces Recycling of the Platelet-derived Growth Factor (PDGF) beta-Receptor but Not the PDGF {alpha}-Receptor

Karlsson, Susann; Kowanetz, Katarzyna; Sandin, Åsa; Persson, Camilla et al.

Ingår i Molecular Biology of the Cell, s. 4846-4855, 2006

• DOI för Loss of T-Cell Protein Tyrosine Phosphatase Induces Recycling of the Platelet-derived Growth Factor (PDGF) beta-Receptor but Not the PDGF {alpha}-Receptor

Alix Facilitates the Interaction between c-Cbl and Platelet-derived Growth Factor beta-Receptor and Thereby Modulates Receptor Down-regulation

Lennartsson, Johan; Wardega, Piotr; Engström, Ulla; Hellman, Ulf et al.

Ingår i Journal of Biological Chemistry, s. 39152-39158, 2006

• DOI för Alix Facilitates the Interaction between c-Cbl and Platelet-derived Growth Factor beta-Receptor and Thereby Modulates Receptor Down-regulation

Regulation of chemotaxis by the cytoplasmic domain of tissue factor

Siegbahn, Agneta; Johnell, Matilda; Sorensen, Brit B.; Petersen, Lars C. et al.

Ingår i Thrombosis and Haemostasis, s. 27-34, 2005

• DOI för Regulation of chemotaxis by the cytoplasmic domain of tissue factor

Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21Waf1/Cip1

Pardali, Katerina; Kowanetz, Marcin; Heldin, Carl-Henrik; Moustakas, Aristidis

Ingår i Journal of Cellular Physiology, s. 260-272, 2005

• DOI för Smad pathway-specific transcriptional regulation of the cell cycle inhibitor p21Waf1/Cip1

TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

Valcourt, Ulrich; Kowanetz, Marcin; Niimi, Hideki; Heldin, Carl-Henrik et al.

Ingår i Molecular Biology of the Cell, s. 1987-2002, 2005

• DOI för TGF-β and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition

The balance between acetylation and deacetylation controls Smad7 stability

Simonsson, Maria; Heldin, Carl-Henrik; Ericsson, Johan; Grönroos, Eva

Ingår i Journal of Biological Chemistry, s. 21797-21803, 2005

• DOI för The balance between acetylation and deacetylation controls Smad7 stability

Non-Smad TGF-{beta} signals

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Journal of Cell Science, s. 3573-3584, 2005

• DOI för Non-Smad TGF-{beta} signals

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

Morén, Anita; Imamura, Takeshi; Miyazono, Kohei; Heldin, Carl-Henrik et al.

Ingår i Journal of Biological Chemistry, s. 22115-22123, 2005

• DOI för Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis

Edlund, Sofia; Lee, So Young; Grimsby, Susanne; Zhang, Shouthing et al.

Ingår i Molecular and Cellular Biology, s. 1475-1488, 2005

• DOI för Interaction between Smad7 and beta-catenin: importance for transforming growth factor beta-induced apoptosis

Smad7 is required for TGF-ß-induced activation of the small GTPase Cdc42

Edlund, Sofia; Landström, Maréne; Heldin, Carl-Henrik; Aspenström, Pontus

Ingår i Journal of Cell Science, s. 1835-1847, 2004

• DOI för Smad7 is required for TGF-ß-induced activation of the small GTPase Cdc42

Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

Furuhashi, Masao; Sjöblom, Tobias; Abramsson, Alexandra; Ellingsen, Jens et al.

Ingår i Cancer Research, s. 2725-2733, 2004

• DOI för Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate

Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases

Persson, Camilla; Sjöblom, Tobias; Groen, Arnoud; Kappert, Kai et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 1886-1891, 2004

• DOI för Preferential oxidation of the second phosphatase domain of receptor-like PTP-alpha revealed by an antibody against oxidized protein tyrosine phosphatases

Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor β and bone morphogenetic protein

Kowanetz, Marcin; Valcourt, Ulrich; Bergström, Rosita; Heldin, Carl-Henrik et al.

Ingår i Molecular and Cellular Biology, s. 4241-4254, 2004

• DOI för Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor β and bone morphogenetic protein

A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity

Chiara, Federica; Goumans, Marie-José; Forsberg, Henrik; Åhgrén, Aive et al.

Ingår i Journal of Biological Chemistry, s. 42516-42527, 2004

• DOI för A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity

Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail

Chiara, Federica; Bishayee, Subal; Heldin, Carl-Henrik; Demoulin, Jean-Baptiste

Ingår i Journal of Biological Chemistry, s. 19732-19738, 2004

• DOI för Autoinhibition of the platelet-derived growth factor beta-receptor tyrosine kinase by its C-terminal tail

Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

Kowanetz, Katarzyna; Crosetto, Nicola; Haglund, Kaisa; Schmidt, Mirko H H et al.

Ingår i Journal of Biological Chemistry, s. 32786-32795, 2004

• DOI för Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins

Demoulin, Jean-Baptiste; Ericsson, Johan; Kallin, Anders; Rorsman, Charlotte et al.

Ingår i Journal of Biological Chemistry, s. 35392-35402, 2004

• DOI för Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins

Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor

Kallin, Anders; Demoulin, Jean-Baptiste; Nishida, Keigo; Hirano, Toshio et al.

Ingår i Journal of Biological Chemistry, s. 17897-17904, 2004

• DOI för Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor

High interstitial fluid pressure - an obstacle in cancer therapy.

Heldin, Carl-Henrik; Rubin, Kristofer; Pietras, Kristian; Östman, Arne

Ingår i Nat Rev Cancer, s. 806-13, 2004

Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.

Leppänen, Olli; Rutanen, Juha; Hiltunen, Mikko O; Rissanen, Tuomas T et al.

Ingår i Circulation, s. 1140-6, 2004

Transforming Growth Factor-β1 (TGF-β)–induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-β-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3

Edlund, Sofia; Bu, Shizhong; Schuster, Norbert; Aspenström, Pontus et al.

Ingår i Molecular Biology of the Cell, s. 529-544, 2003

• DOI för Transforming Growth Factor-β1 (TGF-β)–induced Apoptosis of Prostate Cancer Cells Involves Smad7-dependent Activation of p38 by TGF-β-activated Kinase 1 and Mitogen-activated Protein Kinase Kinase 3

Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

Kurisaki, Keiko; Kurisaki, Akira; Valcourt, Ulrich; Terentiev, Alexei A et al.

Ingår i Molecular and Cellular Biology, s. 4494-4510, 2003

• DOI för Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

Differential ubiquitination defines the functional status of the tumor suppressor Smad4

Morén, Anita; Hellman, Ulf; Inada, Yuri; Imamura, Takeshi et al.

Ingår i Journal of Biological Chemistry, s. 33571-33582, 2003

• DOI för Differential ubiquitination defines the functional status of the tumor suppressor Smad4

Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

Itoh, Susumu; Thorikay, Midory; Kowanetz, Marcin; Moustakas, Aristidis et al.

Ingår i Journal of Biological Chemistry, s. 3751-3761, 2003

• DOI för Elucidation of Smad requirement in transforming growth factor-beta type I receptor-induced responses

STI571 enhances the therapeutic index of epothilone B by a tumor-selectiveincrease of drug uptake.

Pietras, Kristian; Stumm, Michael; Hubert, Martine; Buchdunger, Elisabeth et al.

Ingår i Clin Cancer Res, s. 3779, 2003

PDGF receptors as cancer drug targets.

Pietras, Kristian; Sjöblom, Tobias; Rubin, Kristofer; Heldin, Carl-Henrik et al.

Ingår i Cancer Cell, s. 439, 2003

Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy

Pietras, Kristian; Rubin, Kristofer; Sjöblom, Tobias; Buchdunger, Elisabeth et al.

Ingår i Cancer Research, s. 5476-5484, 2002

SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF β-receptor

Ekman, Simon; Kallin, Anders; Engström, Ulla; Heldin, Carl-Henrik et al.

Ingår i Oncogene, s. 1870-1875, 2002

• DOI för SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF β-receptor

Control of Smad7 stability by competition between acetylation and ubiquitination

Grönroos, Eva; Hellman, Ulf; Heldin, Carl-Henrik; Ericsson, Johan

Ingår i Molecular Cell, s. 483-493, 2002

• DOI för Control of Smad7 stability by competition between acetylation and ubiquitination

Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration

Palumbo, Roberta; Gaetano, Carlo; Antonini, Annalisa; Pompilio, Giulio et al.

Ingår i Arteriosclerosis, Thrombosis and Vascular Biology, s. 405-411, 2002

• DOI för Different effects of high and low shear stress on platelet-derived growth factor isoform release by endothelial cells: consequences for smooth muscle cell migration

Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

Kurisaki, Akira; Kose, Shingo; Yoneda, Yoshihiro; Heldin, Carl-Henrik et al.

Ingår i Molecular Biology of the Cell, s. 1079-1091, 2001

• DOI för Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner

Regulation of Smad signaling by protein kinase C

Yakymovych, Ihor; ten Dijke, Peter; Heldin, Carl-Henrik; Souchelnytskyi, Serhiy

Ingår i The FASEB Journal, s. 553-555, 2001

• DOI för Regulation of Smad signaling by protein kinase C

Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.

Pietras, Kristian; Östman, Arne; Sjöquist, Mats; Buchdunger, Elisabeth et al.

Ingår i Cancer Res, s. 2929, 2001

Growth inhibition of dermatofibrosarcoma protuberans tumors by the platelet-derived growth factor receptor antagonist STI571 through induction of apoptosis.

Sjöblom, Tobias; Shimizu, Akira; O'Brien, Kevin P.; Pietras, Kristian et al.

Ingår i Cancer Res, s. 5778-83, 2001

Binding of factor VIIa to tissue factor on human fibroblasts leads to activation of phospholipase C and enhanced PDGF-BB-stimulated chemotaxis.

Siegbahn, A; Johnell, M; Rorsman, C; Ezban, M et al.

Ingår i Blood, s. 3452-8, 2000

Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis

Rönnstrand, Lars; Siegbahn, Agneta; Rorsman, Charlotte; Johnell, Matilda et al.

Ingår i Journal of Biological Chemistry, s. 22089-22094, 1999

• DOI för Overactivation of phospholipase C-gamma1 renders platelet-derived growth factor beta-receptor-expressing cells independent of the phosphatidylinositol 3-kinase pathway for chemotaxis

Mechanism of action and in vivo role of platelet-derived growth factor

Heldin, Carl-Henrik; Westermark, Bengt

Ingår i Physiological Reviews, s. 1283-1316, 1999

Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling

Heuchel, Rainer; Berg, Ansgar; Tallquist, Michelle; Åhlén, Karina et al.

Ingår i Proc Natl Acad Sci U S A, s. 11410-5, 1999

Mutation of a Src phosphorylation site in the PDGF beta-receptor leads to increased PDGF-stimulated chemotaxis but decreased mitogenesis

Hansen, Klaus; Johnell, Matilda; Siegbahn, Agneta; Rorsman, Charlotte et al.

Ingår i EMBO Journal, s. 5299-5313, 1996

Increased Kit/SCF receptor induced mitogenicity but abolished cell motility after inhibition of protein kinase C.

Blume-Jensen, P; Siegbahn, A; Stabel, S; Heldin, C H et al.

Ingår i EMBO J, s. 4199-209, 1993

Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes

Heldin, Carl-Henrik; Östman, Arne; Eriksson, Anders; Siegbahn, Agneta et al.

Ingår i Kidney International, s. 571-574, 1992

• DOI för Platelet-derived growth factor: isoform-specific signalling via heterodimeric or homodimeric receptor complexes

Activation of the human c-kit product by ligand-induced dimerization mediates circular actin reorganization and chemotaxis

Blume-Jensen, Peter; Claesson-Welsh, Lena; Siegbahn, Agneta; Zsebo, Krisztina M. et al.

Ingår i EMBO Journal, s. 4121-4128, 1991

A glioma-derived PDGF A chain homodimer has different functional activities from a PDGF AB heterodimer purified from human platelets.

Nistér, M; Hammacher, A; Mellström, K; Siegbahn, A et al.

Ingår i Cell, s. 791-9, 1988

Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors

Sanchez-Duffhues, Gonzalo; Williams, Eleanor; Goumans, Marie-Jose; Heldin, Carl-Henrik et al.

Ingår i Bone, 2020

• DOI för Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors
• Ladda ner fulltext (pdf) av Bone morphogenetic protein receptors: Structure, function and targeting by selective small molecule kinase inhibitors

Intracellular trafficking of transforming growth factor beta receptors

Yakymovych, Ihor; Yakymovych, Mariya; Heldin, Carl-Henrik

Ingår i Acta biochimica et biophysica Sinica, s. 3-11, 2018

• DOI för Intracellular trafficking of transforming growth factor beta receptors

Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis

Heldin, Carl-Henrik; Lennartsson, Johan; Westermark, Bengt

Ingår i Journal of Internal Medicine, s. 16-44, 2018

• DOI för Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis

Genome-wide mechanisms of Smad binding

Morikawa, Masato; Koinuma, D; Miyazono, Kohei; Heldin, Carl-Henrik

Ingår i Oncogene, s. 1609-1615, 2013

• DOI för Genome-wide mechanisms of Smad binding

Autocrine PDGF stimulation in malignancies

Heldin, Carl-Henrik

Ingår i Upsala Journal of Medical Sciences, s. 83-91, 2012

• DOI för Autocrine PDGF stimulation in malignancies

Regulation of EMT by TGFβ in cancer

Heldin, Carl-Henrik; Vanlandewijck, Michael; Moustakas, Aristidis

Ingår i FEBS Letters, s. 1959-1970, 2012

• DOI för Regulation of EMT by TGFβ in cancer

Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

Heldin, Carl-Henrik; Landström, Maréne; Moustakas, Aristidis

Ingår i Current Opinion in Cell Biology, s. 166-176, 2009

• DOI för Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

The regulation of TGFβ signal transduction

Moustakas, Aristidis; Heldin, Carl-Henrik

Ingår i Development, s. 3699-3714, 2009

• DOI för The regulation of TGFβ signal transduction

The European Research Council--a new opportunity for European science

Heldin, Carl-Henrik

Ingår i Nature reviews. Molecular cell biology, s. 417-420, 2008

• DOI för The European Research Council--a new opportunity for European science

Signals and receptors

Heldin, Carl-Henrik; Lu, Benson; Evans, Ron; Gutkind, J Silvio

Ingår i Signal transduction, s. 3-29, Cold Spring Harbor Laboratory Press (CSHL), 2014

Transforming growth factor-ß signaling

Heldin, Carl-Henrik

Ingår i TGF-ß in human Disease, s. 3-32, Springer Japan, 2013

• DOI för Transforming growth factor-ß signaling

Platelet-derived growth factor

Östman, Arne; Heldin, Carl-Henrik

Ingår i Molecular oncology, s. 135-143, Cambridge University Press, 2013

• DOI för Platelet-derived growth factor

PDGF and Vessel Maturation

Hellberg, Carina; Östman, Arne; Heldin, Carl-Henrik

Ingår i Angiogenesis inhibition, s. 103-114, Springer-Verlag Berlin Heidelberg, 2010

• DOI för PDGF and Vessel Maturation

Protein tyrosine kinase receptor signaling overview

Heldin, Carl-Henrik

Ingår i Handbook of Cell Signaling, s. 419-426, Elsevier Ltd, 2010

TGF-beta signaling from receptors to Smads

Heldin, Carl-Henrik

Ingår i The TGF-beta Family, s. 259-285, Cold Spring Harbor Laboratory Press, 2008

Foreword: Transforming Growth Factor-beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy

Heldin, Carl-Henrik

Ingår i Transforming Growth Factor-β in Cancer Therapy, Volume II, The Humana Press, Inc., 2008

Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases

Souchelnytskyi, Serhiy; Rönnstrand, Lars; Heldin, Carl-Henrik; ten Dijke, Peter

Ingår i Protein Kinase Protocols, s. 107-120, Humana Press, 2001

• DOI för Phosphorylation of Smad signaling proteins by receptor serine/threonine kinases

SIK phosphorylates and degrades Par3 to mediate tight junction disassembly during epithelial-mesenchymal transition

Vanlandewijck, Michael; Lomnytska, Marta; Busch, Christer; Heldin, Carl-Henrik et al.

2011

Epigenetic coupling of transcription factor CXXC5 regulates stemness genes in glioblastoma

Tzavlaki, Kalliopi; Dadras, Mahsa Shahidi; Mezheyeuski, Artur; Morén, Anita et al.

The liver kinase B1 inhibits transforming growth factor β signaling during mammary epithelial morphogenesis

Tzavlaki, Kalliopi; Morén, Anita; Watanabe, Yukihide; Eriksson, Jens et al.

G3BP1 is a SWI/SNF-bound regulator of PDGFR signalling that controls cell proliferation via ERK1/2 MAP-kinase, c-MYC and STAT3

Sarri, Niki; Lennartsson, Johan; Witek, Barbara; Heldin, Carl-Henrik et al.

SNAI2 knockout induces metabolic and cell cycle changes in breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Heldin, Carl-Henrik; Moustakas, Aristidis

TGF-β induces cholesterol accumulation to regulate the fate of tumor-derived extracellular vesicles

Mendes Rodrigues-Junior, Dorival; Tsirigoti, Chrysoula; Psatha, Konstantina; Kletsas, Dimitris et al.

SNAI1 and SMAD/TGF-β signals antagonize FOXA1 to control PSD4/EFA6B expression and couple integrin-mediated adhesion to endocytic fate in triple-negative breast cancer cells

Tsirigoti, Chrysoula; Ali, Mohamad Moustafa; Mendes Rodrigues-Junior, Dorival; Johansson, Staffan et al.

Glutamine deprivation alters TGF-β signaling in hepatocellular carcinoma

Gélabert, Caroline; Campisano, Sabrina; Golán, Irene C.; Beyene, T. Nathanael et al.

Thematic issue on platelet-derived growth factor

Heldin, Carl-Henrik

Elsevier Ltd., 2004