Gunnar Pejler

Publikationer

Senaste publikationer

• Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier (2025)
• Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics (2024)
• Targeting of the IL-5 pathway in severe asthma reduces mast cell progenitors (2024)
• Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation (2024)
• Blockade of endolysosomal acidification suppresses TLR3-mediated proinflammatory signaling in airway epithelial cells (2024)

Alla publikationer

Artiklar

• Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier (2025)
• Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics (2024)
• Targeting of the IL-5 pathway in severe asthma reduces mast cell progenitors (2024)
• Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation (2024)
• Blockade of endolysosomal acidification suppresses TLR3-mediated proinflammatory signaling in airway epithelial cells (2024)
• A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection (2024)
• Mast cell chymase suppresses functional parameters in primary human airway smooth muscle cells (2024)
• Tendon pain (2023)
• Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity (2023)
• Absence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitis (2023)
• Phenotypic Switch and Growth of Melanoma Spheroids in the Presence of Mast Cells (2023)
• Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3K beta (2023)
• Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model (2023)
• Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue (2023)
• Therapeutic administration of mouse mast cell protease 6 improves functional recovery after traumatic spinal cord injury in mice by promoting remyelination and reducing glial scar formation (2023)
• Monensin induces secretory granule-mediated cell death in eosinophils (2023)
• Treatment of chronic airway diseases using nutraceuticals (2022)
• Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress. (2022)
• The ingenious mast cell (2022)
• Serglycin Is Involved in Adipose Tissue Inflammation in Obesity (2022)
• Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages (2022)
• Structural and functional analysis of human thymidylate kinase isoforms (2022)
• Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase (2022)
• Mefloquine causes selective mast cell apoptosis in cutaneous mastocytosis lesions by a secretory granule-mediated pathway (2022)
• Mast cell chymase has a negative impact on human osteoblasts (2022)
• Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models (2022)
• Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems (2022)
• Mast cell tryptase potentiates neutrophil extracellular trap formation (2022)
• Tryptase reference values in a Swedish middle-aged general population and association with diabetes mellitus (2022)
• Mast cell chymase affects the functional properties of primary human airway fibroblasts (2022)
• Mast cell chymase regulates extracellular matrix remodeling-related events in primary human small airway epithelial cells (2022)
• Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells (2021)
• Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells (2021)
• Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin (2021)
• Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly (2021)
• Monensin induces selective mast cell apoptosis through a secretory granule-mediated pathway. (2021)
• Novel Strategies to Target Mast Cells in Disease (2021)
• Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I (2021)
• Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells (2021)
• Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity (2020)
• How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells? (2020)
• Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA (2020)
• Histone Methyltransferase Inhibition Has a Cytotoxic Impact on Transformed Mast Cells (2020)
• Do Mast Cells Have a Role in Tendon Healing and Inflammation? (2020)
• Identification of a novel thymidylate kinase activity. (2020)
• Protective role of mouse mast cell tryptase Mcpt6 in melanoma. (2020)
• Novel aspects of mast cell and basophil function (2020)
• Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment (2020)
• Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1 (2020)
• Urticaria (2020)
• DNA demethylation regulates gene expression in IgE-activated mouse mast cells. (2020)
• Novel Insight into the in vivo Function of Mast Cell Chymase (2020)
• Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1 (2019)
• Local delivery of temozolomide via a biologically inert carrier (Temodex) prolongs survival in glioma patients, irrespectively of the methylation status of MGMT (2019)
• The Absence of Tryptase Mcpt6 Causes Elevated Cellular Stress in Response to Modulation of the Histone Acetylation Status in Mast Cells (2019)
• Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells (2019)
• Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production (2019)
• The emerging role of mast cell proteases in asthma (2019)
• The emerging role of mast cell proteases in asthma (2019)
• Mouse Mast Cell Protease-4 Recruits Leukocytes in the Inflammatory Phase of Surgically Wounded Skin (2019)
• Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury (2019)
• Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism (2019)
• The controversial role of mast cells in fibrosis (2018)
• Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules (2018)
• Mast cell chymase decreases the severity of group B Streptococcus infections (2018)
• Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction (2018)
• The Effect of Lipopolysaccharide-Induced Experimental Bovine Mastitis on Clinical Parameters, Inflammatory Markers, and the Metabolome (2018)
• Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin (2018)
• Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment (2018)
• Increased mast cell degranulation and co-localization of mast cells with the NMDA receptor-1 during healing after Achilles tendon rupture (2017)
• Inhibition of the BET family of epigenetic reader proteins (2017)
• The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung (2017)
• Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions (2017)
• Copper Regulates Maturation and Expression of an MITF (2017)
• Excessive dietary intake of vitamin A reduces skull bone thickness in mice (2017)
• Tryptase-catalyzed core histone truncation (2017)
• Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization (2017)
• Acidic pH is essential for maintaining mast cell secretory granule homeostasis (2017)
• Mast cells and McPT4 chymase Promote renal impairment after Partial Ureteral Obstruction (2017)
• Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation (2017)
• Equine Airway Mast Cells are Sensitive to Cell Death Induced by Lysosomotropic Agents (2017)
• Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis (2016)
• Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice (2016)
• Mastitis Pathogens with high Virulence in a Mouse Model Produce a Distinct cytokine Profile In Vivo (2016)
• The Role of Mast Cells in Bacterial Infection (2016)
• Live Staphylococcus aureus Induces Expression and Release of Vascular Endothelial Growth Factor in Terminally Differentiated Mouse Mast Cells (2016)
• Increased Bone Mass in Female Mice Lacking Mast Cell Chymase (2016)
• Activated mast cells promote differentiation of B cells into effector cells (2016)
• Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity (2016)
• IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction (2016)
• Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6 (2016)
• IL-6 and IL-17A degradation by mast cells is mediated by a serglycin (2016)
• Mast cells promote melanoma colonization of lungs (2016)
• Approaches for analyzing the roles of mast cells and their proteases in vivo (2015)
• Damnacanthal inhibits IgE receptor-mediated activation of mast cells (2015)
• Ablation of human skin mast cells in situ by lysosomotropic agents (2015)
• Serglycin protects against high fat diet-induced increase in serum LDL in mice (2015)
• Induction of mast cell apoptosis by a novel secretory granule-mediated pathway. (2015)
• MAST CELL GRANULES (2015)
• Serglycin protects against high fat diet-induced increase in plasma LDL in mice (2015)
• Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase (2015)
• Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans (2015)
• Nuclear Receptor 4a3 (Nr4a3) Regulates Murine Mast Cell Responses and Granule Content (2014)
• Proteolytic Histone Modification by Mast Cell Tryptase, a Serglycin Proteoglycan-dependent Secretory Granule Protease (2014)
• Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo (2014)
• Serglycin Proteoglycan Promotes Apoptotic versus Necrotic Cell Death in Mast Cells (2012)
• Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing. (2002)
• Secretory granule proteases in rat mast cells (1997)
• Mouse mast cell tryptase and carboxypeptidase A3 play a protective role in itch induced by endothelin-1
• Compound 48/80-induced itch is attenuated by mouse mast cell tryptase and carboxypeptidase A3