Gunnar Pejler

Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches

Derakhshani, Afshin; Mahajan, Leela; Lesack, Kyle; Saranjam, Navid et al.

Ingår i Pharmacological Reviews, 2026

• DOI för Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches
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Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway

Vraila, Marianthi; Frisk, Jun Mei Hu; Mayavannan, Animamalar; Grujic, Mirjana et al.

Ingår i Cell Death Discovery, 2026

• DOI för Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway
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Serglycin modulates inflammation and metabolism in macrophages

Porteymour, Shirin; Das Sajib, Saikat; von Hofsten, Susannah; Doncheva, Atanaska I. et al.

Ingår i iScience, 2026

• DOI för Serglycin modulates inflammation and metabolism in macrophages
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Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma

Pejler, Gunnar; Paivandy, Aida; Melo, Fabio R.; Allam, Venkata et al.

Ingår i Inflammation, 2026

• DOI för Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma
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Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells

Pano, Filip; Bub, Laura; Parrine, Debora; Paivandy, Aida et al.

Ingår i Cell Death Discovery, 2025

• DOI för Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells
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Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway

Vraila, Marianthi; Frisk, Jun Mei Hu; Mayavannan, Animamalar; Grujic, Mirjana et al.

Ingår i Cell Death Discovery, 2026

• DOI för Trifluoperazine causes mast cell apoptosis through a secretory granule-mediated pathway
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Serglycin modulates inflammation and metabolism in macrophages

Porteymour, Shirin; Das Sajib, Saikat; von Hofsten, Susannah; Doncheva, Atanaska I. et al.

Ingår i iScience, 2026

• DOI för Serglycin modulates inflammation and metabolism in macrophages
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Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma

Pejler, Gunnar; Paivandy, Aida; Melo, Fabio R.; Allam, Venkata et al.

Ingår i Inflammation, 2026

• DOI för Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma
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Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells

Pano, Filip; Bub, Laura; Parrine, Debora; Paivandy, Aida et al.

Ingår i Cell Death Discovery, 2025

• DOI för Mast cell tryptase induces nuclear remodelling and reduced growth in breast cancer cells
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Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria

von Beek, Christopher; Prensa, Grisna I.; Andersson, Julia H. M.; Pejler, Gunnar et al.

Ingår i European Journal of Immunology, 2025

• DOI för Mast Cell Phenotypic Heterogeneity Impacts the Interplay with Pathogenic Salmonella Typhimurium Bacteria
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Melanoma cells suppress mast cell function via a melanin-dependent mechanism

Melo, Fabio R.; Nyman, Lea; Österman Menander, Ida; Grujic, Mirjana et al.

Ingår i The FEBS Journal, s. 6075-6099, 2025

• DOI för Melanoma cells suppress mast cell function via a melanin-dependent mechanism
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Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice

Allam, Venkata; Akula, Srinivas; Waern, Ida; Taha, Sowsan et al.

Ingår i Inflammation, s. 806-819, 2025

• DOI för Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice
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Targeting carboxypeptidase A/B activity with the phosphinic inhibitor C28 reduces the asthmatic response in a mouse model of house dust mite-induced asthma

Allam, Venkata Sita Rama Raju; Montpeyó, David; Beau, Fabrice; Taha, Sowsan et al.

Ingår i Inflammation Research, 2025

• DOI för Targeting carboxypeptidase A/B activity with the phosphinic inhibitor C28 reduces the asthmatic response in a mouse model of house dust mite-induced asthma
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Targeting of the IL-5 pathway in severe asthma reduces mast cell progenitors

Alvarado-Vazquez, Perla Abigail; Méndez-Enriquez, Erika; Salomonsson, Maya; Kopac, Peter et al.

Ingår i Journal of Allergy and Clinical Immunology, s. 1310-1320, 2025

• DOI för Targeting of the IL-5 pathway in severe asthma reduces mast cell progenitors
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Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier

Lundquist, Patrik; Hagforsen, Eva; Wagner, Michael; Alimohammadi, Mohammad et al.

Ingår i Biochimica et Biophysica Acta - Molecular Basis of Disease, 2025

• DOI för Mild-to-moderate psoriasis is associated with subclinical inflammation in the duodenum and a tendency of disturbed intestinal barrier
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Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation

Grujic, Mirjana; Alim, Md Abdul; Hellman, Lars; Peterson, Magnus et al.

Ingår i Inflammation, s. 1820-1836, 2024

• DOI för Mast Cells are Dependent on Glucose Transporter 1 (GLUT1) and GLUT3 for IgE-mediated Activation
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A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection

von Beek, Christopher; Fahlgren, Anna; Geiser, Petra; Di Martino, Maria Letizia et al.

Ingår i Nature Communications, 2024

• DOI för A two-step activation mechanism enables mast cells to differentiate their response between extracellular and invasive enterobacterial infection
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Mast cell chymase suppresses functional parameters in primary human airway smooth muscle cells

Zhao, Xinran O.; Melo, Fabio Rabelo; Sommerhoff, Christian P.; Paivandy, Aida et al.

Ingår i Allergy. European Journal of Allergy and Clinical Immunology, s. 2524-2527, 2024

• DOI för Mast cell chymase suppresses functional parameters in primary human airway smooth muscle cells
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Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

Akula, Srinivas; Alvarado-Vazquez, Abigail; Mendez Enriquez, Erika Haide; Bal, Gürkan et al.

Ingår i International Journal of Molecular Sciences, 2024

• DOI för Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4⁺ and CD8⁺ T Cells, and Skin Mast Cells by Quantitative Transcriptomics
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Blockade of endolysosomal acidification suppresses TLR3-mediated proinflammatory signaling in airway epithelial cells

Pejler, Gunnar; Zhao, Xinran O.; Fagerström, Ella; Paivandy, Aida

Ingår i Journal of Allergy and Clinical Immunology, s. 940-951, 2024

• DOI för Blockade of endolysosomal acidification suppresses TLR3-mediated proinflammatory signaling in airway epithelial cells
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Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3K beta

Kardeby, Caroline; Evans, Alice; Campos, Joana; Al-Wahaibi, Afraa Moosa et al.

Ingår i Journal of Thrombosis and Haemostasis, s. 101-116, 2023

• DOI för Heparin and heparin proteoglycan-mimetics activate platelets via PEAR1 and PI3K beta
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Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model

Lapointe, Catherine; Vincent, Laurence; Giguere, Hugo; Auger-Messier, Mannix et al.

Ingår i Journal of the American Heart Association, 2023

• DOI för Chymase Inhibition Resolves and Prevents Deep Vein Thrombosis Without Increasing Bleeding Time in the Mouse Model
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Therapeutic administration of mouse mast cell protease 6 improves functional recovery after traumatic spinal cord injury in mice by promoting remyelination and reducing glial scar formation

Vangansewinkel, Tim; Lemmens, Stefanie; Tiane, Assia; Geurts, Nathalie et al.

Ingår i The FASEB Journal, 2023

• DOI för Therapeutic administration of mouse mast cell protease 6 improves functional recovery after traumatic spinal cord injury in mice by promoting remyelination and reducing glial scar formation
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Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity

Allam, Venkata; Waern, Ida; Taha, Sowsan; Akula, Srinivas et al.

Ingår i Frontiers in Immunology, 2023

• DOI för Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity
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Monensin induces secretory granule-mediated cell death in eosinophils

Vraila, Marianthi; Asp, Elin; Melo, Fabio R.; Grujic, Mirjana et al.

Ingår i Journal of Allergy and Clinical Immunology, 2023

• DOI för Monensin induces secretory granule-mediated cell death in eosinophils
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Absence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitis

Dahlberg, Josef; Johnzon, Carl-Fredrik; Sun, Li; Pejler, Gunnar et al.

Ingår i Veterinary research (Print), 2023

• DOI för Absence of changes in the milk microbiota during Escherichia coli endotoxin induced experimental bovine mastitis
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Phenotypic Switch and Growth of Melanoma Spheroids in the Presence of Mast Cells: Potential Impact of Nutrient-starvation Effects

Grujic, Mirjana; Nguyen, Thanh; Héchard, Tifaine; Wang, Helen et al.

Ingår i Anticancer Research, s. 1415-1426, 2023

• DOI för Phenotypic Switch and Growth of Melanoma Spheroids in the Presence of Mast Cells: Potential Impact of Nutrient-starvation Effects
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Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue

Meen, Astri J.; Doncheva, Atanaska I.; Boettcher, Yvonne; Dankel, Simon N. et al.

Ingår i International Journal of Molecular Sciences, 2023

• DOI för Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue
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Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress.

Cedervall, Jessica; Herre, Melanie; Dragomir, Anca; Rabelo-Melo, F et al.

Ingår i Oncoimmunology, 2022

• DOI för Neutrophil extracellular traps promote cancer-associated inflammation and myocardial stress.
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Monensin induces selective mast cell apoptosis through a secretory granule-mediated pathway.

Maccarana, Marco; Liu, Jielu; Lampinen, Maria; Rollman, Ola et al.

Ingår i Allergy. European Journal of Allergy and Clinical Immunology, s. 1025-1028, 2022

• DOI för Monensin induces selective mast cell apoptosis through a secretory granule-mediated pathway.
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Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems

Paivandy, Aida; Akula, Srinivas; Lara, Sandra; Fu, Zhirong et al.

Ingår i International Journal of Molecular Sciences, 2022

• DOI för Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems
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Tryptase reference values in a Swedish middle-aged general population and association with diabetes mellitus

Vitte, Joana; Sjölander, Anders; Rydell, Niclas; Molin, Magnus et al.

Ingår i Clinical and Experimental Allergy, s. 1330-1333, 2022

• DOI för Tryptase reference values in a Swedish middle-aged general population and association with diabetes mellitus
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Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma

Zhao, Xinran; Lampinen, Maria; Rollman, Ola; Sommerhoff, Christian P et al.

Ingår i Journal of Allergy and Clinical Immunology, s. 718-727, 2022

• DOI för Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma
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Mast cell chymase regulates extracellular matrix remodeling-related events in primary human small airway epithelial cells

Zhao, xinzh765; Sommerhoff, Christian P.; Paivandy, Aida; Pejler, Gunnar

Ingår i Journal of Allergy and Clinical Immunology, s. 1534-1544, 2022

• DOI för Mast cell chymase regulates extracellular matrix remodeling-related events in primary human small airway epithelial cells
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Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders

Frisk, Junmei Hu; Orn, Stefan; Pejler, Gunnar; Eriksson, Staffan et al.

Ingår i BMC Neuroscience, 2022

• DOI för Differential expression of enzymes in thymidylate biosynthesis in zebrafish at different developmental stages: implications for dtymk mutation-caused neurodegenerative disorders
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Mefloquine causes selective mast cell apoptosis in cutaneous mastocytosis lesions by a secretory granule-mediated pathway

Lampinen, Maria; Hagforsen, Eva; Weström, Simone; Bergström, Anna et al.

Ingår i Experimental dermatology, s. 1729-1740, 2022

• DOI för Mefloquine causes selective mast cell apoptosis in cutaneous mastocytosis lesions by a secretory granule-mediated pathway
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Mast cell tryptase potentiates neutrophil extracellular trap formation

Pejler, Gunnar; Alanazi, Sultan; Grujic, Mirjana; Adler, Jeremy et al.

Ingår i Journal of Innate Immunity, s. 433-446, 2022

• DOI för Mast cell tryptase potentiates neutrophil extracellular trap formation
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Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase

Hu Frisk, Junmei; Pejler, Gunnar; Eriksson, Staffan; Wang, Liya

Ingår i Nucleosides, Nucleotides & Nucleic Acids, s. 1305-1317, 2022

• DOI för Heavy metal tolerance of Mesorhizobium delmotii thymidylate kinase
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Structural and functional analysis of human thymidylate kinase isoforms

Frisk, Junmei Hu; Pejler, Gunnar; Eriksson, Staffan; Wang, Liya

Ingår i Nucleosides, Nucleotides & Nucleic Acids, s. 321-332, 2022

• DOI för Structural and functional analysis of human thymidylate kinase isoforms
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Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models

Liu, Jielu; Nie, Mu; Dong, Caijuan; Säfholm, Jesper et al.

Ingår i Scientific Reports, 2022

• DOI för Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models
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Mast cell chymase has a negative impact on human osteoblasts

Lind, Thomas; Melo, Fabio R.; Gustafson, Ann-Marie; Sundqvist, Anders et al.

Ingår i Matrix Biology, s. 1-19, 2022

• DOI för Mast cell chymase has a negative impact on human osteoblasts
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Serglycin Is Involved in Adipose Tissue Inflammation in Obesity

Doncheva, Atanaska; Norheim, Frode A.; Hjorth, Marit; Grujic, Mirjana et al.

Ingår i Journal of Immunology, s. 121-132, 2022

• DOI för Serglycin Is Involved in Adipose Tissue Inflammation in Obesity

Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells

Alanazi, Sultan; Melo, Fabio Rabelo; Pejler, Gunnar

Ingår i Frontiers in Immunology, 2021

• DOI för Tryptase Regulates the Epigenetic Modification of Core Histones in Mast Cell Leukemia Cells
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Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells

von Beek, Christopher; Alriksson, Linnéa; Palle, Josefine; Gustafson, Ann-Marie et al.

Ingår i PLOS ONE, 2021

• DOI för Dynamin inhibition causes context-dependent cell death of leukemia and lymphoma cells
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Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin

Chanzu, Harry; Lykins, Joshua; Wigna-Kumar, Subershan; Joshi, Smita et al.

Ingår i Journal of Thrombosis and Haemostasis, s. 1082-1095, 2021

• DOI för Platelet α-granule cargo packaging and release are affected by the luminal proteoglycan, serglycin

Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity

Frisk, Junmei Hu; Vanoevelen, Jo M.; Bierau, Jorgen; Pejler, Gunnar et al.

Ingår i ACS Omega, s. 33943-33952, 2021

• DOI för Biochemical Characterizations of Human TMPK Mutations Identified in Patients with Severe Microcephaly: Single Amino Acid Substitutions Impair Dimerization and Abolish Their Catalytic Activity
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Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells

Alim, Abdul; Grujic, Mirjana; Ackerman, Paul W; Kristiansson, Per et al.

Ingår i Cellular & Molecular Immunology, s. 2383-2392, 2021

• DOI för Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells
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Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I

Vincent, Laurence; Lapointe, Catherine; Lo, Modou; Gagnon, Hugo et al.

Ingår i Journal of Pharmacology and Experimental Therapeutics, s. 213-221, 2021

• DOI för Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I

Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1

Magnúsdóttir, Elín Ingibjörg; Grujic, Mirjana; Bergman, Jessica; Pejler, Gunnar et al.

Ingår i Journal of Neuroinflammation, 2020

• DOI för Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1
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Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA

Alanazi, Sultan; Grujic, Mirjana; Lampinen, Maria; Rollman, Ola et al.

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA
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Histone Methyltransferase Inhibition Has a Cytotoxic Impact on Transformed Mast Cells: Implications for Mastocytosis

Alanazi, Sultan; Melo, Fabio R.; Pejler, Gunnar

Ingår i Anticancer Research, s. 2525-2536, 2020

• DOI för Histone Methyltransferase Inhibition Has a Cytotoxic Impact on Transformed Mast Cells: Implications for Mastocytosis

DNA demethylation regulates gene expression in IgE-activated mouse mast cells.

Paivandy, Aida; Grujic, Mirjana; Rafati, Nima; Pejler, Gunnar

Ingår i Allergy. European Journal of Allergy and Clinical Immunology, s. 1776-1780, 2020

• DOI för DNA demethylation regulates gene expression in IgE-activated mouse mast cells.
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Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Grujic, Mirjana; Hellman, Lars; Gustafson, Ann-Marie; Akula, Srinivas et al.

Ingår i Pigment Cell & Melanoma Research, s. 579-590, 2020

• DOI för Protective role of mouse mast cell tryptase Mcpt6 in melanoma.

Identification of a novel thymidylate kinase activity.

Frisk, Junmei Hu; Eriksson, Staffan; Pejler, Gunnar; Wang, Liya

Ingår i Nucleosides, Nucleotides & Nucleic Acids, s. 1359-1368, 2020

• DOI för Identification of a novel thymidylate kinase activity.

How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Ingår i Cells, 2020

• DOI för How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells?: A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells
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Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium

Hallgren, Jenny; Hellman, Lars; Maurer, Marcus; Nilsson, Gunnar P. et al.

Ingår i Allergy. European Journal of Allergy and Clinical Immunology, s. 707-708, 2020

• DOI för Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium
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Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

Akula, Srinivas; Paivandy, Aida; Fu, Zhirong; Thorpe, Michael et al.

Ingår i CELLS, 2020

• DOI för Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity
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Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment

Madjene, Lydia Celia; Danelli, Luca; Dahdah, Albert; Vibhushan, Shamila et al.

Ingår i Kidney International, s. 516-527, 2020

• DOI för Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment

Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism

von Beek, Christopher; Waern, Ida; Eriksson, Jens; Melo, Fabio R. et al.

Ingår i Cellular Microbiology, 2019

• DOI för Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism
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Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression

Melo, Fabio R.; Martin, Sebastin Santosh; Sommerhoff, Christian P.; Pejler, Gunnar

Ingår i Cell Death and Disease, 2019

• DOI för Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression
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Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury

Vangansewinkel, Tim; Lemmens, Stefanie; Geurts, Nathalie; Quanten, Kirsten et al.

Ingår i Scientific Reports, 2019

• DOI för Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury
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The Absence of Tryptase Mcpt6 Causes Elevated Cellular Stress in Response to Modulation of the Histone Acetylation Status in Mast Cells

Martin, Sebastin Santosh; Melo, Fabio R.; Pejler, Gunnar

Ingår i Cells, 2019

• DOI för The Absence of Tryptase Mcpt6 Causes Elevated Cellular Stress in Response to Modulation of the Histone Acetylation Status in Mast Cells
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Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production

Paivandy, Aida; Eriksson, Jens; Melo, Fabio R.; Sellin, Mikael E. et al.

Ingår i Cell Death Discovery, 2019

• DOI för Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production
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The emerging role of mast cell proteases in asthma

Pejler, Gunnar

Ingår i European Respiratory Journal, 2019

Mouse Mast Cell Protease-4 Recruits Leukocytes in the Inflammatory Phase of Surgically Wounded Skin

Succar, Julien; Giatsidis, Giorgio; Yu, Nanze; Hassan, Kazi et al.

Ingår i ADVANCES IN WOUND CARE, s. 469-475, 2019

• DOI för Mouse Mast Cell Protease-4 Recruits Leukocytes in the Inflammatory Phase of Surgically Wounded Skin

Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1

Desbiens, Louisane; Lapointe, Catherine; Gendron, Louis; Gharagozloo, Marjan et al.

Ingår i Journal of Pharmacology and Experimental Therapeutics, s. 437-446, 2019

• DOI för Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1

Local delivery of temozolomide via a biologically inert carrier (Temodex) prolongs survival in glioma patients, irrespectively of the methylation status of MGMT

Karlsson, I; Veevnik, D.; Fedulov, A.; Yurkshtovich, N. et al.

Ingår i Neoplasma (Bratislava), s. 288-293, 2019

• DOI för Local delivery of temozolomide via a biologically inert carrier (Temodex) prolongs survival in glioma patients, irrespectively of the methylation status of MGMT

Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction

Houde, Martin; Schwertani, Adel; Touil, Hanene; Desbiens, Louisane et al.

Ingår i Frontiers in Pharmacology, 2018

• DOI för Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction
• Ladda ner fulltext (pdf) av Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction

Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules

Frisk, Jun Mei Hu; Kjellén, Lena; Melo, Fabio R.; Öhrvik, Helena et al.

Ingår i Frontiers in Immunology, 2018

• DOI för Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules
• Ladda ner fulltext (pdf) av Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules

The Effect of Lipopolysaccharide-Induced Experimental Bovine Mastitis on Clinical Parameters, Inflammatory Markers, and the Metabolome: A Kinetic Approach

Johnzon, Carl-Fredrik; Dahlberg, Josef; Gustafson, Ann-Marie; Waern, Ida et al.

Ingår i Frontiers in Immunology, 2018

• DOI för The Effect of Lipopolysaccharide-Induced Experimental Bovine Mastitis on Clinical Parameters, Inflammatory Markers, and the Metabolome: A Kinetic Approach
• Ladda ner fulltext (pdf) av The Effect of Lipopolysaccharide-Induced Experimental Bovine Mastitis on Clinical Parameters, Inflammatory Markers, and the Metabolome: A Kinetic Approach

Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment

Nyekel, Flavie Ngo; Pacreau, Emeline; Benadda, Samira; Msallam, Rasha et al.

Ingår i Frontiers in Immunology, 2018

• DOI för Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment
• Ladda ner fulltext (pdf) av Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment

Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin

Magnúsdóttir, Elín Ingibjörg; Grujic, Mirjana; Roers, Axel; Hartmann, Karin et al.

Ingår i Molecular Pain, 2018

• DOI för Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin
• Ladda ner fulltext (pdf) av Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin

Mast cell chymase decreases the severity of group B Streptococcus infections

Gendrin, Claire; Shubin, Nicholas J; Boldenow, Erica; Merillat, Sean et al.

Ingår i Journal of Allergy and Clinical Immunology, s. 120-129, 2018

• DOI för Mast cell chymase decreases the severity of group B Streptococcus infections

Acidic pH is essential for maintaining mast cell secretory granule homeostasis

Pejler, Gunnar; Frisk, Jun Mei Hu; Sjöström, Daniel; Paivandy, Aida et al.

Ingår i Cell Death and Disease, 2017

• DOI för Acidic pH is essential for maintaining mast cell secretory granule homeostasis
• Ladda ner fulltext (pdf) av Acidic pH is essential for maintaining mast cell secretory granule homeostasis

The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung

Grujic, Mirjana; Paivandy, Aida; Gustafson, Ann-Marie; Thomsen, Allan R. et al.

Ingår i Oncotarget, s. 25066-25079, 2017

• DOI för The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung
• Ladda ner fulltext (pdf) av The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung

Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells

Paivandy, Aida; Sandelin, Martin; Igelström, Helena; Landelius, Per et al.

Ingår i Frontiers in Immunology, 2017

• DOI för Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells
• Ladda ner fulltext (pdf) av Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells

Mast cells and McPT4 chymase Promote renal impairment after Partial Ureteral Obstruction

Pons, Maguelonne; Ali, Liza; Beghdadi, Walid; Danelli, Luca et al.

Ingår i Frontiers in Immunology, 2017

• DOI för Mast cells and McPT4 chymase Promote renal impairment after Partial Ureteral Obstruction
• Ladda ner fulltext (pdf) av Mast cells and McPT4 chymase Promote renal impairment after Partial Ureteral Obstruction

Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation

Shubin, Nicholas J.; Glukhova, Veronika A.; Clauson, Morgan; Truong, Phuong et al.

Ingår i Journal of Allergy and Clinical Immunology, s. 323-334, 2017

• DOI för Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation

Tryptase-catalyzed core histone truncation: A novel epigenetic regulatory mechanism in mast cells

Melo, Fabio R.; Wallerman, Ola; Paivandy, Aida; Calounova, Gabriela et al.

Ingår i Journal of Allergy and Clinical Immunology, s. 474-485, 2017

• DOI för Tryptase-catalyzed core histone truncation: A novel epigenetic regulatory mechanism in mast cells

Copper Regulates Maturation and Expression of an MITF: Tryptase Axis in Mast Cells

Hu Frisk, Jun Mei; Kjellén, Lena; Kaler, Stephen G; Pejler, Gunnar et al.

Ingår i Journal of Immunology, s. 4132-4141, 2017

• DOI för Copper Regulates Maturation and Expression of an MITF: Tryptase Axis in Mast Cells

Excessive dietary intake of vitamin A reduces skull bone thickness in mice

Lind, Thomas; Öhman, Caroline; Calounova, Gabriela; Rasmusson, Annica et al.

Ingår i PLOS ONE, 2017

• DOI för Excessive dietary intake of vitamin A reduces skull bone thickness in mice
• Ladda ner fulltext (pdf) av Excessive dietary intake of vitamin A reduces skull bone thickness in mice

Increased mast cell degranulation and co-localization of mast cells with the NMDA receptor-1 during healing after Achilles tendon rupture

Alim, Md Abdul; Ackermann, Paul W; Eliasson, Pernilla; Blomgran, Parmis et al.

Ingår i Cell and Tissue Research, s. 451-460, 2017

• DOI för Increased mast cell degranulation and co-localization of mast cells with the NMDA receptor-1 during healing after Achilles tendon rupture
• Ladda ner fulltext (pdf) av Increased mast cell degranulation and co-localization of mast cells with the NMDA receptor-1 during healing after Achilles tendon rupture

Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions

Hagforsen, Eva; Lampinen, Maria; Paivandy, Aida; Weström, Simone et al.

Ingår i British Journal of Dermatology, s. 179-187, 2017

• DOI för Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions
• Ladda ner fulltext (pdf) av Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions

Equine Airway Mast Cells are Sensitive to Cell Death Induced by Lysosomotropic Agents

Wernersson, S.; Riihimäki, M.; Pejler, Gunnar; Waern, I.

Ingår i Scandinavian Journal of Immunology, s. 30-34, 2017

• DOI för Equine Airway Mast Cells are Sensitive to Cell Death Induced by Lysosomotropic Agents

Inhibition of the BET family of epigenetic reader proteins: A novel principle for modulating gene expression in IgE-activated mast cells

Garcia-Faroldi, Gianni; Rönnberg, Elin; Grujic, Mirjana; Pejler, Gunnar

Ingår i Immunity, Inflammation and Disease, s. 141-150, 2017

• DOI för Inhibition of the BET family of epigenetic reader proteins: A novel principle for modulating gene expression in IgE-activated mast cells
• Ladda ner fulltext (pdf) av Inhibition of the BET family of epigenetic reader proteins: A novel principle for modulating gene expression in IgE-activated mast cells

IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction

Tejada, Thor; Tan, Lin; Torres, Rebecca A.; Calvert, John W. et al.

Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 6949-6954, 2016

• DOI för IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction

Live Staphylococcus aureus Induces Expression and Release of Vascular Endothelial Growth Factor in Terminally Differentiated Mouse Mast Cells

Johnzon, Carl-Fredrik; Rönnberg, Elin; Guss, Bengt; Pejler, Gunnar

Ingår i Frontiers in Immunology, 2016

• DOI för Live Staphylococcus aureus Induces Expression and Release of Vascular Endothelial Growth Factor in Terminally Differentiated Mouse Mast Cells

Mast cells promote melanoma colonization of lungs

Öhrvik, Helena; Grujic, Mirjana; Waern, Ida; Gustafson, Ann-Marie et al.

Ingår i Oncotarget, s. 68990-69001, 2016

• DOI för Mast cells promote melanoma colonization of lungs

Mastitis Pathogens with high Virulence in a Mouse Model Produce a Distinct cytokine Profile In Vivo

Johnzon, Carl-Fredrik; Artursson, Karin; Söderlund, Robert; Guss, Bengt et al.

Ingår i Frontiers in Immunology, 2016

• DOI för Mastitis Pathogens with high Virulence in a Mouse Model Produce a Distinct cytokine Profile In Vivo
• Ladda ner fulltext (pdf) av Mastitis Pathogens with high Virulence in a Mouse Model Produce a Distinct cytokine Profile In Vivo

Activated mast cells promote differentiation of B cells into effector cells

Palm, Anna-Karin E.; Garcia-Faroldi, Gianni; Lundberg, Marcus; Pejler, Gunnar et al.

Ingår i Scientific Reports, 2016

• DOI för Activated mast cells promote differentiation of B cells into effector cells

Increased Bone Mass in Female Mice Lacking Mast Cell Chymase

Lind, Thomas; Gustafson, Ann-Marie; Calounova, Gabriela; Hu, Lijuan et al.

Ingår i PLOS ONE, 2016

• DOI för Increased Bone Mass in Female Mice Lacking Mast Cell Chymase
• Ladda ner fulltext (pdf) av Increased Bone Mass in Female Mice Lacking Mast Cell Chymase

Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice

Houde, Martin; Desbiens, Louisane; Schwertani, Adel; Pejler, Gunnar et al.

Ingår i Life Sciences, s. 71-75, 2016

• DOI för Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice

IL-6 and IL-17A degradation by mast cells is mediated by a serglycin: serine protease axis

Waern, Ida; Karlsson, Iulia; Pejler, Gunnar; Wernersson, Sara

Ingår i Immunity, Inflammation and Disease, s. 70-79, 2016

• DOI för IL-6 and IL-17A degradation by mast cells is mediated by a serglycin: serine protease axis
• Ladda ner fulltext (pdf) av IL-6 and IL-17A degradation by mast cells is mediated by a serglycin: serine protease axis

Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis

Desbiens, Louisane; Lapointe, Catherine; Gharagozloo, Marjan; Mahmoud, Shaimaa et al.

Ingår i Mediators of Inflammation, 2016

• DOI för Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis
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Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

Sutton, Vivien R.; Brennan, Amelia J.; Ellis, Sarah; Danne, Jill et al.

Ingår i The FEBS Journal, s. 947-961, 2016

• DOI för Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity

Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6

Vangansewinkel, Tim; Geurts, Nathalie; Quanten, Kirsten; Nelissen, Sofie et al.

Ingår i The FASEB Journal, s. 2040-2057, 2016

• DOI för Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6

Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans

Öhrvik, Helena; Logeman, Brandon; Noguchi, Glyn; Eriksson, Inger et al.

Ingår i Journal of Immunology, s. 3654-3664, 2015

• DOI för Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans
• Ladda ner fulltext (pdf) av Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans

Induction of mast cell apoptosis by a novel secretory granule-mediated pathway.

Melo, Fabio R; Wernersson, Sara; Pejler, Gunnar

Ingår i Methods in Molecular Biology, s. 325-37, 2015

• DOI för Induction of mast cell apoptosis by a novel secretory granule-mediated pathway.

Serglycin protects against high fat diet-induced increase in plasma LDL in mice

Pejler, Gunnar

Ingår i Glycoconjugate Journal, 2015

Approaches for analyzing the roles of mast cells and their proteases in vivo

Galli, Stephen J; Tsai, Mindy; Marichal, Thomas; Tchougounova, Elena et al.

Ingår i Advances in Immunology, s. 45-127, 2015

• DOI för Approaches for analyzing the roles of mast cells and their proteases in vivo

Serglycin protects against high fat diet-induced increase in serum LDL in mice

Meen, Astri J; Drevon, Christian A; Pejler, Gunnar; Jenssen, Trond G et al.

Ingår i Glycoconjugate Journal, s. 703-714, 2015

• DOI för Serglycin protects against high fat diet-induced increase in serum LDL in mice

Damnacanthal inhibits IgE receptor-mediated activation of mast cells

Garcia-Vilas, Javier A.; Medina, Miguel A.; Melo, Fabio R.; Pejler, Gunnar et al.

Ingår i Molecular Immunology, s. 86-93, 2015

• DOI för Damnacanthal inhibits IgE receptor-mediated activation of mast cells

Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase

Semaan, Walid; Desbiens, Louisane; Houde, Martin; Labonte, Julie et al.

Ingår i Biochemical Pharmacology, s. 91-100, 2015

• DOI för Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase

Ablation of human skin mast cells in situ by lysosomotropic agents

Hagforsen, Eva; Paivandy, Aida; Lampinen, Maria; Weström, Simone et al.

Ingår i Experimental dermatology, s. 516-521, 2015

• DOI för Ablation of human skin mast cells in situ by lysosomotropic agents

MAST CELL GRANULES: ARMED WITH HISTAMINE AND FRIENDS

Pejler, Gunnar

Ingår i Inflammation Research, 2015

Nuclear Receptor 4a3 (Nr4a3) Regulates Murine Mast Cell Responses and Granule Content

Garcia-Faroldi, Gianni; Melo, Fabio R.; Bruemmer, Dennis; Conneely, Orla M. et al.

Ingår i PLOS ONE, 2014

• DOI för Nuclear Receptor 4a3 (Nr4a3) Regulates Murine Mast Cell Responses and Granule Content

Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo

Ronnberg, Elin; Johnzon, Carl-Fredrik; Calounova, Gabriela; Faroldi, Gianni Garcia et al.

Ingår i Immunology, s. 155-163, 2014

• DOI för Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo

Proteolytic Histone Modification by Mast Cell Tryptase, a Serglycin Proteoglycan-dependent Secretory Granule Protease

Melo, Fabio R.; Vita, Francesca; Berent-Maoz, Beata; Levi-Schaffer, Francesca et al.

Ingår i Journal of Biological Chemistry, s. 7682-7690, 2014

• DOI för Proteolytic Histone Modification by Mast Cell Tryptase, a Serglycin Proteoglycan-dependent Secretory Granule Protease

Serglycin Proteoglycan Promotes Apoptotic versus Necrotic Cell Death in Mast Cells

Melo, Fabio R.; Grujic, Mirjana; Spirkoski, Jane; Calounova, Gabriela et al.

Ingår i Journal of Biological Chemistry, s. 18142-18152, 2012

• DOI för Serglycin Proteoglycan Promotes Apoptotic versus Necrotic Cell Death in Mast Cells

Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing.

Henningsson, Frida; Ledin, Johan; Lunderius, Carolina; Wilén, M et al.

Ingår i Biological Chemistry, s. 793-801, 2002

Secretory granule proteases in rat mast cells: Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations

Lützelschwab, Claudia; Pejler, Gunnar; Aveskogh, Maria; Hellman, Lars

Ingår i Journal of Experimental Medicine, s. 13-29, 1997

• DOI för Secretory granule proteases in rat mast cells: Cloning of 10 different serine proteases and a carboxypeptidase A from various rat mast cell populations

Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches

Derakhshani, Afshin; Mahajan, Leela; Lesack, Kyle; Saranjam, Navid et al.

Ingår i Pharmacological Reviews, 2026

• DOI för Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches
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Tendon pain: what are the mechanisms behind it?

Ackermann, Paul W.; Alim, Md Abdul; Pejler, Gunnar; Peterson, Magnus

Ingår i Scandinavian Journal of Pain, s. 14-24, 2023

• DOI för Tendon pain: what are the mechanisms behind it?
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Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight

Allam, Venkata; Chellappan, Dinesh Kumar; Jha, Niraj Kumar; Shastri, Madhur D. et al.

Ingår i Critical reviews in food science and nutrition, s. 7576-7590, 2022

• DOI för Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight

The ingenious mast cell: Contemporary insights into mast cell behavior and function

Dahlin, Joakim S.; Maurer, Marcus; Metcalfe, Dean D.; Pejler, Gunnar et al.

Ingår i Allergy. European Journal of Allergy and Clinical Immunology, s. 83-99, 2022

• DOI för The ingenious mast cell: Contemporary insights into mast cell behavior and function
• Ladda ner fulltext (pdf) av The ingenious mast cell: Contemporary insights into mast cell behavior and function

Novel Strategies to Target Mast Cells in Disease

Paivandy, Aida; Pejler, Gunnar

Ingår i Journal of Innate Immunity, s. 131-147, 2021

• DOI för Novel Strategies to Target Mast Cells in Disease
• Ladda ner fulltext (pdf) av Novel Strategies to Target Mast Cells in Disease

Do Mast Cells Have a Role in Tendon Healing and Inflammation?

Alim, Abdul; Peterson, Magnus; Pejler, Gunnar

Ingår i Cells, 2020

• DOI för Do Mast Cells Have a Role in Tendon Healing and Inflammation?
• Ladda ner fulltext (pdf) av Do Mast Cells Have a Role in Tendon Healing and Inflammation?

Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors

Pejler, Gunnar

Ingår i Journal of Innate Immunity, s. 357-372, 2020

• DOI för Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors
• Ladda ner fulltext (pdf) av Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors

Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020

Maurer, Marcus; Eyerich, Kilian; Eyerich, Stefanie; Ferrer, Marta et al.

Ingår i International Archives of Allergy and Immunology, s. 321-333, 2020

• DOI för Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020
• Ladda ner fulltext (pdf) av Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020

The emerging role of mast cell proteases in asthma

Pejler, Gunnar

Ingår i European Respiratory Journal, 2019

• DOI för The emerging role of mast cell proteases in asthma

The controversial role of mast cells in fibrosis

Bradding, Peter; Pejler, Gunnar

Ingår i Immunological Reviews, s. 198-231, 2018

• DOI för The controversial role of mast cells in fibrosis

The Role of Mast Cells in Bacterial Infection

Johnzon, Carl-Fredrik; Ronnberg, Elin; Pejler, Gunnar

Ingår i American Journal of Pathology, s. 4-14, 2016

• DOI för The Role of Mast Cells in Bacterial Infection

Compound 48/80-induced itch is attenuated by mouse mast cell tryptase and carboxypeptidase A3

Magnúsdóttir, Elín Ingibjörg; Grujic, Mirjana; Pejler, Gunnar; Lagerström, Malin C.

Mouse mast cell tryptase and carboxypeptidase A3 play a protective role in itch induced by endothelin-1

Magnúsdóttir, Elín Ingibjörg; Grujic, Mirjana; Bergman, Jessica; Pejler, Gunnar et al.