Karin Hjort
Forskare vid Institutionen för medicinsk biokemi och mikrobiologi; Infektioner och Immunitet; Dan I Andersson
- Mobiltelefon:
- 018-471 45 74
- E-post:
- karin.hjort@imbim.uu.se
- Besöksadress:
- BMC
Husargatan 3
752 37 UPPSALA - Postadress:
- Box 582
751 23 UPPSALA
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Kort presentation
I am working as a senior researcher on antibiotic resistance. I am trying to understand how antibiotic resistance develops in clinical settings as well as in laboratory experiments.
- Antibiotic resistance development in biofilm.
- Understanding the genetic background of heteroresistance (a clonal sample with different levels of minimal inhibitory concentrations against antibiotics) in clinical samples.
- Antibiotic resistance development at sub-MIC concentrations of antibiotics
Nyckelord
- antibiotic resistance
- biofilm
- heteroresistance
- sub-mic
Biografi
My research are within a broad range of topics connected to Microbiology. I started with cell cycle regulation of hyperthermophilic Archaea, followed by microbial ecology and metagenomics to find enzymes that suppresses fungal growth, evolution of mitochondrial remnants and currently I am working with antibiotic resistance. Within antibiotic resistance I am perticular interested in resistance in biofilm, resistance development and mechanisms behind resistance in heteroresistance and at sub-inhibitory concentrations of antibiotics.
Publikationer
Senaste publikationer
- High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes (2024)
- Influence of surface characteristics of polypropylene on E. coli and S. aureus biofilms (2024)
- Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance (2024)
- Antibiofilm Properties of Linoleic Acid-loaded Bone Cement with and without Gentamicin (2023)
- Antibiotic Minimal Selective Concentrations and Fitness Costs during Biofilm and Planktonic Growth (2022)
Alla publikationer
Artiklar
- High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes (2024)
- Influence of surface characteristics of polypropylene on E. coli and S. aureus biofilms (2024)
- Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance (2024)
- Antibiotic Minimal Selective Concentrations and Fitness Costs during Biofilm and Planktonic Growth (2022)
- Modular 3D-Printed Peg Biofilm Device for Flexible Setup of Surface-Related Biofilm Studies (2022)
- Stable 3D Inertial Focusing by High Aspect Ratio Curved Microfluidics (2021)
- The highly dynamic nature of bacterial heteroresistance impairs its clinical detection (2021)
- A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy (2021)
- Antimicrobial Peptide Exposure Selects for Resistant and Fit Stenotrophomonas maltophilia Mutants That Show Cross-Resistance to Antibiotics (2020)
- Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment (2020)
- Structure-activity relationship studies on the inhibition of the bacterial translation of novel Odilorhabdins analogues (2020)
- Mechanisms and clinical relevance of bacterial heteroresistance (2019)
- Inhibition of translation termination by small molecules targeting ribosomal release factors (2019)
- The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification (2019)
- Evolution of high-level resistance during low-level antibiotic exposure (2018)
- Antimicrobial peptide exposure selects for Staphylococcus aureus resistance to human defence peptides (2017)
- Unstable tandem gene amplification generates heteroresistance (variation in resistance within a population) to colistin in Salmonella enterica (2016)
- Rolf Bernander (1956-2014) (2014)
- Bacterial chitinase with phytopathogen control capacity from suppressive soil revealed by functional metagenomics (2014)
- Time lapse investigation of antibiotic susceptibility using a microfluidic linear gradient 3D culture device (2014)
- Hydrogenosomes in the diplomonad Spironucleus salmonicida (2013)
- Bacterial community diversity in paper mills processing recycled paper. (2010)
- Chitinase genes revealed and compared in bacterial isolates, DNA extracts and a metagenomic library from a phytopathogen-suppressive soil. (2010)
- Diversity and reductive evolution of mitochondria among microbial eukaryotes (2010)
- Community structure of actively growing bacterial populations in plant pathogen suppressive soil. (2007)
- Eclipse-synchrony relationship in Escherichia coli strains with mutations affecting sequestration, initiation of replication and superhelicity of the bacterial chromosome. (2003)
- Convergent within-host evolution of a multi-resistant Klebsiella pneumoniae clone during a 5-year hospital outbreak
Konferenser
