Karin Hjort
Forskare vid Institutionen för medicinsk biokemi och mikrobiologi; Infektioner och Immunitet; Dan I Andersson
- E-post:
- karin.hjort@imbim.uu.se
- Besöksadress:
- BMC
Husargatan 3
752 37 UPPSALA - Postadress:
- Box 582
751 23 UPPSALA
Kort presentation
I am working as a senior researcher on antibiotic resistance. I am trying to understand how antibiotic resistance develops in clinical settings as well as in laboratory experiments.
- Antibiotic resistance development in biofilm.
- Understanding the genetic background of heteroresistance (a clonal sample with different levels of minimal inhibitory concentrations against antibiotics) in clinical samples.
- Antibiotic resistance development at sub-MIC concentrations of antibiotics
Nyckelord
- antibiotic resistance
- biofilm
- heteroresistance
- sub-mic
Biografi
My research are within a broad range of topics connected to Microbiology. I started with cell cycle regulation of hyperthermophilic Archaea, followed by microbial ecology and metagenomics to find enzymes that suppresses fungal growth, evolution of mitochondrial remnants and currently I am working with antibiotic resistance. Within antibiotic resistance I am perticular interested in resistance in biofilm, resistance development and mechanisms behind resistance in heteroresistance and at sub-inhibitory concentrations of antibiotics.

Publikationer
Senaste publikationer
Ingår i Polymer testing, 2025
- DOI för Influence of printing configuration on the resulting topology and antibacterial effectiveness of PVDF-graphene composites
- Ladda ner fulltext (pdf) av Influence of printing configuration on the resulting topology and antibacterial effectiveness of PVDF-graphene composites
Machine learning detection of heteroresistance in Escherichia coli
Ingår i EBioMedicine, 2025
- DOI för Machine learning detection of heteroresistance in Escherichia coli
- Ladda ner fulltext (pdf) av Machine learning detection of heteroresistance in Escherichia coli
Ingår i Lancet Microbe, 2025
- DOI för Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study
- Ladda ner fulltext (pdf) av Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study
Ingår i Nature Communications, 2024
- DOI för Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance
- Ladda ner fulltext (pdf) av Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance
Ingår i PLoS biology, 2024
- DOI för High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes
- Ladda ner fulltext (pdf) av High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes
Alla publikationer
Artiklar i tidskrift
Ingår i Polymer testing, 2025
- DOI för Influence of printing configuration on the resulting topology and antibacterial effectiveness of PVDF-graphene composites
- Ladda ner fulltext (pdf) av Influence of printing configuration on the resulting topology and antibacterial effectiveness of PVDF-graphene composites
Machine learning detection of heteroresistance in Escherichia coli
Ingår i EBioMedicine, 2025
- DOI för Machine learning detection of heteroresistance in Escherichia coli
- Ladda ner fulltext (pdf) av Machine learning detection of heteroresistance in Escherichia coli
Ingår i Nature Communications, 2024
- DOI för Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance
- Ladda ner fulltext (pdf) av Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance
Ingår i PLoS biology, 2024
- DOI för High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes
- Ladda ner fulltext (pdf) av High prevalence of heteroresistance in Staphylococcus aureus is caused by a multitude of mutations in core genes
Ingår i JAC - Antimicrobial Resistance, 2024
- DOI för Heteroresistance to piperacillin/tazobactam in Klebsiella pneumoniae is mediated by increased copy number of multiple β-lactamase genes
- Ladda ner fulltext (pdf) av Heteroresistance to piperacillin/tazobactam in Klebsiella pneumoniae is mediated by increased copy number of multiple β-lactamase genes
Ingår i Applied Materials Today, 2024
- DOI för Influence of surface characteristics of polypropylene on E. coli and S. aureus biofilms: From conventional to additive manufacturing of bioprocess equipment
- Ladda ner fulltext (pdf) av Influence of surface characteristics of polypropylene on E. coli and S. aureus biofilms: From conventional to additive manufacturing of bioprocess equipment
Modular 3D-Printed Peg Biofilm Device for Flexible Setup of Surface-Related Biofilm Studies
Ingår i Frontiers in Cellular and Infection Microbiology, 2022
- DOI för Modular 3D-Printed Peg Biofilm Device for Flexible Setup of Surface-Related Biofilm Studies
- Ladda ner fulltext (pdf) av Modular 3D-Printed Peg Biofilm Device for Flexible Setup of Surface-Related Biofilm Studies
Antibiotic Minimal Selective Concentrations and Fitness Costs during Biofilm and Planktonic Growth
Ingår i mBio, 2022
The highly dynamic nature of bacterial heteroresistance impairs its clinical detection
Ingår i Communications Biology, 2021
- DOI för The highly dynamic nature of bacterial heteroresistance impairs its clinical detection
- Ladda ner fulltext (pdf) av The highly dynamic nature of bacterial heteroresistance impairs its clinical detection
Stable 3D Inertial Focusing by High Aspect Ratio Curved Microfluidics
Ingår i Journal of Micromechanics and Microengineering, 2021
- DOI för Stable 3D Inertial Focusing by High Aspect Ratio Curved Microfluidics
- Ladda ner fulltext (pdf) av Stable 3D Inertial Focusing by High Aspect Ratio Curved Microfluidics
A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
Ingår i Scientific Reports, 2021
- DOI för A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
- Ladda ner fulltext (pdf) av A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy
Ingår i Journal of Infectious Diseases, s. 1011-1020, 2020
- DOI för Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment
- Ladda ner fulltext (pdf) av Dynamics of Extensive Drug Resistance Evolution of Mycobacterium tuberculosis in a Single Patient During 9 Years of Disease and Treatment
Ingår i mSphere, 2020
- DOI för Antimicrobial Peptide Exposure Selects for Resistant and Fit Stenotrophomonas maltophilia Mutants That Show Cross-Resistance to Antibiotics
- Ladda ner fulltext (pdf) av Antimicrobial Peptide Exposure Selects for Resistant and Fit Stenotrophomonas maltophilia Mutants That Show Cross-Resistance to Antibiotics
Ingår i Bioorganic & Medicinal Chemistry, 2020
Inhibition of translation termination by small molecules targeting ribosomal release factors
Ingår i Scientific Reports, 2019
- DOI för Inhibition of translation termination by small molecules targeting ribosomal release factors
- Ladda ner fulltext (pdf) av Inhibition of translation termination by small molecules targeting ribosomal release factors
Ingår i Nature Microbiology, s. 504-514, 2019
Evolution of high-level resistance during low-level antibiotic exposure
Ingår i Nature Communications, 2018
- DOI för Evolution of high-level resistance during low-level antibiotic exposure
- Ladda ner fulltext (pdf) av Evolution of high-level resistance during low-level antibiotic exposure
Ingår i Journal of Antimicrobial Chemotherapy, s. 115-127, 2017
- DOI för Antimicrobial peptide exposure selects for Staphylococcus aureus resistance to human defence peptides
- Ladda ner fulltext (pdf) av Antimicrobial peptide exposure selects for Staphylococcus aureus resistance to human defence peptides
Ingår i Molecular Microbiology, s. 274-289, 2016
- DOI för Unstable tandem gene amplification generates heteroresistance (variation in resistance within a population) to colistin in Salmonella enterica
- Ladda ner fulltext (pdf) av Unstable tandem gene amplification generates heteroresistance (variation in resistance within a population) to colistin in Salmonella enterica
Rolf Bernander (1956-2014): pioneer of the archaeal cell cycle Obituary
Ingår i Molecular Microbiology, s. 903-909, 2014
Ingår i Lab on a Chip, s. 3409-3418, 2014
Ingår i Applied Microbiology and Biotechnology, s. 2819-2828, 2014
- DOI för Bacterial chitinase with phytopathogen control capacity from suppressive soil revealed by functional metagenomics
- Ladda ner fulltext (pdf) av Bacterial chitinase with phytopathogen control capacity from suppressive soil revealed by functional metagenomics
Hydrogenosomes in the diplomonad Spironucleus salmonicida
Ingår i Nature Communications, s. 2493, 2013
Ingår i FEMS Microbiology Ecology, s. 197-207, 2010
Bacterial community diversity in paper mills processing recycled paper.
Ingår i Journal of Industrial Microbiology & Biotechnology, s. 1061-9, 2010
Diversity and reductive evolution of mitochondria among microbial eukaryotes
Ingår i Philosophical Transactions of the Royal Society of London. Biological Sciences, s. 713-27, 2010
Community structure of actively growing bacterial populations in plant pathogen suppressive soil.
Ingår i Microbial Ecology, s. 399-413, 2007
Ingår i Journal of Molecular Biology, s. 919-31, 2003
Artiklar, forskningsöversikt
Mechanisms and clinical relevance of bacterial heteroresistance
Ingår i Nature Reviews Microbiology, s. 479-496, 2019
Konferensbidrag
Investigation of linoleic acid as an antibacterial additive in bone cement
2024
Antibiofilm Properties of Linoleic Acid-loaded Bone Cement with and without Gentamicin
Ingår i 33rd Annual Conference of the European Society for Biomaterials, s. 46-46, 2023
A microfluidic approach for dynamic investigation of the antibiotic susceptibility of bacteria
Ingår i MME 2013 24th Micromechanics and Microsystems Europe Conference, 2013
Manuskript (preprint)
Övriga
Ingår i Lancet Microbe, 2025
- DOI för Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study
- Ladda ner fulltext (pdf) av Prevalence, misclassification, and clinical consequences of the heteroresistant phenotype in Escherichia coli bloodstream infections in patients in Uppsala, Sweden: a retrospective cohort study