Rolf Larsson

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Mansoori, Sharmineh; Blom, Kristin; Andersson, Claes; Fryknäs, Mårten et al.

Ingår i Oncology Reports, 2026

• DOI för Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model
• Ladda ner fulltext (pdf) av Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Ingår i Scientific Reports, 2026

• DOI för Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus
• Ladda ner fulltext (pdf) av Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients

Enblad, Anna Pia; Krali, Olga; Gezelius, Henrik; Lundmark, Anders et al.

Ingår i HemaSphere, 2025

• DOI för Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients
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Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Selvin, Tove; Berglund, Malin; Akerstrom, Anders; Zia, Marco et al.

Ingår i SLAS TECHNOLOGY, 2024

• DOI för Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models
• Ladda ner fulltext (pdf) av Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Ingår i BMC Pharmacology & Toxicology, 2024

• DOI för Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
• Ladda ner fulltext (pdf) av Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Mansoori, Sharmineh; Blom, Kristin; Andersson, Claes; Fryknäs, Mårten et al.

Ingår i Oncology Reports, 2026

• DOI för Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model
• Ladda ner fulltext (pdf) av Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells ex vivo and in an in vivo mouse model

Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Eloranta, Maija-Leena; Nygren, Peter; Larsson, Rolf; Loskog, Angelica et al.

Ingår i Scientific Reports, 2026

• DOI för Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus
• Ladda ner fulltext (pdf) av Efficacy of mebendazole in the spontaneous NZBxNZWF1 animal model of systemic lupus erythematosus

Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients

Enblad, Anna Pia; Krali, Olga; Gezelius, Henrik; Lundmark, Anders et al.

Ingår i HemaSphere, 2025

• DOI för Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients
• Ladda ner fulltext (pdf) av Ex vivo drug responses and molecular profiles of 597 pediatric acute lymphoblastic leukemia patients

Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Selvin, Tove; Berglund, Malin; Akerstrom, Anders; Zia, Marco et al.

Ingår i SLAS TECHNOLOGY, 2024

• DOI för Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models
• Ladda ner fulltext (pdf) av Exploratory insights from the immuno-oncology hollow fiber assay: A pilot approach bridging In Vitro and In Vivo models

Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Lindskog, Magnus et al.

Ingår i BMC Pharmacology & Toxicology, 2024

• DOI för Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment
• Ladda ner fulltext (pdf) av Immuno-oncological effects of standard anticancer agents and commonly used concomitant drugs: an in vitro assessment

Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Selvin, Tove; Berglund, Malin; Lenhammar, Lena; Jarvius, Malin et al.

Ingår i BMC Cancer, 2023

• DOI för Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death
• Ladda ner fulltext (pdf) av Phenotypic screening platform identifies statins as enhancers of immune cell-induced cancer cell death

Ex vivo assessment of chemotherapy sensitivity of colorectal cancer peritoneal metastases

Cashin, Peter; Söderström, Maria; Blom, Kristin; Artursson, Sara et al.

Ingår i British Journal of Surgery, s. 1080-1083, 2023

• DOI för Ex vivo assessment of chemotherapy sensitivity of colorectal cancer peritoneal metastases
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Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients

Andersson, Claes; Ye, Jiawei; Blom, Kristin; Fryknäs, Mårten et al.

Ingår i Anti-Cancer Drugs, s. 92-102, 2023

• DOI för Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients
• Ladda ner fulltext (pdf) av Assessment in vitro of interactions between anti-cancer drugs and noncancer drugs commonly used by cancer patients

Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells

Karlsson, Henning; Fryknäs, Mårten; Senkowski, Wojciech; Larsson, Rolf et al.

Ingår i Oncology Letters, 2022

• DOI för Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells
• Ladda ner fulltext (pdf) av Selective radiosensitization by nitazoxanide of quiescent clonogenic colon cancer tumour cells

Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome

Bjersand, Kathrine; Blom, Kristin; Sundström Poromaa, Inger; Stålberg, Karin et al.

Ingår i International Journal of Oncology, 2022

• DOI för Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome
• Ladda ner fulltext (pdf) av Ex vivo assessment of cancer drug sensitivity in epithelial ovarian cancer and its association with histopathological type, treatment history and clinical outcome

Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model

Selvin, Tove; Fasterius, Erik; Jarvius, Malin; Fryknäs, Mårten et al.

Ingår i Scientific Reports, 2022

• DOI för Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model
• Ladda ner fulltext (pdf) av Single-cell transcriptional pharmacodynamics of trifluridine in a tumor-immune model

Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Lu, Xi; Maturi, Naga Prathyusha; Jarvius, Malin; Yildirim, Irem et al.

Ingår i Nature Communications, 2022

• DOI för Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival
• Ladda ner fulltext (pdf) av Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

Nyberg, Frida; Blom, Kristin; Selvin, Tove; Rudfeldt, Jakob et al.

Ingår i Scientific Reports, 2022

• DOI för Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma
• Ladda ner fulltext (pdf) av Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma

A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer

Mansoori, Sharmineh; Fryknäs, Mårten; Alvfors, Carina; Loskog, Angelica et al.

Ingår i Scientific Reports, 2021

• DOI för A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer
• Ladda ner fulltext (pdf) av A phase 2a clinical study on the safety and efficacy of individualized dosed mebendazole in patients with advanced gastrointestinal cancer

DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)

Krali, Olga; Palle, J; Bäcklin, Christofer; Abrahamsson, Jonas et al.

Ingår i Genes, 2021

• DOI för DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)
• Ladda ner fulltext (pdf) av DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)

Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients

Bülow Anderberg, Sara; Luther, Tomas; Berglund, Malin; Larsson, Rolf et al.

Ingår i Cytokine, 2021

• DOI för Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients
• Ladda ner fulltext (pdf) av Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients

Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Byrgazov, Konstantin; Lind, Thomas; Rasmusson, Annica J.; Andersson, Claes et al.

Ingår i Bone Reports, 2021

• DOI för Melphalan flufenamide inhibits osteoclastogenesis by suppressing proliferation of monocytes

Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide

Byrgazov, Konstantin; Andersson, Claes; Salzer, Benjamin; Bozsaky, Eva et al.

Ingår i Therapeutic Advances in Medical Oncology, 2020

• DOI för Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide
• Ladda ner fulltext (pdf) av Targeting aggressive osteosarcoma with a peptidase-enhanced cytotoxic melphalan flufenamide

Antibacterial pyrrolidinyl and piperidinyl substituted 2,4-diacetylphloroglucinols from Pseudomonas protegens UP46

Levenfors, Jolanta J.; Nord, Christina; Bjerketorp, Joakim; Stahlberg, Jerry et al.

Ingår i Journal of antibiotics (Tokyo. 1968), s. 739-747, 2020

• DOI för Antibacterial pyrrolidinyl and piperidinyl substituted 2,4-diacetylphloroglucinols from Pseudomonas protegens UP46

Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria

Nord, Christina; Bjerketorp, Joakim; Levenfors, Jolanta J.; Cao, Sha et al.

Ingår i ACS Chemical Biology, s. 2937-2944, 2020

• DOI för Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria
• Ladda ner fulltext (pdf) av Isopedopeptins A-H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria

Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway

Andersson, Claes; Selvin, Tove; Blom, Kristin; Rubin, Jenny et al.

Ingår i Scientific Reports, 2020

• DOI för Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway
• Ladda ner fulltext (pdf) av Mebendazole is unique among tubulin-active drugs in activating the MEK-ERK pathway

Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing.

Hartmann, Rafael; Fahrner, Raphael; Shevshenko, Denys; Fryknäs, Mårten et al.

Ingår i ChemMedChem, s. 2500-2512, 2020

• DOI för Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing.
• Ladda ner fulltext (pdf) av Rational Design of Azastatin as a Potential ADC Payload with Reduced Bystander Killing.

Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids

Steinmetz, Julia; Senkowski, Wojciech; Lengqvist, Johan; Rubin, Jenny et al.

Ingår i ACS Omega, s. 17242-17254, 2020

• DOI för Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids
• Ladda ner fulltext (pdf) av Descriptive Proteome Analysis to Investigate Context-Dependent Treatment Responses to OXPHOS Inhibition in Colon Carcinoma Cells Grown as Monolayer and Multicellular Tumor Spheroids

Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Blom, Kristin; Eriksson, Jenny; Berglund, Malin; Jarvius, Malin et al.

Ingår i BMC Research Notes, 2019

• DOI för Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition
• Ladda ner fulltext (pdf) av Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity

Niklasson, Mia; Bergström, Tobias; Jarvius, Malin; Sundström, Anders et al.

Ingår i Journal of Pathology, s. 295-307, 2019

• DOI för Mesenchymal transition and increased therapy resistance of glioblastoma cells is related to astrocyte reactivity

Ex vivo activity of cytotoxic drugs and targeted agents in small intestinal neuroendocrine tumors

Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

Ingår i Endocrine-Related Cancer, s. 471-480, 2018

• DOI för Ex vivo activity of cytotoxic drugs and targeted agents in small intestinal neuroendocrine tumors

Ex Vivo Activity of Cytotoxic Drugs and Targeted Agents in Small Intestinal Neuroendocrine Tumors

Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

Ingår i Neuroendocrinology, s. 189-189, 2018

• DOI för Ex Vivo Activity of Cytotoxic Drugs and Targeted Agents in Small Intestinal Neuroendocrine Tumors

Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Jiang, Yiwen; Marinescu, Voichita Dana; Xie, Yuan; Jarvius, Malin et al.

Ingår i Cell Reports, s. 977-990, 2017

• DOI för Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin
• Ladda ner fulltext (pdf) av Glioblastoma Cell Malignancy and Drug Sensitivity Are Affected by the Cell of Origin

Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.

Eriksson, Anna; Chantzi, Efthymia; Fryknäs, Mårten; Gullbo, Joachim et al.

Ingår i Leukemia Research, s. 41-46, 2017

• DOI för Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.
• Ladda ner fulltext (pdf) av Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects.

Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism

Kashif, Muhammad; Andersson, Claes; Mansoori, Sharmineh; Larsson, Rolf et al.

Ingår i Oncotarget, s. 103952-103967, 2017

• DOI för Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism
• Ladda ner fulltext (pdf) av Bliss and Loewe interaction analyses of clinically relevant drug combinations in human colon cancer cell lines reveal complex patterns of synergy and antagonism

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

Karlsson, Henning; Fryknäs, Mårten; Strese, Sara; Gullbo, Joachim et al.

Ingår i Oncotarget, s. 30217-30234, 2017

• DOI för Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity
• Ladda ner fulltext (pdf) av Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

In vitro and in vivo anti-leukemic activity of the peptidase-potentiated alkylator melflufen in acute myeloid leukemia

Strese, Sara; Hassan, Saadia Bashir; Velander, Ebba; Haglund, Caroline et al.

Ingår i Oncotarget, s. 6341-6352, 2017

• DOI för In vitro and in vivo anti-leukemic activity of the peptidase-potentiated alkylator melflufen in acute myeloid leukemia

Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Sreedharan, Smitha; Maturi, Naga Prathyusha; Xie, Yuan; Sundström, Anders et al.

Ingår i Cancer Research, s. 802-812, 2017

• DOI för Mouse models of pediatric supratentorial high-grade glioma reveal how cell-of-origin influences tumor development and phenotype

Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

De Rosa, Maria; Lu, Lu; Zamaratski, Edouard; Szałaj, Natalia et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 897-911, 2017

• DOI för Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)
• Ladda ner fulltext (pdf) av Design, synthesis and in vitro biological evaluation of oligopeptides targeting E. coli type I signal peptidase (LepB)

Mass spectrometry based metabolomics for in vitro systems pharmacology: pitfalls, challenges, and computational solutions.

Herman, Stephanie; Emami Khoonsari, Payam; Aftab, Obaid; Krishnan, Shibu et al.

Ingår i Metabolomics, 2017

• DOI för Mass spectrometry based metabolomics for in vitro systems pharmacology: pitfalls, challenges, and computational solutions.
• Ladda ner fulltext (pdf) av Mass spectrometry based metabolomics for in vitro systems pharmacology: pitfalls, challenges, and computational solutions.

Targeting tumor cells based on Phosphodiesterase 3A expression

Nazir, Madiha; Senkowski, Wojciech; Nyberg, Frida; Blom, Kristin et al.

Ingår i Experimental Cell Research, s. 308-315, 2017

• DOI för Targeting tumor cells based on Phosphodiesterase 3A expression

The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Blom, Kristin; Senkowski, Wojciech; Jarvius, Malin; Berglund, Malin et al.

Ingår i Immunopharmacology and immunotoxicology, s. 199-210, 2017

• DOI för The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

Predictive Value of Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy: A Meta-Analysis

Blom, Kristin; Nygren, Peter; Larsson, Rolf; Andersson, Claes R.

Ingår i SLAS TECHNOLOGY, s. 306-314, 2017

• DOI för Predictive Value of Ex Vivo Chemosensitivity Assays for Individualized Cancer Chemotherapy: A Meta-Analysis

Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Segerman, Anna; Niklasson, Mia; Haglund, Caroline; Bergström, Tobias et al.

Ingår i Cell Reports, s. 2994-3009, 2016

• DOI för Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition
• Ladda ner fulltext (pdf) av Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition

Characterizing the effects of epigenetic regulation in assays using peripheral blood mononuclear cells from patients with inflammatory diseases

Berg, L.; Sundström, Y.; Aftab, Obaid; Bergqvist, F. et al.

Ingår i Scandinavian Journal of Rheumatology, s. 44-45, 2016

In vitro and in vivo activity of melflufen (J1) in lymphoma

Delforoush, Maryam; Strese, Sara; Wickström, Malin; Larsson, Rolf et al.

Ingår i BMC Cancer, 2016

• DOI för In vitro and in vivo activity of melflufen (J1) in lymphoma

Preclinical activity of melflufen (J1) in ovarian cancer

Carlier, Charlotte; Strese, Sara; Viktorsson, Kristina; Velander, Ebba et al.

Ingår i Oncotarget, s. 59322-59335, 2016

• DOI för Preclinical activity of melflufen (J1) in ovarian cancer

Iron chelators target both proliferating and quiescent cancer cells

Fryknäs, Mårten; Zhang, Xiaonan; Bremberg, Ulf; Senkowski, Wojciech et al.

Ingår i Scientific Reports, 2016

• DOI för Iron chelators target both proliferating and quiescent cancer cells
• Ladda ner fulltext (pdf) av Iron chelators target both proliferating and quiescent cancer cells

Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Senkowski, Wojciech; Jarvius, Malin; Rubin, Jenny; Lengqvist, Johan et al.

Ingår i CELL CHEMICAL BIOLOGY, s. 1428-1438, 2016

• DOI för Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Repositioning Of Quinacrine For Treatment Of Acute Myeloid Leukemia - Synergies And In Vivo Effects

Eriksson, Anna; Gustafsson, Mats; Fryknäs, Mårten; Gullbo, Joachim et al.

Ingår i Haematologica, s. 367-368, 2016

Ex Vivo Assessment of Drug Activity in Patient Tumor Cells as a Basis for Tailored Cancer Therapy

Blom, Kristin; Nygren, Peter; Alvarsson, Jonathan; Larsson, Rolf et al.

Ingår i JALA, s. 178-187, 2016

• DOI för Ex Vivo Assessment of Drug Activity in Patient Tumor Cells as a Basis for Tailored Cancer Therapy

Vascular repair utilising immobilised heparin conjugate for protection against early activation of inflammation and coagulation

Nordling, Sofia; Hong, Jaan; Fromell, Karin; Edin, Fredrik et al.

Ingår i Thrombosis and Haemostasis, s. 1312-1322, 2015

• DOI för Vascular repair utilising immobilised heparin conjugate for protection against early activation of inflammation and coagulation

The Mutational Landscape in Pediatric Acute Lymphoblastic Leukemia Deciphered by Whole Genome Sequencing

Lindqvist, C Mårten; Nordlund, Jessica; Ekman, Diana; Johansson, Anna et al.

Ingår i Human Mutation, s. 118-128, 2015

• DOI för The Mutational Landscape in Pediatric Acute Lymphoblastic Leukemia Deciphered by Whole Genome Sequencing

Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

Aftab, Obaid; Fryknäs, Mårten; Hassan, Saadia; Nygren, Peter et al.

Ingår i Chemometrics and Intelligent Laboratory Systems, s. 24-32, 2015

• DOI för Label free quantification of time evolving morphologies using time-lapse video microscopy enables identity control of cell lines and discovery of chemically induced differential activity in iso-genic cell line pairs

Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Senkowski, Wojciech; Zhang, Xiaonan; Nygren, Peter; Olofsson, Maria Hagg et al.

Ingår i Cancer Research, 2015

• DOI för Spheroid-based high throughput screening for identification of molecules targeting different tumor microenvironment characteristics

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Isacson, Ruben et al.

Ingår i Molecular Cancer Therapeutics, s. 1504-1516, 2015

• DOI för Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Mazurkiewicz, Magdalena; Brnjic, Slavica; Fryknas, Marten; Sun, Chao et al.

Ingår i Cancer Research, 2015

• DOI för The anticancer activity of the DUB inhibitor b-AP15 is associated with accumulation of proteasome bound ubiquitin and oxidative stress

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

Eriksson, Anna; Österroos, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood Cancer Journal, 2015

• DOI för Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia
• Ladda ner fulltext (pdf) av Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index

Kashif, Muhammad; Andersson, Claes; Hassan, Sadia; Karlsson, Henning et al.

Ingår i Scientific Reports, 2015

• DOI för In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index
• Ladda ner fulltext (pdf) av In vitro discovery of promising anti-cancer drug combinations using iterative maximisation of a therapeutic index

DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

Nordlund, Jessica; Bäcklin, Christofer; Zachariadis, Vasilios; Cavelier, Lucia et al.

Ingår i Clinical Epigenetics, 2015

• DOI för DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia
• Ladda ner fulltext (pdf) av DNA methylation-based subtype prediction for pediatric acute lymphoblastic leukemia

Perfusion Of Porcine Kidneys With Macromolecular Heparin Ameliorates Early Ischemia Reperfusion Injury

Sedigh, Amir; Nordling, Sofia; Larsson, Rolf; Larsson, Erik et al.

Ingår i Transplant International, s. 94-95, 2015

Drug Sensitivity Testing in Cytoreductive Surgery and Intraperitoneal Chemotherapy of Pseudomyxoma Peritonei

Bjersand, Kathrine; Mahteme, Haile; Sundström Poromaa, Inger; Andreasson, Håkan et al.

Ingår i Annals of Surgical Oncology, 2015

• DOI för Drug Sensitivity Testing in Cytoreductive Surgery and Intraperitoneal Chemotherapy of Pseudomyxoma Peritonei

Detection of cell aggregation and altered cell viability by automated label-free video microscopy: A promising alternative to endpoint viability assays in high throughput screening

Aftab, Obaid; Fryknäs, Mårten; Hammerling, Ulf; Larsson, Rolf et al.

Ingår i Journal of Biomolecular Screening, s. 372-381, 2015

• DOI för Detection of cell aggregation and altered cell viability by automated label-free video microscopy: A promising alternative to endpoint viability assays in high throughput screening

Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

Kolosenko, Iryna; Fryknäs, Mårten; Forsberg, Sofi; Johnsson, Per et al.

Ingår i International Journal of Cancer, 2015

• DOI för Cell crowding induces interferon regulatory factor 9, which confers resistance to chemotherapeutic drugs

A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Senkowski, Wojciech; Zhang, Xiaonan; Olofsson, Maria Hagg; Linder, Stig et al.

Ingår i Cancer Research, 2014

• DOI för A spheroid-based screen identifies mitochondrial targeting as a promising strategy for cancer treatment and drug repositioning

Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Brnjic, Slavica; Mazurkiewicz, Magdalena; Fryknäs, Mårten; Sun, Chao et al.

Ingår i Antioxidants and Redox Signaling, s. 2271-2285, 2014

• DOI för Induction of Tumor Cell Apoptosis by a Proteasome Deubiquitinase Inhibitor Is Associated with Oxidative Stress

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Ingår i Nature Communications, s. 3295, 2014

The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Wang, Xin; Stafford, William; Mazurkiewicz, Magdalena; Fryknäs, Mårten et al.

Ingår i Molecular Pharmacology, s. 932-945, 2014

• DOI för The 19S Deubiquitinase Inhibitor b-AP15 Is Enriched in Cells and Elicits Rapid Commitment to Cell Death

Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Aftab, Obaid; Fryknäs, Mårten; Zhang, Xiaonan; De Milito, Angelo et al.

Ingår i Autophagy, s. 57-69, 2014

• DOI för Label-free detection and dynamic monitoring of drug-induced intracellular vesicle formation enabled using a 2-dimensional matched filter

Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy

Hultman, Bo; Mahteme, Haile; Sundbom, Magnus; Ljungman, Martin et al.

Ingår i Journal of Experimental & Clinical Cancer Research, 2014

• DOI för Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy
• Ladda ner fulltext (pdf) av Benchmarking of gastric cancer sensitivity to anti-cancer drugs ex vivo as a basis for drug selection in systemic and intraperitoneal therapy

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Zhang, Xiaonan; Fryknäs, Mårten; Hernlund, Emma; Fayad, Walid et al.

Ingår i Nature Communications, s. 3295, 2014

• DOI för Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments
• Ladda ner fulltext (pdf) av Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Antigen Signaling Enhances Proliferation and Cytotoxic Capacity of CD19-Targeting CD28/4-1BB CAR T Cells During Expansion Without Inducing Exhaustion

Karlsson, Hannah; Gigg, Camilla; Svensson, Emma; Larsson, Rolf et al.

Ingår i Molecular Therapy, 2014

Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome

von Heideman, Anne; Tholander, Bengt; Grundmark, Birgitta; Cajander, Stefan et al.

Ingår i Acta Oncologica, s. 242-250, 2014

• DOI för Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome

Modifying the vessel walls in porcine kidneys during machine perfusion

Sedigh, Amir; Larsson, Rolf; Brännström, Johan; Magnusson, Peetra et al.

Ingår i Journal of Surgical Research, s. 455-462, 2014

• DOI för Modifying the vessel walls in porcine kidneys during machine perfusion

Beneficial Effects of Coating Alginate Microcapsules with Macromolecular Heparin Conjugates-In Vitro and In Vivo Study

Vaithilingam, Vijayaganapathy; Kollarikova, Gabriela; Qi, Meirigeng; Larsson, Rolf et al.

Ingår i Tissue Engineering. Part A, s. 324-334, 2014

• DOI för Beneficial Effects of Coating Alginate Microcapsules with Macromolecular Heparin Conjugates-In Vitro and In Vivo Study

AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

Eriksson, Anna; Kalushkova, Antonia; Jarvius, Malin; Hilhorst, Riet et al.

Ingår i Biochemical Pharmacology, s. 284-291, 2014

• DOI för AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia
• Ladda ner fulltext (pdf) av AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia

Label free high throughput screening for apoptosis inducing chemicals using time-lapse microscopy signal processing

Aftab, Obaid; Nazir, Madiha; Fryknäs, Mårten; Hammerling, Ulf et al.

Ingår i Apoptosis (London), s. 1411-1418, 2014

• DOI för Label free high throughput screening for apoptosis inducing chemicals using time-lapse microscopy signal processing

Drug repositioning from bench to bedside: Tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer

Nygren, Peter; Larsson, Rolf

Ingår i Acta Oncologica, s. 427-428, 2014

• DOI för Drug repositioning from bench to bedside: Tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer

Identification of an inhibitor of the ubiquitin-proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function

Haglund, Caroline; Mohanty, Chitralekha; Fryknäs, Mårten; D'Arcy, Padraig et al.

Ingår i MedChemComm, s. 376-385, 2014

• DOI för Identification of an inhibitor of the ubiquitin-proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function
• Ladda ner fulltext (pdf) av Identification of an inhibitor of the ubiquitin-proteasome system that induces accumulation of polyubiquitinated proteins in the absence of blocking of proteasome function

A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Kashif, Muhammad; Andersson, Claes; Åberg, Magnus; Nygren, Peter et al.

Ingår i Molecular Cancer Therapeutics, s. 1964-1976, 2014

• DOI för A Pragmatic Definition of Therapeutic Synergy Suitable for Clinically Relevant In Vitro Multicompound Analyses

Repositioning of Quinacrine for Treatment of Acute Myeloid Leukemia

Eriksson, Anna; Osterros, Albin; Hassan, Sadia Bashir; Gullbo, Joachim et al.

Ingår i Blood, 2014

Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

Nordlund, Jessica; Bäcklin, Christofer L; Wahlberg, Per; Busche, Stephan et al.

Ingår i Genome Biology, 2013

• DOI för Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia

Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer

Cashin, Peter H; Mahteme, Haile; Graf, Wilhelm; Karlsson, Henning et al.

Ingår i BMC Cancer, s. 435, 2013

• DOI för Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer
• Ladda ner fulltext (pdf) av Activity ex vivo of cytotoxic drugs in patient samples of peritoneal carcinomatosis with special focus on colorectal cancer

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Fryknäs, Mårten; Gullbo, Joachim; Wang, Xin; Rickardson, Linda et al.

Ingår i BMC Cancer, s. 374, 2013

• DOI för Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance
• Ladda ner fulltext (pdf) av Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Effects of hypoxia on human cancer cell line chemosensitivity

Strese, Sara; Fryknäs, Mårten; Larsson, Rolf; Gullbo, Joachim

Ingår i BMC Cancer, s. 331, 2013

• DOI för Effects of hypoxia on human cancer cell line chemosensitivity
• Ladda ner fulltext (pdf) av Effects of hypoxia on human cancer cell line chemosensitivity

Attachment of macromolecular heparin conjugate to gelatin scaffolds improves endothelial cell infiltration

Leijon, Jonas; Carlsson, Fredrik; Brännström, Johan; Sanchez, Javier et al.

Ingår i Tissue Engineering. Parts A, B and C, s. 1336-1348, 2013

• DOI för Attachment of macromolecular heparin conjugate to gelatin scaffolds improves endothelial cell infiltration
• Ladda ner fulltext (pdf) av Attachment of macromolecular heparin conjugate to gelatin scaffolds improves endothelial cell infiltration

Evaluation of the blood compatibility of materials, cells and tissues: Basic concepts, test models and practical guidelines

Nilsson Ekdahl, Kristina; Hong, Jaan; Hamad, Osama; Larsson, Rolf et al.

Ingår i Advances in Experimental Medicine and Biology, s. 257-270, 2013

• DOI för Evaluation of the blood compatibility of materials, cells and tissues: Basic concepts, test models and practical guidelines

Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

Felth, Jenny; Lesiak-Mieczkowska, Karolina; Haglund, Caroline; Gullbo, Joachim et al.

Ingår i Investigational new drugs, s. 587-598, 2013

• DOI för Gambogic acid is cytotoxic to cancer cells through inhibition of the ubiquitin-proteasome system

Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo

Wickstrom, Malin; Dyberg, Cecilia; Shimokawa, Takashi; Milosevic, Jelena et al.

Ingår i International Journal of Cancer, s. 1516-1524, 2013

• DOI för Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Jarvius, Malin; Fryknäs, Mårten; D'Arcy, Padraig; Sun, Chao et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 117-123, 2013

• DOI för Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding

Tamm, Katia Pokrovskaja; Kolosenko, Iryna; Fryknäs, Mårten; Johnsson, Per et al.

Ingår i Cytokine, s. 303-303, 2013

• DOI för Association of interferon stimulated genes and IRF9 upregulation with drug resistance in multicellular spheroids and monolayer cells upon crowding

The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

Strese, Sara; Wickström, Malin; Fuchs, Peder Fredlund; Fryknäs, Mårten et al.

Ingår i Biochemical Pharmacology, s. 888-895, 2013

• DOI för The novel alkylating prodrug melflufen (J1) inhibits angiogenesis in vitro and in vivo

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

Nygren, Peter; Fryknäs, Mårten; Anagel, Bengt; Larsson, Rolf

Ingår i Journal of Cancer Research and Clinical Oncology, s. 2133-2140, 2013

• DOI för Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer
• Ladda ner fulltext (pdf) av Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Hernlund, Emma; Olofsson, Maria Hägg; Fayad, Walid; Fryknäs, Mårten et al.

Ingår i European Journal of Cancer, s. 396-406, 2012

• DOI för The phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 is effective in inhibiting regrowth of tumour cells after cytotoxic therapy

Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Dimberg, Lina Y.; Dimberg, Anna; Ivarsson, Karolina; Fryknäs, Mårten et al.

Ingår i BMC Cancer, s. 318, 2012

• DOI för Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma
• Ladda ner fulltext (pdf) av Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma

Conducting Nanocellulose Polypyrrole Membranes Intended for Hemodialysis

Carlsson, Daniel O; Ferraz, Natalia; Hong, Jaan; Larsson, Rolf et al.

Ingår i European Cells & Materials, s. 32-32, 2012

The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia

Eriksson, Anna; Hermanson, Monica; Wickström, Malin; Lindhagen, Elin et al.

Ingår i Blood Cancer Journal, 2012

• DOI för The novel tyrosine kinase inhibitor AKN-028 has significant antileukemic activity in cell lines and primary cultures of acute myeloid leukemia

Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

Karlsson, Henning; Fryknäs, Mårten; Larsson, Rolf; Nygren, Peter

Ingår i Experimental Cell Research, s. 1577-1585, 2012

• DOI för Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification

Ferraz, Natalia; Carlsson, Daniel O.; Hong, Jaan; Larsson, Rolf et al.

Ingår i Journal of the Royal Society Interface, s. 1943-1955, 2012

• DOI för Haemocompatibility and ion exchange capability of nanocellulose polypyrrole membranes intended for blood purification

In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

Haglund, Caroline; Åleskog, Anna; Nygren, Peter; Gullbo, Joachim et al.

Ingår i Cancer Chemotherapy and Pharmacology, s. 697-707, 2012

• DOI för In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia

Lönnerholm, Gudmar; Thörn, Ingrid; Sundström, Christer; Frost, Britt-Marie et al.

Ingår i Leukemia Research, s. 472-478, 2011

• DOI för In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia

Brunn: an open source laboratory information system for microplates with a graphical plate layout design process

Alvarsson, Jonathan; Andersson, Claes; Spjuth, Ola; Larsson, Rolf et al.

Ingår i BMC Bioinformatics, 2011

• DOI för Brunn: an open source laboratory information system for microplates with a graphical plate layout design process
• Ladda ner fulltext (pdf) av Brunn: an open source laboratory information system for microplates with a graphical plate layout design process

Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Fayad, Walid; Rickardson, Linda; Haglund, Caroline; Hägg Olofsson, Maria et al.

Ingår i Chemical Biology and Drug Design, s. 547-557, 2011

• DOI för Identification of Agents that Induce Apoptosis of Multicellular Tumour Spheroids: Enrichment for Mitotic Inhibitors with Hydrophobic Properties

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Gullbo, Joachim; Fryknäs, Mårten; Rickardson, Linda; Darcy, Padraig et al.

Ingår i Biochemical Pharmacology, s. 139-147, 2011

• DOI för Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia

Hallböök, Helene; Felth, Jenny; Eriksson, Anna; Fryknäs, Mårten et al.

Ingår i PLOS ONE, 2011

• DOI för Ex Vivo Activity of Cardiac Glycosides in Acute Leukaemia

Antimicrobial and antineoplastic activities of Agelasine analogs modified in the purine 2-position

Roggen, Heidi; Charnock, Colin; Burman, Robert; Felth, Jenny et al.

Ingår i Archiv der Pharmazie, s. 50-55, 2011

• DOI för Antimicrobial and antineoplastic activities of Agelasine analogs modified in the purine 2-position

Novel activity of acriflavine against colorectal cancer tumor cells

Hassan, Saadia; Laryea, Daniel; Mahteme, Haile; Felth, Jenny et al.

Ingår i Cancer Science, s. 2206-2213, 2011

• DOI för Novel activity of acriflavine against colorectal cancer tumor cells

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

D'Arcy, Padraig; Brnjic, Slavica; Olofsson, Maria Hägg; Fryknäs, Mårten et al.

Ingår i Nature Medicine, s. 1636-1640, 2011

• DOI för Inhibition of proteasome deubiquitinating activity as a new cancer therapy

High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Leuchowius, Karl-Johan; Jarvius, Malin; Wickström, Malin; Rickardson, Linda et al.

Ingår i Molecular & Cellular Proteomics, s. 178-183, 2010

• DOI för High content screening for inhibitors of protein interactions and post-translational modifications in primary cells by proximity ligation

Anchoring of vascular endothelial growth factor to surface-immobilized heparin on pancreatic islets: implications for stimulating islet angiogenesis

Cabric, Sanja; Sanchez, Javier; Johansson, Ulrika; Larsson, Rolf et al.

Ingår i Tissue engineering. Part A, s. 961-970, 2010

• DOI för Anchoring of vascular endothelial growth factor to surface-immobilized heparin on pancreatic islets: implications for stimulating islet angiogenesis

The FMCA-GM assays, high throughput non-clonogenic alternatives to CFU-GM in preclinical hematotoxicity testing

Haglund, Caroline; Åleskog, Anna; Håkansson, Lena Douhan; Höglund, Martin et al.

Ingår i Toxicology Letters, s. 102-107, 2010

• DOI för The FMCA-GM assays, high throughput non-clonogenic alternatives to CFU-GM in preclinical hematotoxicity testing

Characterization of the cytotoxic properties of the benzimidazole fungicides, benomyl and carbendazim, in human tumour cell lines and primary cultures of patient tumour cells

Laryea, Daniel; Gullbo, Joachim; Isaksson, Anders; Larsson, Rolf et al.

Ingår i Anti-Cancer Drugs, s. 33-42, 2010

• DOI för Characterization of the cytotoxic properties of the benzimidazole fungicides, benomyl and carbendazim, in human tumour cell lines and primary cultures of patient tumour cells

Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index

Hu, Kefei; Berenjian, Saideh; Larsson, Rolf; Gullbo, Joachim et al.

Ingår i International Journal of Nanomedicine, s. 51-62, 2010

The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan

Wickström, Malin; Viktorsson, Kristina; Lundholm, Lovisa; Aesoy, Reidun et al.

Ingår i Biochemical Pharmacology, s. 1281-1290, 2010

• DOI för The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan

Alpha Terpineol: A Potential Anticancer Agent which Acts through Suppressing NF-kappa B Signalling

Hassan, Saadia Bashir; Gali-Muhtasib, Hala; Göransson, Hanna; Larsson, Rolf

Ingår i Anticancer Research, s. 1911-1919, 2010

Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

von Heideman, Anne; Berglund, Åke; Larsson, Rolf; Nygren, Peter

Ingår i Cancer Chemotherapy and Pharmacology, s. 1165-1172, 2010

• DOI för Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia

Eriksson, Anna; Höglund, Martin; Lindhagen, Elin; Åleskog, Anna et al.

Ingår i Biochemical Pharmacology, s. 1507-1516, 2010

• DOI för Identification of AKN-032, a novel 2-aminopyrazine tyrosine kinase inhibitor, with significant preclinical activity in acute myeloid leukemia

In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia

Lönnerholm, Gudmar; Thörn, Ingrid; Sundström, Christer; Frost, Britt-Marie et al.

Ingår i Leukemia Research, s. 46-53, 2009

• DOI för In vitro cellular drug sensitivity at diagnosis is correlated to minimal residual disease at end of induction therapy in childhood acute lymphoblastic leukemia

Effects of streptozotocin-induced diabetes in domestic pigs with focus on the amino acid metabolism

Jensen-Waern, M.; Andersson, M.; Kruse, R.; Nilsson, Bo et al.

Ingår i Laboratory Animals, s. 249-254, 2009

• DOI för Effects of streptozotocin-induced diabetes in domestic pigs with focus on the amino acid metabolism

ChemGPS-NP mapping of chemical compounds for prediction of anticancer mode of action

Rosén, Josefin; Rickardson, Linda; Backlund, Anders; Gullbo, Joachim et al.

Ingår i QSAR & combinatorial science (Print), s. 436-446, 2009

• DOI för ChemGPS-NP mapping of chemical compounds for prediction of anticancer mode of action

In vitro activity of bortezomib in cultures of patient tumour cells-potential utility in haematological malignancies

Wiberg, Kristina; Carlson, Kristina; Åleskog, Anna; Larsson, Rolf et al.

Ingår i Medical Oncology, s. 193-201, 2009

• DOI för In vitro activity of bortezomib in cultures of patient tumour cells-potential utility in haematological malignancies

Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients

Laryea, Daniel; Isaksson, Anders; Wright, Colin; Larsson, Rolf et al.

Ingår i Investigational new drugs, s. 402-411, 2009

• DOI för Characterization of the cytotoxic activity of the indoloquinoline alkaloid cryptolepine in human tumour cell lines and primary cultures of tumour cells from patients

Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines

Larsson, Dhana E.; Hassan, Sadia; Larsson, Rolf; Öberg, Kjell et al.

Ingår i Cancer Chemotherapy and Pharmacology, s. 5-12, 2009

• DOI för Combination analyses of anti-cancer drugs on human neuroendocrine tumor cell lines

Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

Berndtsson, Maria; Beaujouin, Melanie; Rickardson, Linda; Havelka, Aleksandra Mandic et al.

Ingår i International Journal of Cancer, s. 1463-1469, 2009

• DOI för Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system

Utilization of a right-handed coiled-coil protein from archaebacterium Staphylothermus marinus as a carrier for cisplatin

Eriksson, Mathilda; Hassan, Saadia; Larsson, Rolf; Linder, Stig et al.

Ingår i Anticancer Research, s. 11-18, 2009

Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids

Lönnerholm, Gudmar; Nordgren, A.; Frost, Britt-Marie; Jonsson, O. G. et al.

Ingår i Leukemia, s. 209-212, 2009

• DOI för Dic(9;20)(p13;q11) in childhood acute lymphoblastic leukaemia is related to low cellular resistance to asparaginase, cytarabine and corticosteroids

Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

Fayad, Walid; Fryknäs, Mårten; Brnjic, Slavica; Olofsson, Maria Hägg et al.

Ingår i PLOS ONE, 2009

• DOI för Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters

Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

Ahlin, Gustav; Karlsson, Johan; Pedersen, Jenny M; Gustavsson, Lena et al.

Ingår i Journal of Medicinal Chemistry, s. 5932-5942, 2008

• DOI för Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1

A new method for incorporating functional heparin onto the surface of islets of Langerhans

Cabric, Sanja; Eich, Torsten; Sanchez, Javier; Nilsson, Bo et al.

Ingår i Tissue Engineering. Part C, Methods, s. 141-147, 2008

• DOI för A new method for incorporating functional heparin onto the surface of islets of Langerhans

Significant cytotoxic activity in vitro of the EGFR tyrosine kinase inhibitor gefitinib in acute myeloblastic leukaemia

Lindhagen, Elin; Eriksson, Anna; Wickström, Malin; Danielsson, Katarina et al.

Ingår i European Journal of Haematology, s. 344-353, 2008

• DOI för Significant cytotoxic activity in vitro of the EGFR tyrosine kinase inhibitor gefitinib in acute myeloblastic leukaemia

The fluorometric microculture cytotoxicity assay

Lindhagen, Elin; Nygren, Peter; Larsson, Rolf

Ingår i Nature Protocols, s. 1364-1369, 2008

• DOI för The fluorometric microculture cytotoxicity assay

Anti colon cancer components from lebanese sage (Salvia libanotica) essential oil: Mechanistic basis

Itani, Wafica; El-Banna, Sarah; Hassan, Saadia; Larsson, Rolf et al.

Ingår i Cancer Biology & Therapy, s. 1765-1773, 2008

• DOI för Anti colon cancer components from lebanese sage (Salvia libanotica) essential oil: Mechanistic basis

Gene expression signature-based chemcial genomics and activity pattern in a panel of tumour cell lines propose linalyl acetate as a protein kinase/NF-κB inhibitor

Hassan, Saadia; Lindhagen, Elin; Göransson, Hanna; Fryknäs, Mårten et al.

Ingår i Gene Therapy and Molecular Biology, s. 359-370, 2008

Surface-adsorbed fibrinogen and fibrin may activate the contact activation system

Sanchez, Javier; Elgue, Graciela; Larsson, Rolf; Nilsson, Bo et al.

Ingår i Thrombosis Research, s. 257-263, 2008

• DOI för Surface-adsorbed fibrinogen and fibrin may activate the contact activation system

The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

Wickström, Malin; Haglund, Caroline; Lindman, Henrik; Nygren, Peter et al.

Ingår i Investigational new drugs, s. 195-204, 2008

• DOI för The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

Towards high-throughput single cell/clone cultivation and analysis

Lindström, Sara; Larsson, Rolf; Svahn, Helene Andersson

Ingår i Electrophoresis, s. 1219-1227, 2008

• DOI för Towards high-throughput single cell/clone cultivation and analysis

Heterogeneous activity of cytotoxic drugs in patient samples of peritoneal carcinomatosis

Mahteme, Haile; von Heideman, Anne; Grundmark, Birgitta; Tholander, B. et al.

Ingår i European Journal of Surgical Oncology, s. 547-552, 2008

• DOI för Heterogeneous activity of cytotoxic drugs in patient samples of peritoneal carcinomatosis

The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo

Wickström, Malin; Johnsen, John Inge; Ponthan, Frida; Segerström, Lova et al.

Ingår i Molecular Cancer Therapeutics, s. 2409-2417, 2007

• DOI för The novel melphalan prodrug J1 inhibits neuroblastoma growth in vitro and in vivo

Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells

Milani, Lili; Gupta, Manu; Andersen, M.; Dhar, Sumeer et al.

Ingår i Nucleic Acids Research, 2007

• DOI för Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells

STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

Fryknäs, Mårten; Dhar, Sumeer; Öberg, Fredrik; Rickardson, Linda et al.

Ingår i International Journal of Cancer, s. 189-195, 2007

• DOI för STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

Image-based screening for the identification of novel proteasome inhibitors

Rickardson, Linda; Wickström, Malin; Larsson, Rolf; Lövborg, Henrik

Ingår i Journal of Biomolecular Screening, s. 203-210, 2007

• DOI för Image-based screening for the identification of novel proteasome inhibitors

R-etodolac (SDX-101) and the related indole-pyran analogues SDX-308 and SDX-309 potentiate the antileukemic activity of standard cytotoxic agents in primary chronic lymphocytic leukaemia cells

Lindhagen, Elin; Nissle, Sara; Leoni, L.; Elliott, G. et al.

Ingår i Cancer Chemotherapy and Pharmacology, s. 545-553, 2007

• DOI för R-etodolac (SDX-101) and the related indole-pyran analogues SDX-308 and SDX-309 potentiate the antileukemic activity of standard cytotoxic agents in primary chronic lymphocytic leukaemia cells

Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs

Vik, Anders; Hedner, Erik; Charnock, Colin; Tangen, Linda et al.

Ingår i Bioorganic & Medicinal Chemistry, s. 4016-4037, 2007

• DOI för Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs

The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications

Trulson, Agneta; Byström, Jonas; Engström, Åke; Larsson, Rolf et al.

Ingår i Clinical and Experimental Allergy, s. 208-218, 2007

• DOI för The functional heterogeneity of eosinophil cationic protein is determined by a gene polymorphism and post-translational modifications

Modeling of in vitro drug activity and prediction of clinical outcome in acute myeloid leukemia

Quartino, Angelica; Karlsson, Mats O.; Freijs, Agneta; Jonsson, Niclas et al.

Ingår i Journal of clinical pharmacology, s. 1014-1021, 2007

• DOI för Modeling of in vitro drug activity and prediction of clinical outcome in acute myeloid leukemia

Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals high solid tumour activity of SDX-308 in vitro

Lindhagen, Elin; Rickardson, Linda; Elliott, Gary; Leoni, Lorenzo et al.

Ingår i Investigational new drugs, s. 297-303, 2007

• DOI för Pharmacological profiling of novel non-COX-inhibiting indole-pyran analogues of etodolac reveals high solid tumour activity of SDX-308 in vitro

Primary lymphocytes as predictors for species differences in cytotoxic drug sensitivity

Hassan, Saadia B.; Haglund, Caroline; Åleskog, Anna; Larsson, Rolf et al.

Ingår i Toxicology in Vitro, s. 1174-1181, 2007

• DOI för Primary lymphocytes as predictors for species differences in cytotoxic drug sensitivity

Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

Wickström, Malin; Danielsson, Katarina; Rickardson, Linda; Gullbo, Joachim et al.

Ingår i Biochemical Pharmacology, s. 25-33, 2007

• DOI för Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency

Andersson, Claes R.; Fryknäs, Mårten; Rickardson, Linda; Larsson, Rolf et al.

Ingår i Journal of chemical information and modeling, s. 239-248, 2007

• DOI för In vitro drug sensitivity-gene expression correlations involve a tissue of origin dependency

Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Lövborg, Henrik; Öberg, Fredrik; Rickardson, Linda; Gullbo, Joachim et al.

Ingår i International Journal of Cancer, s. 1577-1580, 2006

• DOI för Inhibition of proteasome activity, nuclear factor-KB translocation and cell survival by the antialcoholism drug disulfiram

Effects on blood compatibility in vitro by combining a direct P2Y(12) receptor inhibitor and heparin coating of stents

Christensen, Kjeld; Larsson, Rolf; Emanuelsson, Håkan; Elgue, Graciela et al.

Ingår i Platelets, s. 318-327, 2006

• DOI för Effects on blood compatibility in vitro by combining a direct P2Y(12) receptor inhibitor and heparin coating of stents

p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line

Orre, Lukas M.; Stenerlöw, Bo; Dhar, Sumeer; Larsson, Rolf et al.

Ingår i Biochemical and Biophysical Research Communications - BBRC, s. 1211-7, 2006

• DOI för p53 is involved in clearance of ionizing radiation-induced RAD51 foci in a human colon cancer cell line

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

Fryknäs, Mårten; Rickardson, Linda; Wickström, Malin; Dhar, Sumeer et al.

Ingår i Journal of Biomolecular Screening, s. 457-468, 2006

• DOI för Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

CHS 828 kill tumour cells by inhibiting the nuclear factor-kappa B translocation but unlikely through down-regulation of proteasome

Hassan, Saadia B.; Lövborg, Henrik; Lindhagen, Elin; Karlsson, Mats O. et al.

Ingår i Anticancer Research, s. 4431-4436, 2006

Identification and evaluation of potential anti-cancer drugs on human neuroendocrine tumor cell lines

Larsson, Dhana E.; Lövborg, Henrik; Rickardson, Linda; Larsson, Rolf et al.

Ingår i Anticancer Research, s. 4125-4129, 2006

(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities.

Vik, Anders; Hedner, Erik; Charnock, Colin; Samuelsen, Orjan et al.

Ingår i J Nat Prod, s. 381-6, 2006

Improved blood compatibility of a stent graft by combining heparin coating and abciximab.

Christensen, Kjeld; Larsson, Rolf; Emanuelsson, HÃ¥kan; Elgue, Graciela et al.

Ingår i Thromb Res, s. 245-53, 2005

Bioactive heparin immobilized onto microfluidic channels in poly(dimethylsiloxane) results in hydrophilic surface properties.

Thorslund, Sara; Sanchez, Javier; Larsson, Rolf; Nikolajeff, Fredrik et al.

Ingår i Colloids Surf B Biointerfaces, s. 240-7, 2005

Functionality and stability of heparin immobilized onto poly(dimethylsiloxane)

Thorslund, Sara; Sanchez, Javier; Larsson, Rolf; Nikolajeff, Fredrik et al.

Ingår i Colloids and Surfaces B, s. 76-81, 2005

• DOI för Functionality and stability of heparin immobilized onto poly(dimethylsiloxane)

Bioactive heparin immobilized onto microfluidic channels in poly(dimethylsiloxane) results in hydrophilic surface properties,

Thorslund, Sara; Sanchez, Javier; Larsson, Rolf; Nikolajeff, Fredrik et al.

Ingår i Colloids and Surfaces B: Biointerfaces, s. 106-113, 2005

In vitro activity of imatinib in cells from patients with adult acute lymphoblastic leukemia

Hallböök, Helene; Barbany, Gisela; Åleskog, Anna; Björnberg, Annelie et al.

Ingår i Anti-Cancer Drugs, s. 631-634, 2005

Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemia

Frost, B M; Forestier, E; Gustafsson, G; Nygren, Peter et al.

Ingår i Leukemia, s. 165-169, 2005

• DOI för Translocation t(1;19) is related to low cellular drug resistance in childhood acute lymphoblastic leukaemia

Predictive value of in vitro assessment of cytotoxic drug activity in advanced breast cancer.

Villman, Kenneth; Blomqvist, Carl; Larsson, Rolf; Nygren, Peter

Ingår i Anticancer Drugs, s. 609-15, 2005

In vitro activity of the flt3-inhibitor su5614 and standard cytotoxic agents in tumour cells from patients with wild type and mutated flt3 acute myeloid leukaemia.

Åleskog, Anna; Höglund, Martin; Pettersson, Jenny; Hermansson, Monica et al.

Ingår i Leuk Res, s. 1079-81, 2005

In vitro drug resistance in B cell chronic lymphocytic leukemia: a comparison with acute myelocytic and acute lymphocytic leukemia.

Åleskog, Anna; Larsson, Rolf; Höglund, Martin; Kristensen, Jörgen et al.

Ingår i Anticancer Drugs, s. 277-83, 2005

Screening for apoptosis--classical and emerging techniques.

Lövborg, Henrik; Gullbo, Joachim; Larsson, Rolf

Ingår i Anticancer Drugs, s. 593-9, 2005

Identification of molecular mechanisms for cellular drug resistance by combining drug activity and gene expression profiles

Rickardson, Linda; Fryknäs, Mårten; Dhar, Sumeer; Lövborg, Henrik et al.

Ingår i British Journal of Cancer, s. 483-492, 2005

Cellular drug sensitivity in MLL-rearranged childhood acute leukaemia is correlated to partner genes and cell lineage.

Palle, J; Frost, B M; Forestier, E; Gustafsson, G et al.

Ingår i Br J Haematol, s. 189-98, 2005

Pharmacokinetic-pharmacodynamic modelling of the schedule-dependent effect of the anti-cancer agent CHS 828 in a rat hollow fibre model.

Friberg, Lena E; Hassan, Saadia B; Lindhagen, Elin; Larsson, Rolf et al.

Ingår i Eur J Pharm Sci, s. 163-73, 2005

Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia

Frost, Britt-Marie; Forestier, Erik; Gustafsson, Göran; Nygren, Peter et al.

Ingår i Blood, s. 2452-7, 2004

• DOI för Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia

Pharmacodynamic differences between species exemplified by the novel anticancer agent CHS 828

Lindhagen, Elin; Vig-Hjarnaa, Pernille; Friberg, Lena E; Latini, Scilla et al.

Ingår i Drug development research, s. 218-226, 2004

• DOI för Pharmacodynamic differences between species exemplified by the novel anticancer agent CHS 828

Multiparametric evaluation of apoptosis: effects of standard cytotoxic agents and the cyanoguanidine CHS 828

Lövborg, Henrik; Nygren, Peter; Larsson, Rolf

Ingår i Molecular Cancer Therapeutics, s. 521-526, 2004

Cytotoxic cyclotides from Viola tricolor

Svangård, Erika; Göransson, Ulf; Hocaoglu, Zozan; Gullbo, Joachim et al.

Ingår i Journal of natural products (Print), s. 144-7, 2004

• DOI för Cytotoxic cyclotides from Viola tricolor

Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo.

Gullbo, Joachim; Lindhagen, Elin; Bashir-Hassan, Saadia; Tullberg, Marcus et al.

Ingår i Invest New Drugs, s. 411-20, 2004

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguadine CHS 828

Gullbo, Joachim; Lövborg, Henrik; Dhar, Sumeer; Lukinius, Agneta et al.

Ingår i Anti-Cancer Drugs, s. 45-54, 2004

VH gene mutation status and cellular drug resistance in chronic lymphocytic leukemia

Åleskog, Anna; Tobin, Gerard; Laurell, Anna; Thunberg, Ulf et al.

Ingår i Eur J Haematol, s. 407-411, 2004

Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity.

Olsen, Lone Stengelshøj; Hjarnaa, Pernille-Julia Vig; Latini, Scilla; Holm, Pernille Kaae et al.

Ingår i Int J Cancer, s. 198-205, 2004

Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia.

Lindemalm, Synnöve; Liliemark, Jan; Juliusson, Gunnar; Larsson, Rolf et al.

Ingår i Cancer Lett, s. 171-7, 2004

Cytotoxic effect in vivo and in vitro of CHS 828 on human myeloma cell lines.

Hovstadius, Peter; Lindhagen, Elin; Hassan, Sadia; Nilsson, Kenneth et al.

Ingår i Anticancer Drugs, s. 63-70, 2004

Cytotoxic activity of a new paclitaxel formulation, Pacliex, in vitro and in vivo.

Hassan, Saadia; Dhar, Sumeer; Sandstrom, M; Arsenau, D et al.

Ingår i Cancer Chemother Pharmacol., 2004

Characterization of heparin surfaces using photoelectron spectroscopy and quartz crystal microbalance

Kristensen, E; Rensmo, H; Larsson, R; Siegbahn, H

Ingår i Biomaterials, s. 4153-4159, 2003

Antitumor activity of the novel melphalan containing tripeptide J3 (L-prolyl-melphalanyl-p-L-fluorophenylalanine ethyl ester): Comparison with its m-L-sarcolysin analogue P2

Gullbo, Joachim; Wallinder, Charlotta; Tullberg, Marcus; Lövborg, Henrik et al.

Ingår i Molecular Cancer Therapeutics, s. 1331-1339, 2003

Structure activity relationship for alkylating dipeptide nitrogen mustard derivatives

Gullbo, Joachim; Tullberg, Marcus; Våbeno, Jon; Ehrsson, Hans et al.

Ingår i Oncology Research, s. 113-132, 2003

Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia

Frost, Britt-Marie; Nygren, Peter; Gustafsson, G; Forestier, E et al.

Ingår i British Journal of Haematology, s. 376-385, 2003

• DOI för Increased in vitro cellular drug resistance is related to poor outcome in high-risk childhood acute lymphoblastic leukaemia

Small, novel proteins from the mistletoe Phoradendron tomentosum exhibit highly selective cytotoxicity to human breast cancer cells

Johansson, S.; Gullbo, Joachim; Lindholm, P.; Ek, B. et al.

Ingår i Cellular and Molecular Life Sciences (CMLS), s. 165-175, 2003

• DOI för Small, novel proteins from the mistletoe Phoradendron tomentosum exhibit highly selective cytotoxicity to human breast cancer cells

Overview of the clinical efficacy of investigational anticancer drugs.

Nygren, Peter; Larsson, Rolf

Ingår i J Intern Med., s. 46, 2003

Population pharmacokinetic modelling of unbound and total plasma concentrations of paclitaxel in cancer patients.

Henningsson, A; Sparreboom, A; Sandström, M; Freijs, A et al.

Ingår i Eur J Cancer., s. 1105, 2003

Antitumor activity of the alkylating oligopeptides J1(L-melphalanyl-p-L-fluorophenylalanine ethyl ester) and P2(L-prolyl-m-L-fluorophenylalanine ethyl ester):comparison with melphalan.

Gullbo, Joachim; Dhar, Sumeer; Luthman, K; Ehrsson, H et al.

Ingår i Anticancer Drugs., s. 617, 2003

Inhibition of thrombin abrogates the instant blood-mediated inflammatory reaction triggered by isolated human islets: possible application of the thrombin inhibitor melagatran in clinical islet transplantation.

Moberg, Lisa; Ekdahl, Kristina Nilsson; Elgue, Graciela; Larsson, Rolf et al.

Ingår i Diabetes, s. 1779-84, 2002

C3 adsorbed to a polymer surface can form an initiating alternative pathway convertase.

Andersson, Jonas; Nilsson Ekdahl, Kristina; Larsson, Rolf; Nilsson, Ulf R et al.

Ingår i J Immunol, s. 5786, 2002

Cell adhesion and tissue factor upregulation in oxygenators used during coronary artery bypass grafting are modified by the Corline Heparin Surface

Johnell, Matilda; Elgue, Graciela; Thelin, Stefan; Larsson, Rolf et al.

Ingår i Scandinavian Cardiovascular Journal, s. 351-357, 2002

• DOI för Cell adhesion and tissue factor upregulation in oxygenators used during coronary artery bypass grafting are modified by the Corline Heparin Surface

Coagulation, fibrinolysis and cell activation in patients and shed mediastinal blood during coronary artery bypass grafting using a new heparin-coated surface

Johnell, Matilda; Elgue, Graciela; Larsson, Rolf; Larsson, Anders et al.

Ingår i Journal of Thoracic and Cardiovascular Surgery, s. 321-332, 2002

• DOI för Coagulation, fibrinolysis and cell activation in patients and shed mediastinal blood during coronary artery bypass grafting using a new heparin-coated surface

Cyclotides: a novel type of cytotoxic agents

Lindholm, Petra; Göransson, Ulf; Johansson, Senia; Claeson, Per et al.

Ingår i Molecular Cancer Therapeutics, s. 365-369, 2002

In vitro activity of the novel cytotoxic agent CHS 828 in childhood acute leukemia

Frost, Britt-Marie; Lönnerholm, Gudmar; Nygren, Peter; Larsson, Rolf et al.

Ingår i Anti-Cancer Drugs, s. 735-742, 2002

Ligatoxin B, a new cytotoxic protein with a novel helix-turn-helix DNA-binding domain from the mistletoe Phoradendron liga

Li, Shi-Sheng; Gullbo, Joachim; Lindholm, Petra; Larsson, Rolf et al.

Ingår i Biochemical Journal, s. 405-13, 2002

• DOI för Ligatoxin B, a new cytotoxic protein with a novel helix-turn-helix DNA-binding domain from the mistletoe Phoradendron liga

A phase I study of CHS 828 in patients with solid tumor malignancy.

Hovstadius, Peter; Larsson, Rolf; Jonsson, Elin; Skov, T et al.

Ingår i Clin Cancer Res., s. 2843, 2002

In vitro evaluation of the efficacy of idarubicin in human tumour cells from patients with low-grade non-Hodgkin´s lymphoma.

Åleskog, Anna; Jonsson, Elin; Larsson, Rolf; Nygren, Peter et al.

Ingår i Br J Haematol, s. 563, 2002

Action of a novel anticancer agent, CHS 828, on mouse fibroblasts: increased sensitivity of cells lacking poly (ADP-Ribose) polymerase-1

Lövborg, Henrik; Wojciechowski, J; Larsson, Rolf; Wesierska-Gadek, J

Ingår i Cancer Res., s. 4206, 2002

DNA-dependent protein kinase in leukaemia cells and correlation with drug sensitivity.

Eriksson, A; Lewensohn, R; Larsson, Rolf; Nilsson, A

Ingår i Anticancer Res., s. 1787, 2002

Metabolic effects of the cytotoxic guanidino-containing drug CHS 828 in human U-937 lymphoma cells.

Ekelund, Sara; Larsson, Rolf; Nygren, Peter

Ingår i Anticancer Res, s. 2269, 2002

Interactions between the new cytotoxic drug CHS 828 and amiloride and mitomycin C in a human tumour cell line and in tumour cells from patients.

Ekelund, Sara; Persson, I; Larsson, Rolf; Nygren, Peter

Ingår i Chemotherapy, s. 196, 2002

Cytotoxic activity of a new lipid formulation of doxorubicin in cell lines and primary tumor cells.

Gullbo, Joachim; Arsenau, D; Grundmark, Birgitta; Alvfors, Carina et al.

Ingår i Anticancer Res, s. 4191, 2002

Assessment of drug activity and proliferation ex vivo for prediction ofoutcome in aggressive non-Hodgkin's lymphomas.

Ericsson, SM; Larsson, Rolf; Nygren, Peter; Sundstrom, C et al.

Ingår i Acta Oncol, s. 36, 2002

Selection of chemotherapy by ex vivo assessment of tumor sensitivity tocytotoxic drugs: results of a clinical trial.

Berglund, A; Glimelius, B; Bergh, J; Brodin, O et al.

Ingår i Med Oncol, s. 151, 2002

CHS 828 inhibits neuroblastoma growth in mice alone and in combination with antiangiogeneic drugs.

Svensson, Å; Bäckman, U; Jonsson, Elin; Larsson, Rolf et al.

Ingår i Pediatric Res, s. 607, 2002

Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells.

Lövborg, Henrik; Martinsson, Petra; Gullbo, Joachim; Ekelund, Sara et al.

Ingår i Biochem Pharmacol, s. 1491, 2002

The combination of the antitumoural pyridyl cyanoguanidine CHS 828 and etoposide in vitro from cytotoxic synergy to complete inhibition of apoptosis.

Martinsson, Petra; Ekelund, Sara; Nygren, Peter; Larsson, Rolf

Ingår i Br J Pharmacol, s. 568, 2002

Contact between a polymer and whole blood: sequence of events leading to thrombin generation.

Hong, Jaan; Larsson, Anders; Ekdahl, Kristina; Elgue, Graciela et al.

Ingår i J Lab Clin Med, s. 139, 2001

Binding of a model regulator of complement activation (RCA) to a biomaterial surface: surface-bound factor H inhibits complement activation.

Andersson, Jonas; Larsson, Rolf; Richter, Ralf; Nilsson Ekdahl, Kristina et al.

Ingår i Biomaterials, s. 2435, 2001

A new in vitro model for the study of pig-to human vascular hyperacute rejection.

Bennet, W; Wundberg, B; Elgue, Graciela; Larsson, Rolf et al.

Ingår i Xentotransplantation, s. 176, 2001

Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells

Johansson, Senia; Lindholm, Petra; Gullbo, Joachim; Larsson, Rolf et al.

Ingår i Anti-Cancer Drugs, s. 475-83, 2001

Temporal effects of the novel antitumour pyridyl cyanoguanidine CHS 828, on human lymphoma cells.

Martinsson, Petra; Liminga, Gunnar; Dhar, Sumeer; de la Torre, M et al.

Ingår i Eur J Cancer, s. 260, 2001

Cellular pharmacodynamics of the cytotoxic guanidino-containing drug CHS 828. Comparison with methylglyoxal-bis (guanylhydrazone).

Ekelund, Sara; Sjoholm, Å; Nygren, Peter; Binderup, L et al.

Ingår i Eur J Pharmacol, s. 39, 2001

Activity of CHS 828 in primary cultures of human hematological and solidtumors in vitro.

Åleskog, Anna; Bashir-Hassan, Saadai; Hovstadius, Peter; Kristensen, J et al.

Ingår i Anti-Cancer Drugs, s. 821, 2001

Model for time dependency of the cytotoxic effect of CHS 828 in vitro suggests two different mechanisms of action.

Hassan, Sadia; Jonsson, Elin; Larsson, Rolf; Karlsson, MO

Ingår i J Pharmacol Exp Ther, s. 1140, 2001

Characteristics of etoposide induced apoptopic cell death in the U-937 human lymphoma cell line.

Martinsson, Petra; Liminga, Gunnar; Nygren, Peter; Larsson, Rolf

Ingår i Anti-Cancer Drugs, s. 699, 2001

Guanidino-containing drugs in cancer chemotherapy: biochemical and clinical pharmacology.

Ekelund, Sara; Nygren, Peter; Larsson, Rolf

Ingår i Biochem Pharmacol, s. 1183, 2001

A hollow fiber model for in vitro studies of cytotoxic compounds: activityof the cyanoguanidine CHS 828.

Hassan, Saadia B; de la Torre, M; Nygren, Peter; Karlsson, MO et al.

Ingår i Anti-Cancer Drugs, s. 33, 2001

In vivo activity of CHS 828 on hollow-fibre cultures of primary humantumour cells from patients.

Jonsson, Elin; Friberg, LE; Karlsson, MO; Hassan, Saadia B et al.

Ingår i Cancer Lett, s. 193, 2001

Cell death with atypical features induced by the novel antitumoral drug CHS 828, in human U-937 GTB cells.

Martinsson, Petra; de la Torre, M; Binderup, L; Nygren, Peter et al.

Ingår i Eur J Pharmacol, s. 181, 2001

Evaluation of drug interactions in the established FEC regimen in primary cultures of tumour cells from patients

von Heideman, A; Sandström, M; Csoka, K; Tholander, Bengt et al.

Ingår i Annals of Oncology, s. 1301-1307, 2000

Antitumor effect of suramin analogues in human tumour cell lines and primary cultures of tumour cells

Dhar, Sumeer; Gullbo, Joachim; Csoka, Katalin; Eriksson, E et al.

Ingår i Eur J Cancer, s. 803, 2000

Cellular cytotoxic drug sensitivity in children with leukemia and Down´s syndrome: an explanation differences in clinical outcome?

Frost, BM; Gustafsson, G; Nygren, Peter; Larsson, Rolf et al.

Ingår i Leukemia, 2000

Early stimulation of acidification rate by novel cytotoxic pyridyl cyanoguanidines in human tumor cells: comparison with m-iodobenzylguanidine

Ekelund, Sara; Liminga, Gunnar; Bjorkling, F; Ottosen, E et al.

Ingår i Biochem Pharmacol, s. 839, 2000

Differential activity of topotecan, irinotecan and SN-38 in primary cultures of human tumor cells but not in cell lines.

Jonsson, Elin; Dhar, Sumeer; Jonsson, B; Nygren, Peter et al.

Ingår i Eur J Cancer, s. 2120, 2000

Determination of drug effect on tumor cells, host animal toxicity and drug pharmacokinetics in a hollow fiber model in rats.

Jonsson, Elin; Simonsen, LE; Hassan, Sadia; Freijs, A et al.

Ingår i Cancer Chemother Pharmacol, s. 493, 2000

Cyanoguanidine CHS 828 induces programmed cell death with apoptotic features in human breast cancer cells in vitro.

Hansen, CM; Hansen, D; Holm, PK; Larsson, Rolf et al.

Ingår i Anticancer Res., s. 4211, 2000

Apoptosis induced by calcein acetoxymethyl ester in the human histiocytic lymphoma cell line U-937 GTB.

Liminga, Gunnar; Martinsson, Petra; Jonsson, B; Nygren, Peter et al.

Ingår i Biochem Pharmacol, s. 1751, 2000

Melflufen: a peptidase-potentiated alkylating agent in clinical trials

Wickström, Malin; Nygren, Peter; Larsson, Rolf; Harmenberg, Johan et al.

Ingår i Oncotarget, s. 66641-66655, 2017

• DOI för Melflufen: a peptidase-potentiated alkylating agent in clinical trials
• Ladda ner fulltext (pdf) av Melflufen: a peptidase-potentiated alkylating agent in clinical trials

Aminopeptidase N (CD13) as a target for cancer chemotherapy

Wickström, Malin; Larsson, Rolf; Nygren, Peter; Gullbo, Joachim

Ingår i Cancer Science, s. 501-508, 2011

• DOI för Aminopeptidase N (CD13) as a target for cancer chemotherapy

Hemocompatibility of Nanocellulose Polypyrrole Membranes Intended for Hemodialysis

Ferraz, Natalia; Carlsson, Daniel O; Hong, Jaan; Larsson, Rolf et al.

Ingår i 9th World Biomaterials Congress, June 1-5, 2012, Chengdu, China, 2012

Ex vivo activity of cytotoxic drugs and targeted agents in Small Intestinal NETs

Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

Drug combination screening in multicellular tumor spheroids identifies synthetic lethalities in quiescent cancer cells

Senkowski, Wojciech; Nazir, Madiha; Gustafsson, Mats G; Nygren, Peter et al.

Paired glioblastoma cell cultures of the fluorescent bulk tumor and non-fluorescent tumor margin display differential phenotypes and cell states across patients

Neves, Inês; Lu, Xi; Maturi, Nagaprathyusha; Dang, Yonglong et al.

Functional Phenotyping Reveals Treatment-Response Heterogeneity Across Molecular Subtypes of Pediatric BCP-ALL

Enblad, Anna Pia; Krali, Olga; Lundmark, Anders; Lysenkova Wiklander, Mariya et al.