Fredrik Clausen

Persistent increase of Nogo-A-positive cells and dynamic reduction in oligodendroglia lineage cells in white matter regions following experimental and clinical traumatic brain injury

Ruscher, Karsten; Michalettos, Georgios; Abu Hamdeh, Sami; Clausen, Fredrik et al.

Ingår i Journal of Neuropathology and Experimental Neurology, s. 423-435, 2025

• DOI för Persistent increase of Nogo-A-positive cells and dynamic reduction in oligodendroglia lineage cells in white matter regions following experimental and clinical traumatic brain injury
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Post-injury treatment with 7,8-dihydroxyflavone attenuates white matter pathology in aged mice following focal traumatic brain injury

Michalettos, Georgios; Clausen, Fredrik; Rostami, Elham; Marklund, Niklas

Ingår i Neurotherapeutics, 2025

• DOI för Post-injury treatment with 7,8-dihydroxyflavone attenuates white matter pathology in aged mice following focal traumatic brain injury
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Impaired oligodendrogenesis in the white matter of aged mice following diffuse traumatic brain injury

Michalettos, Georgios; Clausen, Fredrik; Ozen, Ilknur; Ruscher, Karsten et al.

Ingår i Glia, s. 728-747, 2024

• DOI för Impaired oligodendrogenesis in the white matter of aged mice following diffuse traumatic brain injury
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A Dedicated 21-Plex Proximity Extension Assay Panel for High-Sensitivity Protein Biomarker Detection Using Microdialysis in Severe Traumatic Brain Injury: The Next Step in Precision Medicine?

Dyhrfort, Philip; Svedung-Wettervik, Teodor; Clausen, Fredrik; Enblad, Per et al.

Ingår i NEUROTRAUMA REPORTS, s. 25-40, 2023

• DOI för A Dedicated 21-Plex Proximity Extension Assay Panel for High-Sensitivity Protein Biomarker Detection Using Microdialysis in Severe Traumatic Brain Injury: The Next Step in Precision Medicine?
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Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits

Özen, Ilknur; Mai, Hongcheng; De Maio, Alessandro; Ruscher, Karsten et al.

Ingår i Acta neuropathologica communications, 2022

• DOI för Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits
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Persistent increase of Nogo-A-positive cells and dynamic reduction in oligodendroglia lineage cells in white matter regions following experimental and clinical traumatic brain injury

Ruscher, Karsten; Michalettos, Georgios; Abu Hamdeh, Sami; Clausen, Fredrik et al.

Ingår i Journal of Neuropathology and Experimental Neurology, s. 423-435, 2025

• DOI för Persistent increase of Nogo-A-positive cells and dynamic reduction in oligodendroglia lineage cells in white matter regions following experimental and clinical traumatic brain injury
• Ladda ner fulltext (pdf) av Persistent increase of Nogo-A-positive cells and dynamic reduction in oligodendroglia lineage cells in white matter regions following experimental and clinical traumatic brain injury

Post-injury treatment with 7,8-dihydroxyflavone attenuates white matter pathology in aged mice following focal traumatic brain injury

Michalettos, Georgios; Clausen, Fredrik; Rostami, Elham; Marklund, Niklas

Ingår i Neurotherapeutics, 2025

• DOI för Post-injury treatment with 7,8-dihydroxyflavone attenuates white matter pathology in aged mice following focal traumatic brain injury
• Ladda ner fulltext (pdf) av Post-injury treatment with 7,8-dihydroxyflavone attenuates white matter pathology in aged mice following focal traumatic brain injury

Impaired oligodendrogenesis in the white matter of aged mice following diffuse traumatic brain injury

Michalettos, Georgios; Clausen, Fredrik; Ozen, Ilknur; Ruscher, Karsten et al.

Ingår i Glia, s. 728-747, 2024

• DOI för Impaired oligodendrogenesis in the white matter of aged mice following diffuse traumatic brain injury
• Ladda ner fulltext (pdf) av Impaired oligodendrogenesis in the white matter of aged mice following diffuse traumatic brain injury

A Dedicated 21-Plex Proximity Extension Assay Panel for High-Sensitivity Protein Biomarker Detection Using Microdialysis in Severe Traumatic Brain Injury: The Next Step in Precision Medicine?

Dyhrfort, Philip; Svedung-Wettervik, Teodor; Clausen, Fredrik; Enblad, Per et al.

Ingår i NEUROTRAUMA REPORTS, s. 25-40, 2023

• DOI för A Dedicated 21-Plex Proximity Extension Assay Panel for High-Sensitivity Protein Biomarker Detection Using Microdialysis in Severe Traumatic Brain Injury: The Next Step in Precision Medicine?
• Ladda ner fulltext (pdf) av A Dedicated 21-Plex Proximity Extension Assay Panel for High-Sensitivity Protein Biomarker Detection Using Microdialysis in Severe Traumatic Brain Injury: The Next Step in Precision Medicine?

Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits

Özen, Ilknur; Mai, Hongcheng; De Maio, Alessandro; Ruscher, Karsten et al.

Ingår i Acta neuropathologica communications, 2022

• DOI för Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits
• Ladda ner fulltext (pdf) av Purkinje cell vulnerability induced by diffuse traumatic brain injury is linked to disruption of long-range neuronal circuits

Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism

Watanabe, Hiroyuki; Nosova, Olga; Sarkisyan, Daniil; Storm Andersen, Marlene et al.

Ingår i Brain Communications, 2020

• DOI för Ipsilesional versus contralesional postural deficits induced by unilateral brain trauma: a side reversal by opioid mechanism
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Interleukin-1 Beta Neutralization Attenuates Traumatic Brain Injury-Induced Microglia Activation and Neuronal Changes in the Globus Pallidus

Ozen, Ilknur; Ruscher, Karsten; Nilsson, Robert; Flygt, Johanna et al.

Ingår i International Journal of Molecular Sciences, 2020

• DOI för Interleukin-1 Beta Neutralization Attenuates Traumatic Brain Injury-Induced Microglia Activation and Neuronal Changes in the Globus Pallidus
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Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care

Dyhrfort, Philip; Shen, Qiujin; Clausen, Fredrik; Thulin, Måns et al.

Ingår i Journal of Neurotrauma, s. 2872-2885, 2019

• DOI för Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care
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Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease

Zysk, Marlena; Clausen, Fredrik; Aguilar, Ximena; Sehlin, Dag et al.

Ingår i Journal of Alzheimer's Disease, s. 161-180, 2019

• DOI för Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer's Disease
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Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord

Kononenko, Olga; Watanabe, Hiroyuki; Stålhandske, Lada; Zarelius, Ann et al.

Ingår i Restorative Neurology and Neuroscience, s. 87-96, 2019

• DOI för Focal traumatic brain injury induces neuroplastic molecular responses in lumbar spinal cord
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Acute Inflammatory Biomarker Responses to Diffuse Traumatic Brain Injury in the Rat Monitored by a Novel Microdialysis Technique

Clausen, Fredrik; Marklund, Niklas; Hillered, Lars

Ingår i Journal of Neurotrauma, s. 201-211, 2019

• DOI för Acute Inflammatory Biomarker Responses to Diffuse Traumatic Brain Injury in the Rat Monitored by a Novel Microdialysis Technique

Neutralization of Interleukin-1 beta following Diffuse Traumatic Brain Injury in the Mouse Attenuates the Loss of Mature Oligodendrocytes

Flygt, Johanna; Ruscher, Karsten; Norberg, Amanda; Mir, Anis et al.

Ingår i Journal of Neurotrauma, s. 2837-2849, 2018

• DOI för Neutralization of Interleukin-1 beta following Diffuse Traumatic Brain Injury in the Mouse Attenuates the Loss of Mature Oligodendrocytes
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Reduced Intracranial Pressure After Treatment With Anti-Secretory Factor 16 In A Rat Model Of Traumatic Brain Injury

Clausen, Fredrik; Hansson, Hans-Arne

Ingår i Journal of Neurotrauma, 2018

Asymmetric Hindlimb Motor Response To Focal Traumatic Brain Injury Is Controlled By Side-Specific Opioid Mechanism

Watanabe, Hiroyuki; Zhang, Mengliang; Sarkisyan, Daniil; Kononenko, Olga et al.

Ingår i Journal of Neurotrauma, 2018

A Dedicated 21-Plex Pea Panel For High-Sensitive Protein Biomarker Detection Using Micro-Dialysis In Traumatic Brain Injury

Lewén, Anders; Dyhrfort, Philip; Clausen, Fredrik; Enblad, Per et al.

Ingår i Journal of Neurotrauma, 2018

Biomechanical analysis of fluid percussion model of brain injury

Mao, Haojie; Lu, Lihong; Bian, Kewei; Clausen, Fredrik et al.

Ingår i Journal of Biomechanics, s. 228-232, 2018

• DOI för Biomechanical analysis of fluid percussion model of brain injury

Intranasal Administration of the Antisecretory Peptide AF-16 Reduces Edema and Improves Cognitive Function Following Diffuse Traumatic Brain Injury in the Rat

Clausen, Fredrik; Hansson, Hans-Arne; Raud, Johan; Marklund, Niklas

Ingår i Frontiers in Neurology, 2017

• DOI för Intranasal Administration of the Antisecretory Peptide AF-16 Reduces Edema and Improves Cognitive Function Following Diffuse Traumatic Brain Injury in the Rat
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Diffuse traumatic brain injury in the mouse induces a transient proliferation of oligodendrocyte progenitor cells in injured white matter tracts

Flygt, Johanna; Clausen, Fredrik; Marklund, Niklas

Ingår i Restorative Neurology and Neuroscience, s. 251-263, 2017

• DOI för Diffuse traumatic brain injury in the mouse induces a transient proliferation of oligodendrocyte progenitor cells in injured white matter tracts

Direct imaging of elemental distributions in tissue sections by laser ablation mass spectrometry

Shariatgorji, Mohammadreza; Nilsson, Anna; Bonta, Maximilian; Gan, Jinrui et al.

Ingår i Methods, s. 86-92, 2016

• DOI för Direct imaging of elemental distributions in tissue sections by laser ablation mass spectrometry

Diffuse traumatic axonal injury in mice induces complex behavioural alterations that are normalized by neutralization of interleukin-1β

Ekmark-Lewén, Sara; Flygt, Johanna; Fridgeirsdottir, Gudrun A.; Kiwanuka, Olivia et al.

Ingår i European Journal of Neuroscience, s. 1016-1033, 2016

• DOI för Diffuse traumatic axonal injury in mice induces complex behavioural alterations that are normalized by neutralization of interleukin-1β

Extracellular Ezrin - a Novel Biomarker for Traumatic Brain Injury

Lööv, Camilla; Nadadhur, Aishwarya; Hillered, Lars; Clausen, Fredrik et al.

Ingår i Journal of Neurotrauma, s. 244-251, 2015

• DOI för Extracellular Ezrin - a Novel Biomarker for Traumatic Brain Injury

Cerebral microdialysis for protein biomarker monitoring in the neurointensive care setting - a technical approach

Hillered, Lars; Dahlin, Andreas P; Clausen, Fredrik; Chu, Jiangtao et al.

Ingår i Frontiers in Neurology, s. 245, 2014

• DOI för Cerebral microdialysis for protein biomarker monitoring in the neurointensive care setting - a technical approach
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Escalated handling of young C57BL/6 mice results in altered Morris water maze performance

Fridgeirsdottir, Gudrun Andrea; Hillered, Lars; Clausen, Fredrik

Ingår i Upsala Journal of Medical Sciences, s. 1-9, 2014

• DOI för Escalated handling of young C57BL/6 mice results in altered Morris water maze performance

Combination of growth factor treatment and scaffold deposition following traumatic brain injury has only a temporary effect on regeneration

Clausen, Fredrik; Lindh, Tone; Shabnam, Salimi; Erlandsson, Anna

Ingår i Brain Research, s. 37-48, 2014

• DOI för Combination of growth factor treatment and scaffold deposition following traumatic brain injury has only a temporary effect on regeneration

Novel Microdialysis Method to Study The Acute Cytokine Response to Diffuse Traumatic Brain Injury in the Rat

Clausen, Fredrik; Dahlin, Andreas; Chu, Jiangtao; Kaller, Bodil et al.

Ingår i Journal of Neurotrauma, 2014

Refined microdialysis method for protein biomarker sampling in acute brain injury in the neurointensive care setting

Dahlin, Andreas P; Purins, Karlis; Clausen, Fredrik; Chu, Jiangtao et al.

Ingår i Analytical Chemistry, s. 8671-8679, 2014

• DOI för Refined microdialysis method for protein biomarker sampling in acute brain injury in the neurointensive care setting

Identification of Injury Specific Proteins in a Cell Culture Model of Traumatic Brain Injury

Loov, Camilla; Shevchenko, Ganna; Nadadhur, Aishwarya Geeyarpuram; Clausen, Fredrik et al.

Ingår i PLOS ONE, 2013

• DOI för Identification of Injury Specific Proteins in a Cell Culture Model of Traumatic Brain Injury
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Hyponatremia augments kainic-acid induced status epilepticus in the mouse: A model for dysmetabolic status epilepticus

Zelano, Johan; Halawa, Imad; Clausen, Fredrik; Kumlien, Eva

Ingår i Epilepsy Research, s. 29-34, 2013

• DOI för Hyponatremia augments kainic-acid induced status epilepticus in the mouse: A model for dysmetabolic status epilepticus

Combination of Growth Factor Treatment and Scaffold Deposition Following Experimental Traumatic Brain Injury Show a Temporary Effect on Cellular Regeneration

Clausen, Fredrik; Erlandsson, Anna

Ingår i Glia, 2013

Hyponatremia augments kainic-acid induced status epilepticus in the mouse: A model for dysmetabolic status epilepticus

Zelano, Johan; Halawa, Imad; Clausen, Fredrik; Kumlien, Eva

Ingår i Epilepsia, s. 106-106, 2013

Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice

Kenne, Ellinor; Erlandsson, Anna; Lindbom, Lennart; Hillered, Lars et al.

Ingår i Journal of Neuroinflammation, s. 17, 2012

• DOI för Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice
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Functional and Histological Outcome after Focal Traumatic Brain Injury Is Not Improved in Conditional EphA4 Knockout Mice

Hanell, Anders; Clausen, Fredrik; Djupsjö, Anders; Vallstedt, Anna et al.

Ingår i Journal of Neurotrauma, s. 2660-2671, 2012

• DOI för Functional and Histological Outcome after Focal Traumatic Brain Injury Is Not Improved in Conditional EphA4 Knockout Mice

Exploring a new approach to treating brain injury: Anti-inflammatory effect of pulsed electromagnetic fields

Clausen, Fredrik

Ingår i Neuroscience Letters, s. 1-3, 2012

• DOI för Exploring a new approach to treating brain injury: Anti-inflammatory effect of pulsed electromagnetic fields

Interstitial F₂-Isoprostane 8-Iso-PGF_2α As a Biomarker of Oxidative Stress after Severe Human Traumatic Brain Injury

Clausen, Fredrik; Marklund, Niklas; Lewén, Anders; Enblad, Per et al.

Ingår i Journal of Neurotrauma, s. 766-775, 2012

• DOI för Interstitial F₂-Isoprostane 8-Iso-PGF_2α As a Biomarker of Oxidative Stress after Severe Human Traumatic Brain Injury

Facilitated assessment of tissue loss following experimental traumatic brain injury

Hanell, Anders; Hedin, Johanna; Clausen, Fredrik; Marklund, Niklas

Ingår i Journal of Neurotrauma, 2012

• DOI för Facilitated assessment of tissue loss following experimental traumatic brain injury

The free radical scavenger S-PBN significantly prolongs DSG-mediated graft survival in experimental xenotransplantation

Biglarnia, Alireza; Emanuelsson, Cecilia; Quach, My; Clausen, Fredrik et al.

Ingår i Xenotransplantation, s. 166-176, 2012

• DOI för The free radical scavenger S-PBN significantly prolongs DSG-mediated graft survival in experimental xenotransplantation

Endogenous free radical production by NADPH oxidase 2 contributes to the secondary injury cascade after traumatic brain injury in mice

Kocak, Oyku; Fridgeirsdottir, Gudrun Andrea; Hillered, Lars; Clausen, Fredrik

Ingår i Brain Injury, s. 503-504, 2012

• DOI för Endogenous free radical production by NADPH oxidase 2 contributes to the secondary injury cascade after traumatic brain injury in mice

Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice

Kenne, Ellinor; Erlandsson, Anna; Lindbom, Lennart; Hillered, Lars et al.

Ingår i The FASEB Journal, 2012

Neutralization of interleukin-1 beta reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice

Clausen, Fredrik; Hånell, Anders; Israelsson, Charlotte; Hedin, Johanna et al.

Ingår i European Journal of Neuroscience, s. 110-123, 2011

• DOI för Neutralization of interleukin-1 beta reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice

Cerebral glucose metabolism after traumatic brain injury in the rat studied by C-13-glucose and microdialysis

Clausen, Fredrik; Hillered, Lars; Gustafsson, Jan

Ingår i Acta Neurochirurgica, s. 653-658, 2011

• DOI för Cerebral glucose metabolism after traumatic brain injury in the rat studied by C-13-glucose and microdialysis

Genetic Deletion and Pharmacological Inhibition of Nogo-66 Receptor Impairs Cognitive Outcome after Traumatic Brain Injury in Mice

Hånell, Anders; Clausen, Fredrik; Björk, Maria; Jansson, Kristine et al.

Ingår i Journal of Neurotrauma, s. 1297-1309, 2010

• DOI för Genetic Deletion and Pharmacological Inhibition of Nogo-66 Receptor Impairs Cognitive Outcome after Traumatic Brain Injury in Mice

Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice

Marklund, Niklas; Morales, D; Clausen, Fredrik; Hånell, Anders et al.

Ingår i Neuroscience, s. 540-551, 2009

• DOI för Functional outcome is impaired following traumatic brain injury in aging Nogo-A/B-deficient mice

Nandrolone decanoate administration elevates hippocampal prodynorphin mRNA expression and impairs Morris water maze performance in male rats

Magnusson, Kristina; Hånell, Anders; Bazov, Igor; Clausen, Fredrik et al.

Ingår i Neuroscience Letters, s. 189-193, 2009

• DOI för Nandrolone decanoate administration elevates hippocampal prodynorphin mRNA expression and impairs Morris water maze performance in male rats

Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice

Lord, Anna; Englund, Hillevi; Söderberg, Linda; Tucker, Stina et al.

Ingår i The FEBS Journal, s. 995-1006, 2009

• DOI för Amyloid-β protofibril levels correlate with spatial learning in Arctic Alzheimer’s disease transgenic mice

Grafted neural progenitors migrate and form neurons after experimental traumatic brain injury

Wallenquist, Ulrika; Brännvall, Karin; Clausen, Fredrik; Lewén, Anders et al.

Ingår i Restorative Neurology and Neuroscience, s. 323-334, 2009

• DOI för Grafted neural progenitors migrate and form neurons after experimental traumatic brain injury

Neutralization of interleukin-1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice

Clausen, Fredrik; Hånell, Anders; Björk, Maria; Hillered, Lars et al.

Ingår i European Journal of Neuroscience, s. 385-396, 2009

• DOI för Neutralization of interleukin-1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice

The nitrone free radical scavenger NXY-059 is neuroprotective when administered after traumatic brain injury in the rat

Clausen, Fredrik; Marklund, Niklas; Lewén, Anders; Hillered, Lars

Ingår i Journal of Neurotrauma, s. 1449-1457, 2008

• DOI för The nitrone free radical scavenger NXY-059 is neuroprotective when administered after traumatic brain injury in the rat

T Lymphocyte trafficking: A novel target for neuroprotection in traumatic brain injury

Clausen, Fredrik; Lorant, Tomas; Lewén, Anders; Hillered, Lars

Ingår i Journal of Neurotrauma, s. 1295-1307, 2007

• DOI för T Lymphocyte trafficking: A novel target for neuroprotection in traumatic brain injury

Correlation of hippocampal morphological changes and Morris Water Maze performance after cortical contusion injury in rats: Experimental studies

Clausen, Fredrik; Lewén, Anders; Marklund, Niklas; Olsson, Yngve et al.

Ingår i Neurosurgery, s. 154-162, 2005

• DOI för Correlation of hippocampal morphological changes and Morris Water Maze performance after cortical contusion injury in rats: Experimental studies

Intracranial pressure changes during fluid percussion, controlled cortical impact and weight drop injury in rats.: Experimental Research

Clausen, Fredrik; Hillered, Lars

Ingår i Acta Neurochirurgica, s. 775-780, 2005

• DOI för Intracranial pressure changes during fluid percussion, controlled cortical impact and weight drop injury in rats.: Experimental Research

Oxygen free radical-dependent activation of extracellular signal-regulated kinase mediates apoptosis-like cell death after traumatic brain injury

Clausen, Fredrik; Lundqvist, Hanna; Ekmark, Sara; Lewen, Anders et al.

Ingår i Journal of Neurotrauma, s. 1168-1182, 2004

• DOI för Oxygen free radical-dependent activation of extracellular signal-regulated kinase mediates apoptosis-like cell death after traumatic brain injury

Animal models of traumatic brain injury

Clausen, Fredrik

Ingår i Experimental Neurosurgery in Animal Models, s. 1-12, Springer-Verlag New York, 2016

• DOI för Animal models of traumatic brain injury

Diffuse traumatic brain injury in the mouse induces a transient proliferation of oligodendrocyte progenitor cells in injured white matter tracts

Flygt, Johanna; Clausen, Fredrik; Marklund, Niklas

2016

Reduced loss of mature Oligodendrocytes following Diffuse Traumatic Brain Injury in the mouse by Neutralization of Interleukin-1β

Flygt, Johanna; Ruscher, Karsten; Norberg, Amanda; Mir, AK et al.