Lieuwe Appel

Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human

Appel, Lieuwe; Risinger, Robert; Wall, Anders; Murck, Harald et al.

Ingår i Psychopharmacology, s. 565-580, 2026

• DOI för Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human
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A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism using ¹¹C-PE2I PET

Falk, Linus; Brunius, Carl; Bojkovic, Tea Crnic; Appel, Lieuwe et al.

Ingår i NeuroImage, 2026

• DOI för A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism using ¹¹C-PE2I PET
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Impact of image reconstruction on cerebral blood flow measured with ¹⁵O-water positron emission tomography

Bäck, Elin; Jonasson, My; Lindström, Elin; Tolf, Andreas et al.

Ingår i EJNMMI Physics, 2025

• DOI för Impact of image reconstruction on cerebral blood flow measured with ¹⁵O-water positron emission tomography
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Quantitation of mitral regurgitation using positron emission tomography

Sigfridsson, Jonathan; Baron, Tomasz; Bergsten, Johannes; Harms, Hendrik J. et al.

Ingår i EJNMMI Research, 2024

• DOI för Quantitation of mitral regurgitation using positron emission tomography
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Evaluation of [¹¹C]UCB-A positron emission tomography in human brains

Xiong, Mengfei; Lubberink, Mark; Appel, Lieuwe; Fang, Xiaotian Tsong et al.

Ingår i EJNMMI Research, 2024

• DOI för Evaluation of [¹¹C]UCB-A positron emission tomography in human brains
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Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human

Appel, Lieuwe; Risinger, Robert; Wall, Anders; Murck, Harald et al.

Ingår i Psychopharmacology, s. 565-580, 2026

• DOI för Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human
• Ladda ner fulltext (pdf) av Ascending single-dose study of the safety, pharmacokinetics, and pharmacodynamics of CSTI-500, a novel monoamine triple reuptake inhibitor, first-in-human

A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism using ¹¹C-PE2I PET

Falk, Linus; Brunius, Carl; Bojkovic, Tea Crnic; Appel, Lieuwe et al.

Ingår i NeuroImage, 2026

• DOI för A data-driven SSM/PCA analysis approach for differential diagnosis of parkinsonism using ¹¹C-PE2I PET
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Impact of image reconstruction on cerebral blood flow measured with ¹⁵O-water positron emission tomography

Bäck, Elin; Jonasson, My; Lindström, Elin; Tolf, Andreas et al.

Ingår i EJNMMI Physics, 2025

• DOI för Impact of image reconstruction on cerebral blood flow measured with ¹⁵O-water positron emission tomography
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Quantitation of mitral regurgitation using positron emission tomography

Sigfridsson, Jonathan; Baron, Tomasz; Bergsten, Johannes; Harms, Hendrik J. et al.

Ingår i EJNMMI Research, 2024

• DOI för Quantitation of mitral regurgitation using positron emission tomography
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Evaluation of [¹¹C]UCB-A positron emission tomography in human brains

Xiong, Mengfei; Lubberink, Mark; Appel, Lieuwe; Fang, Xiaotian Tsong et al.

Ingår i EJNMMI Research, 2024

• DOI för Evaluation of [¹¹C]UCB-A positron emission tomography in human brains
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Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system

Sousa, Joao M.; Appel, Lieuwe; Engstrom, Mathias; Nyholm, Dag et al.

Ingår i Physica medica (Testo stampato), 2024

• DOI för Comparison of quantitative [11C]PE2I brain PET studies between an integrated PET/MR and a stand-alone PET system
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Striatal dopamine transporter and receptor availability correlate with relative cerebral blood flow measured with [¹¹C]PE2I, [¹⁸F]FE-PE2I and [¹¹C]raclopride PET in healthy individuals

Jonasson, My; Frick, Andreas; Fazio, Patrik; Hjorth, Olof et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 1206-1215, 2023

• DOI för Striatal dopamine transporter and receptor availability correlate with relative cerebral blood flow measured with [¹¹C]PE2I, [¹⁸F]FE-PE2I and [¹¹C]raclopride PET in healthy individuals

Image-derived input functions from dynamic O-15-water PET scans using penalised reconstruction

Young, Peter; Appel, Lieuwe; Tolf, Andreas; Kosmidis, Savvas et al.

Ingår i EJNMMI Physics, 2023

• DOI för Image-derived input functions from dynamic O-15-water PET scans using penalised reconstruction
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Composite attenuation correction method using a ⁶⁸Ge-transmission multi-atlas for quantitative brain PET/MR.

Sousa, Joao M.; Appel, Lieuwe; Engström, Mathias; Papadimitriou, Stergios et al.

Ingår i Physica medica (Testo stampato), s. 36-43, 2022

• DOI för Composite attenuation correction method using a ⁶⁸Ge-transmission multi-atlas for quantitative brain PET/MR.
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Cerebral blood flow measurements with ¹⁵O-water PET using a non-invasive machine-learning-derived arterial input function

Kuttner, Samuel; Wickstrøm, Kristoffer Knutsen; Lubberink, Mark; Tolf, Andreas et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 2229-2241, 2021

• DOI för Cerebral blood flow measurements with ¹⁵O-water PET using a non-invasive machine-learning-derived arterial input function
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Evaluation of Arterial Spin Labeling MRI: Comparison with ¹⁵O-Water PET on an Integrated PET/MR Scanner

Fahlström, Markus; Appel, Lieuwe; Kumlien, Eva; Danfors, Torsten et al.

Ingår i Diagnostics (Basel), 2021

• DOI för Evaluation of Arterial Spin Labeling MRI: Comparison with ¹⁵O-Water PET on an Integrated PET/MR Scanner
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Accuracy and precision of zero-echo-time, single- and multi-atlas attenuation correction for dynamic [¹¹C]PE2I PET-MR brain imaging

Sousa, João M.; Appel, Lieuwe; Merida, Inés; Heckemann, Rolf A. et al.

Ingår i EJNMMI Physics, 2020

• DOI för Accuracy and precision of zero-echo-time, single- and multi-atlas attenuation correction for dynamic [¹¹C]PE2I PET-MR brain imaging
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Evaluation of zero-echo-time attenuation correction for integrated PET/MR brain imaging-comparison to head atlas and ⁶⁸Ge-transmission-based attenuation correction

Sousa, João M.; Appel, Lieuwe; Engström, Mathias; Papadimitriou, Stergios et al.

Ingår i EJNMMI Physics, 2018

• DOI för Evaluation of zero-echo-time attenuation correction for integrated PET/MR brain imaging-comparison to head atlas and ⁶⁸Ge-transmission-based attenuation correction
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Association between amygdala neurokinin-1 receptor availability and anxiety-related personality traits

Motilla Hoppe, Johanna; Frick, Andreas; Åhs, Fredrik; Linnman, Clas et al.

Ingår i Translational Psychiatry, s. 168, 2018

• DOI för Association between amygdala neurokinin-1 receptor availability and anxiety-related personality traits
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Blood Flow Dependence of Early [C-11]PE2I and [F-18]FE-PE2I PET SUVR Measurements Used In the Differential Diagnosis of Parkinsonian Disorders

Jonasson, My; Langaas, G.; Appel, Lieuwe; Danfors, Torsten et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018

Quantitative accuracy of ¹⁵O-water cerebral blood flow images based on penalized likelihood reconstruction

Sousa, Joao; Appel, Lieuwe; Fang, Xiaotian T.; Engström, M. et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018

• DOI för Quantitative accuracy of ¹⁵O-water cerebral blood flow images based on penalized likelihood reconstruction

Differential diagnosis of patients with parkinsonian syndrome using multilinear regression to disease-specific C-11-PE2I-PET templates and classification tree learning

Lubberink, Mark; Widström, Charles; Jonasson, My; Appel, Lieuwe et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2018

Visualization of painful inflammation in patients with pain after traumatic ankle sprain using [(11)C]-D-deprenyl PET/CT.

Aarnio, Mikko; Appel, Lieuwe; Fredriksson, Mats; Gordh, Torsten et al.

Ingår i Scandinavian Journal of Pain, s. 418-424, 2017

• DOI för Visualization of painful inflammation in patients with pain after traumatic ankle sprain using [(11)C]-D-deprenyl PET/CT.

Development of a clinically feasible [11C]PE2I PET method for differential diagnosis of parkinsonism using reduced scan duration and automated reference region extraction.

Jonasson, My; Appel, Lieuwe; Danfors, Torsten; Nyholm, Dag et al.

Ingår i American Journal of Nuclear Medicine and Molecular Imaging, s. 263-274, 2017

• Ladda ner fulltext (pdf) av Development of a clinically feasible [11C]PE2I PET method for differential diagnosis of parkinsonism using reduced scan duration and automated reference region extraction.

Tracer kinetic analysis of the SV2A ligand ¹¹C-UCBA as a PET marker for synaptic density in humans

Lubberink, Mark; Appel, Lieuwe; Gaging, Johannes; Lindskog, Karolina et al.

Ingår i Journal of Nuclear Medicine, 2017

Validation of an image derived input function estimation method on PET/MR

Khalighi, Mohammad Mehdi; Engström, Mathias; Fan, Audrey; Gulaka, Praveen et al.

Ingår i Journal of Nuclear Medicine, 2017

Correlation between regional cerebral blood flow based on simultaneously acquired arterial spin labelling MRI and ¹⁵O-water-PET using zero-echo-time-based attenuation correction

Fahlström, Markus; Lindskog, Karolina; Appel, Lieuwe; Engström, Mathias et al.

Ingår i Journal of Nuclear Medicine, 2017

Validation of an image-derived input function method for O-15-water PET/MR brain scans

Lubberink, Mark; Khalighi, M. M.; Appel, Lieuwe; Engstrom, M. et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 80-81, 2017

Quantitative assessment of synaptic density using the SV2A ligand C-11-UCBA in humans

Lubberink, Mark; Appel, Lieuwe; Lindskog, K.; Danfors, Torsten et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, s. 74-74, 2017

Alterations in the serotonergic and substance P systems in posttraumatic stress disorder

Frick, Andreas; Åhs, Fredrik; Palmquist, Åsa M.; Pissiota, A. et al.

Ingår i Molecular Psychiatry, s. 1323-1323, 2016

• DOI för Alterations in the serotonergic and substance P systems in posttraumatic stress disorder

Decreased Brain Neurokinin-1 Receptor Availability in Chronic Tennis Elbow

Linnman, Clas; Catana, Ciprian; Svärdsudd, Kurt; Appel, Lieuwe et al.

Ingår i PLOS ONE, 2016

• DOI för Decreased Brain Neurokinin-1 Receptor Availability in Chronic Tennis Elbow
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Validation of Zero-Echo Time PET-MR against stand-alone PET using dynamic dopamine transporter imaging

Sousa, Joao M.; Appel, Lieuwe; Papadimitriou, S.; Nyholm, Dag et al.

Ingår i European Journal of Nuclear Medicine and Molecular Imaging, 2016

Overlapping expression of serotonin transporters and neurokinin-1 receptors in posttraumatic stress disorder: a multi-tracer PET study

Frick, Andreas; Åhs, Fredrik; Michelgård Palmquist, Åsa; Pissiota, Anna et al.

Ingår i Molecular Psychiatry, s. 1400-1407, 2016

• DOI för Overlapping expression of serotonin transporters and neurokinin-1 receptors in posttraumatic stress disorder: a multi-tracer PET study

Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder.

Furmark, Tomas; Marteinsdottir, Ina; Frick, Andreas; Heurling, Kerstin et al.

Ingår i Journal of Psychopharmacology, s. 1028-1035, 2016

• DOI för Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder.

Reduced serotonin synthesis and regional cerebral blood flow after anxiolytic treatment of social anxiety disorder

Frick, Andreas; Åhs, Fredrik; Appel, Lieuwe; Jonasson, My et al.

Ingår i European Neuropsychopharmacology, s. 1775-1783, 2016

• DOI för Reduced serotonin synthesis and regional cerebral blood flow after anxiolytic treatment of social anxiety disorder

Increased neurokinin-1 receptor availability in the amygdala in social anxiety disorder: a positron emission tomography study with [(11)C]GR205171

Frick, Andreas; Åhs, Fredrik; Linnman, Clas; Jonasson, My et al.

Ingår i Translational Psychiatry, 2015

• DOI för Increased neurokinin-1 receptor availability in the amygdala in social anxiety disorder: a positron emission tomography study with [(11)C]GR205171
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Serotonin Synthesis and Reuptake in Social Anxiety Disorder: A Positron Emission Tomography Study.

Frick, Andreas; Åhs, Fredrik; Engman, Jonas; Jonasson, My et al.

Ingår i JAMA psychiatry, s. 794-802, 2015

• DOI för Serotonin Synthesis and Reuptake in Social Anxiety Disorder: A Positron Emission Tomography Study.

Use of C-11-PE2I PET in Differential Diagnosis of Parkinsonian Disorders

Appel, Lieuwe; Jonasson, My; Danfors, Torsten; Nyholm, Dag et al.

Ingår i Journal of Nuclear Medicine, s. 234-242, 2015

• DOI för Use of C-11-PE2I PET in Differential Diagnosis of Parkinsonian Disorders

Association between amygdala reactivity and a dopamine transporter gene polymorphism

Bergman, O.; Åhs, Fredrik; Furmark, Tomas; Appel, Lieuwe et al.

Ingår i Translational Psychiatry, 2014

• DOI för Association between amygdala reactivity and a dopamine transporter gene polymorphism

Amygdala-frontal couplings characterizing SSRI and placebo response in social anxiety disorder

Faria, Vanda; Åhs, Fredrik; Appel, Lieuwe; Linnman, Clas et al.

Ingår i International Journal of Neuropsychopharmacology, s. 1149-1157, 2014

• DOI för Amygdala-frontal couplings characterizing SSRI and placebo response in social anxiety disorder

Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: Dopamine transporter occupancy as measured by PET

Appel, Lieuwe; Bergström, Mats; Lassen, Jorgen Buus; Långström, Bengt

Ingår i European Neuropsychopharmacology, s. 251-261, 2014

• DOI för Tesofensine, a novel triple monoamine re-uptake inhibitor with anti-obesity effects: Dopamine transporter occupancy as measured by PET

PET-Scan Shows Peripherally Increased Neurokinin 1 Receptor Availability in Chronic Tennis Elbow: Visualizing Neurogenic Inflammation?

Peterson, Magnus; Svärdsudd, Kurt; Appel, Lieuwe; Engler, Henry et al.

Ingår i PLOS ONE, 2013

• DOI för PET-Scan Shows Peripherally Increased Neurokinin 1 Receptor Availability in Chronic Tennis Elbow: Visualizing Neurogenic Inflammation?
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Validation of parametric methods for [(11)C]PE2I positron emission tomography

Jonasson, My; Appel, Lieuwe; Engman, Jonas; Frick, Andreas et al.

Ingår i NeuroImage, s. 172-178, 2013

• DOI för Validation of parametric methods for [(11)C]PE2I positron emission tomography

Age, sex and NK1 receptors in the human brain: A positron emission tomography study with [C-11]GR205171

Engman, Jonas; Åhs, Fredrik; Furmark, Tomas; Linnman, Clas et al.

Ingår i European Neuropsychopharmacology, s. 562-568, 2012

• DOI för Age, sex and NK1 receptors in the human brain: A positron emission tomography study with [C-11]GR205171

Amygdala Subregions Tied to SSRI and Placebo Response in Patients with Social Anxiety Disorder

Faria, Vanda; Appel, Lieuwe; Åhs, Fredrik; Linnman, Clas et al.

Ingår i Neuropsychopharmacology, s. 2222-2232, 2012

• DOI för Amygdala Subregions Tied to SSRI and Placebo Response in Patients with Social Anxiety Disorder

Parametric methods for [¹¹C]PE2I positron emission tomography

Jonasson, My; Appel, Lieuwe; Engman, Jonas; Frick, Andreas et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, 2012

• DOI för Parametric methods for [¹¹C]PE2I positron emission tomography

Effect of variations in cerebellum kinetics on robustness of [C-11]DASB parametric images

Jonasson, My; Appel, Lieuwe; Engman, Jonas; Frick, Andreas et al.

Ingår i Journal of Cerebral Blood Flow and Metabolism, 2012

• DOI för Effect of variations in cerebellum kinetics on robustness of [C-11]DASB parametric images

Increased neurokinin-1 receptor availability in temporal lobe epilepsy: A positron emission tomography study using [(11)C]GR205171

Danfors, Torsten; Åhs, Fredrik; Appel, Lieuwe; Linnman, Clas et al.

Ingår i Epilepsy Research, s. 183-189, 2011

• DOI för Increased neurokinin-1 receptor availability in temporal lobe epilepsy: A positron emission tomography study using [(11)C]GR205171

Occupancy of human brain GABA(A) receptors by the novel alpha 5 subtype-selective benzodiazepine site inverse agonist alpha 5IA as measured using [C-11]flumazenil PET imaging

Eng, W.; Atack, J. R.; Bergström, M.; Sanabria, S. et al.

Ingår i Neuropharmacology, s. 635-639, 2010

• DOI för Occupancy of human brain GABA(A) receptors by the novel alpha 5 subtype-selective benzodiazepine site inverse agonist alpha 5IA as measured using [C-11]flumazenil PET imaging

Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic pain

Linnman, Clas; Appel, Lieuwe; Furmark, Tomas; Söderlund, Anne et al.

Ingår i Pain, s. 64-70, 2010

• DOI för Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic pain

Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder

Furmark, Tomas; Henningsson, Susanne; Appel, Lieuwe; Åhs, Fredrik et al.

Ingår i Journal of Psychiatry & Neuroscience, s. 30-40, 2009

Disentangling the web of fear: amygdala reactivity and functional connectivity in spider and snake phobia

Åhs, Fredrik; Pissiota, Anna; Michelgård, Åsa; Frans, Örjan et al.

Ingår i Psychiatry Research, s. 103-108, 2009

• DOI för Disentangling the web of fear: amygdala reactivity and functional connectivity in spider and snake phobia

Chronic whiplash symptoms are related to altered regional cerebral blood flow in the resting state

Linnman, Clas; Appel, Lieuwe; Söderlund, Anne; Frans, Örjan et al.

Ingår i European Journal of Pain, s. 65-70, 2009

• DOI för Chronic whiplash symptoms are related to altered regional cerebral blood flow in the resting state

BL-1020, a novel antipsychotic candidate with GABA-enhancing effects: D2 receptor occupancy study in humans

Appel, Lieuwe; Geffen, Yona; Heurling, Kerstin; Eriksson, Catarina et al.

Ingår i European Neuropsychopharmacology, s. 841-850, 2009

• DOI för BL-1020, a novel antipsychotic candidate with GABA-enhancing effects: D2 receptor occupancy study in humans

A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety

Furmark, Tomas; Appel, Lieuwe; Henningsson, Susanne; Ahs, Fredrik et al.

Ingår i Journal of Neuroscience, s. 13066-74, 2008

• DOI för A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety

In a nervous voice: Acoustic analysis and perception of anxiety in social phobics' speech

Laukka, Petri; Linnman, Clas; Åhs, Fredrik; Pissiota, Anna et al.

Ingår i Journal of nonverbal behavior, s. 195-214, 2008

• DOI för In a nervous voice: Acoustic analysis and perception of anxiety in social phobics' speech

Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor systems

Michelgård, Åsa; Appel, Lieuwe; Pissiota, Anna; Frans, Örjan et al.

Ingår i Biological Psychiatry, s. 1002-1006, 2007

• DOI för Symptom provocation in specific phobia affects the substance P neurokinin-1 receptor systems

Altered NK1-receptor availability in patients with post traumatic stress disorder

Appel, Lieuwe; Michelgård, Åsa; Linnman, Claes; Fernandez, Manuel et al.

Ingår i [Biological Psychiatry 2009, 65(8), Suppl. 1, 118S, no. 394], 2009

• DOI för Altered NK1-receptor availability in patients with post traumatic stress disorder

Composite ⁶⁸Ge attenuation correction for quantitative brain PET/MR

Sousa, Joao M.; Appel, Lieuwe; Engström, Mathias; Papadimitrio, Stergios et al.

Comparison of quantitative [¹¹C]PE2I PET scans acquired on PET/MR and stand-alone PET

Sousa, Joao M.; Appel, Lieuwe; Engström, Mathias; Papadimitriou, Stergios et al.

Cerebral blood flow in multiple sclerosis: an ¹⁵O-water PET study

Tolf, Andreas; Hedman, Karolina; Appel, Lieuwe; Larsson, Elna-Marie et al.