Måns Ehrenberg
Professor emeritus vid Institutionen för cell- och molekylärbiologi; Molekylärbiologi
- E-post:
- mans.ehrenberg@icm.uu.se
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 596
751 24 Uppsala
Professor emeritus vid Institutionen för cell- och molekylärbiologi; Uppsala RNA Research Centre - URRC
- Besöksadress:
- Husargatan 3
752 37 Uppsala - Postadress:
- Box 596
751 24 Uppsala
- Akademiska meriter:
- TeknD
Publikationer
Senaste publikationer
Dynamics of release factor recycling during translation termination in bacteria
Ingår i Nucleic Acids Research, s. 5774-5790, 2023
- DOI för Dynamics of release factor recycling during translation termination in bacteria
- Ladda ner fulltext (pdf) av Dynamics of release factor recycling during translation termination in bacteria
Uncovering translation roadblocks during the development of a synthetic tRNA
Ingår i Nucleic Acids Research, s. 10201-10211, 2022
- DOI för Uncovering translation roadblocks during the development of a synthetic tRNA
- Ladda ner fulltext (pdf) av Uncovering translation roadblocks during the development of a synthetic tRNA
Ingår i Nucleic Acids Research, s. 2684-2699, 2021
- DOI för N-6-Methyladenosines in mRNAs reduce the accuracy of codon reading by transfer RNAs and peptide release factors
- Ladda ner fulltext (pdf) av N-6-Methyladenosines in mRNAs reduce the accuracy of codon reading by transfer RNAs and peptide release factors
Estimation of peptide elongation times from ribosome profiling spectra
Ingår i Nucleic Acids Research, s. 5124-5142, 2021
- DOI för Estimation of peptide elongation times from ribosome profiling spectra
- Ladda ner fulltext (pdf) av Estimation of peptide elongation times from ribosome profiling spectra
Ingår i eLIFE, 2019
- DOI för The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation
- Ladda ner fulltext (pdf) av The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation
Alla publikationer
Artiklar i tidskrift
Dynamics of release factor recycling during translation termination in bacteria
Ingår i Nucleic Acids Research, s. 5774-5790, 2023
- DOI för Dynamics of release factor recycling during translation termination in bacteria
- Ladda ner fulltext (pdf) av Dynamics of release factor recycling during translation termination in bacteria
Uncovering translation roadblocks during the development of a synthetic tRNA
Ingår i Nucleic Acids Research, s. 10201-10211, 2022
- DOI för Uncovering translation roadblocks during the development of a synthetic tRNA
- Ladda ner fulltext (pdf) av Uncovering translation roadblocks during the development of a synthetic tRNA
Ingår i Nucleic Acids Research, s. 2684-2699, 2021
- DOI för N-6-Methyladenosines in mRNAs reduce the accuracy of codon reading by transfer RNAs and peptide release factors
- Ladda ner fulltext (pdf) av N-6-Methyladenosines in mRNAs reduce the accuracy of codon reading by transfer RNAs and peptide release factors
Estimation of peptide elongation times from ribosome profiling spectra
Ingår i Nucleic Acids Research, s. 5124-5142, 2021
- DOI för Estimation of peptide elongation times from ribosome profiling spectra
- Ladda ner fulltext (pdf) av Estimation of peptide elongation times from ribosome profiling spectra
Ingår i eLIFE, 2019
- DOI för The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation
- Ladda ner fulltext (pdf) av The mechanism of error induction by the antibiotic viomycin provides insight into the fidelity mechanism of translation
Ingår i Nature Communications, 2019
- DOI för The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy
- Ladda ner fulltext (pdf) av The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy
Ingår i mBio, 2019
- DOI för Reiterative Synthesis by the Ribosome and Recognition of the N-Terminal Formyl Group by Biosynthetic Machinery Contribute to Evolutionary Conservation of the Length of Antibiotic Microcin C Peptide Precursor
- Ladda ner fulltext (pdf) av Reiterative Synthesis by the Ribosome and Recognition of the N-Terminal Formyl Group by Biosynthetic Machinery Contribute to Evolutionary Conservation of the Length of Antibiotic Microcin C Peptide Precursor
Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg2+ ions
Ingår i Nucleic Acids Research, s. 1362-1374, 2018
- DOI för Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg2+ ions
- Ladda ner fulltext (pdf) av Accuracy of genetic code translation and its orthogonal corruption by aminoglycosides and Mg2+ ions
2'-O-methylation in mRNA disrupts tRNA decoding during translation elongation
Ingår i Nature Structural & Molecular Biology, s. 208-216, 2018
Ingår i Nucleic Acids Research, s. 5861-5874, 2018
- DOI för Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-Tu(H84A)
- Ladda ner fulltext (pdf) av Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-Tu(H84A)
The Structural Basis for Initiation Factor 2 Activation during Translation Initiation
Ingår i Biophysical Journal, 2018
How 2 '-O-Methylation in mRNA Disrupts tRNA Decoding during Translation Elongation
Ingår i Biophysical Journal, 2018
Transcriptional accuracy modeling suggests two-step proofreading by RNA polymerase
Ingår i Nucleic Acids Research, s. 11582-11593, 2017
- DOI för Transcriptional accuracy modeling suggests two-step proofreading by RNA polymerase
- Ladda ner fulltext (pdf) av Transcriptional accuracy modeling suggests two-step proofreading by RNA polymerase
Ingår i Nature Communications, 2017
- DOI för A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria
- Ladda ner fulltext (pdf) av A conformational switch in initiation factor 2 controls the fidelity of translation initiation in bacteria
Ribosomes are optimized for autocatalytic production
Ingår i Nature, s. 293-297, 2017
Two proofreading steps amplify the accuracy of genetic code translation
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 13744-13749, 2016
Complete kinetic mechanism for recycling of the bacterial ribosome
Ingår i RNA, s. 10-21, 2016
Key Intermediates in Ribosome Recycling Visualized by Time-Resolved Cryoelectron Microscopy
Ingår i Structure, s. 2092-2101, 2016
N-6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
Ingår i Nature Structural & Molecular Biology, s. 110-+, 2016
Proofreading neutralizes potential error hotspots in genetic code translation by transfer RNAs
Ingår i RNA, s. 896-904, 2016
- DOI för Proofreading neutralizes potential error hotspots in genetic code translation by transfer RNAs
- Ladda ner fulltext (pdf) av Proofreading neutralizes potential error hotspots in genetic code translation by transfer RNAs
Ingår i Nucleic Acids Research, s. 3264-3275, 2016
- DOI för Mechanism of fusidic acid inhibition of RRF- and EF-G-dependent splitting of the bacterial post-termination ribosome
- Ladda ner fulltext (pdf) av Mechanism of fusidic acid inhibition of RRF- and EF-G-dependent splitting of the bacterial post-termination ribosome
Molecular mechanism of viomycin inhibition of peptide elongation in bacteria
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 978-983, 2016
On the pH Dependence of Class-1 RF-Dependent Termination of mRNA Translation
Ingår i Journal of Molecular Biology, s. 1848-1860, 2015
- DOI för On the pH Dependence of Class-1 RF-Dependent Termination of mRNA Translation
- Ladda ner fulltext (pdf) av On the pH Dependence of Class-1 RF-Dependent Termination of mRNA Translation
DNA Template Dependent Accuracy Variation of Nucleotide Selection in Transcription
Ingår i PLOS ONE, 2015
- DOI för DNA Template Dependent Accuracy Variation of Nucleotide Selection in Transcription
- Ladda ner fulltext (pdf) av DNA Template Dependent Accuracy Variation of Nucleotide Selection in Transcription
Ingår i Journal of Biological Chemistry, s. 3440-3454, 2015
Determinants of the Rate of mRNA Translocation in Bacterial Protein Synthesis
Ingår i Journal of Molecular Biology, s. 1835-1847, 2015
- DOI för Determinants of the Rate of mRNA Translocation in Bacterial Protein Synthesis
- Ladda ner fulltext (pdf) av Determinants of the Rate of mRNA Translocation in Bacterial Protein Synthesis
Accuracy of initial codon selection by aminoacyl-tRNAs on the mRNA-programmed bacterial ribosome
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 9602-9607, 2015
- DOI för Accuracy of initial codon selection by aminoacyl-tRNAs on the mRNA-programmed bacterial ribosome
- Ladda ner fulltext (pdf) av Accuracy of initial codon selection by aminoacyl-tRNAs on the mRNA-programmed bacterial ribosome
Free RNA polymerase in Escherichia coli
Ingår i Biochimie, s. 80-91, 2015
Peptide Formation by N-Methyl Amino Acids in Translation Is Hastened by Higher pH and tRNAPro
Ingår i ACS Chemical Biology, s. 1303-1311, 2014
Thermodynamic Modeling of Variations in the Rate of RNA Chain Elongation of E-coli rrn Operons
Ingår i Biophysical Journal, s. 55-64, 2014
A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids
Ingår i RNA, s. 632-643, 2014
- DOI för A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids
- Ladda ner fulltext (pdf) av A tRNA body with high affinity for EF-Tu hastens ribosomal incorporation of unnatural amino acids
The Impact of Aminoglycosides on the Dynamics of Translation Elongation
Ingår i Cell Reports, s. 497-508, 2013
Optimal control of gene expression for fast proteome adaptation to environmental change
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 20527-20532, 2013
Optimal Strategy for Rapid Proteome Re-Arrangements in Bacterial Populations
Ingår i Biophysical Journal, 2013
Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1
Ingår i eLife, 2013
- DOI för Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1
- Ladda ner fulltext (pdf) av Cryo-EM visualization of the ribosome in termination complex with apo-RF3 and RF1
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 131-136, 2012
Inefficient delivery but fast peptide bond formation of unnatural l -aminoacyl-tRNAs in translation
Ingår i Journal of the American Chemical Society, s. 17955-17962, 2012
Positive allosteric feedback regulation of the stringent response enzyme RelA by its product
Ingår i EMBO Reports, s. 835-839, 2012
Activation of initiation factor 2 by ligands and mutations for rapid docking of ribosomal subunits
Ingår i EMBO Journal, s. 289-301, 2011
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 79-84, 2011
Comment on "The mechanism for activation of GTP hydrolysis on the ribosome"
Ingår i Science, s. 37, 2011
Identification of enzyme inhibitory mechanisms from steady-state kinetics
Ingår i Biochimie, s. 1623-1629, 2011
Ingår i Journal of Molecular Biology, s. 838-846, 2010
Protein synthesis: Translocation in slow motion
Ingår i Nature, s. 325-326, 2010
Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance
Ingår i Molecular Microbiology, s. 1299-1313, 2010
- DOI för Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance
- Ladda ner fulltext (pdf) av Error-prone initiation factor 2 mutations reduce the fitness cost of antibiotic resistance
Ribosomes lacking protein S20 are defective in mRNA binding and subunit association
Ingår i Journal of Molecular Biology, s. 767-776, 2010
Ingår i Biochimie, s. 12-20, 2010
tmRNA-SmpB complex mimics native aminoacyl-tRNAs in the A site of stalled ribosomes.
Ingår i Journal of Structural Biology, s. 342-348, 2010
Ingår i Journal of Molecular Biology, s. 621-626, 2009
Varying rate of RNA chain elongation during rrn transcription in Escherichia coli.
Ingår i Journal of Bacteriology, s. 3740-3746, 2009
Erythromycin resistance by L4/L22 mutations and resistance masking by drug efflux pump deficiency
Ingår i EMBO Journal, s. 736-744, 2009
Slow peptide bond formation by proline and other N-alkylamino acids in translation
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 50-54, 2009
Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 1063-1068, 2009
Drug efflux pump deficiency and drug target resistance masking in growing bacteria
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 8215-8220, 2009
Cis-acting resistance peptides reveal dual ribosome inhibitory action of the macrolide josamycin
Ingår i Biochimie, s. 989-995, 2009
The kinetics of ribosomal peptidyl transfer revisited
Ingår i Molecular Cell, s. 589-598, 2008
Complementary roles of initiation factor 1 and ribosome recycling factor in 70S ribosome splitting
Ingår i EMBO Journal, s. 1706-1717, 2008
The pretranslocation ribosome is targeted by GTP-bound EF-G in partially activated form.
Ingår i Proceedings of the National Academy of Sciences of the United States of America, s. 15678-83, 2008
Co-factor dependent conformational switching of GTPases
Ingår i Biophysical Journal, s. 1704-1715, 2008
Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM
Ingår i EMBO Journal, s. 3322-3331, 2008
The bacterial toxin ReIE induces specific mRNA cleavage in the A site of the eukaryote ribosome
Ingår i RNA, s. 233-239, 2008
Ingår i Journal of Molecular Biology, s. 1345-1358, 2007
Structure probing of tmRNA in distinct stages of trans-translation
Ingår i RNA, s. 713-722, 2007
RF3 induces ribosomal conformational changes responsible for dissociation of class I release factors
Ingår i Cell, s. 929-941, 2007
Bistable bacterial growth rate in response to antibiotics with low membrane permeability
Ingår i Physical Review Letters, 2006
How initiation factors tune the rate of initiation of protein synthesis in bacteria.
Ingår i EMBO Journal, s. 2539-50, 2006
Class-1 release factor eRF1 promotes GTP binding by class-2 release factor eRF3
Ingår i Biochimie, s. 747-757, 2006
Trigger factor binding to ribosomes with nascent peptide chains of varying lengths and sequences
Ingår i Journal of Biological Chemistry, s. 28033-28038, 2006
Rate, accuracy and cost of ribosomes in bacterial cells
Ingår i Biochimie, s. 951-961, 2006
Ingår i Molecular Cell, s. 183-193, 2006
The molecular mechanism of peptide-mediated erythromycin resistance.
Ingår i J Biol Chem, s. 6742-50, 2006
Two-step selection of mRNAs in initiation of protein synthesis.
Ingår i Mol Cell, s. 155-6, 2006
Interactions of the release factor RF1 with the ribosome as revealed by cryo-EM.
Ingår i J Mol Biol, s. 1144-53, 2006
What makes ribosome-mediated transcriptional attenuation sensitive to amino
Ingår i PloS Computational Biology, 2005
Mapping the interaction of SmpB with ribosomes by footprinting of ribosomal RNA.
Ingår i Nucleic Acids Res, s. 3529-39, 2005
Splitting of the posttermination ribosome into subunits by the concerted action of RRF and EF-G.
Ingår i Mol Cell, s. 675-86, 2005
A Time-resolved Investigation of Ribosomal Subunit Association
Ingår i Journal of Molecular Biology, s. 1243-1258, 2005
Ingår i J Biol, s. 9, 2005
Ingår i J Mol Biol, s. 16-24, 2005
Selective charging of tRNA isoacceptors induced by amino-acid starvation.
Ingår i EMBO Rep, s. 151-7, 2005
Ribosome bypassing at serine codons as a test of the model of selective transfer RNA charging.
Ingår i EMBO Rep, s. 147-50, 2005
Near-critical behavior of aminoacyl-tRNA pools in E. coli at rate-limiting supply of amino acids.
Ingår i Biophys J, s. 132-46, 2005
Mechanism for the disassembly of the posttermination complex inferred from cryo-EM studies.
Ingår i Mol Cell, s. 663-74, 2005
tmRNA-induced release of messenger RNA from stalled ribosomes.
Ingår i J Mol Biol, s. 897-905, 2005
The cryo-EM structure of a translation initiation complex from Escherichia coli.
Ingår i Cell, s. 703-12, 2005
Ingår i Mol Cell, s. 929-38, 2005
Ribosome formation from subunits studied by stopped-flow and Rayleigh light scattering
Ingår i Biol Procedure Online, 2004
Spontaneous separation of bi-stable biochemical systems into spatial domains of opposite phases
Ingår i Systems Biology, s. 230-236, 2004
Ingår i J Struct Biol, s. 283-90, 2004
Simultaneous binding of trigger factor and signal recognition particle to the E. coli ribosome.
Ingår i Biochimie, s. 495-500, 2004
Kinetics of macrolide action: the josamycin and erythromycin cases.
Ingår i J Biol Chem, s. 53506-15, 2004
Ribosome rescue by tmRNA requires truncated mRNAs.
Ingår i J Mol Biol, s. 33-41, 2004
Pre-binding of small protein B to a stalled ribosome triggers trans-translation.
Ingår i J Biol Chem, s. 25978-85, 2004
Targeting and insertion of heterologous membrane proteins in E. coli
Ingår i Biochimie, s. 659-668, 2003
Ingår i J. Cell Biology, s. 679-684, 2003
Termination of translation: interplay of mRNA, rRNAs and release factors?
Ingår i EMBO J., s. 175-182, 2003
Selective loss of charging of tRNA isoacceptors during amino acid limitation.
Ingår i Science, s. 1718-1722, 2003
Ingår i J Mol Biol, s. 1005-14, 2003
A new beginning of the end of translation
Ingår i journal, s. 85-87, 2002
Artiklar, forskningsöversikt
Ingår i Annual Review of Biophysics, s. 525-548, 2018
A recent intermezzo at the Ribosome Club
Ingår i Philosophical Transactions of the Royal Society of London. Biological Sciences, 2017
- DOI för A recent intermezzo at the Ribosome Club
- Ladda ner fulltext (pdf) av A recent intermezzo at the Ribosome Club
Medium-dependent control of the bacterial growth rate
Ingår i Biochimie, s. 643-658, 2013
Rate and accuracy of bacterial protein synthesis revisited
Ingår i Current Opinion in Microbiology, s. 141-147, 2008
The role of tRNA as a molecular spring in decoding, accommodation, and peptidyl transfer.
Ingår i FEBS Lett, s. 959-62, 2005
Control of rRNA synthesis in Escherichia coli: a systems biology approach.
Ingår i Microbiol Mol Biol Rev, s. 639-68, 2004
A cryo-electron microscopic study of ribosome-bound termination factor RF2
Ingår i Nature, s. 87-90, 2003
Böcker
Structural aspects of protein synthesis
World Scientific, 2013
Kapitel i böcker, delar av antologi
Large DNA Template Dependent Error Variation During Transcription
Ingår i Biophysics and Structure to Counter Threats and Challenges, s. 39-57, Springer Netherlands, 2014
Translation Termination, the Prion [Psi+], and Ribosomal Recycling
Ingår i Translational Control in Biology and Medicine, s. 173-196, Cold Spring Harbor Laboratory Press, 2007
Mesoscopic kinetics and its applications in protein synthesis
Ingår i Systems Biology, s. 95-118, Springer-Verlag GmbH, 2005
Konferensbidrag
Rate and accuracy of ribosomal peptidyl transfer
Ingår i Ribosomes, s. 225-235, 2011
Initiation of bacterial protein synthesis with wild type and novel mutants of initiation factor
Ingår i Ribosomes, s. 129-141, 2011
Ingår i ASPECTS OF PHYSICAL BIOLOGY: BIOLOGICAL WATER, PROTEIN SOLUTIONS, TRANSPORT AND REPLICATION, s. 189-213, 2008